Target Validation Information
TTD ID	T62292
Target Name	GABA(A) receptor alpha-3 (GABRA3)
Type of Target	Successful
Drug Potency against Target	(2E,4S)-4-ammoniopent-2-enoate	Drug Info	IC50 = 2600 nM	[8]
	(4R)-4-ammoniopentanoate	Drug Info	IC50 = 2500 nM	[8]
	(4S)-4-ammoniopentanoate	Drug Info	IC50 = 2900 nM	[8]
	3-(3-Methyl-butoxy)-9H-beta-carboline	Drug Info	Ki = 3000 nM	[7]
	3-(benzyloxy)-9H-pyrido[3,4-b]indole	Drug Info	Ki = 3000 nM	[7]
	3-(hexa-1,3-dienyloxy)-9H-pyrido[3,4-b]indole	Drug Info	Ki = 859 nM	[7]
	3-Butoxy-9H-beta-carboline	Drug Info	Ki = 245 nM	[7]
	3-Ethoxy-9H-beta-carboline	Drug Info	Ki = 28.2 nM	[7]
	3-Isobutoxy-9H-beta-carboline	Drug Info	Ki = 139.2 nM	[7]
	3-Propoxy-9H-beta-carboline	Drug Info	Ki = 68.8 nM	[7]
	5-[(1R)-1-ammonioethyl]isoxazol-3-olate	Drug Info	IC50 = 9500 nM	[8]
	5-[(1S)-1-ammonioethyl]isoxazol-3-olate	Drug Info	IC50 = 5800 nM	[8]
	6-benzyl-3-ethoxycarbonyl-4-quinolone	Drug Info	Ki = 7.2 nM	[4]
	6-bromo-3-ethoxycarbonyl-4-quinolone	Drug Info	Ki = 26 nM	[4]
	6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone	Drug Info	Ki = 89 nM	[4]
	9H-beta-Carboline-3-carboxylic acid ethyl ester	Drug Info	Ki = 5.7 nM	[7]
	AMENTOFLAVONE	Drug Info	Ki = 6 nM	[1]
	Beta-Carboline-3-carboxylic acid t-butyl ester	Drug Info	Ki = 18.9 nM	[7]
	CI-218872	Drug Info	Ki = 1161 nM	[7]
	Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate	Drug Info	Ki = 34 nM	[7]
	GSK683699	Drug Info	Ki = 200 nM	[9]
	L-655708	Drug Info	Ki = 11 nM	[2]
	MRK016	Drug Info	Ki = 0.2 nM	[3]
	Ro-15-3505	Drug Info	Ki = 9.2 nM	[6]
	Ro-4938581	Drug Info	Ki = 14 nM	[5]
	Ro-4938581	Drug Info	Ki = 80 nM	[5]
	RY-066	Drug Info	Ki = 48 nM	[11]
	Sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate	Drug Info	Ki = 116 nM	[7]
	[3H]Ro154513	Drug Info	Ki = 2.5 nM	[10]
References
REF 1	Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4.
REF 2	3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor li... J Med Chem. 2004 Mar 25;47(7):1807-22.
REF 3	7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-a... J Med Chem. 2005 Nov 17;48(23):7089-92.
REF 4	4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33.
REF 5	The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment... Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4.
REF 6	The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15;18(22):7731-8.
REF 7	Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64.
REF 8	gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83.
REF 9	New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide. J Med Chem. 1980 Jun;23(6):702-4.
REF 10	Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABA... J Med Chem. 1996 Apr 26;39(9):1928-34.
REF 11	Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines a... J Med Chem. 1998 Oct 8;41(21):4130-42.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.