Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T61400 | Target Info | |||
| Target Name | Dihydroorotate dehydrogenase (DHODH) | ||||
| Synonyms |
Dihydroorotate oxidase; Dihydroorotate dehydrogenase (quinone), mitochondrial; DHOdehase; DHODH
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|
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| Target Type | Successful Target | ||||
| Gene Name | DHODH | ||||
| Biochemical Class | CH-CH donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 162 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Cyclosporin A
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|
Phase 2 Trial | Compound Info | ||
| Synonyms |
cyclosporin A; cyclosporine; Neoral; Cyclosporin; Ciclosporine; Sandimmun; Sang-35
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-bromo-2-methylphenyl)-2-naphthamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-(4-bromo-2-methylphenyl)-2-naphthamide; N-(4-bromo-2-methylphenyl)naphthalene-2-carboxamide; 429627-41-8; naphthamide compound 2; AC1LGMF3; ChemBridge compound no. 2; CHEMBL217951; CTK1C8257; BDBM14710; DTXSID40356417; MolPort-002-208-677; ZINC342068; STK222653; AKOS000202277; MCULE-5174732523; AG-670/40742092; 2-Naphthalenecarboxamide, N-(4-bromo-2-methylphenyl)-
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|
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| Activity |
Ki = 50900 nM
|
[2] | |||
| Compound Name |
N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide; 331846-06-1; benzamide compound 3; AC1LGPDD; Asinex compound no. 6; Oprea1_295970; Oprea1_049304; CHEMBL217893; SCHEMBL18120561; CTK1B1898; BDBM14711; DTXSID50355395; MolPort-001-496-487; ZINC304714; STK020274; AKOS003270080; MCULE-1240652686; ST50693254; Benzamide, N-(3,5-dichlorophenyl)-2-methyl-3-nitro-; N-(3,5-dichlorophenyl)(2-methyl-3-nitrophenyl)carboxamide
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|
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| Activity |
Ki = 64400 nM
|
[2] | |||
| Compound Name |
Diethyl 2-((biphenyl-3-ylamino)methylene)malonate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217897; ZINC14956351; diethyl [(biphenyl-3-ylamino)methylidene]propanedioate
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|
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| Activity |
IC50 = 104200 nM
|
[2] | |||
| Compound Name |
5-Pyridin-4-yl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118645; BDBM50066578; 3-[[4-(Trifluoromethyl)phenyl]amino]-5-(4-pyridinyl)-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Hexyl-isoxazole-4-carbothioic acid (4-trifluoromethyl-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306831; BDBM50071408
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
6-Methyl-2-[4-[5-(pyrrolidine-1-carbonyl)pyridin-3-yl]phenyl]-1H-benzimidazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593981; BDBM50096205
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|
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
5-Cyclopropyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307768; BDBM50071407
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-Benzyl-N'-[4-(pyrrolidine-1-ylcarbonyl)phenyl]-1-(4-methoxyphenyl)-1H-pyrazole-3,5-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359171; BDBM50119490
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
5-Methyl-4-(4-trifluoromethylphenyl)aminothiocarbonylisoxazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL69131; SCHEMBL8484731; BDBM50071395; 5-Methyl-isoxazole-4-carbothioic acid (4-trifluoromethyl-phenyl)-amide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carbothioamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(3,5-Bis-trifluoromethyl-phenylamino)-5-methyl-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332480; BDBM50066606
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-N-Benzhydryl-5-N-benzyl-1-(4-methoxyphenyl)pyrazole-3,5-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341694; BDBM50119486; 1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzhydryl-amide 5-benzylamide
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
5-Cyclohexyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL305052; BDBM50071386
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S,3S,4S)-2-Cyano-3-(4-((3-fluorophenyl)ethynyl)phenyl)-4-(hydroxymethyl)-N-propylazetidine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
BRD7539; CHEMBL2362347; BRD-7539; BDBM50231826; BRD-K31857539-001-01-9
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
1-(4-Chlorophenyl)-5-N-phenyl-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341925; SCHEMBL16742069; BDBM50119489; 1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[Methyl[4-(trifluoromethyl)phenyl]amino]-5-methyl-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119780; BDBM50066579; 5-Methyl-3-[methyl-(4-trifluoromethyl-phenyl)-amino]-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Hexyl-isoxazole-4-carbothioic acid (4-cyano-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71958; BDBM50071388
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(5-Methyl-4-phenyl-1H-pyrazol-3-yl)-(4-trifluoromethyl-phenyl)-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326960; BDBM50066587; N-[4-(Trifluoromethyl)phenyl]-4-phenyl-5-methyl-1H-pyrazole-3-amine
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Tert-Butyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL305284; BDBM50071409
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(4-Chloro-3-fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784575; DSM215; SCHEMBL1681690; BDBM50345405; N-(4-chloro-3-fluoro-phenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
5-Tert-Butyl-isoxazole-4-carbothioic acid (4-trifluoromethyl-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL305002; BDBM50071391
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Phenyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445375; BDBM50066607
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Methyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL69668; BDBM50071405
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Methyl-N-[4-(trifluoromethylsulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784566; DSM217; SCHEMBL1681616; BDBM50345415; 5-Methyl-N-(4-(trifuoromethylthio)phenyl)-[1,2,4]triazolo[1,5-a]-pyrimidin-7-amine
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-(3-Bromo-4-trifluoromethyl-phenylamino)-5-methyl-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118997; BDBM50066611
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Ethylamino-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334117; BDBM50066608
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Methyl-3-(4-trifluoromethyl-benzylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331399; BDBM50066581; 3-[[4-(Trifluoromethyl)benzyl]amino]-5-methyl-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Pyridin-3-yl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118647; BDBM50066592; 3-[[4-(Trifluoromethyl)phenyl]amino]-5-(3-pyridinyl)-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-N-(oxolan-2-ylmethyl)-5-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL442030; BDBM50119484
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-N-Benzyl-1-(4-chlorophenyl)-5-N-phenylpyrazole-3,5-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL143628; SCHEMBL16742039; BDBM50119488; X1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-phenylamide
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|
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| Activity |
Ki = 50000 nM
|
[5] | |||
| Compound Name |
5-Tert-Butyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118586; BDBM50066596; 3-[[4-(Trifluoromethyl)phenyl]amino]-5-tert-butyl-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Hexyl-isoxazole-4-carbothioic acid (4-dimethylamino-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71795; BDBM50071410
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Tert-Butyl-isoxazole-4-carbothioic acid (4-trifluoromethoxy-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71934; BDBM50071404
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Hydroxy-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333276; BDBM50066589
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-Chlorophenyl)-5-N-(4-piperidin-1-ylphenyl)-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142444; BDBM50119483
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
5-Hexyl-isoxazole-4-carbothioic acid (4-trifluoromethoxy-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68539; BDBM50071397
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Cyclohexyl-isoxazole-4-carbothioic acid (4-trifluoromethoxy-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303167; BDBM50071385
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Amino-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119193; SCHEMBL18040267; BDBM50066602; 5-amino-3-[4-(trifluoromethyl)anilino]-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(4-Aminophenyl)amino]-5-methyl-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121898; BDBM50066584; 3-(4-Amino-phenylamino)-5-methyl-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrothiophene-3-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
ethyl 2-((4-chlorophenyl)amino)-4-oxo-4,5-dihydrothiophene-3-carboxylate; CBMicro_047882; regid7978180; CHEMBL1732938; SCHEMBL14985049; HMS2420A20; ZINC350502; STK158531; AKOS000670569; MCULE-1259714285; BIM-0047762.P001; CS-0117892; ethyl 2-(4-chloroanilino)-4-oxo-thiophene-3-carboxylate
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|
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
5-Furan-2-yl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118727; BDBM50066610; 3-[[4-(Trifluoromethyl)phenyl]amino]-5-(2-furanyl)-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Thiophen-2-yl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119676; BDBM50066605; 3-[[4-(Trifluoromethyl)phenyl]amino]-5-(2-thienyl)-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Methyl-3-(2-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118455; BDBM50066593; 3-[[2-(Trifluoromethyl)phenyl]amino]-5-methyl-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(5-Bromoindan-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784591; DSM220; SCHEMBL1681733; BDBM50345392; N-(5-bromo-2,3-dihydro-1H-inden-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; N-(5-Bromo-2,3-dihydro-1H-inden-2-yl)-5-methyl-[1,2,4]triazolo-[1,5-a]pyrimidin-7-amine
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-Carbamoyl-5-[3-(3-methylphenyl)phenyl]benzoic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
AMX08; CHEMBL382039; SCHEMBL18120863; BDBM16103; 3''-Methyl-5-carbamoyl-1,1':3',1''-terbenzene-3-carboxylic acid; 5-carbamoyl-3 -methyl-1,1 :3 ,1 -terphenyl-3-carboxylic acid
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| Activity |
Ki = 50000 nM
|
[9] | |||
| Compound Name |
N-(5-Fluoroindan-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784590; DSM218; SCHEMBL1681578; BDBM50345389; N-(5-fluoro-2,3-dihydro-1H-inden-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; N-(5-Fluoro-2,3-dihydro-1H-inden-2-yl)-5-methyl-[1,2,4]triazolo-[1,5-a]pyrimidin-7-amine
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
5-Tert-Butyl-isoxazole-4-carbothioic acid (4-cyano-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL67656; BDBM50071390
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Cyclohexyl-isoxazole-4-carbothioic acid (4-cyano-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71320; BDBM50071402
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Methyl-3-phenylamino-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119697; BDBM50066597; 3-(Phenylamino)-5-methyl-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Cyclopentyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118489; BDBM50066582; 3-[[4-(Trifluoromethyl)phenyl]amino]-5-cyclopentyl-1H-pyrazole-4-carbonitrile
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Methyl-3-(3-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL119564; BDBM50066600; 3-[[3-(Trifluoromethyl)phenyl]amino]-5-methyl-1H-pyrazole-4-carbonitrile
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Cyclohexyl-isoxazole-4-carbothioic acid (4-trifluoromethyl-phenyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL71682; BDBM50071399
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Methyl-3-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118921; SCHEMBL10488661; BDBM50066604; 3-[[4-(Trifluoromethyl)phenyl]amino]-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1,3-Dimethyl-5-(4-trifluoromethyl-phenylamino)-1H-pyrazole-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL118499; BDBM50066595; AKOS013062045; 1,3-Dimethyl-5-[[4-(trifluoromethyl)phenyl]amino]-1H-pyrazole-4-carbonitrile
Click to Show/Hide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-Chlorophenyl)-3-N-[(4-methylphenyl)methyl]-5-N-phenylpyrazole-3,5-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL143868; BDBM50119492; 1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(4-methyl-benzylamide) 5-phenylamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
5-N-Benzyl-1-(4-methoxyphenyl)-3-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141338; BDBM50119482
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-N-Benzyl-1-(4-chlorophenyl)-5-N-(2-methylpropyl)pyrazole-3,5-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141304; BDBM50119487; 1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-(isobutyl-amide)
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-N-Benzyl-5-N-(4-carbamoylphenyl)-1-(4-chlorophenyl)pyrazole-3,5-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL342220; BDBM50119481; 1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[(4-carbamoyl-phenyl)-amide]
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
(2S,3S,4S)-3-(3',4'-Bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-cyano-4-(hydroxymethyl)-N-propylazetidine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BRD9185; CHEMBL4064731; BRD-9185; BDBM50231827; HY-120924; CS-0079645; BRD-K43789185-001-01-7
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Chembl4226738
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461896
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-N-(2-methylpropyl)-5-N-[4-(pyrrolidine-1-carbonyl)phenyl]pyrazole-3,5-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL143345; BDBM50119491
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[4-(2-Acetamidophenyl)phenyl]-1H-benzimidazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593984; BDBM50096207
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[4] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-5-methylquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217919; BDBM50201898
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[11] | |||
| Compound Name |
2-[4-[5-(Pyrrolidin-1-ylmethyl)pyridin-3-yl]phenyl]-1H-benzimidazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593990; BDBM50096146
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[4] | |||
| Compound Name |
2-[4-(4-Acetamidophenyl)phenyl]-1H-benzimidazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593986; BDBM50096143
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[4] | |||
| Compound Name |
2-(4-Bromophenyl)-3-hydroxy-7,8-dimethylquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374432; BDBM50201914
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[11] | |||
| Compound Name |
Ethyl (Z)-2-cyano-3-[(9-ethylcarbazol-3-yl)amino]prop-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218703; SCHEMBL18120679; BDBM50268993
Click to Show/Hide
|
||||
| Activity |
Ki = 60400 nM
|
[2] | |||
| Compound Name |
2-[(4-Methoxyphenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177854; BDBM50397824
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[12] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-7,8-dimethylquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267210; BDBM50201902
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[11] | |||
| Compound Name |
2-Aminoethanol;5-[4-(3-methoxycarbonylphenyl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3901641; BDBM50211947
Click to Show/Hide
|
||||
| Activity |
Ki = 73500 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[4-(5-carboxynaphthalen-2-yl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3981004; BDBM50211697
Click to Show/Hide
|
||||
| Activity |
Ki = 76000 nM
|
[13] | |||
| Compound Name |
(Z)-N-[4-(3-Chlorophenyl)-2-(trifluoromethyl)phenyl]-2-cyano-3-hydroxybut-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484602
Click to Show/Hide
|
||||
| Activity |
IC50 = 86600 nM
|
[14] | |||
| Compound Name |
2-Benzylsulfanyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135703; 2-(benzylsulfanyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol; 2-(benzylthio)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one; 2-(benzylsulfanyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one; 2-Benzylthio-5-methyl-s-triazolo[1,5-a]pyrimidin-7-ol; 2-BENZYLTHIO-5-METHYL-S-TRIAZOLO(1,5-A)PYRIMIDIN-7-OL; MLS000552058; SCHEMBL20160737; CTK4J4607; KS-00002YTX; DTXSID90365731; HMS2158M07; HMS3323C01; 2-(benzylsulfanyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol; BDBM50397822; STK217664; STK596878; ZINC18219592; AKOS002265075; AKOS005076966; ZINC100126423; MCULE-6126276816; SDCCGSBI-0139152.P001; SMR000145783; ST50167121; 11D-541; 2-(Benzylthio)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol; 2-Benzylsulfanyl-5-methyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one; 5-methyl-2-(phenylmethylthio)-4,8-dihydro-1,2,4-triazolo[1,5-a]pyrimidin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[12] | |||
| Compound Name |
3-[3-(4-Tert-butylphenyl)phenyl]-5-carbamoylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AMX01; CHEMBL202667; BDBM16104; 4 -tert-butyl-5-carbamoyl-1,1 :3 ,1 -terphenyl-3-carboxylic acid; 4''-tert-Butyl-5-carbamoyl-1,1':3',1''-terbenzene-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 90000 nM
|
[9] | |||
| Compound Name |
3-Carbamoyl-5-[3-[4-(trifluoromethyl)phenyl]phenyl]benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-carbamoyl-5-{3-[4-(trifluoromethyl)phenyl]phenyl}benzoic acid; AMX10; CHEMBL264901; BDBM16105; 5-carbamoyl-4 -(trifluoromethyl)-1,1 :3 ,1 -terphenyl-3-carboxylic acid; 4''-(Trifluoromethyl)-5-carbamoyl-1,1':3',1''-terbenzene-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 90000 nM
|
[9] | |||
| Compound Name |
Ethyl (E)-3-(dibenzothiophen-2-ylamino)-2-nitroprop-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073917; BDBM50269004
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
5-Methyl-N-tetralin-6-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784578; DSM159; SCHEMBL12808199; BDBM50345441; 5-Methyl-N-(5,6,7,8-tetrahydronaphthalen-2yl)-[1,2,4]triazolo-[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(4-Isopropylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL600255; MLS000116597; DSM103; SCHEMBL13730353; HMS2263C07; ZINC2499433; BDBM50345421; 5-methyl-N-(4-propan-2-ylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; AKOS000482451; MCULE-8494846446; SMR000093564; SJ000066425
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-(1,1-Difluoropropyl)-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956289; SCHEMBL14053657; BDBM50365226
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(4-Tert-butylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784561; DSM129; SCHEMBL13730827; ZINC7735882; BDBM50345420; MCULE-7418935407
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
7-Methyl-N-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrimidin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172226; MMV011229; 7-methyl-N-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrimidin-5-amine; DSM151; SCHEMBL1681168; BDBM50396723
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
N-(4-Ethylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1714424; CBMicro_034673; Cambridge id 5837577; Oprea1_075381; Oprea1_271724; MLS001204397; DSM101; CHEMBL4581497; SCHEMBL13730345; HMS2846B10; BDBM50345402; STK846925; ZINC85945221; (4-Ethyl-phenyl)-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-amine; AKOS000676814; AKOS005627412; ZINC102491773; MCULE-3016647769; SMR000523872; BIM-0034748.P001; SR-01000358056; SR-01000358056-1; 4-ethyl-N-[(7E)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ylidene]aniline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Isopropyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956268; SCHEMBL1681411; BDBM50365242; 5-methyl-2-(1-methylethyl)-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine; 5-methyl-2-propan-2-yl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-Methyl-N-(2-naphthyl)pyrazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172234; DSM68; SCHEMBL13730760; BDBM50396725; 5-methyl-N-naphthalen-2-ylpyrazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-(1,1-Difluoropropyl)-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956288; SCHEMBL1681422; BDBM50365227
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784579; DSM127; SCHEMBL13730961; ZINC4822135; BDBM50345403; AKOS000676658; MCULE-5996126250; N-(Benzo[d][1,3]dioxol-5-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
7-Methyl-N-(2-naphthyl)imidazo[1,2-a]pyrimidin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172236; DSM71; SCHEMBL13730583; BDBM50396726; 7-methyl-N-naphthalen-2-ylimidazo[1,2-a]pyrimidin-5-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-Tert-butyl-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956273; BDBM50365239
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-Methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DSM74; DSM-74; 5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; BRD-K89082768-001-01-7; CHEMBL492529; SCHEMBL4099123; BDBM28817; ZINC40423124; DB08008; triazolopyrimidine-based compound, DSM74; EC-000.2310; Q27097235
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[4-Chloro-3-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452392; SCHEMBL4103081; BDBM28837; DSM-124; ZINC4923154; AKOS000482229; CCG-317480; MCULE-8269218726; triazolopyrimidine-based compound, DSM124; F9995-4281
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-Benzylsulfanyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177862; BDBM50397815
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172238; DSM154; BDBM50396728
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
N-(3,4-Bis(trifluoromethyl)phenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784576; N-[3,4-bis(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; DSM238; SCHEMBL12807980; BDBM50345404
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Butan-2-yl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956274; BDBM50365238; 5-methyl-2-sec-butyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-Methyl-N-[4-methyl-3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437480; SCHEMBL4105506; BDBM28839; DSM-122; ZINC40822742; triazolopyrimidine-based compound, DSM122; (5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-(4-methyl-3-trifluoromethyl-phenyl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
5-Methyl-N-(4-pentylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784557; DSM116; SCHEMBL13730644; BDBM50345399; N-(4-Pentylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
CID 53392537
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956272; BDBM50365240; 2-tert-butyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Ethyl (Z)-3-[(9-ethylcarbazol-3-yl)amino]-2-nitroprop-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094476; BDBM50269003
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[3-Fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492720; SCHEMBL4096045; BDBM28843; DSM-125; triazolopyrimidine-based compound, DSM125
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(4-Butylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784556; DSM104; SCHEMBL13730148; BDBM50345400
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(4-Chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(4-Chloro-phenyl)-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-amine; Oprea1_506464; Oprea1_721317; MLS001204456; CHEMBL452465; cid_741601; DSM-89; SCHEMBL4090635; BDBM28814; HMS2834I21; ZINC9122216; STK324948; STL038242; AKOS000676545; AKOS005691950; ZINC102491792; MCULE-3975680212; triazolopyrimidine-based compound, DSM89; SMR000523870; ST50025212; SR-01000422734; SR-01000422734-1; N-(4-chlorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; (4-chlorophenyl)(7-methyl(4-hydro-1,2,4-triazolo[1,5-a]pyrimidin-5-yl))amine; 4-chloro-N-[(7E)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ylidene]aniline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(4-Ethynylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784564; DSM157; SCHEMBL13730315; BDBM50345417
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-(Trifluoromethyl)-N-(4-trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784712; DSM235; SCHEMBL12807981; BDBM50345435; 5-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-Chloro-N-(4-trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784713; DSM252; BDBM50345436; AKOS034076351; 5-chloro-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Dsm-265
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DSM265; UNII-0Q42P4YI6B; 0Q42P4YI6B; CHEMBL1956285; GTPL9644; SCHEMBL14053411; BCP17584; EX-A3571; DSM-265; DSM 265; BDBM50365230; DB12397; SB17069; HY-100184; CS-0018179; A17069; Q27237094
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-Cyclopropyl-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956279; SCHEMBL14053758; BDBM50365233
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(4-Bromophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_581626; CHEMBL492520; DSM-98; SCHEMBL4105140; BDBM28815; ZINC1242850; STL148265; AKOS001632677; AKOS005748208; ZINC101063755; MCULE-6879528647; triazolopyrimidine-based compound, DSM98; EU-0004886; SR-01000080620; 4-p-Bromoanilino-6-methyl-1,3,3a,7-tetrazaindene; SR-01000080620-1; N-(4-bromophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; 4-bromo-N-[(7Z)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ylidene]aniline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-Ethoxy-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956473; SCHEMBL14053316; BDBM50365220
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-Methyl-N-(4-vinylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784563; DSM115; SCHEMBL13730214; BDBM50345418; N-(4-ethenylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; N-(4-Vinylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Ethyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956264; SCHEMBL4097550; BDBM50365244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-Cyclopropyl-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956278; SCHEMBL1681423; BDBM50365234; 2-cyclopropyl-5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-Ethoxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956472; SCHEMBL1681659; BDBM50365221; 2-(ethyloxy)-5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(3,4-Dimethylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(3,4-dimethylphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; Oprea1_326525; Oprea1_871089; MLS001204388; CHEMBL447995; SCHEMBL4096412; CHEMBL4526077; BDBM28840; DSM-123; ZINC1303238; STK988263; STL040149; AKOS000676752; AKOS005693662; ZINC102491474; MCULE-5419152068; (3,4-Dimethyl-phenyl)-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-amine; SMR000523867; triazolopyrimidine-based compound, DSM123; ST50303722; AB00980822-01; Z74773113; N-(3,4-dimethylphenyl)-N-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(4-Cyclopropylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784562; DSM316; SCHEMBL12807954; BDBM50345419
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
CID 53392883
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956470; BDBM50365223; N-(3-chlorophenyl)-2-ethoxy-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(1,1-Difluoroethyl)-5-Methyl-N-[4-(Trifluoromethyl)phenyl][1,2,4]triazolo[1,5-A]pyrimidin-7-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1738786; SCHEMBL1681243; DSM-267; BDBM50365231; Q27459093
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-(2,3-Dihydro-1H-inden-5-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TCMDC-123574; CHEMBL586157; DSM160; SCHEMBL13730329; ZINC4898044; BDBM50345443; AKOS027249145; CCG-330881; MCULE-8891445555; SR-01000330866; SR-01000330866-1; Z74773017; N-indan-5-yl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; N-(2,3-Dihydro1H-inden-5-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
CID 53392704
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956286; BDBM50365229; N-(4-chlorophenyl)-2-(1,1-difluoropropyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
CID 53392619
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956276; BDBM50365236; N-(4-chlorophenyl)-2-cyclopropyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(3-Fluoro-4-methylphenyl)-6,7-dihydro-5H-cyclopenta[d][1,2,4]triazolo[1,5-a]pyrimidin-8-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784717; DSM174; SCHEMBL12808062; BDBM50345440; ZINC15786673; AKOS000481791; CCG-191894; MCULE-2474757306
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
CID 53392884
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956471; BDBM50365222; N-(4-chlorophenyl)-2-ethoxy-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-Methyl-6-propyl-N-p-tolyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784716; DSM166; BDBM50345439; ZINC13364969; AKOS000478824; CCG-130227; MCULE-2175606174; NCGC00323812-01; AB01318682-02; 5-methyl-6-propyl-N-(p-tolyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; 5-methyl-N-(4-methylphenyl)-6-propyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-[(3,4-Dichlorophenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178511; BDBM50397814
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
6-Ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784714; SCHEMBL12807979; BDBM50345437; ZINC15785760; CCG-191091; MCULE-1397172550; 6-ethyl-N-(4-isopropylphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[4-Bromo-3-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL13380; SCHEMBL4092058; BDBM28838; DSM-128; triazolopyrimidine-based compound, DSM128
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
CID 53392620
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956277; BDBM50365235; N-(3-chlorophenyl)-2-cyclopropyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-Ethyl-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956265; SCHEMBL14053416; BDBM50365243; 2-ethyl-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-Ethyl-N-(4-trifluoromethyl)phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784711; DSM247; BDBM50345434; 5-ethyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-Methyl-2-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956290; SCHEMBL12807972; DSM-195; BDBM50365225
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-(4-Chlorophenyl)-2-(1,1-difluoroethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956283; SCHEMBL14132886; BDBM50365232
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(3-Fluoro-4-methylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000033310; CHEMBL492719; DSM-83; SCHEMBL4096383; BDBM28842; HMS2351P14; ZINC804526; CCG-28378; AKOS000482442; MCULE-8966816632; triazolopyrimidine-based compound, DSM83; SMR000014073; EU-0025210; SJ000066413; Z118514972; N-(3-fluoro-4-methyl-phenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; N-(3-fluoro-4-methylphenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-Butan-2-yl-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956275; BDBM50365237
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-4-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172237; DSM155; BDBM50396727
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
5-Methyl-N-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492530; DSM-87; SCHEMBL4101302; BDBM28819; ZINC1368901; AKOS000791478; MCULE-9789558912; triazolopyrimidine-based compound, DSM87; (5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-(4-trifluoromethoxy-phenyl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
5-Methyl-N-(4-propylphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784555; DSM102; SCHEMBL13729911; BDBM50345401; N-(4-Propylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[3,5-Difluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784577; N-(3,5-Difluoro-4-(trifluoromethyl)phenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; DSM190; SCHEMBL12808071; DSM-190; BDBM50345442
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
2-Isopropyl-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956269; SCHEMBL14053248; BDBM50365241
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(4-Pentafluorosulfenylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784567; DSM161; SCHEMBL13732023; BDBM50345414; 5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(3-Chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000116675; CHEMBL499296; SCHEMBL4101165; BDBM28810; HMS2263F22; ZINC804508; AKOS000481429; MCULE-1539320304; triazolopyrimidine-based compound, DSM75; SMR000093639; 4-m-Chloroanilino-6-methyl-1,3,3a,7-tetrazaindene; N-(3-chlorophenyl)-5-methyl[1,2,4]triazolo-[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
6-Ethyl-5-methyl-N-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784715; 6-ethyl-5-methyl-N-[4-(trifluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; DSM172; SCHEMBL12808069; BDBM50345438; ZINC21093230; MCULE-1873699857; 6-ethyl-5-methyl-N-[4-(trifluoromethoxy)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
CID 60166620
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178512; BDBM50397813; N-benzyl-2-benzylsulfanyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N,N-Dimethyl-N'-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-benzene-1,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GNF-Pf-2905; CHEMBL582694; Cambridge id 5845326; Oprea1_146294; Oprea1_429486; MLS001209357; DSM130; SCHEMBL13730868; HMS2816D05; BDBM50345412; SMR000515981; SR-01000422737; SR-01000422737-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Methyl-N-(2-naphthyl)-9H-purin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172233; DSM23; SCHEMBL4013214; BDBM50396724; 2-methyl-N-naphthalen-2-yl-7H-purin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
CID 53392705
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956287; BDBM50365228; N-(3-chlorophenyl)-2-(1,1-difluoropropyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-Aminoethanol;5-[4-(2-methoxycarbonylphenyl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3956130; BDBM50211696
Click to Show/Hide
|
||||
| Activity |
Ki = 102000 nM
|
[13] | |||
| Compound Name |
Diethyl [(1h-indazol-5-ylamino)methylidene]propanedioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435137; SCHEMBL18120680
Click to Show/Hide
|
||||
| Activity |
IC50 = 123300 nM
|
[2] | |||
| Compound Name |
2-Aminoethanol;5-[2-(4-carboxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944370; BDBM50211692
Click to Show/Hide
|
||||
| Activity |
Ki ~ 125000 nM
|
[13] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218083; BDBM50201933
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[11] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-3,4-difluoro-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218520
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[20] | |||
| Compound Name |
8-Bromo-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384039; BDBM50201926
Click to Show/Hide
|
||||
| Activity |
IC50 = 132000 nM
|
[11] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-6-(thiophen-3-yl)quinoline-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387288; BDBM50201946
Click to Show/Hide
|
||||
| Activity |
IC50 = 134000 nM
|
[11] | |||
| Compound Name |
6-(4-Carboxyphenyl)-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216706; BDBM50201941
Click to Show/Hide
|
||||
| Activity |
IC50 = 135000 nM
|
[11] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-trifluoromethylquinoline-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219364; BDBM50201938
Click to Show/Hide
|
||||
| Activity |
IC50 = 136000 nM
|
[11] | |||
| Compound Name |
2-Aminoethanol;5-[2-[6-(methoxymethoxy)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917382; BDBM50211694
Click to Show/Hide
|
||||
| Activity |
Ki = 139000 nM
|
[13] | |||
| Compound Name |
8-Chloro-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384543; BDBM50201895
Click to Show/Hide
|
||||
| Activity |
IC50 = 141000 nM
|
[11] | |||
| Compound Name |
2-Aminoethanol;2,4-dioxo-5-[2-[3-(trifluoromethyl)phenyl]ethyl]-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899009; BDBM50211745
Click to Show/Hide
|
||||
| Activity |
Ki = 142000 nM
|
[13] | |||
| Compound Name |
Cinchophen
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Phenylquinoline-4-carboxylic acid; 2-Phenyl-4-quinolinecarboxylic acid; Cinchopen; 2-Phenylcinchoninic acid; Cinconal; Atophan; Cinchophene; Phenoquin; Quinofen; Quinophan; Quinophen; Tervalon; Atofan; Cinchophenic acid; Aciphenochinolinium; Polyphlogin; Aminophan; Artexin; Cincosal; Ikterosan; Mylofanol; Phenophan; Rhematan; Rheumin; Tophosan; Traubofan; Viophan; Agotan; Alutyl; Artam; Atigoa; Atocin; Tophol; Vantyl; Aciphenochinoline; CINCOPHEN; 2-Phenylcinchonic acid; 4-Quinolinecarboxylic acid, 2-phenyl-; Cinchoninic acid, 2-phenyl-; 2-Phenyl-quinoline-4-carboxylic acid; NSC 2617; UNII-39Y533Z02M; MLS000053018; CHEMBL348000; MFCD00006750; 39Y533Z02M; NCGC00018221-06; NCGC00018221-08; Acifenokinolin; Artamin; SMR000059017; Aciphenochinolinum; DSSTox_CID_20705; DSSTox_RID_79555; DSSTox_GSID_40705; Cincofene [DCIT]; Cinchophenum; Cincofene; Cincofeno; WLN: T66 BNJ CR & EVQ; Cincofeno [INN-Spanish]; Cinchophene [INN-French]; Cinchophenum [INN-Latin]; Phenylcinchoninic Acid; HSDB 2085; 2-Phenylquinoline-4-carboxlic acid; SR-01000000141; EINECS 205-067-1; BRN 0192803; Cinchophen [INN:BAN:NF]; Rheumatan; Alutyo; AI3-15400; Cinchophen (BAN); Cincain (TN); ACMC-209bpl; Opera_ID_819; N-Cyclohexyl-2-phenyl-4-chinolincarboxamid; Cambridge id 5117240; TimTec1_001239; Oprea1_652483; SCHEMBL25519; 5-22-03-00484 (Beilstein Handbook Reference); MLS000069591; MLS001074296; DTXSID0040705; CTK0H5112; NSC2617; HMS1537I07; HMS2236H09; HMS3264N13; HMS3369G13; HMS3652D09; Pharmakon1600-01504508; ZINC125047; HY-B0972; KS-00000UU3; NSC-2617; NSC70178; Tox21_110841; Tox21_400022; ANW-19447; BBL011719; BDBM50097100; CCG-34161; NSC-70178; NSC758887; SBB000885; STK076256; 2-phenyl-4-quinoline-carboxylic acid; 2-Phenylquinolinecarboxylic acid-(4); 4-Quinolinecarboxylicacid, 2-phenyl-; AKOS000264299; Tox21_110841_1; CS-4461; DB13551; MCULE-5908309566; NE10455; NSC-758887; SB18446; NCGC00018221-01; NCGC00018221-02; NCGC00018221-03; NCGC00018221-04; NCGC00018221-05; NCGC00018221-07; NCGC00018221-09; NCGC00018221-10; NCGC00018221-13; NCGC00021229-04; NCGC00021229-05; NCGC00021229-06; AS-56238; ST013890; 2-Phenyl-4-quinolinecarboxylic acid, 99%; SBI-0207075.P001; DB-000656; EU-0096447; FT-0623825; P1301; S4190; SW089640-2; X6853; 4-Quinolinecarboxylic acid, 2-phenyl- (9CI); A16453; D07280; AB00275103-10; AB00275103-16; AB00275103_18; AB00275103_19; AE-641/00678051; J-006195; Q5120196; SR-01000000141-2; SR-01000000141-4; BRD-K72915123-001-01-7; BRD-K72915123-001-11-6; Z56782585; F0391-0013
Click to Show/Hide
|
||||
| Activity |
IC50 = 144000 nM
|
[10] | |||
| Compound Name |
Diethyl 2-(4-toluidinomethylene)malonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Diethyl 2-((p-tolylamino)methylene)malonate; diethyl 2-((p-toluidino)methylene)malonate; CHEMBL219856; diethyl 2-[(4-methylanilino)methylidene]propanedioate; SCHEMBL5046712; KS-00001XIV; ZINC2555734; MFCD00173346; AKOS005094713; MCULE-4700142566; DB-044735; FT-0608921; 5J-032; 2-(p-Tolylaminomethylene)malonic acid diethyl ester; diethyl {[(4-methylphenyl)amino]methylidene}propanedioate; 2-(4-Methylphenylaminomethylene)malonic acid diethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 145700 nM
|
[2] | |||
| Compound Name |
2-Aminoethanol;5-[2-(4-fluoro-3-methylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908056; BDBM50211732
Click to Show/Hide
|
||||
| Activity |
Ki = 147000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-[5-(methylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947426; BDBM50211707
Click to Show/Hide
|
||||
| Activity |
Ki = 149000 nM
|
[13] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-7-methoxyquinoline-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219233; BDBM50201935
Click to Show/Hide
|
||||
| Activity |
IC50 = 151000 nM
|
[11] | |||
| Compound Name |
2-Aminoethanol;5-[2-[1-[(2-methylpropan-2-yl)oxycarbonyl]-2,3-dihydroindol-5-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976207; BDBM50211701
Click to Show/Hide
|
||||
| Activity |
Ki = 195000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 96 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
GNF-PF-85
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GNF-PF-85; 3-[(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino]naphthalen-2-ol; 3-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}amino)naphthalen-2-ol; BAS 01083131; AC1LFFF4; Oprea1_463466; Oprea1_430691; SCHEMBL4939616; CHEMBL487518; BDBM24409; ZINC267589; AKOS024371314; Triazolopyrimidine-Based Compound, 16; MCULE-8335313178; ST51007753; SR-01000326143; SR-01000326143-1; 3-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ylamino)-naphthalen-2-ol
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
Ethyl 3-(biphenyl-3-ylamino)-2-cyanoacrylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387254; ethyl (2z)-3-(biphenyl-3-ylamino)-2-cyanoprop-2-enoate
Click to Show/Hide
|
||||
| Activity |
IC50 = 219800 nM
|
[2] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-2-hydroxy-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218524
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
Chembl4228730
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461861
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-4-formyl-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218530
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-2-hydroxy-5-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218525
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N,5-Dimethyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486490; BDBM24404; Triazolopyrimidine-Based Compound, 11; N,5-dimethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
Chembl4227966
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461883
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-2-hydroxy-5-(hydroxymethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218529
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
Chembl4225152
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ZINC5719955; BDBM50461884
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
Chembl4226739
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461868
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
2-{[(6-Bromonaphthalen-2-yl)carbonyl](methyl)amino}benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372561; BDBM16095; 2-[(6-bromonaphthalene-2-)(methyl)amido]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218512
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
5-Ethyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484294; SCHEMBL4941496; BDBM24402; Triazolopyrimidine-Based Compound, 9; 5-ethyl-n-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; 5-ethyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; 5-ethyl-N-naphthalen-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-2-hydroxy-3-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218523
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-2-hydroxy-3-(hydroxymethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218527
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
4-Chloro-N-(2,2-diphenylethyl)-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218516
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
2-[(Biphenyl-4-ylcarbonyl)(methyl)amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199572; BDBM16093; 2-[methyl(4-phenylbenzene)amido]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
5,6-Dimethyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486489; SCHEMBL4935877; BDBM24403; Triazolopyrimidine-Based Compound, 10; 5,6-dimethyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; 5,6-dimethyl-N-naphthalen-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; 5,6-dimethyl-n-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-Anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(anthracen-2-yl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; CHEMBL475814; SCHEMBL4933198; JMC521864 Compund DSM2; BDBM24413; N-(anthracen-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; Triazolopyrimidine-Based Compound, 20; DB08006; Q27097232; N-(2-anthryl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-(2-Naphthyl)-5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519836; SCHEMBL4940254; BDBM24401; Triazolopyrimidine-Based Compound, 8; N-(naphthalen-2-yl)-5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; N-naphthalen-2-yl-5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
5-Bromo-N-(2,2-diphenylethyl)-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218519
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
2-Methyl-7-[(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino]chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484305; BDBM24410; Triazolopyrimidine-Based Compound, 17; 2-methyl-7-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}amino)-4H-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-3-fluoro-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217764
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
5-Methyl-N-naphthalen-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TCMDC-125840; 5-methyl-n-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; GW648495; Oprea1_485733; MLS000077665; CHEMBL475813; SCHEMBL4935254; JMC521864 Compund DSM1; CHEMBL4569279; BDBM24400; HMS2480E04; ZINC9186742; MFCD01099828; MMV011099; STK562517; Triazolopyrimidine-Based Compound, 7; AKOS005488471; AKOS030519061; ZINC102491752; MCULE-3510262811; NCGC00020041-01; NCGC00020041-02; SMR000057971; 5-methyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; (5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-naphthalen-2-yl-amine; 5-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
2-[Methyl(naphthalen-2-ylcarbonyl)amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199575; BDBM16097; AKOS002435379; 2-[methyl(naphthalene-2-)amido]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
Chembl4226410
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461862
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
N-Benzyl-5-methyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486697; BDBM24405; Triazolopyrimidine-Based Compound, 12; N-benzyl-5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
5-Methyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_363124; Oprea1_526551; CHEMBL446825; SCHEMBL18118625; BDBM24412; JMC521864 Compund DSM12; HMS1653D15; ZINC1260422; CCG-16594; STK564643; AKOS000676633; AKOS005490188; Triazolopyrimidine-Based Compound, 19; ZINC102491497; MCULE-8236944069; ST50984981; 4-Anilino-6-methyl-1,3,3a,7-tetrazaindene; (7-methyl(4-hydro-1,2,4-triazolo[1,5-a]pyrimidin-5-yl))phenylamine; N-[(7Z)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ylidene]aniline
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
5-Chloro-N-(2,2-diphenylethyl)-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218517
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-2-hydroxy-4-(hydroxymethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218528
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N-(2,2-Diphenylethyl)-2-hydroxy-5-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218522
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
3,5-Dichloro-N-(2,2-diphenylethyl)-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218518
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)quinolin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}quinolin-6-amine; CHEMBL451880; SCHEMBL4090421; BDBM24408; Triazolopyrimidine-Based Compound, 15
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
4-({5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}amino)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-[(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino]benzamide; CHEMBL487517; BDBM24406; Triazolopyrimidine-Based Compound, 13
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
3-Chloro-N-(2,2-diphenylethyl)-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3218515
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)quinolin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}quinolin-3-amine; CHEMBL503135; SCHEMBL4101989; BDBM24407; Triazolopyrimidine-Based Compound, 14
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
Chembl4228737
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461866
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
N-[(7E)-5-Methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-ylidene]naphthalen-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_128544; Oprea1_691528; CHEMBL449358; BDBM24411; ZINC6921846; STL046125; AKOS000481369; AKOS005699253; Triazolopyrimidine-Based Compound, 18; ZINC102491840; MCULE-1734827587; ST50006998; SR-01000432670; SR-01000432670-1; 5-methyl-N-(1-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; (7-methyl(4-hydro-1,2,4-triazolo[1,5-a]pyrimidin-5-yl))naphthylamine; 5-methyl-N-(naphthalen-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
Chembl4227860
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461869
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-methylquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375815; BDBM50201893
Click to Show/Hide
|
||||
| Activity |
IC50 = 212000 nM
|
[11] | |||
| Compound Name |
2-Aminoethanol;5-[4-(4-methoxycarbonylphenyl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929601; BDBM50211948
Click to Show/Hide
|
||||
| Activity |
Ki = 217000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-(2-naphthalen-1-ylethyl)-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955618; BDBM50211938
Click to Show/Hide
|
||||
| Activity |
Ki = 217000 nM
|
[13] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-6-phenylquinoline-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384983; BDBM50201922
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[11] | |||
| Compound Name |
2-Aminoethanol;5-[2-[6-(ethylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908653; BDBM50211945
Click to Show/Hide
|
||||
| Activity |
Ki = 236000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(4-ethylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3920594; BDBM50211730
Click to Show/Hide
|
||||
| Activity |
Ki = 248000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[1-(2-methoxycarbonylphenyl)triazol-4-yl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3980064; BDBM50211718
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(8-benzamidonaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942246; BDBM50211720
Click to Show/Hide
|
||||
| Activity |
Ki = 262000 nM
|
[13] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-isopropylquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218780; BDBM50201928
Click to Show/Hide
|
||||
| Activity |
IC50 = 283000 nM
|
[11] | |||
| Compound Name |
Diethyl 2-(2-toluidinomethylene)malonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
diethyl 2-[(2-methylanilino)methylidene]propanedioate; Diethyl 2-(2-toluidinmethylene)malonate; Diethyl 2-((o-tolylamino)methylene)malonate; MLS000546393; CHEMBL413583; CHEMBL3198553; SCHEMBL10864509; 2-(O-TOLYLAMINOMETHYLENE)MALONIC ACID DIETHYL ESTER; HMS2392O18; KS-00001YE0; AKOS005097340; ZINC100071689; MCULE-4043412837; SMR000169563; DB-044765; FT-0608887; 6J-022; diethyl {[(2-methylphenyl)amino]methylidene}propanedioate
Click to Show/Hide
|
||||
| Activity |
IC50 = 292200 nM
|
[2] | |||
| Compound Name |
8-Sec-butyl-2-(4-chlorophenyl)-3-hydroxyquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218727; BDBM50201916
Click to Show/Hide
|
||||
| Activity |
IC50 = 301000 nM
|
[11] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-hydroxy-8-methoxyquinoline-4-carboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385893; BDBM50201948
Click to Show/Hide
|
||||
| Activity |
IC50 = 306000 nM
|
[11] | |||
| Compound Name |
2-Aminoethanol;5-[3-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]propyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909905; BDBM50211728
Click to Show/Hide
|
||||
| Activity |
Ki > 313000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-(3-aminopropyl)-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891863; BDBM50211950
Click to Show/Hide
|
||||
| Activity |
Ki > 313000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-(3-benzamidopropyl)-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960872; BDBM50211724
Click to Show/Hide
|
||||
| Activity |
Ki > 313000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952177; BDBM50211949
Click to Show/Hide
|
||||
| Activity |
Ki > 313000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[4-(2-carboxyphenyl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910672; BDBM50211708
Click to Show/Hide
|
||||
| Activity |
Ki = 319000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;2,4-dioxo-5-[2-[4-(trifluoromethyl)phenyl]ethyl]-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3897952; BDBM50211962
Click to Show/Hide
|
||||
| Activity |
Ki = 360000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(3-methoxycarbonylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898445; BDBM50211700
Click to Show/Hide
|
||||
| Activity |
Ki = 382000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[1-(4-methoxycarbonylphenyl)triazol-4-yl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3927463; BDBM50211729
Click to Show/Hide
|
||||
| Activity |
Ki = 420000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(3-methoxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3978933; BDBM50211955
Click to Show/Hide
|
||||
| Activity |
Ki = 484000 nM
|
[13] | |||
| Compound Name |
Diethyl 2-[(3H-benzimidazol-5-ylamino)methylidene]propanedioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219855; AKOS024411784; ZINC100390458; MCULE-9821515917; diethyl 2-[(1H-benzimidazol-5-ylamino)methylene]malonate; diethyl [(1h-benzimidazol-5-ylamino)methylidene]propanedioate
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
2-Aminoethanol;5-[2-[6-(2-hydroxyethylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3919626; BDBM50211946
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[13] | |||
| Compound Name |
Diethyl 2-[(4-phenylanilino)methylidene]propanedioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373493; SCHEMBL10861116; ZINC14956344; diethyl [(biphenyl-4-ylamino)methylidene]propanedioate
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
2-Aminoethanol;5-[2-(4-carbamoylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967690; BDBM50211704
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[13] | |||
| Compound Name |
3-(Biphenyl-4-ylamino)-2-cyano-acrylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ethyl (2z)-3-(biphenyl-4-ylamino)-2-cyanoprop-2-enoate; CHEMBL374338; ethyl (2Z)-3-({[1,1'-biphenyl]-4-yl}amino)-2-cyanoprop-2-enoate; BBL103260; MFCD06660447; STL557070; ZINC12356977; AKOS005257294
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
2-Aminoethanol;5-[2-[4-(methylcarbamoyl)phenyl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946910; BDBM50211719
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(2-methoxycarbonylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926494; BDBM50211963
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(3-carbamoylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916433; BDBM50211711
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(3,5-dimethoxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3889490; BDBM50211691
Click to Show/Hide
|
||||
| Activity |
Ki = 530000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[3-(naphthalene-1-carbonylamino)propyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3900846; BDBM50211953
Click to Show/Hide
|
||||
| Activity |
Ki > 625000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[3-(naphthalene-2-carbonylamino)propyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971994; BDBM50211678
Click to Show/Hide
|
||||
| Activity |
Ki > 625000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-(2-isoquinolin-1-ylethyl)-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895455; BDBM50211964
Click to Show/Hide
|
||||
| Activity |
Ki > 625000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-[6-(dimethylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979005; BDBM50211717
Click to Show/Hide
|
||||
| Activity |
Ki = 637000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(6-carboxynaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890631; BDBM50211706
Click to Show/Hide
|
||||
| Activity |
Ki = 893000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[4-(6-carboxynaphthalen-2-yl)butyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3983745; BDBM50211713
Click to Show/Hide
|
||||
| Activity |
Ki = 986000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-[3-(methylcarbamoyl)phenyl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938116; BDBM50211937
Click to Show/Hide
|
||||
| Activity |
Ki = 1035000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-[6-(methylcarbamoyl)naphthalen-2-yl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950984; BDBM50211703
Click to Show/Hide
|
||||
| Activity |
Ki = 1111000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(3-carboxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3907470; BDBM50211923
Click to Show/Hide
|
||||
| Activity |
Ki = 1200000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(4-methoxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917513; BDBM50211793
Click to Show/Hide
|
||||
| Activity |
Ki = 1255000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(3-chlorophenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910083; BDBM50211689
Click to Show/Hide
|
||||
| Activity |
Ki = 1285000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;2,4-dioxo-5-(2-quinolin-3-ylethyl)-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908781; BDBM50211693
Click to Show/Hide
|
||||
| Activity |
Ki = 1300000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(4-methoxycarbonylphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935411; BDBM50211919
Click to Show/Hide
|
||||
| Activity |
Ki = 1395000 nM
|
[13] | |||
| Compound Name |
5-[2-(8-Acetamidonaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid;2-aminoethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971851; BDBM50212055
Click to Show/Hide
|
||||
| Activity |
Ki = 1980000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(5-carboxynaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959702; BDBM50211944
Click to Show/Hide
|
||||
| Activity |
Ki > 2500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(6-carbamoylnaphthalen-2-yl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979926; BDBM50212057
Click to Show/Hide
|
||||
| Activity |
Ki > 2500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(2-methoxyphenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908568; BDBM50211788
Click to Show/Hide
|
||||
| Activity |
Ki > 2500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-[4-(cyanomethyl)phenyl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915927; BDBM50211690
Click to Show/Hide
|
||||
| Activity |
Ki > 2500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;2,4-dioxo-5-[2-[2-(trifluoromethyl)phenyl]ethyl]-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925433; BDBM50211698
Click to Show/Hide
|
||||
| Activity |
Ki > 2500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-[2-(hydroxymethyl)phenyl]ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924053; BDBM50211699
Click to Show/Hide
|
||||
| Activity |
Ki > 2500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;2,4-dioxo-5-(2-phenylethyl)-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934806; BDBM50212060
Click to Show/Hide
|
||||
| Activity |
Ki > 2500000 nM
|
[13] | |||
| Compound Name |
2-Aminoethanol;5-[2-(3,4-difluorophenyl)ethyl]-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984707; BDBM50211961
Click to Show/Hide
|
||||
| Activity |
Ki > 2500000 nM
|
[13] | |||
| Compound Name |
3-Carbamoyl-5-[4-[4-(trifluoromethyl)phenyl]phenyl]benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-carbamoyl-5-{4-[4-(trifluoromethyl)phenyl]phenyl}benzoic acid; AMX04; CHEMBL206157; SCHEMBL18120865; BDBM16106; 5-carbamoyl-4 -(trifluoromethyl)-1,1 :4 ,1 -terphenyl-3-carboxylic acid; 4''-(Trifluoromethyl)-5-carbamoyl-1,1':4',1''-terbenzene-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 100000000 nM
|
[9] | |||
| Compound Name |
3-Carbamoyl-5-[4-(4-methylphenyl)phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AMX03; CHEMBL382342; BDBM16108; 5-carbamoyl-4 -methyl-1,1 :4 ,1 -terphenyl-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 100000000 nM
|
[9] | |||
| Compound Name |
3-[4-(4-Tert-butylphenyl)phenyl]-5-carbamoylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AMX05; CHEMBL206240; BDBM16107; 4 -tert-butyl-5-carbamoyl-1,1 :4 ,1 -terphenyl-3-carboxylic acid; 4''-tert-Butyl-5-carbamoyl-1,1':4',1''-terbenzene-3-carboxylic acid
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| Activity |
Ki > 100000000 nM
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[9] | |||
| Compound Name |
3-Carbamoyl-5-(3,5-diphenylphenyl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
AMX-09; CHEMBL378734
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| Activity |
Ki > 100000000 nM
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[9] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations. J Med Chem. 1998 Aug 27;41(18):3530-8. | ||||
| REF 2 | Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem. 2007 Jan 25;50(2):186-91. | ||||
| REF 3 | Isoxazolylthioamides as potential immunosuppressants a combinatorial chemistry approach. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2203-8. | ||||
| REF 4 | Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH. Bioorg Med Chem. 2015 Aug 1;23(15):4669-4680. | ||||
| REF 5 | Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase. J Med Chem. 2002 Oct 10;45(21):4669-78. | ||||
| REF 6 | Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017 Feb 27;8(4):438-442. | ||||
| REF 7 | Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. J Med Chem. 2011 Jun 9;54(11):3935-49. | ||||
| REF 8 | Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24. | ||||
| REF 9 | Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1610-5. | ||||
| REF 10 | Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase. J Med Chem. 2018 Jun 28;61(12):5162-5186. | ||||
| REF 11 | Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem. 2007 Jan 11;50(1):21-39. | ||||
| REF 12 | Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases. J Med Chem. 2012 Jun 28;55(12):5841-50. | ||||
| REF 13 | Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase. Bioorg Med Chem. 2017 Feb 15;25(4):1465-1470. | ||||
| REF 14 | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93. | ||||
| REF 15 | Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3878-3882. | ||||
| REF 16 | Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem. 2011 Aug 11;54(15):5540-61. | ||||
| REF 17 | Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. J Med Chem. 2012 Sep 13;55(17):7425-36. | ||||
| REF 18 | Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem. 2014 Jun 26;57(12):5381-94. | ||||
| REF 19 | Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem. 2009 Apr 9;52(7):1864-72. | ||||
| REF 20 | N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors. Medchemcomm. 2011;2:895-8. | ||||
| REF 21 | Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falcipa... J Med Chem. 2008 Jun 26;51(12):3649-53. | ||||
| REF 22 | The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. | ||||
| REF 23 | Pyrimidine-based antimalarials: design strategies and antiplasmodial effects. Medchemcomm. 2016;7:749-68. | ||||
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