Drug Information
Drug General Information | Top | |||
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Drug ID |
D01RLF
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Former ID |
DNC011393
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Drug Name |
9H-beta-Carboline-3-carboxylic acid ethyl ester
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Synonyms |
Ethyl beta-carboline-3-carboxylate; beta-CCE; 74214-62-3; Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate; beta-Carboline-3-carboxylic acid ethyl ester; UNII-HYW8K5N21Y; Ethyl 9H-pyrido(3,4-b)indole-3-carboxylate; HYW8K5N21Y; Ro 15-2538; CHEMBL11709; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, ethyl ester; MLS000069492; CHEMBL454606; KOVRZNUMIKACTB-UHFFFAOYSA-N; SMR000059107; 9H-Pyrido[3,4-b]indole-3-carboxylic acid, ethyl ester; b-cce; Ethylbeta-carboline-3-carboxylate; Beta CCE
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C14H12N2O2
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Canonical SMILES |
CCOC(=O)C1=NC=C2C(=C1)C3=CC=CC=C3N2
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InChI |
1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3
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InChIKey |
KOVRZNUMIKACTB-UHFFFAOYSA-N
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CAS Number |
CAS 74214-62-3
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:92850
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Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1], [2] |
GABA(A) receptor alpha-2 (GABRA2) | Target Info | Inhibitor | [2] | |
GABA(A) receptor alpha-3 (GABRA3) | Target Info | Inhibitor | [2] | |
GABA(A) receptor alpha-5 (GABRA5) | Target Info | Inhibitor | [2] | |
GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1], [2] | |
Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1], [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
Iron uptake and transport | ||||
SIDS Susceptibility Pathways |
References | Top | |||
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REF 1 | beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic a... J Med Chem. 1983 Apr;26(4):499-503. | |||
REF 2 | Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. |
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