Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O9MG
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| Former ID |
DNC003524
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| Drug Name |
L-655708
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| Synonyms |
130477-52-0; CHEMBL52030; NCGC00025115-02; Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate; Lopac0_000700; SCHEMBL5533646; YKYOQIXTECBVBB-AWEZNQCLSA-N; MolPort-003-983-605; HMS3262K21; ZINC2584032; Tox21_500700; MFCD02684528; BN0287; BDBM50067424; AKOS024456530; FG-8094; API0007742; LP00700; CCG-204785; CS-4943; NCGC00261385-01; NCGC00025115-04; NCGC00025115-03; HY-14426; KB-78047; EU-0100700; L-655,708, >
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H19N3O4
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| Canonical SMILES |
CCOC(=O)C1=C2C3CCCN3C(=O)C4=C(N2C=N1)C=CC(=C4)OC
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| InChI |
1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
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| InChIKey |
YKYOQIXTECBVBB-AWEZNQCLSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [2] |
| GABA(A) receptor alpha-2 (GABRA2) | Target Info | Inhibitor | [2] | |
| GABA(A) receptor alpha-3 (GABRA3) | Target Info | Inhibitor | [2] | |
| GABA(A) receptor alpha-5 (GABRA5) | Target Info | Inhibitor | [2] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [2] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4238). | |||
| REF 2 | 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor li... J Med Chem. 2004 Mar 25;47(7):1807-22. | |||
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