Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D4MM
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| Former ID |
DNC011247
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| Drug Name |
Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate
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| Synonyms |
CHEMBL1269786; iodo-betaCCE; ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate; SCHEMBL7380021; LTYUPBZLKIUGQX-UHFFFAOYSA-N; BDBM50329629; 6-iodo-beta-carboline-3-carboxylic-acid-ethylester; 6-Iodo-beta-carbolin-3-carboxylic acid ethyl ester
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H11IN2O2
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| Canonical SMILES |
CCOC(=O)C1=NC=C2C(=C1)C3=C(N2)C=CC(=C3)I
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| InChI |
1S/C14H11IN2O2/c1-2-19-14(18)12-6-10-9-5-8(15)3-4-11(9)17-13(10)7-16-12/h3-7,17H,2H2,1H3
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| InChIKey |
LTYUPBZLKIUGQX-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor alpha-2 (GABRA2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor alpha-3 (GABRA3) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor alpha-5 (GABRA5) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. | |||
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