Target Regulator(s) Information (Transcription Factor)
Target General Information | Top | ||||
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Target ID | T15334 | Target Info | |||
Target Name | Cholesteryl ester transfer protein (CETP) | ||||
Synonyms | Lipid transfer protein I; Cholesterol ester transfer protein | ||||
Target Type | Clinical trial Target | ||||
Gene Name | CETP | ||||
Biochemical Class | Bactericidal permeability increasing protein | ||||
UniProt ID |
The Transcription Factors (TFs) Regulating This Target | Top | ||||
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TF Name | Delta transcription factor (YY-1) homodimer | ||||
Classification | Superclass | Zinc-coordinating DNA-binding domains | |||
Class | Cys2His2 zinc finger domain | ||||
Family | Ubiquitous factors | ||||
Regulation Mechanism | CETPpromoterfragments contain some elements, which contain the binding of the transcription factors, including YY-1. | [1] | |||
Evidence Score (E-score) | 2 | + | |||
1 | Electrophoretic Mobility Shift Assay | [1] | |||
2 | Electrophoretic Mobility Shift Assay | [5] | |||
UniProt ID | |||||
Sequence |
MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHG
GGGGHGHAGHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDG LRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKKGGGKKS GKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEE QIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPH KGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGC GKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ |
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The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
Cyclins | [+] 1 Cyclins Co-regulated By This TF | + | |||
1 | Proliferating cell nuclear antigen (PCNA) | Clinical trial Target | Target Info | [7] | |
Cytokines / Cytokine receptors | [+] 1 Cytokines / Cytokine receptors Co-regulated By This TF | + | |||
1 | Interferon-gamma (IFNG) | Successful Target | Target Info | [8] | |
Ester hydrolases | [+] 1 Ester hydrolases Co-regulated By This TF | + | |||
1 | M-phase inducer phosphatase 3 (MPIP3) | Literature-reported Target | Target Info | [9] | |
Glycoproteins | [+] 1 Glycoproteins Co-regulated By This TF | + | |||
1 | Cholesteryl ester transfer protein (CETP) | Clinical trial Target | Target Info | [1] | |
Oxidoreductases | [+] 1 Oxidoreductases Co-regulated By This TF | + | |||
1 | Dopamine beta hydroxylase (DBH) | Clinical trial Target | Target Info | [10] | |
Transcription factors | [+] 1 Transcription factors Co-regulated By This TF | + | |||
1 | Cellular tumor antigen p53 (TP53) | Clinical trial Target | Target Info | [11] | |
Transferrins | [+] 1 Transferrins Co-regulated By This TF | + | |||
1 | Transferrin (TF) | Clinical trial Target | Target Info | [12] | |
TF Name | Sp1 transcription factor (SP1) | ||||
Classification | Superclass | Zinc-coordinating DNA-binding domains | |||
Class | Cys2His2 zinc finger domain | ||||
Family | Ubiquitous factors | ||||
Regulation Type | Increase | ||||
Regulation Mechanism | Sp1 and other HepG2 nuclear proteins bind to CETP gene promoter site A. | [2] | |||
Evidence Score (E-score) | 2 | + | |||
1 | DNase I Footprint Analysis, Electrophoretic Mobility Shift Assay | [2] | |||
2 | Electrophoretic Mobility Shift Assay | [6] | |||
UniProt ID | |||||
Sequence |
MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSP
LALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTS KEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQ TVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQG LANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVT SGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVS GLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPL SGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQ TITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS GIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTR REACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTW SYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALS VGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINI SGNGF |
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The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
Acyltransferases | [+] 2 Acyltransferases Co-regulated By This TF | + | |||
1 | Glutathione S-transferase P (GSTP1) | Clinical trial Target | Target Info | [13] | |
2 | Lecithin-cholesterol acyltransferase (LCAT) | Clinical trial Target | Target Info | [14] | |
Apolipoproteins | [+] 2 Apolipoproteins Co-regulated By This TF | + | |||
1 | Apolipoprotein A-I (APOA1) | Clinical trial Target | Target Info | [15] | |
2 | Apolipoprotein E (APOE) | Clinical trial Target | Target Info | [16] | |
Apoptosis regulators | [+] 1 Apoptosis regulators Co-regulated By This TF | + | |||
1 | Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) | Clinical trial Target | Target Info | [17] | |
Carbon-nitrogen hydrolases | [+] 1 Carbon-nitrogen hydrolases Co-regulated By This TF | + | |||
1 | Adenosine deaminase (ADA) | Successful Target | Target Info | [18] | |
Caveolin proteins | [+] 1 Caveolin proteins Co-regulated By This TF | + | |||
1 | Caveolin 1 (CAV1) | Literature-reported Target | Target Info | [19] | |
Collagens | [+] 1 Collagens Co-regulated By This TF | + | |||
1 | Collagen I (COL1A2) | Clinical trial Target | Target Info | [20] | |
Cytokines / Cytokine receptors | [+] 2 Cytokines / Cytokine receptors Co-regulated By This TF | + | |||
1 | Erythropoietin Receptor (EPOR) | Successful Target | Target Info | [21] | |
2 | Interferon-gamma (IFNG) | Successful Target | Target Info | [8] | |
Ester hydrolases | [+] 2 Ester hydrolases Co-regulated By This TF | + | |||
1 | Acetylcholinesterase (AChE) | Successful Target | Target Info | [22] | |
2 | M-phase inducer phosphatase 3 (MPIP3) | Literature-reported Target | Target Info | [23] | |
G protein-coupled receptors | [+] 3 G protein-coupled receptors Co-regulated By This TF | + | |||
1 | 5-HT 1A receptor (HTR1A) | Successful Target | Target Info | [24] | |
2 | C-X-C chemokine receptor type 4 (CXCR4) | Successful Target | Target Info | [25] | |
3 | Thromboxane A2 receptor (TBXA2R) | Successful Target | Target Info | [26] | |
Glycoproteins | [+] 2 Glycoproteins Co-regulated By This TF | + | |||
1 | Cholesteryl ester transfer protein (CETP) | Clinical trial Target | Target Info | [2] | |
2 | Tracheobronchial mucin 5A (MUC5AC) | Literature-reported Target | Target Info | [27] | |
Growth factors | [+] 4 Growth factors Co-regulated By This TF | + | |||
1 | Platelet-derived growth factor A (PDGFA) | Clinical trial Target | Target Info | [28] | |
2 | Platelet-derived growth factor B (PDGFB) | Clinical trial Target | Target Info | [29] | |
3 | Thrombomodulin (THBD) | Discontinued Target | Target Info | [30] | |
4 | Transforming growth factor beta 1 (TGFB1) | Successful Target | Target Info | [31] | |
Immunoglobulins | [+] 1 Immunoglobulins Co-regulated By This TF | + | |||
1 | Intercellular adhesion molecule ICAM-1 (ICAM1) | Successful Target | Target Info | [32] | |
Integrins | [+] 1 Integrins Co-regulated By This TF | + | |||
1 | Integrin alpha-2 (ITGA2) | Clinical trial Target | Target Info | [33] | |
Kinases | [+] 5 Kinases Co-regulated By This TF | + | |||
1 | Casein kinase II alpha (CSNK2A1) | Clinical trial Target | Target Info | [34] | |
2 | Epidermal growth factor receptor (EGFR) | Successful Target | Target Info | [35] | |
3 | Serine/threonine-protein kinase pim-1 (PIM1) | Clinical trial Target | Target Info | [36] | |
4 | Telomerase reverse transcriptase (TERT) | Clinical trial Target | Target Info | [37] | |
5 | Thymidine kinase 1 (TK1) | Successful Target | Target Info | [38] | |
Lipoprotein receptors | [+] 1 Lipoprotein receptors Co-regulated By This TF | + | |||
1 | Low-density lipoprotein receptor (LDL-R) | Successful Target | Target Info | [39] | |
Lyases | [+] 2 Lyases Co-regulated By This TF | + | |||
1 | Histidine decarboxylase (HDC) | Clinical trial Target | Target Info | [40] | |
2 | Leukotriene C4 synthase (LTC4S) | Patented-recorded Target | Target Info | [41] | |
Nuclear hormone receptors | [+] 2 Nuclear hormone receptors Co-regulated By This TF | + | |||
1 | Hepatocyte nuclear factor 4-alpha (HNF4A) | Literature-reported Target | Target Info | [42] | |
2 | Progesterone receptor (PGR) | Successful Target | Target Info | [43] | |
Oxidoreductases | [+] 9 Oxidoreductases Co-regulated By This TF | + | |||
1 | Arachidonate 12-lipoxygenase (12-LOX) | Literature-reported Target | Target Info | [44] | |
2 | Bacterial Triosephosphate isomerase (Bact TPI) | Literature-reported Target | Target Info | [45] | |
3 | Catalase (CAT) | Clinical trial Target | Target Info | [46] | |
4 | Cholesterol desmolase (CYP11A1) | Successful Target | Target Info | [47] | |
5 | Dopamine beta hydroxylase (DBH) | Clinical trial Target | Target Info | [48] | |
6 | Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) | Clinical trial Target | Target Info | [49] | |
7 | Heme oxygenase 1 (HMOX1) | Clinical trial Target | Target Info | [50] | |
8 | Nitric-oxide synthase endothelial (NOS3) | Clinical trial Target | Target Info | [51] | |
9 | Superoxide dismutase Cu-Zn (SOD Cu-Zn) | Clinical trial Target | Target Info | [52] | |
Peptidases | [+] 4 Peptidases Co-regulated By This TF | + | |||
1 | Caspase-8 (CASP8) | Patented-recorded Target | Target Info | [53] | |
2 | Cathepsin D (CTSD) | Clinical trial Target | Target Info | [54] | |
3 | Dibasic-processing enzyme (Furin) | Preclinical Target | Target Info | [55] | |
4 | Neutral endopeptidase (MME) | Clinical trial Target | Target Info | [56] | |
Pro-neuropeptides | [+] 1 Pro-neuropeptides Co-regulated By This TF | + | |||
1 | Neuropeptide Y (NPY) | Literature-reported Target | Target Info | [57] | |
Small GTPases | [+] 1 Small GTPases Co-regulated By This TF | + | |||
1 | GTPase HRas (HRAS) | Literature-reported Target | Target Info | [58] | |
Somatotropin / Prolactins | [+] 1 Somatotropin / Prolactins Co-regulated By This TF | + | |||
1 | Somatotropin (GH1) | Clinical trial Target | Target Info | [59] | |
Transcription factors | [+] 2 Transcription factors Co-regulated By This TF | + | |||
1 | Transcription factor Sp1 (SP1) | Clinical trial Target | Target Info | [60] | |
2 | Wilms tumor protein (WT1) | Clinical trial Target | Target Info | [61] | |
Transferrins | [+] 1 Transferrins Co-regulated By This TF | + | |||
1 | Transferrin (TF) | Clinical trial Target | Target Info | [12] | |
Zinc-fingers | [+] 1 Zinc-fingers Co-regulated By This TF | + | |||
1 | Utrophin (UTRN) | Clinical trial Target | Target Info | [62] | |
TF Name | Retinoid X receptor alpha (RXR-A) | ||||
Classification | Superclass | Zinc-coordinating DNA-binding domains | |||
Class | Cys4 zinc finger of nuclear receptor type | ||||
Family | Thyroid hormone receptor-like factors | ||||
Subfamily | Retinoid X receptors | ||||
Regulation Type | Increase | ||||
Regulation Mechanism | Hepatic CETP gene expression is increased in response to dietary hypercholesterolemia, an effect that is mediated by the activity of liver X receptor/retinoid X receptor (LXR/RXR) on a direct repeat 4 element in the CETP promoter. | [3] | |||
Evidence Score (E-score) | 1 | + | |||
1 | Electrophoretic Mobility Shift Assay | [3] | |||
UniProt ID | |||||
Sequence |
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT |
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The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
Acyltransferases | [+] 1 Acyltransferases Co-regulated By This TF | + | |||
1 | Carnitine O-palmitoyltransferase I (CPT1B) | Successful Target | Target Info | [63] | |
Apolipoproteins | [+] 4 Apolipoproteins Co-regulated By This TF | + | |||
1 | Apolipoprotein A-I (APOA1) | Clinical trial Target | Target Info | [64] | |
2 | Apolipoprotein A-II (APOA2) | Literature-reported Target | Target Info | [65] | |
3 | Apolipoprotein C-III (ApoCIII) | Clinical trial Target | Target Info | [66] | |
4 | Apolipoprotein E (APOE) | Clinical trial Target | Target Info | [67] | |
Ester hydrolases | [+] 1 Ester hydrolases Co-regulated By This TF | + | |||
1 | Lipoprotein lipase (LPL) | Successful Target | Target Info | [68] | |
G protein-coupled receptors | [+] 1 G protein-coupled receptors Co-regulated By This TF | + | |||
1 | Extracellular calcium-sensing receptor (CASR) | Successful Target | Target Info | [69] | |
Glycoproteins | [+] 2 Glycoproteins Co-regulated By This TF | + | |||
1 | Cholesteryl ester transfer protein (CETP) | Clinical trial Target | Target Info | [3] | |
2 | Phospholipid transfer protein (PLTP) | Literature-reported Target | Target Info | [70] | |
Kinases | [+] 1 Kinases Co-regulated By This TF | + | |||
1 | Epidermal growth factor receptor (EGFR) | Successful Target | Target Info | [71] | |
Mitochondrial carriers | [+] 1 Mitochondrial carriers Co-regulated By This TF | + | |||
1 | Mitochondrial uncoupling protein 3 (UCP3) | Clinical trial Target | Target Info | [27] | |
Nuclear hormone receptors | [+] 4 Nuclear hormone receptors Co-regulated By This TF | + | |||
1 | Hepatocyte nuclear factor 4-alpha (HNF4A) | Literature-reported Target | Target Info | [42] | |
2 | Retinoic acid receptor beta (RARB) | Successful Target | Target Info | [72] | |
3 | Retinoic acid receptor gamma (RARG) | Successful Target | Target Info | [73] | |
4 | Retinoic acid receptor RXR-gamma (RXRG) | Successful Target | Target Info | [74] | |
TF Name | C/EBP alpha (CEBPA) homodimer | ||||
Classification | Superclass | Basic Domains | |||
Class | Leucine zipper factors (bZIP) | ||||
Family | C/EBP-like factors | ||||
Regulation Type | Increase | ||||
Regulation Mechanism | The human CETP gene promoter contains a sequence that closely resembles the binding site for the transcription factor CCAAT/enhancer-binding protein (C/EBP). This site is capable of binding C/EBP, as shown by electrophoretic mobility shift and DNase I footprint analyses. C/EBP may play an important role in the proper maintenance of CETP gene promoter activity. | [4] | |||
Evidence Score (E-score) | 1 | + | |||
1 | Electrophoretic Mobility Shift Assay, DNase I Footprint Analysis | [4] | |||
UniProt ID | |||||
Sequence |
MESADFYEAEPRPPMSSHLQSPPHAPSSAAFGFPRGAGPAQPPAPPAAPEPLGGICEHET
SIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAVGPTGGGGGGDFDYPGAPAGPGGAVM PGGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFP YQPPPPPPPSHPHPHPPPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPA LGAAGLPGPGSALKGLGAAHPDLRASGGSGAGKAKKSVDKNSNEYRVRRERNNIAVRKSR DKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA |
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The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
Apolipoproteins | [+] 3 Apolipoproteins Co-regulated By This TF | + | |||
1 | Apolipoprotein A-II (APOA2) | Literature-reported Target | Target Info | [75] | |
2 | Apolipoprotein B-100 (APOB) | Clinical trial Target | Target Info | [76] | |
3 | Apolipoprotein E (APOE) | Clinical trial Target | Target Info | [77] | |
Calcium-binding proteins | [+] 1 Calcium-binding proteins Co-regulated By This TF | + | |||
1 | Calgranulin B (S100A9) | Clinical trial Target | Target Info | [78] | |
Coagulation factors | [+] 1 Coagulation factors Co-regulated By This TF | + | |||
1 | Coagulation factor VIII (F8) | Successful Target | Target Info | [79] | |
Cytokines / Cytokine receptors | [+] 1 Cytokines / Cytokine receptors Co-regulated By This TF | + | |||
1 | Granulocyte colony-stimulating factor receptor (G-CSF-R) | Successful Target | Target Info | [80] | |
Glycoproteins | [+] 1 Glycoproteins Co-regulated By This TF | + | |||
1 | Cholesteryl ester transfer protein (CETP) | Clinical trial Target | Target Info | [4] | |
Integrins | [+] 1 Integrins Co-regulated By This TF | + | |||
1 | Integrin alpha-2 (ITGA2) | Clinical trial Target | Target Info | [81] | |
Lipoprotein receptors | [+] 1 Lipoprotein receptors Co-regulated By This TF | + | |||
1 | Low-density lipoprotein receptor (LDL-R) | Successful Target | Target Info | [82] | |
Oxidoreductases | [+] 1 Oxidoreductases Co-regulated By This TF | + | |||
1 | Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2) | Literature-reported Target | Target Info | [83] | |
Peptidases | [+] 1 Peptidases Co-regulated By This TF | + | |||
1 | Coagulation factor IX (F9) | Successful Target | Target Info | [84] | |
Somatotropin / Prolactins | [+] 1 Somatotropin / Prolactins Co-regulated By This TF | + | |||
1 | Prolactin (PRL) | Discontinued Target | Target Info | [85] | |
Transferrins | [+] 1 Transferrins Co-regulated By This TF | + | |||
1 | Transferrin (TF) | Clinical trial Target | Target Info | [86] | |
TF Name | COUP transcription factor 2 (COUP-TF2) homodimer | ||||
Classification | Superclass | Zinc-coordinating DNA-binding domains | |||
Class | Cys4 zinc finger of nuclear receptor type | ||||
Regulation Type | Decrease | ||||
Regulation Mechanism | Overexpression of ARP-1 or Ear-3/COUP-TF with CETP promoter/chloramphenicol acetyltransferase gene reporter plasmids repressed transcriptional activity of the CETP promoter containing sequences up to -300, but activated transcription in the context of larger constructs containing sequences up to -636. | [2] | |||
Evidence Score (E-score) | 1 | + | |||
1 | DNase I Footprint Analysis, Electrophoretic Mobility Shift Assay | [2] | |||
UniProt ID | |||||
Sequence |
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQ
GGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSG YISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITD QVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVE KLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRF GKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ |
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The Genes (Co-regulated by This TF) Grouped Based on Their Biochemical Classes | |||||
Apolipoproteins | [+] 4 Apolipoproteins Co-regulated By This TF | + | |||
1 | Apolipoprotein A-I (APOA1) | Clinical trial Target | Target Info | [87] | |
2 | Apolipoprotein A-II (APOA2) | Literature-reported Target | Target Info | [88] | |
3 | Apolipoprotein B-100 (APOB) | Clinical trial Target | Target Info | [89] | |
4 | Apolipoprotein C-III (ApoCIII) | Clinical trial Target | Target Info | [90] | |
Glycoproteins | [+] 1 Glycoproteins Co-regulated By This TF | + | |||
1 | Cholesteryl ester transfer protein (CETP) | Clinical trial Target | Target Info | [2] | |
Nuclear hormone receptors | [+] 1 Nuclear hormone receptors Co-regulated By This TF | + | |||
1 | Hepatocyte nuclear factor 4-alpha (HNF4A) | Literature-reported Target | Target Info | [42] |
References | Top | ||||
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REF 1 | Sterol regulatory element binding protein-1 activates the cholesteryl ester transfer protein gene in vivo but is not required for sterol up-regulation of gene expression. J Biol Chem. 1998 Aug 28;273(35):22409-14. | ||||
REF 2 | Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. J Biol Chem. 1995 Dec 15;270(50):29916-22. | ||||
REF 3 | The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem. 2001 Jul 6;276(27):24767-73. | ||||
REF 4 | The CCAAT/enhancer-binding protein trans-activates the human cholesteryl ester transfer protein gene promoter. J Biol Chem. 1992 Nov 5;267(31):22336-9. | ||||
REF 5 | Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines. Exp Cell Res. 2005 Apr 15;305(1):83-98. | ||||
REF 6 | New functional promoter polymorphism, CETP/-629, in cholesteryl ester transfer protein (CETP) gene related to CETP mass and high density lipoprotei... Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):507-15. | ||||
REF 7 | Transcription factors RFX1/EF-C and ATF-1 associate with the adenovirus E1A-responsive element of the human proliferating cell nuclear antigen promoter. Nucleic Acids Res. 1995 Sep 25;23(18):3732-41. | ||||
REF 8 | The nuclear factor YY1 suppresses the human gamma interferon promoter through two mechanisms: inhibition of AP1 binding and activation of a silence... Mol Cell Biol. 1996 Sep;16(9):4744-53. | ||||
REF 9 | Characterization of the TATA-less core promoter of the cell cycle-regulated cdc25C gene. Nucleic Acids Res. 1997 Dec 15;25(24):4933-9. | ||||
REF 10 | Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine beta-hydroxylase gene. J Neurosci. 1996 Jul 1;16(13):4102-12. | ||||
REF 11 | YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity. Mol Cell Biol. 1996 Oct;16(10):5933-45. | ||||
REF 12 | YY1 and Sp1 transcription factors bind the human transferrin gene in an age-related manner. J Gerontol A Biol Sci Med Sci. 1996 Jan;51(1):B66-75. | ||||
REF 13 | Sp1-mediated transcriptional activation of the human Pi class glutathione S-transferase promoter. J Biol Chem. 1996 Jan 12;271(2):1054-60. | ||||
REF 14 | Binding and functional effects of transcription factors Sp1 and Sp3 on the proximal human lecithin:cholesterol acyltransferase promoter. J Lipid Res. 1998 May;39(5):969-77. | ||||
REF 15 | Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription. J Biol Chem. 1995 Mar 24;270(12):7004-10. | ||||
REF 16 | Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors. J Biol Chem. 1990 Jun 5;265(16):9496-504. | ||||
REF 17 | Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. J Biol Chem. 1999 Jan 15;274(3):1801-13. | ||||
REF 18 | Sp1 is essential for both enhancer-mediated and basal activation of the TATA-less human adenosine deaminase promoter. Nucleic Acids Res. 1994 Feb 25;22(4):669-77. | ||||
REF 19 | Intracellular cholesterol transport in synchronized human skin fibroblasts. Biochemistry. 1999 Feb 23;38(8):2506-13. | ||||
REF 20 | Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem. 1994 May 20;269(20):14828-34. | ||||
REF 21 | Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs. Nucleic Acids Res. 1995 Aug 11;23(15):3041-9. | ||||
REF 22 | Transcription factor repression and activation of the human acetylcholinesterase gene. J Biol Chem. 1995 Oct 6;270(40):23511-9. | ||||
REF 23 | Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1. Nucleic Acids Res. 1995 Oct 11;23(19):3822-30. | ||||
REF 24 | The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J Biol Chem. 1996 Feb 23;271(8):4417-30. | ||||
REF 25 | Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J Biol Chem. 1998 Feb 20;273(8):4754-60. | ||||
REF 26 | Novel role for Sp1 in phorbol ester enhancement of human platelet thromboxane receptor gene expression. J Biol Chem. 1996 Aug 16;271(33):19696-704. | ||||
REF 27 | The human uncoupling protein-3 gene promoter requires MyoD and is induced by retinoic acid in muscle cells. FASEB J. 2000 Nov;14(14):2141-3. | ||||
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