Drug Information
Drug General Information | Top | |||
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Drug ID |
D0HQ1I
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Former ID |
DNC014813
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Drug Name |
GNF-PF-85
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Synonyms |
GNF-PF-85; 3-[(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)amino]naphthalen-2-ol; 3-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}amino)naphthalen-2-ol; BAS 01083131; AC1LFFF4; Oprea1_463466; Oprea1_430691; SCHEMBL4939616; CHEMBL487518; BDBM24409; ZINC267589; AKOS024371314; Triazolopyrimidine-Based Compound, 16; MCULE-8335313178; ST51007753; SR-01000326143; SR-01000326143-1; 3-(5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ylamino)-naphthalen-2-ol
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C16H13N5O
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Canonical SMILES |
CC1=NC2=NC=NN2C(=C1)NC3=CC4=CC=CC=C4C=C3O
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InChI |
1S/C16H13N5O/c1-10-6-15(21-16(19-10)17-9-18-21)20-13-7-11-4-2-3-5-12(11)8-14(13)22/h2-9,20,22H,1H3
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InChIKey |
OMQCQQGZRWJBCI-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | Target Info | Inhibitor | [1] |
KEGG Pathway | Pyrimidine metabolism | |||
Metabolic pathways | ||||
Pathwhiz Pathway | Pyrimidine Metabolism | |||
Reactome | Pyrimidine biosynthesis | |||
WikiPathways | Metabolism of nucleotides |
References | Top | |||
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REF 1 | Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falcipa... J Med Chem. 2008 Jun 26;51(12):3649-53. |
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