Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MEP --- Cathepsin B | 3R-(2-oxo-1-(2-oxo-2-(4-oxopent-2-enylamino)ethyl)-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl 4-chloro-2-(trifluoromethyl)phenylcarbamate | Drug Info |
| MEP --- Cathepsin B | 3-[(R)-2-Cyano-2-((S)-3-phenyl-2-phenylamino-propionylamino)-ethoxymethyl]-benzoic acid | Drug Info |
| MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-5-bromothiophene-2-carboxamide | Drug Info |
| MEP --- Cathepsin B | (4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid (3R)-2-oxo-1-{[4-oxo-(1S)-1-phenethylpent-2-enylcarbamoyl]-methyl}-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethylester | Drug Info |
| MEP --- Cathepsin B | 2-Chloro-5-[(R)-2-cyano-2-((S)-2-phenylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-benzoic acid | Drug Info |
| MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-(2-methoxyethyl)piperazin-1-yl)thiazol-4-yl)benzamide | Drug Info |
| MEP --- Cathepsin B | (S)-N-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethyl]-3-(naphthalene-1-sulfonylamino)-succinamic acid methyl ester | Drug Info |
| MEP --- Cathepsin B | 4-[(R)-2-Cyano-2-((S)-2-phenylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-benzoic acid | Drug Info |
| MEP --- Cathepsin B | (S)-2-((S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2,2,2-trifluoroethylamino)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methylpentanamide | Drug Info |
| MEP --- Cathepsin B | (S)-N-[(R)-Cyano-(3-tetrazol-1-yl-benzyloxymethyl)-methyl]-2-(3-oxo-1,3-dihydro-isobenzofuran-5-ylamino)-3-m-tolyl-propionamide | Drug Info |
| MEP --- Cathepsin B | N-Cyanomethyl-2-diphenylacetylamino-3-phenyl-propionamide | Drug Info |
| MEP --- Cathepsin B | 3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-propionylamino)-ethoxymethyl]-benzoic acid | Drug Info |
| MEP --- Cathepsin B | (S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-4-ylamino)-pentanoic acid cyanomethyl-amide | Drug Info |
| MEP --- Cathepsin B | amino(4-(2-(3-carboxyoxirane-2-carboxamido)-4-methylpentanamido)butylamino)methaniminium | Drug Info |
| MEP --- Cathepsin B | {1-[2-Oxo-1-phenethyl-3-(3-phenyl-propylsulfanyl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid pyridin-3-ylmethyl ester | Drug Info |
| MEP --- Cathepsin B | 9-(3-hydroxy-propyl)-6-(4-methyl-benzylamino)-9H-purine-2-carbonitrile | Drug Info |
| MEP --- Cathepsin B | ethyl 3-((S)-3-((S)-2-(benzyloxycarbonyl)-3-phenylpropanamido)-2-oxo-4-phenylbutylthio)propanoate | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-3-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)-1-oxopropan-2-yl)benzamide | Drug Info |
| MEP --- Cathepsin B | N-[(3R)-1-cyano-3-pyrrolidinyl]-N'-phenylurea | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-2-phenylethyl)-2-cyclopropyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)acetamide | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid ((S)-1-benzyl-2-oxo-ethyl)-amide | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-2-phenylethyl)-3-phenyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)propanamide | Drug Info |
| MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-tert-butylpiperazin-1-yl)thiazol-4-yl)benzamide | Drug Info |
| MEP --- Cathepsin B | benzyl (S)-1-((S)-4-(2-(methylamino)-2-oxoethylthio)-3-oxo-1-phenylbutan-2-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate | Drug Info |
| MEP --- Cathepsin B | (4-chloro-2-trifluoromethyl-phenyl)-carbamic acid 1-{[3-benzenesulfonyl-(1S)-1-phenethyl-allylcarbamoyl]-methyl}-(3R)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethylester | Drug Info |
| MEP --- Cathepsin B | 9-(3-hydroxypropyl)-6-(3-(pyridin-3-yl)benzylamino)-9H-purine-2-carbonitrile | Drug Info |
| MEP --- Cathepsin B | 4'-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| MEP --- Cathepsin B | (S)-2-(3-Benzyl-ureido)-3-methyl-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| MEP --- Cathepsin B | 6-(3-(furan-3-yl)benzylamino)-9-(3-hydroxypropyl)-9H-purine-2-carbonitrile | Drug Info |
| MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-3-bromobenzamide | Drug Info |
| MEP --- Cathepsin B | (4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid 1-[(3-cyano-allylcarbamoyl)-methyl]-(3R)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl ester | Drug Info |
| MEP --- Cathepsin B | 1-(1-(3,5-dichlorophenyl)-3-phenylpropylidene)thiosemicarbazide | Drug Info |
| MEP --- Cathepsin B | {(S)-1-[2,5-Dioxo-1-(3-phenyl-propyl)-piperidin-4-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester | Drug Info |
| MEP --- Cathepsin B | 2-(p-tolyl(3-(trifluoromethyl)phenyl)methylene)hydrazinecarbothioamide | Drug Info |
| MEP --- Cathepsin B | 2-tert-Butyloxycarbonylamino-6,7-methylenedioxy-1-(4-methoxyphenyl)-2H-isoquinolin-3-one | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(pyridin-4-yl)biphenyl-4-yl)ethylamino)pentanamide | Drug Info |
| MEP --- Cathepsin B | Cyclohexanecarboxylic acid [(S)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-2-phenylethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide | Drug Info |
| MEP --- Cathepsin B | (S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide | Drug Info |
| MEP --- Cathepsin B | benzyl (S)-4-methyl-1-oxo-1-((S)-3-oxo-1-phenyl-4-(3-phenylpropylthio)butan-2-ylamino)pentan-2-ylcarbamate | Drug Info |
| MEP --- Cathepsin B | [(3-Bromophenyl)-(2,4-ditrifluoromethylphenyl)-ketone]thiosemicarbazone | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-1-oxo-3-(3-(pyridin-2-yl)phenyl)propan-2-yl)benzamide | Drug Info |
| MEP --- Cathepsin B | 2-Amino-6,7-dibenzyloxy-1-(4-methoxyphenyl)-2Hisoquinolin-3-one | Drug Info |
| MEP --- Cathepsin B | (S)-1-{(S)-2-[((2S,3S)-3-Isobutylcarbamoyl-oxiranecarbonyl)-amino]-3-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid | Drug Info |
| MEP --- Cathepsin B | [(S)-1-(1-Isobutyl-2,5-dioxo-piperidin-4-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| MEP --- Cathepsin B | (S)-N-(1-(cyanomethylamino)-1-oxo-3-(3-(pyridazin-3-yl)phenyl)propan-2-yl)benzamide | Drug Info |
| MEP --- Cathepsin B | 2-(1-(3-chlorophenyl)-3-phenylpropylidene)hydrazinecarbothioamide | Drug Info |
| MEP --- Cathepsin B | N-(cyanomethyl)-3-(3,5-dimethylphenyl)-2-(2,2-diphenylacetamido)propanamide | Drug Info |
| MEP --- Cathepsin B | 5-{(R)-2-Cyano-2-[(S)-2-(3-oxo-1,3-dihydro-isobenzofuran-5-ylamino)-3-m-tolyl-propionylamino]-ethoxymethyl}-2-fluoro-benzoic acid | Drug Info |
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