Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D04FYN
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| Former ID |
DNC007067
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| Drug Name |
Diethyl 2-((biphenyl-3-ylamino)methylene)malonate
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| Synonyms |
CHEMBL217897; ZINC14956351; diethyl [(biphenyl-3-ylamino)methylidene]propanedioate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H21NO4
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| Canonical SMILES |
CCOC(=O)C(C=NC1=CC=CC(=C1)C2=CC=CC=C2)C(=O)OCC
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| InChI |
1S/C20H21NO4/c1-3-24-19(22)18(20(23)25-4-2)14-21-17-12-8-11-16(13-17)15-9-6-5-7-10-15/h5-14,18H,3-4H2,1-2H3
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| InChIKey |
WHQSBENLMFJXRC-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem. 2007 Jan 25;50(2):186-91. | |||
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