Target Poor or Non Binder(s) Information

Target General Information

Target ID

T33754

Target Info

Target Name

Phosphodiesterase 3 (PDE3)

Synonyms

Phosphodiesterase III; PDE3; Cyclic GMP inhibited phosphodiesterase; Cyclic AMP phosphodiesterase III; CGI-PDE; CAMP phosphodiesterase III

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Target Type

Successful Target

Gene Name

NO-GeName

Biochemical Class

Phosphoric diester hydrolase

UniProt ID

Family

Poor Binders of This Target (in total, 180 binders)

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Compound Name

Rhucin

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Approved

Compound Info

Synonyms

sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine; BNRNXUUZRGQAQC-UHFFFAOYSA-N; 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; Sildenafil

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Activity

IC50 = 65000 nM

[1]

Compound Name

ROLIPRAM

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Phase 2

Compound Info

Synonyms

61413-54-5; ZK 62711; Rolipramum; Rolipramum [Latin]; 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; Adeo; Rolipram [USAN:INN]; 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone; (R,S)-rolipram; ZK-62711; CHEMBL63; EINECS 262-771-1; BRN 1588548; MLS000069691; CHEBI:104872; HJORMJIFDVBMOB-UHFFFAOYSA-N; 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone; [3H]rolipram

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

LY294002

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Phase 1

Compound Info

Synonyms

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 154447-36-6; LY 294002; LY-294002; 2-morpholino-8-phenyl-4H-chromen-4-one; 2-morpholin-4-yl-8-phenyl-4H-chromen-4-one; UNII-31M2U1DVID; LY-294,002; 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one; 31M2U1DVID; 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE; CHEMBL98350; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-; CHEBI:65329; 2-morpholino-8-phenyl-chromen-4-one; AK162301; 2-(morpholin-4-yl)-8-phenylchromen-4-one; LY2; 15447-36-6; IN1266; IN1268; Lys 294002; BMK1-D5; H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI); 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholin-4-yl-8-phenylchromen-4-one; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl; 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI); 8-Phenyl-2-(morpholin-4-yl)-chromen-4-one; 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One

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Activity

IC50 = 100000 nM

[3]

Compound Name

Piroximone

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Discontinued in Phase 3

Compound Info

Synonyms

MDL-19205

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Activity

IC50 ~ 100000 nM

[4]

Compound Name

CI-1018

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Discontinued in Phase 2

Compound Info

Synonyms

CI-1018; UNII-Y4O6325SYW; Y4O6325SYW; CHEMBL111925; DSSTox_CID_27248; DSSTox_RID_82208; DSSTox_GSID_47248; SCHEMBL185627; CAS-NOCAS_47248; DTXSID0047248; NOCAS_47248; Tox21_300203; BDBM50217550; NCGC00254191-01; NCGC00247925-01; 179024-48-7; PD-168787; (+)-CI-1018; CI-1018, (+)-; UNII-05127JZ9KQ component KYFWUBJMTHVBIF-QFIPXVFZSA-N; 4-Pyridinecarboxamide, N-(3,4,6,7-tetrahydro-9-methyl-4-oxo-1-phenylpyrrolo(3,2,1-jk)(1,4)benzodiazepin-3-yl)-, (R)-; 4-Pyridinecarboxamide, N-((3R)-3,4,6,7-tetrahydro-9-methyl-4-oxo-1-phenylpyrrol

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Activity

IC50 ~ 100000 nM

[5]

Compound Name

E-4021

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Discontinued in Phase 2

Compound Info

Synonyms

E-4021; CHEMBL25616; E4021

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

ZAPRINAST

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Terminated

Compound Info

Activity

IC50 ~ 100000 nM

[1]

Compound Name

Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine

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Investigative

Compound Info

Synonyms

CHEMBL118944; Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine; SCHEMBL7280806; FNTPEBIGZTYDQK-UHFFFAOYSA-N; BDBM50033290; 4-Phenylmethylamino-2-(1-Imidazolyl)Quinazoline

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Activity

IC50 = 50000 nM

[7]

Compound Name

Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine

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Investigative

Compound Info

Synonyms

CHEMBL119841; AC1LDIC6; Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine; Oprea1_641196; MLS001163907; cid_667555; ZINC5903; SCHEMBL7286130; MolPort-002-565-372; HMS2878H17; PCOP-956263; BDBM50033284; STK536221; NCGC00012858; AKOS001104531; MCULE-1376892352; NCGC00012858-02; SMR000539306; benzyl(2-(3-pyridyl)quinazolin-4-yl)amine; N-benzyl-2-pyridin-3-ylquinazolin-4-amine; N-Benzyl-2-(3-pyridinyl)quinazolin-4-amine; ST50015136; N-benzyl-2-(pyridin-3-yl)quinazolin-4-amine

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Activity

IC50 ~ 100000 nM

[7]

Compound Name

Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine

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Investigative

Compound Info

Synonyms

CHEMBL117108; Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine; MLS000334673; SCHEMBL7287132; AC1MA981; HMS3383C08; HMS2596E12; BDBM50033291; MCULE-3637836664; NCGC00184968-01; SMR000249431

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Activity

IC50 ~ 100000 nM

[7]

Compound Name

CI-1044

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Investigative

Compound Info

Synonyms

CI-1044; UNII-O4T475XIIY; O4T475XIIY; 197894-84-1; DSSTox_CID_27291; DSSTox_RID_82245; DSSTox_GSID_47291; CAS-NOCAS_47291; SCHEMBL6441242; CHEMBL342285; DTXSID5047291; NOCAS_47291; Tox21_300455; NCGC00254387-01; NCGC00248057-01; PD-189659; HY-100246; CS-0018397; (+)-CI-1044; 3-Pyridinecarboxamide, N-((3R)-9-amino-3,4,6,7-tetrahydro-4-oxo-1-phenylpyrrolo(3,2,1-jk)(1,4)benzodiazepin-3-yl)-; 3-Pyridinecarboxamide, N-(9-amino-3,4,6,7-tetrahydro-4-oxo-1-phenylpyrrolo(3,2,1-jk)(1,4)benzodiazepin-3-yl)-, (R)-

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

Benzyl-(2-phenyl-quinazolin-4-yl)-amine

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Investigative

Compound Info

Synonyms

Benzyl-(2-phenyl-quinazolin-4-yl)-amine; N-Benzyl-2-phenyl-4-quinazolinamine; CHEMBL72650; N-benzyl-2-phenylquinazolin-4-amine; AC1LFMYC; BAS 01023367; Oprea1_781281; Oprea1_710967; MLS001210388; SCHEMBL1083763; MolPort-001-952-692; HMS2816J14; KUC104420N; ZINC274067; STL227888; BDBM50033296; KSC-1-145; benzyl(2-phenylquinazolin-4-yl)amine; AKOS000533392; MCULE-1161339740; SMR000515839

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Activity

IC50 ~ 100000 nM

[7]

Compound Name

Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine

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Investigative

Compound Info

Synonyms

CHEMBL118462; AC1LJDWH; N-benzyl-2-pyridin-4-ylquinazolin-4-amine; Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine; SCHEMBL7277479; MolPort-000-723-072; ZINC509842; BDBM50033302; AKOS030512862

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Activity

IC50 ~ 100000 nM

[7]

Compound Name

6-(4-(1H-Imidazol-1-yl)phenyl)-5-methylpyridazin-3(2H)-one

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Investigative

Compound Info

Synonyms

CHEMBL31105; 6-[4-(1H-Imidazol-1-yl)phenyl]-5-methylpyridazin-3(2H)-one; SCHEMBL7290528; CTK2I3158; DTXSID10555899; BDBM50018613; ZINC29213003; 3-(4-imidazol-1-ylphenyl)-4-methyl-1H-pyridazin-6-one; 6-(4-Imidazol-1-yl-phenyl)-5-methyl-2H-pyridazin-3-one; 3(2H)-Pyridazinone, 6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-

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Activity

IC50 = 50000 nM

[8]

Compound Name

1-Butyl-4-(7-ethoxy-2,3-bis-hydroxymethyl-5-methoxy-naphthalen-1-yl)-3,6-dihydro-1H-pyridin-2-one

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Investigative

Compound Info

Synonyms

CHEMBL91042; BDBM50052085

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Activity

IC50 = 50000 nM

[9]

Compound Name

2-[4-[2,3-Bis(hydroxymethyl)naphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL553539

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Activity

IC50 = 50000 nM

[10]

Compound Name

1-Butyl-4-(6,7-diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-3,6-dihydro-1H-pyridin-2-one

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Investigative

Compound Info

Synonyms

CHEMBL327834; BDBM50052099

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Activity

IC50 = 50000 nM

[9]

Compound Name

4-(3-Chloro-4-methoxy-benzylamino)-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester

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Investigative

Compound Info

Synonyms

CHEMBL41950; SCHEMBL7159513; BDBM50141581

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Activity

IC50 ~ 50000 nM

[11]

Compound Name

6-(4-Methylsulfonyl-2,3-dihydro-1,4-benzoxazin-6-yl)-2-pentyl-4,5-dihydropyridazin-3-one

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Investigative

Compound Info

Synonyms

CHEMBL127452; SCHEMBL7342251; BDBM50228467

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Activity

IC50 = 50000 nM

[12]

Compound Name

6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one

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Investigative

Compound Info

Synonyms

CHEMBL124021; SCHEMBL7341641; BDBM50228455; 3-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)-4,5-dihydro-1H-pyridazin-6-one; 4,5-Dihydro-6-[(2,3-dihydro-4H-1,4-benzoxazin)-6-yl]pyridazin-3(2H)-one

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Activity

IC50 = 50000 nM

[12]

Compound Name

N-Benzyl-6-chloro-2-pyridin-3-ylquinazolin-4-amine;dihydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL544816

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Activity

IC50 ~ 50000 nM

[7]

Compound Name

Sulmazole

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Investigative

Compound Info

Synonyms

sulmazol; Sulmazolum; 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine; Vardax; CHEMBL286020; NCGC00016924-02; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-1H-imidazo(4,5-b)pyridine; Sulmazole [INN]; Sulmazol [INN-Spanish]; Sulmazolum [INN-Latin]; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-3H-imidazo(4,5-b)pyridine; 2-(2-Methoxy-4-(methylsulfinyl)phenyl)-3H-imidazo[4,5-b]pyridine; 2-(2-Methoxy-4-[methylsulfinyl]phenyl)-1H-imidazo(4,5-b)pyridine; 2-[2-methoxy-4-(methylsulfinyl)phenyl]-3H-imidazo[4,5-b]pyridine; AR-L 115BS; AR-L 115-BS; SR-01000841215; EINECS 277-406-1; BRN 0818370; 2-(2-methoxy-4-(methylsulfinyl)phenyl)-1H-imidazo[4,5-b]pyridine; Prestwick_1012; Spectrum_001155; Prestwick0_000641; Prestwick1_000641; Prestwick2_000641; Prestwick3_000641; Spectrum3_000733; Spectrum4_001246; Spectrum5_002074; 1H-Imidazo(4,5-b)pyridine, 2-(2-methoxy-4-(methylsulfinyl)phenyl)-; DSSTox_CID_20617; DSSTox_RID_79513; DSSTox_GSID_40617; BSPBio_000641; BSPBio_002286; KBioGR_001772; KBioSS_001635; MLS002153927; DivK1c_000276; SCHEMBL187165; SPECTRUM1501159; SPBio_002562; BPBio1_000707; DTXSID1040617; AR-L-115-BS; CTK5D7914; CTK9A2962; HMS500N18; KBio1_000276; KBio2_001635; KBio2_004203; KBio2_006771; KBio3_001506; NINDS_000276; HMS1570A03; HMS2097A03; HMS2230O09; HMS3371L17; HMS3714A03; Pharmakon1600-01501159; Tox21_110685; BDBM50000056; BDBM50225309; CCG-38446; NSC757867; CCG-220641; NSC-757867; IDI1_000276; NCGC00016924-01; NCGC00095999-01; DA-03205; SMR001233271; SBI-0051668.P002; AB00052230; FT-0748740; C13749; SR-01000841215-2; SR-01000841215-3; BRD-A22081593-001-04-6; BRD-A22081593-001-06-1; Q27116354; 2-methoxy-4-(methylsulfinyl)-phenylimidazo[4,5-b]pyridine; 2-(2-methoxy-4-methylsulfinyl-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine; 2-Methyl-6-oxo-1,6-dihydro-[3,4'']bipyridinyl-5-carbonitrile; 3H-Imidazo[4,5-b]pyridine,2-[2-methoxy-4-(methylsulfinyl)phenyl]-; (sulmazole)2-(4-Methanesulfinyl-2-methoxy-phenyl)-3H-imidazo[4,5-b]pyridine; 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine (sulmazole); 2-(4-Methanesulfinyl-2-methoxy-phenyl)-1H-imidazo[4,5-b]pyridine(sulmazole)

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Activity

IC50 = 50118.72 nM

[13]

Compound Name

4-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-3,5-dichlorobenzamide

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Investigative

Compound Info

Synonyms

CHEMBL146218; SCHEMBL7156583; BDBM50473085

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Activity

IC50 = 51600 nM

[2]

Compound Name

4-Ethyl-2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-4-methyl-3H-pyrazol-3-one

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Investigative

Compound Info

Synonyms

CHEMBL44279; SCHEMBL7383999; BDBM50225753; 4-ethyl-3-(4-imidazol-1-ylphenyl)-4-methyl-1H-pyrazol-5-one; 4-Ethyl-2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-4-methyl-3H-pyrazol-3one

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Activity

IC50 = 52000 nM

[14]

Compound Name

6-Methoxy-1,2,3,4-tetrahydroquinoline-2,4-dione

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Investigative

Compound Info

Synonyms

CHEMBL100112; 6-Methoxyquinoline-2,4(1H,3H)-dione; ZINC5687045; 6-Methoxy-1H-quinoline-2,4-dione; BDBM50226551; AKOS026728990; MCULE-8983342049; NE21814

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Activity

IC50 = 53000 nM

[15]

Compound Name

N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]quinoline-3-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL144404; BDBM50473081

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Activity

IC50 = 53900 nM

[2]

Compound Name

1-(4-Imidazol-1-ylphenyl)-2,3-diazaspiro[4.4]non-1-en-4-one

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Investigative

Compound Info

Synonyms

CHEMBL49593; BDBM50225946

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Activity

IC50 = 54000 nM

[14]

Compound Name

Tert-butyl N-[4-[[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]carbamoyl]pyridin-3-yl]carbamate

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Investigative

Compound Info

Synonyms

CHEMBL357616; BDBM50473086

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Activity

IC50 = 54700 nM

[2]

Compound Name

4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-1-(2-methoxy-ethyl)-3,6-dihydro-1H-pyridin-2-one

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Investigative

Compound Info

Synonyms

CHEMBL91632; BDBM50052095

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Activity

IC50 = 57000 nM

[9]

Compound Name

2-Butyl-4-(benzyloxy)thieno[3,2-d]pyrimidine

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Investigative

Compound Info

Synonyms

CHEMBL128461; BDBM50471839

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Activity

IC50 = 58000 nM

[16]

Compound Name

N-Benzyl-2-(2-methylpropyl)thieno[3,2-d]pyrimidin-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL132107; BDBM50471840

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Activity

IC50 = 58000 nM

[16]

Compound Name

Tert-butyl N-[4-[[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]carbamoyl]pyridin-3-yl]carbamate

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Investigative

Compound Info

Synonyms

CHEMBL423931; SCHEMBL6051289; BDBM50473080

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Activity

IC50 = 58200 nM

[2]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-[[4-(ethoxycarbonyl)piperidino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24328; BDBM50075704

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Activity

IC50 = 60000 nM

[6]

Compound Name

9-Benzyl-N,N-dimethyl-2-(trifluoromethyl)purin-6-amine

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Investigative

Compound Info

Synonyms

CHEMBL299959; (9-Benzyl-2-trifluoromethyl-9H-purin-6-yl)-dimethyl-amine; N,N-Dimethyl-2-(trifluoromethyl)-9-benzyl-9H-purin-6-amine

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Activity

IC50 = 61000 nM

[17]

Compound Name

Hydroxyhomosildenafil

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Investigative

Compound Info

Synonyms

Hydroxyhomo Sildenafil; UNII-80X7B1F6NW; CHEMBL53538; 80X7B1F6NW; Hydroxyhomosidenafil; SCHEMBL1058; PYR383; SCHEMBL18416781; C23H32N6O5S; CTK8E7607; DTXSID60161161; KS-000000OD; BDBM50287550; MFCD00908400; ZINC21981375; AKOS030228062; AS-75169; HY-123210; CS-0081887; FT-0669662; Y0499; J-007310

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Activity

IC50 = 62000 nM

[1]

Compound Name

3(2H)-Isoquinolinone, 4-chloro-6,7-dimethoxy-1-methyl-

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Investigative

Compound Info

Synonyms

CHEMBL27919; SCHEMBL7308411; BDBM50227412; 4-chloro-6,7-dimethoxy-1-methyl-2H-isoquinolin-3-one

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Activity

IC50 = 62000 nM

[18]

Compound Name

4-Chloro-N-[(11R)-6-methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide

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Investigative

Compound Info

Synonyms

CHEMBL332853; SCHEMBL7491547; BDBM50217549

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Activity

IC50 = 62000 nM

[5]

Compound Name

5-Phenyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

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Investigative

Compound Info

Synonyms

CHEMBL431544; BDBM50287548; ZINC29485894; 5-Phenyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one

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Activity

IC50 = 63000 nM

[1]

Compound Name

N-(2,6-Difluorobenzyl)-2-butylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL30407; BDBM50223125

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Activity

IC50 = 64000 nM

[16]

Compound Name

(R)-7-Isopropyl-5-methyl-2-(4-methyl-pentyl)-7,8-dihydro-3H,5H-imidazo[2,1-b]purin-4-one

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Investigative

Compound Info

Synonyms

CHEMBL18524; SCHEMBL8334703; BDBM50073694

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Activity

IC50 = 65000 nM

[19]

Compound Name

2-Methyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

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Investigative

Compound Info

Synonyms

CHEMBL89202; BDBM50034772

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Activity

IC50 = 67000 nM

[20]

Compound Name

2-Butyl-5-phenyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

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Investigative

Compound Info

Synonyms

CHEMBL90289; BDBM50218530

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Activity

IC50 = 68000 nM

[20]

Compound Name

2-Butyl-4-pyrrolizinothieno[3,2-d]pyrimidine

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Investigative

Compound Info

Synonyms

CHEMBL31063; BDBM50223120

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Activity

IC50 = 68000 nM

[16]

Compound Name

N-Benzylthieno[3,2-d]pyrimidin-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL31877; SCHEMBL4352890; ZINC8756051; BDBM50223123; 4-benzylaminothieno[3,2-d]pyrimidine; AKOS009095771; CCG-301289; MCULE-2893333446; N-Benzylthieno[3,2-d]pyrimidine-4-amine; Z196118054

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Activity

IC50 = 68000 nM

[16]

Compound Name

1,3,7,8-Tetramethylimidazo[4,5-b]quinolin-2-one

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Investigative

Compound Info

Synonyms

CHEMBL99441; BDBM50229554

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Activity

IC50 = 70000 nM

[21]

Compound Name

N-[(11R)-6-Acetamido-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL357197; SCHEMBL7818726; BDBM50473072

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Activity

IC50 = 70000 nM

[2]

Compound Name

3(2H)-Pyridazinone, 5-ethyl-4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-

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Investigative

Compound Info

Synonyms

CHEMBL30362; ACMC-20l9l5; SCHEMBL11206290; CTK3B1886; DTXSID00530655; BDBM50018614; 4-ethyl-3-(4-imidazol-1-ylphenyl)-4,5-dihydro-1H-pyridazin-6-one; 3-[4-(1H-Imidazole-1-yl)phenyl]-4-ethyl-4,5-dihydropyridazine-6(1H)-one; 5-Ethyl-6-(4-imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one; 5-Ethyl-6-[4-(1H-imidazol-1-yl)phenyl]-4,5-dihydropyridazin-3(2H)-one

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Activity

IC50 = 74000 nM

[22]

Compound Name

3-[2-(3,4-Dimethoxyphenyl)-1-methylimidazol-4-yl]-1H-pyridazin-6-one

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Investigative

Compound Info

Synonyms

CHEMBL89955; BDBM50226148

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Activity

IC50 = 75000 nM

[23]

Compound Name

CID 13756813

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Investigative

Compound Info

Synonyms

CHEMBL109043; BDBM50226558; N-cyclohexyl-N-methyl-4-[(1-methyl-2-oxo-3,5-dihydroimidazo[2,1-b]quinazolin-7-yl)oxy]butanamide

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Activity

IC50 = 76000 nM

[24]

Compound Name

6-Methoxy-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-12-one

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Investigative

Compound Info

Synonyms

CHEMBL109754; SCHEMBL7490467; BDBM50223645; ZINC26975777

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Activity

IC50 = 77000 nM

[25]

Compound Name

6,7-Dimethoxy-3-(pyrrolidine-1-carbonyl)-1-(3,4,5-trimethoxy-phenyl)-naphthalene-2-carboxylic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL282796; BDBM50075703; 1-(3,4,5-Trimethoxyphenyl)-3-(pyrrolizinocarbonyl)-6,7-dimethoxy-2-naphthoic acid methyl ester

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Activity

IC50 = 77000 nM

[6]

Compound Name

N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-3,5-dichloropyridine-4-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL144287; SCHEMBL6051196; BDBM50473090

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Activity

IC50 = 80000 nM

[2]

Compound Name

3(2H)-Isoquinolinone, 6,8-dimethoxy-1-methyl-

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Investigative

Compound Info

Synonyms

CHEMBL27746; BDBM50227414; 1-Methyl-6,8-dimethoxyisoquinoline-3-ol

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Activity

IC50 = 80000 nM

[18]

Compound Name

2-[5-[2,3-Bis(hydroxymethyl)-6,7-dimethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL536785

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Activity

IC50 = 80000 nM

[10]

Compound Name

(11R,15S)-8-Methyl-4-propyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one

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Investigative

Compound Info

Synonyms

CHEMBL275204; BDBM50059047; 5-methyl-2-propyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one; (6aR,9aS)-2-Propyl-5,6a,7,8,9,9a-hexahydro-5-methylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one

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Activity

IC50 = 80000 nM

[19]

Compound Name

1-[(1-Butyl-2-oxo-1,2-dihydropyridin)-4-yl]-6,7-dimethoxynaphthalene-2,3-dimethanol

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Investigative

Compound Info

Synonyms

CHEMBL2115234; SCHEMBL7287261; BDBM50454211

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Activity

IC50 = 80000 nM

[9]

Compound Name

(11R,15S)-4-Heptan-4-yl-8-methyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one

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Investigative

Compound Info

Synonyms

CHEMBL280307; BDBM50073697; 5-methyl-2-(1-propylbutyl)-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one

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Activity

IC50 = 80000 nM

[19]

Compound Name

N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL126581; SCHEMBL8342507; BDBM50217560

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Activity

IC50 = 82000 nM

[5]

Compound Name

N-[2-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-phenyl]-methanesulfonamide

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Investigative

Compound Info

Synonyms

CHEMBL52245; BDBM50287551; N-(2-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)methanesulfonamide

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Activity

IC50 = 83000 nM

[1]

Compound Name

2-Isopropyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

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Investigative

Compound Info

Synonyms

CHEMBL91952; BDBM50218419

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Activity

IC50 = 86000 nM

[20]

Compound Name

4-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide

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Investigative

Compound Info

Synonyms

CHEMBL144570; SCHEMBL7159233; BDBM50473082

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Activity

IC50 = 86800 nM

[2]

Compound Name

3-[(E)-2-[4-(4,5-Dimethylimidazol-1-yl)phenyl]ethenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one

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Investigative

Compound Info

Synonyms

CHEMBL117783; BDBM50228046

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Activity

IC50 = 87000 nM

[26]

Compound Name

3-Amino-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL356548; BDBM50473074

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Activity

IC50 = 90000 nM

[2]

Compound Name

N-Benzyl-2-butylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL30379; BDBM50223129

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Activity

IC50 = 97000 nM

[16]

Compound Name

1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7,8-trimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24327; BDBM50075718

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

3,4-Dipropyl-8,9-dihydro-7H-pyrimido[2,1-f]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL109550; BDBM50471411; 3,4-Dipropyl-3,4,5,7,8,9-hexahydropyrimido[2,1-i]purine-5-one

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

2-[4-[2,3-Bis(hydroxymethyl)-7-methoxy-6-phenylmethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;dihydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL543491; BDBM50026879

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Activity

IC50 ~ 100000 nM

[10]

Compound Name

6,9-Dipropyltetrazolo[5,1-f]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL322358; BDBM50471410; 6,9-Dipropyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

1-(3-Chloro-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL26348; BDBM50075705

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

6-Methoxy-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-12-one

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Investigative

Compound Info

Synonyms

CHEMBL113368; SCHEMBL6441960; BDBM50147632; 4-Methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-benzo[cd]azulen-9-one

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Activity

IC50 ~ 100000 nM

[25]

Compound Name

N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL144605; SCHEMBL7491635; BDBM50473076

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

T 0156 Hydrochloride

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Investigative

Compound Info

Synonyms

T-0156 hydrochloride; t-0156; CHEMBL540294; SR-01000076180; SCHEMBL1148363; CTK8I2006; AKOS024456743; NCGC00094459-01; EU-0101212; T 8067; SR-01000076180-1; SR-01000076180-3; Q15634075

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Activity

IC50 ~ 100000 nM

[28]

Compound Name

4-Propyl-1,4-dihydro-5H-imidazo[2,1-i]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL326285; BDBM50471418

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

1-(2-Thienyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL26622; BDBM50075709

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

CCK antagonist synthetic 14

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Investigative

Compound Info

Synonyms

CHEMBL306760; SCHEMBL8746513; BDBM50019252; PDSP1_000937; PDSP2_000923; N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)-1H-indole-2-carboxamide

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Activity

IC50 ~ 100000 nM

[5]

Compound Name

1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL283360; BDBM50075684

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL125828; SCHEMBL7492234; BDBM50217556

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

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Investigative

Compound Info

Synonyms

Imidazosagatriazinone; UK-088800; UNII-E4M9V1JW7V; E4M9V1JW7V; CHEMBL54079; MFCD03093929; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-7(6H)-one; SCHEMBL1202; MLS000704311; PYR115; CTK8B8749; DTXSID40358476; HMS2511C22; BCP16444; ZINC8855176; ANW-61165; BDBM50111899; STL452917; 5-(2-ethoxyphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one; AKOS015911946; AC-26314; AK-59084; DS-16277; SMR000230865; AB0071601; DB-049819; E1134; FT-0668119; Z2913; J-007314; Q27276861; 5-(2-Ethoxyphenyl)-l-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolol-; 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL112366; SCHEMBL5607953; BDBM50223647

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

1-(3-Amino-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL26054; BDBM50075717

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

5-(2-Ethoxyphenyl)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

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Investigative

Compound Info

Synonyms

CHEMBL51814; SCHEMBL1392; BDBM50287546; 5-(2-ethoxyphenyl)-1,3-dimethyl-4H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxy-phenyl)-1,3-dimethyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Ethoxyphenyl)-1,3-dimethyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one; 5-(2-Ethoxyphenyl)-1,3-dimethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

2-Methoxy-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide

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Investigative

Compound Info

Synonyms

CHEMBL339749; SCHEMBL7495975; BDBM50217553

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Activity

IC50 ~ 100000 nM

[5]

Compound Name

N-[6-Chloro-9-(2-fluorophenyl)-12-oxo-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL331051; BDBM50217554; L003399

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Activity

IC50 ~ 100000 nM

[5]

Compound Name

[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-[3-hydroxymethyl-6,7-dimethoxy-4-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanone

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Investigative

Compound Info

Synonyms

CHEMBL281771; BDBM50075715

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

4-Amino-3,5-dichloro-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide

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Investigative

Compound Info

Synonyms

CHEMBL341304; SCHEMBL7490773; BDBM50217545

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Activity

IC50 ~ 100000 nM

[5]

Compound Name

1-(1,3-Benzodioxole-5-yl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL25356; BDBM50075696

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-2-methoxybenzamide

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Investigative

Compound Info

Synonyms

CHEMBL434516; SCHEMBL7822162; BDBM50473084

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

(4-Methyl-piperazin-1-yl)-[8-(3-nitro-phenyl)-[1,7]naphthyridin-6-yl]-methanone

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Investigative

Compound Info

Synonyms

CHEMBL161602; BDBM50085134

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Activity

IC50 ~ 100000 nM

[29]

Compound Name

1-Methyl-5-(2-nitrophenyl)-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

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Investigative

Compound Info

Synonyms

CHEMBL52072; BDBM50287547; 1-Methyl-5-(2-nitro-phenyl)-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Nitrophenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-[(4-oxopiperidino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL23990; BDBM50075702

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-(piperidinocarbonyl)-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL283218; BDBM50075688

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3,4-Dichlorophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL431107; BDBM50075697

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-7-chloro-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL26441; BDBM50075713

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-5-chloro-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24752; SCHEMBL19197655; BDBM50075691

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24385; BDBM50075687

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

N-[(11R)-6-Methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL339408; SCHEMBL7495202; BDBM50217552

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-7-methyl-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24321; BDBM50075716

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

4-[8-(3-Chlorophenyl)-1,7-naphthyridin-6-yl]benzoic Acid

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Investigative

Compound Info

Synonyms

CHEMBL161115; BDBM50085138; 4-[8-(3-Chloro-phenyl)-[1,7]naphthyridin-6-yl]-benzoic acid

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Activity

IC50 ~ 100000 nM

[29]

Compound Name

5-(2-Hydroxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-D]pyrimidin-7-one

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Investigative

Compound Info

Synonyms

CHEMBL300416; CTK6D4973; DTXSID70658198; BDBM50287544; ZINC29485680; 5-(2-Hydroxy-phenyl)-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-Hydroxyphenyl)-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

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Activity

IC50 ~ 100000 nM

[1]

Compound Name

N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-3-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL144370; BDBM50473069

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

6,7-Dimethoxy-4-(trifluoromethyl)-3H-quinazolin-2-one

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Investigative

Compound Info

Synonyms

CHEMBL284798; BDBM50226915

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Activity

IC50 = 100000 nM

[30]

Compound Name

1,4-Dipropyl-1,4-dihydro-5H-imidazo[2,1-i]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL109574; BDBM50471421

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

1,4-Dipropyl-7,8-dihydroimidazo[2,1-f]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL111486; BDBM50471413; 1,4-Dipropyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[27]

Compound Name

1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24715; BDBM50075693

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

6,7-Dipropyltetrazolo[5,1-f]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL320350; BDBM50471422; 6,7-Dipropyl-6,7-dihydro-5H-tetrazolo[5,1-i]purin-5-one

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

3,4-Dipropyl-7,8,9,10-tetrahydro-[1,3]diazepino[2,1-f]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL109427; BDBM50471408; 3,4-Dipropyl-3,4,7,8,9,10-hexahydro-5H-[1,3]diazepino[2,1-i]purin-5-one

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-[[4-(hydroxymethyl)piperidino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL282965; BDBM50075685

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-2-yl)-methanol

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Investigative

Compound Info

Synonyms

CHEMBL90974; BDBM50052089; ZINC13756799; 6,7-Dimethoxynaphthalene-2,3-dimethanol

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Activity

IC50 ~ 100000 nM

[9]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-[(4-methylpiperazino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24659; BDBM50075706

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-2,3-naphthalenedicarboxylic acid dimethyl ester

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Investigative

Compound Info

Synonyms

CHEMBL25671; BDBM50075683; 6,7-Dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalene-2,3-dicarboxylic acid dimethyl ester

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

6-Propyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL111990; BDBM50471415

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

1-(2-Bromo-4-pyridyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24801; BDBM50075692

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

4,7-Dimethyl-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyrazolo[5,1-c][1,2,4]triazine-3-carboxamide

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL125123; SCHEMBL7490389; BDBM50217546

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

N-Cyclohexyl-N-methyl-4-[(2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-9-yl)oxy]butanamide

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL447536; SCHEMBL10374642; BDBM50226677

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Activity

IC50 ~ 100000 nM

[24]

Compound Name

1,4-Dipropyl-8,9-dihydro-7H-pyrimido[2,1-f]purin-5-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL109639; BDBM50471414; 1,4-Dipropyl-1,4,5,7,8,9-hexahydropyrimido[2,1-i]purine-5-one

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

N-(6-Methoxy-12-oxo-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-11-yl)pyridine-3-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL112996; SCHEMBL6440075; BDBM50147630; N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9-tetrahydro-5,7,9a-triaza-benzo[cd]azulen-8-yl)-nicotinamide; N-(4-methoxy-9-oxo-6-phenyl-1,2,8,9-tetrahydro-5,7,9a-triazabenzo[cd]azulen-8-yl)nicotinamide

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Activity

IC50 ~ 100000 nM

[25]

Compound Name

N-(13-Oxo-10-phenyl-1,11-diazatricyclo[7.4.1.05,14]tetradeca-5(14),6,8,10-tetraen-12-yl)-1H-indole-2-carboxamide

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Investigative

Compound Info

Synonyms

CHEMBL333585; BDBM50217548; L003400

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Activity

IC50 ~ 100000 nM

[5]

Compound Name

3-(4-Acetyl-2,3-dihydro-1,4-benzoxazin-6-yl)-4,5-dihydro-1H-pyridazin-6-one

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Investigative

Compound Info

Synonyms

CHEMBL123734; SCHEMBL7346310; BDBM50228469; 4,5-Dihydro-6-[(4-acetyl-2,3-dihydro-4H-1,4-benzoxazin)-6-yl]pyridazin-3(2H)-one

Click to Show/Hide

Activity

IC50 = 100000 nM

[12]

Compound Name

6-Trifluoromethylsulfonyloxy-8-(3-nitrophenyl)-1,7-naphthyridine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL351900; SCHEMBL7015361; BDBM50085141; [8-(3-nitrophenyl)-1,7-naphthyridin-6-yl] trifluoromethanesulfonate; Trifluoro-methanesulfonic acid 8-(3-nitro-phenyl)-[1,7]naphthyridin-6-yl ester

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[29]

Compound Name

[7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-naphtho[2,3-d][1,3]dioxol-6-yl]-methanol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL91728; BDBM50052093; 5-(3,4,5-Trimethoxyphenyl)naphtho[2,3-d]-1,3-dioxole-6,7-dimethanol

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[9]

Compound Name

N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL340860; SCHEMBL13350333; BDBM50217561

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[5]

Compound Name

Methyl 7-[(2-methylpyridin-4-yl)methyl]-8-oxo-2-(pyridin-2-ylmethoxy)-5-(3,4,5-trimethoxyphenyl)-1,7-naphthyridine-6-carboxylate;hydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL540031

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[28]

Compound Name

3,4-Dipropyl-3,4-dihydro-5H-imidazo[2,1-i]purin-5-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL326464; BDBM50471409

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]methyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL25765; BDBM50075701

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

6,7-Dimethoxy-2-methyl-4-(3,4,5-trimethoxy-phenyl)-benzo[f]isoindole-1,3-dione

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL26546; BDBM50075694; 2-Methyl-4-(3,4,5-trimethoxyphenyl)-6,7-dimethoxy-1H-benzo[f]isoindole-1,3(2H)-dione

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

3-Isoquinolinecarboxylic acid, 2-(4-aminophenyl)-1,2-dihydro-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester, sulfate (1:1)

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Investigative

Compound Info

Synonyms

t-1032; CHEMBL77971; UNII-H68FTS7316; H68FTS7316; SCHEMBL1148164; NCGC00094482-01; EU-0101241; T 7692; SR-01000076176; SR-01000076176-1; Q27279696

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Activity

IC50 ~ 100000 nM

[28]

Compound Name

2-Phenethyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL330315; BDBM50218547

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Activity

IC50 ~ 100000 nM

[20]

Compound Name

PDE4 inhibitor intermediate 1

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL344944; methyl (3S,4S)-3-acetyl-4-(3-cyclopentyloxy-4-methoxyphenyl)-3-methylpyrrolidine-1-carboxylate; SCHEMBL5357822; BDBM50048241; HY-U00410; CS-7357; GW-3600

Click to Show/Hide

Activity

Ki ~ 100000 nM

[31]

Compound Name

Methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(2-pyridin-2-ylethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate;hydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL539783

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Activity

IC50 ~ 100000 nM

[28]

Compound Name

(3Z)-3-[[3-(2-Bicyclo[2.2.1]heptanyloxy)-4-methoxyphenyl]methylidene]-1H-indol-2-one

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Investigative

Compound Info

Synonyms

CHEMBL60985; BDBM50213335

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Activity

IC50 = 100000 nM

[32]

Compound Name

4-Propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL111466; SCHEMBL8133177; BDBM50471417; 4-Propyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

4-Propyl-7,8,9,10-tetrahydropyrimido[2,1-f]purin-5-one

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Investigative

Compound Info

Synonyms

CHEMBL111071; BDBM50471419; 4-Propyl-1,4,5,7,8,9-hexahydropyrimido[2,1-i]purine-5-one

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

3,5-Dichloro-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL422828; BDBM50473068

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Activity

IC50 ~ 100000 nM

[2]

Compound Name

6-(4-Carboxyphenyl)-8-(3-cyanophenyl)-1,7-naphthyridine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL161740; SCHEMBL7018568; 4-[8-(3-cyanophenyl)-1,7-naphthyridin-6-yl]benzoic Acid; BDBM50085139; 4-[8-(3-Cyano-phenyl)-[1,7]naphthyridin-6-yl]-benzoic acid

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[29]

Compound Name

N-[(3R)-1-(2-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indol-3-yl]-1H-indole-2-carboxamide

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL333994; DSSTox_CID_28712; NCGC00183006-01; NCGC00183009-01; DSSTox_RID_82981; DSSTox_GSID_48786; SCHEMBL9120074; DTXSID3048786; FK480; Tox21_113263; BDBM50084033; HY-U00363; (R)-FK-480; CS-7419; CHEMBL333994 (FK-480)

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[5]

Compound Name

1-(2-Methyl-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL282371; BDBM50075700

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-[(4-hydroxypiperidino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24719; BDBM50075708

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-ethoxy-7-methoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL24495; BDBM50075698

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

Desmethylsildenafil

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Investigative

Compound Info

Synonyms

N-Desmethyl Sildenafil; UNII-L6WO34R9YG; CHEMBL910; L6WO34R9YG; UK-103320; N-Demethylsildenafil; N-Desmethylsildenafil; SCHEMBL1141; SCHEMBL19518061; CTK8E7611; DTXSID00161160; BCP34330; KS-00000RE8; BDBM50287543; MFCD00908398; ZINC21981371; AKOS027322024; N-Desmethyl sildenafil (UK-103,320); AK312666; BS-15489; FT-0666208; Y0500; J-007308; Q27282788

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[1]

Compound Name

2-Methyl-6-(4-methylsulfonyl-2,3-dihydro-1,4-benzoxazin-6-yl)-4,5-dihydropyridazin-3-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL127289; SCHEMBL7344382; BDBM50228449

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Activity

IC50 = 100000 nM

[12]

Compound Name

1-[(E)-3,4,5-Trimethoxystyryl]-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL26556; BDBM50075690

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

4-[8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl]benzoic Acid

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Investigative

Compound Info

Synonyms

CHEMBL74078; 4-(8-(3-nitrophenyl)-1,7-naphthyridin-6-yl)benzoic acid; SCHEMBL21067893; CTK0J0116; DTXSID80433973; BDBM50085135; DB08299; Q27097520; 4-[8-(3-nitrophenyl)-[1,7]naphthyridin-6-yl]benzoic acid; 4-[8-(3-Nitrophenyl)-1,7-naphthyridine-6-yl]benzoic acid; 4-[8-(3-Nitro-phenyl)-[1,7]naphthyridin-6-yl]-benzoic acid; Benzoic acid, 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]-

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Activity

IC50 ~ 100000 nM

[29]

Compound Name

4-Propyl-8,9,10,11-tetrahydro-7H-[1,3]diazepino[2,1-f]purin-5-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL108884; BDBM50471420; 4-Propyl-1,4,7,8,9,10-hexahydro-5H-[1,3]diazepino[2,1-i]purin-5-one

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Activity

IC50 ~ 100000 nM

[27]

Compound Name

6-Methoxy-1,3-benzoxazin-2-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL103557; SCHEMBL8800213; BDBM50226550

Click to Show/Hide

Activity

IC50 = 100000 nM

[15]

Compound Name

3,4-Dipropyl-7,8-dihydroimidazo[2,1-f]purin-5-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL333599; SCHEMBL5964490; BDBM50471416; XT-611

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[27]

Compound Name

1-(3,5-Dichlorophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL285363; BDBM50075707

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

1-(3-Nitrophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL287642; BDBM50075689

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[6]

Compound Name

3-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL343243; SCHEMBL7821995; BDBM50473075

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[2]

Compound Name

1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-methoxy-2-naphthoic acid methyl ester

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL25192; BDBM50075686

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Activity

IC50 ~ 100000 nM

[6]

Compound Name

2(1H)-Quinazolinone, 6,7-dimethoxy-4-methyl-

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL30699; SCHEMBL7408010; BDBM50226903; 6,7-dimethoxy-4-methyl-2(1H)quinazolinone; 6,7-dimethoxy-4-methyl-3H-quinazolin-2-one; 6,7-Dimethoxy-4-methylquinazolin-2(1H)-one

Click to Show/Hide

Activity

IC50 = 100000 nM

[30]

Compound Name

1-(3,4,5-Trimethoxyphenyl)-3-(morpholinocarbonyl)-6,7-dimethoxy-2-naphthoic acid methyl ester

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL25935; BDBM50075699

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[6]

Compound Name

N-[(11S)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL338657; SCHEMBL9123499; BDBM50217547

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[5]

Compound Name

N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL420335; SCHEMBL84897; BDBM50217562; PD-0190749

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[5]

Compound Name

2-Tert-Butyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL88442; BDBM50218420

Click to Show/Hide

Activity

IC50 ~ 100000 nM

[20]

Compound Name

9-Benzyl-2-(trifluoromethyl)purin-6-amine

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL299203; NSC409920; DTXSID40325385; NSC-409920; 2-(Trifluoromethyl)-9-benzyl-9H-purin-6-amine

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Activity

IC50 = 101000 nM

[17]

Compound Name

2-(Cyclohexylmethyl)-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL314734; BDBM50218502

Click to Show/Hide

Activity

IC50 = 102000 nM

[20]

Compound Name

6-(4-Imidazol-1-yl-phenyl)-2-methyl-4,5-dihydro-2H-pyridazin-3-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL31112; SCHEMBL7280036; BDBM50018616; 6-(4-imidazol-1-ylphenyl)-2-methyl-4,5-dihydropyridazin-3-one; 4,5-dihydro-2-methyl-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone

Click to Show/Hide

Activity

IC50 = 110000 nM

[22]

Compound Name

2-Butyl-5-(cyclohexylmethyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL314537; BDBM50218534

Click to Show/Hide

Activity

IC50 = 111000 nM

[20]

Compound Name

4,4-Diethyl-3-(4-imidazol-1-ylphenyl)-1H-pyrazol-5-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL50602; BDBM50226224

Click to Show/Hide

Activity

IC50 = 120000 nM

[14]

Compound Name

2-Pentyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL315764; BDBM50218543

Click to Show/Hide

Activity

IC50 = 120000 nM

[20]

Compound Name

9-[(2-Fluorophenyl)methyl]-N-methylpurin-6-amine;methanesulfonic acid

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL445098

Click to Show/Hide

Activity

IC50 = 121000 nM

[17]

Compound Name

N-Ethyl-N-[[4-[2-(tetrazol-2-yl)phenyl]phenyl]methyl]-[1,2,4]thiadiazolo[2,3-a]benzimidazol-2-amine

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Investigative

Compound Info

Synonyms

CHEMBL150038; BDBM50216458

Click to Show/Hide

Activity

IC50 = 125000 nM

[33]

Compound Name

2-Methyl-5-propyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester

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Investigative

Compound Info

Synonyms

CHEMBL2069917; BDBM50485534

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Activity

IC50 = 125100 nM

[34]

Compound Name

3-[2-(3,4-Dimethoxyphenyl)-1-methylimidazol-4-yl]-4,5-dihydro-1H-pyridazin-6-one

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Investigative

Compound Info

Synonyms

CHEMBL89048; BDBM50226151

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Activity

IC50 = 128000 nM

[23]

Compound Name

4-Cyclopentyl-6,7-dimethoxy-1-methyl-2H-isoquinolin-3-one

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Investigative

Compound Info

Synonyms

CHEMBL30027; BDBM50227404

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Activity

IC50 = 128000 nM

[18]

Compound Name

2-Methyl-5-benzyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

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Investigative

Compound Info

Synonyms

CHEMBL2069985; BDBM50485545

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Activity

IC50 = 128300 nM

[34]

Compound Name

5,8-Dimethoxy-4-methyl-3H-quinazolin-2-one

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Investigative

Compound Info

Synonyms

CHEMBL30629; BDBM50226904

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Activity

IC50 = 129000 nM

[30]

Compound Name

2-Butyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

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Investigative

Compound Info

Synonyms

CHEMBL3144657; BDBM50218421

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Activity

IC50 = 136000 nM

[20]

Compound Name

4-Methylquinazolin-2(1H)-one

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Investigative

Compound Info

Synonyms

4-methyl-3H-quinazolin-2-one; 4-Methylquinazolin-2(3H)-one; CHEMBL281242; EINECS 252-215-6; 2-Hydroxy-4-methylquinazoline; methylquinazolinone; 2(1H)-Quinazolinone, 4-methyl-; 4-methyl-2-quinazolinol; SCHEMBL530191; 4-Methyl-1H-quinazolin-2-one; SCHEMBL11581679; CTK4H3038; 2(3H)-Quinazolinone,4-methyl-; DTXSID20188334; 4234AB; BDBM50226916; ZINC29213634; AKOS006230525; AKOS016013595; AKOS022171453; 4-methyl-1,2-dihydroquinazolin-2-one

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Activity

IC50 = 138000 nM

[30]

Compound Name

3-(4-Imidazol-1-ylphenyl)-4-methyl-1,4-dihydropyrazol-5-one

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Investigative

Compound Info

Synonyms

CHEMBL49619; BDBM50225948

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Activity

IC50 = 140000 nM

[14]

Compound Name

(11R,15S)-4-Ethyl-8-methyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one

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Investigative

Compound Info

Synonyms

CHEMBL418367; BDBM50073699; 2-ethyl-5-methyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one

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Activity

IC50 = 150000 nM

[19]

Compound Name

(11R,15S)-8-Methyl-4-pentan-3-yl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one

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Investigative

Compound Info

Synonyms

CHEMBL18964; BDBM50073693; 2-(1-ethylpropyl)-5-methyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one

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Activity

IC50 = 150000 nM

[19]

Compound Name

3-(3-Methyl-2-phenylimidazol-4-yl)-1H-pyridazin-6-one

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Investigative

Compound Info

Synonyms

CHEMBL312938; SCHEMBL10651516; BDBM50226150

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Activity

IC50 = 160000 nM

[23]

Compound Name

6-Methoxy-1-methylisoquinolin-3-ol

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Investigative

Compound Info

Synonyms

CHEMBL284897; ChemDiv3_014976; 6-methoxy-1-methyl-2H-isoquinolin-3-one; 3(2H)-Isoquinolinone, 6-methoxy-1-methyl-; SCHEMBL16740907; HMS1515I16; BDBM50227415; 6-Methoxy-1-methylisoquinolin-3(2H)-one

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Activity

IC50 = 160000 nM

[18]

Compound Name

2-Methyl-5-benzyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester

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Investigative

Compound Info

Synonyms

CHEMBL2069918; BDBM50485535

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Activity

IC50 = 163500 nM

[34]

Compound Name

Ethyl 5-[(2,4-dichlorophenyl)methyl]-2-methyl-6-oxo-1H-pyridine-3-carboxylate

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Investigative

Compound Info

Synonyms

CHEMBL2069914; SCHEMBL18796691; BDBM50485541

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Activity

IC50 = 172130 nM

[34]

Compound Name

2-Methyl-5-(4-methylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester

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Investigative

Compound Info

Synonyms

CHEMBL2069916; SCHEMBL18820635; BDBM50485533

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Activity

IC50 = 172500 nM

[34]

Compound Name

6,8-Dimethoxy-4-methyl-3H-quinazolin-2-one

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Investigative

Compound Info

Synonyms

CHEMBL30541; BDBM50226911

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Activity

IC50 = 190000 nM

[30]

Compound Name

6-(4-Methylsulfonyl-2,3-dihydro-1,4-benzoxazin-6-yl)-2-phenyl-4,5-dihydropyridazin-3-one

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Investigative

Compound Info

Synonyms

CHEMBL331862; BDBM50228456

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Activity

IC50 = 200000 nM

[12]

Compound Name

2-Butyl-N-[(4-phenylphenyl)methyl]thieno[3,2-d]pyrimidin-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL132267; BDBM50471844

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Activity

IC50 = 200000 nM

[16]

Click to Show/Hide the Information of All Poor Binders

Non Binders of This Target (in total, 58 non binders)

Download

Top

Compound Name

PMID28870136-Compound-48

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Patented

Compound Info

Activity

IC50 = 240000 nM

[27]

Compound Name

Ro 20-1724

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Terminated

Compound Info

Synonyms

4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; RO 20-1724; 29925-17-5; 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one; ro-20-1724; Ro 201724; CHEMBL18701; 4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one; 2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)-; RO-201724; 2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)-, (+-)-; 4-(3-butoxy-4-methoxy-benzyl)imidazolidin-2-one; 34185-37-0; 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone; SR-01000075647; keratan sulfate I; Keratan sulphate I; Naphthoquinone analogs

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Activity

IC50 > 300000 nM

[27]

Compound Name

9-BENZYL-9H-ADENINE

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Investigative

Compound Info

Synonyms

9-Benzyladenine; 4261-14-7; 9-benzyl-9H-purin-6-amine; N9-Benzyladenine; 9-Benzylaminopurine; ADENINE, 9-BENZYL-; 9-Bap; 9-Benzyl-6-aminopurine; N(sup 9)-Benzyladenine; 9-BENZYL-9H-ADENINE; 9-Benzyl-9H-purin-6-ylamine; 9H-Purin-6-amine, 9-(phenylmethyl)-; CCRIS 6908; SQ 21611; 9-benzylpurin-6-amine; NSC 35649; 9-(Phenylmethyl)-9H-purin-6-amine; CHEMBL266094; 9H-Purin-6-amine,9-(phenylmethyl)-; AC1L2FWA; MLS000660735; SCHEMBL104932; 9-Benzyl-9H-purine-6-amine; CTK4I6467; DTXSID70195371; MRHCSNNEUHXNIC-UHFFFAOYSA-N; HMS2676M21

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Activity

IC50 > 200000 nM

[17]

Compound Name

NITRAQUAZONE

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Investigative

Compound Info

Synonyms

Nitraquazone; UNII-1YF1KXP4QF; 1YF1KXP4QF; 56739-21-0; Nitraquazonum; Nitraquazona; nitraquazone[inn]; Nitraquazone [INN]; Nitraquazonum [Latin]; Nitraquazona [Spanish]; AC1L2AEJ; CHEMBL88990; SCHEMBL125623; ZINC1819; AC1Q21K9; GNWCRBFQZDJFTI-UHFFFAOYSA-N; BDBM50218545; 3-ethyl-1-(3-nitrophenyl)quinazoline-2,4-dione; 3-Ethyl-1-(m-nitrophenyl)-2,4(1H,3H)-quinazolinedione; 1-(m-nitrophenyl)-3-ethylquinazoline-2,4 (1H, 3H)-dione; 1-(m-nitrophenyl)- 3-ethylquinazoline-2,4(1H, 3H)-dione; 1-(m-nitrophenyl)-3-ethylquinazoline-2,4(1H,

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Activity

IC50 > 200000 nM

[20]

Compound Name

1-Benzyl-3-propylquinoxaline-2(1H)-one

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Investigative

Compound Info

Synonyms

CHEMBL130514; BDBM50471843

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Activity

IC50 > 200000 nM

[16]

Compound Name

4-Benzylsulfanyl-2-butylthieno[3,2-d]pyrimidine

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Investigative

Compound Info

Synonyms

CHEMBL341519; BDBM50471852

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-Benzyl-2-(4-butylphenoxy)thieno[3,2-d]pyrimidin-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL132156; BDBM50471845

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-Benzyl-2-(cyclohexylmethyl)thieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL31795; BDBM50223128

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Activity

IC50 > 200000 nM

[16]

Compound Name

2-Propyl-4-benzylpyrido[2,3-b]pyrazine-3(4H)-one

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Investigative

Compound Info

Synonyms

CHEMBL131059; BDBM50471850

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-Benzyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL334988; BDBM50471841

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Activity

IC50 > 200000 nM

[16]

Compound Name

2-Butyl-5-(3-aminobenzyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

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Investigative

Compound Info

Synonyms

CHEMBL90888; BDBM50218531

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Activity

IC50 > 200000 nM

[20]

Compound Name

9-[(2-Fluorophenyl)methyl]-6-piperidin-1-ylpurine;hydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL544491

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Activity

IC50 > 200000 nM

[17]

Compound Name

N-Benzyl-2-phenethylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL32673; BDBM50223127

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Activity

IC50 > 200000 nM

[16]

Compound Name

N,N-Dibenzyl-2-butylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL31773; BDBM50223124

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Activity

IC50 > 200000 nM

[16]

Compound Name

2-Butyl-5-phenethyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

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Investigative

Compound Info

Synonyms

CHEMBL88853; BDBM50218546

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Activity

IC50 > 200000 nM

[20]

Compound Name

N-Benzyl-N-methyl-2-butylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL288545; BDBM50223189

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Activity

IC50 > 200000 nM

[16]

Compound Name

2-Butyl-3-benzylquinazoline-4(3H)-one

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Investigative

Compound Info

Synonyms

CHEMBL128146; BDBM50471851

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-(Cyclohexylmethyl)-2-butylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL31439; BDBM50223055

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-Methyl-9-(2-phenylethyl)-2-(trifluoromethyl)purin-6-amine

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Investigative

Compound Info

Synonyms

CHEMBL52231

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Activity

IC50 > 200000 nM

[17]

Compound Name

N,2-Dibenzyl-7H-purin-6-amine

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Investigative

Compound Info

Synonyms

CHEMBL132273; BDBM50471848

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-Butyl-9-[(2-fluorophenyl)methyl]purin-6-amine;hydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL542617

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Activity

IC50 > 200000 nM

[17]

Compound Name

N-Benzyl-2-phenylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL435363; BDBM50223131

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Activity

IC50 > 200000 nM

[16]

Compound Name

3-Benzyl-2-butylpyrido[2,3-d]pyrimidin-4-one

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Investigative

Compound Info

Synonyms

CHEMBL132346; BDBM50471853

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Activity

IC50 > 200000 nM

[16]

Compound Name

9-[(2-Fluorophenyl)methyl]-N,8-dimethylpurin-6-amine;methanesulfonic acid

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Investigative

Compound Info

Synonyms

CHEMBL295315

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Activity

IC50 > 200000 nM

[17]

Compound Name

N-Benzyl-2-piperidin-1-ylthieno[3,2-d]pyrimidin-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL434822; BDBM50471846

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-(2-Butylthieno[3,2-d]pyrimidin-4-yl)benzamide

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Investigative

Compound Info

Synonyms

CHEMBL128788; BDBM50471838

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Activity

IC50 > 200000 nM

[16]

Compound Name

(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL50378; (2R,3S)-EHNA; (2R,3S)-3-(6-aminopurin-9-yl)nonan-2-ol; (2R,3S)-3-(adenin-9-yl)-2-nonanol; (2R,3S)-9-(2-hydroxy-3-nonyl)adenine; erythro-9-(2-hydroxy-3-nonyl)adenine; (R,S)-6-amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol; EHNA.HCl; HWC 52; eh-na; Tocris-1261; (-)-erythro-9-(2-hydroxy-3-nonyl)adenine; Lopac0_000504; BSPBio_001061; KBioGR_000401; KBioSS_000401; SCHEMBL1742893; DTXSID6043880; BCBcMAP01_000066; CTK2H9386; KBio2_000401; KBio2_002969; KBio2_005537; KBio3_000761; KBio3_000762; Bio1_000430; Bio1_000919; Bio1_001408; Bio2_000361; Bio2_000841; HMS1792E03; HMS1990E03; HMS3403E03; ZINC1614354; (R-(R*,S*))-6-Amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol; BDBM50034908; CCG-36414; 9H-Purine-9-ethanol, 6-amino-beta-hexyl-alpha-methyl-, (R*,S*)-(+-)-; 9H-Purine-9-ethanol, 6-amino-beta-hexyl-alpha-methyl-, (R-(R*,S*))-; SDCCGSBI-0050488.P002; 3-(6-Amino-purin-9-yl)-nonan-2-ol; IDI1_002116; SMP2_000310; NCGC00025087-01; NCGC00025087-02; NCGC00025087-03; NCGC00025087-04; NCGC00025087-05; NCGC00025087-06; NCGC00025087-08; (EHNA)3-(6-Amino-purin-9-yl)-nonan-2-ol; 3-(6-Amino-purin-9-yl)-nonan-2-ol(EHNA); (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol; (2R,3S)-3-(6-Amino-9H-purine-9-yl)2-nonanol; (2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol; BRD-K27450477-001-03-9; (2R,3S)-rel-3-(6-Amino-9H-purin-9-yl)nonan-2-ol

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Activity

Ki > 200000 nM

[17]

Compound Name

2-Butyl-N-cyclohexylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL31530; BDBM50223118

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-Benzyl-2-(cyclopentylmethyl)thieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL30966; BDBM50223187

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Activity

IC50 > 200000 nM

[16]

Compound Name

N-Benzyl-N-propyl-2-butylthieno[3,2-d]pyrimidine-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL31305; BDBM50223133

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Activity

IC50 > 200000 nM

[16]

Compound Name

9-[(2-Fluorophenyl)methyl]-N-methyl-2-phenylpurin-6-amine;methanesulfonic acid

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Investigative

Compound Info

Synonyms

CHEMBL52284

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Activity

IC50 > 200000 nM

[17]

Compound Name

2-(Cyclobutylmethyl)-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one

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Investigative

Compound Info

Synonyms

CHEMBL91007; BDBM50218537

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Activity

IC50 > 200000 nM

[20]

Compound Name

N-(6-Methyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)acetamide

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Investigative

Compound Info

Synonyms

Ici 58301; ICI-58301; CHEMBL358641; DTXSID40177846; 3-Acetamido-6-methyl-8-n-propyl-s-triazolo(4,3alpha)pyrazine; BDBM50225505; Acetamide, N-(6-methyl-8-propyl-1,2,4-triazolo(4,3-a)pyrazin-3-yl)-

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Activity

Ki = 217000 nM

[35]

Compound Name

4,4-Dimethyl-3-(4-pyridin-4-ylphenyl)-1H-pyrazol-5-one

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Investigative

Compound Info

Synonyms

CHEMBL48952; BDBM50225947

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Activity

IC50 = 220000 nM

[14]

Compound Name

4-(4-Imidazol-1-yl-phenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

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Investigative

Compound Info

Synonyms

CHEMBL30358; BDBM50018612

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Activity

IC50 = 220000 nM

[22]

Compound Name

2-(4-Imidazol-1-ylanilino)-1,4-dihydroimidazol-5-one

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Investigative

Compound Info

Synonyms

CHEMBL68833; BDBM50227202; DB-105212; 2-[[4-(N-imidazolyl)phenyl]amino]-2-imidazolin-4-one

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Activity

IC50 = 250000 nM

[4]

Compound Name

9-[(2-Fluorophenyl)methyl]-N,2-dimethylpurin-6-amine;methanesulfonic acid

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Investigative

Compound Info

Synonyms

CHEMBL51315

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Activity

IC50 = 250000 nM

[17]

Compound Name

6-[4-(2-Ethoxy-2-phenylethyl)piperazin-1-yl]sulfonyl-N-methyl-N-phenylquinazolin-4-amine

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Investigative

Compound Info

Synonyms

CHEMBL150093; SCHEMBL11010231; BDBM50225506

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Activity

Ki = 270000 nM

[35]

Compound Name

4-Ethyl-3-(4-imidazol-1-ylphenyl)-1,4-dihydropyrazol-5-one

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Investigative

Compound Info

Synonyms

CHEMBL296349; BDBM50225750

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Activity

IC50 = 270000 nM

[14]

Compound Name

5-[(2,4-Dichlorophenyl)methyl]-2-methyl-6-oxo-1H-pyridine-3-carbonitrile

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Investigative

Compound Info

Synonyms

CHEMBL2069988; BDBM50485539

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Activity

IC50 = 280700 nM

[34]

Compound Name

5,6a(R),7,8,9,9a(S)-Hexahydro-2,5-dimethylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one

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Investigative

Compound Info

Synonyms

CHEMBL278644; SCHEMBL236619; BDBM50059028; 2,5-dimethyl-(6aR,9aS)-3,4,5,8-tetrahydrocyclopenta[4,5]imidazo[2,1-b]purin-4-one; 2,5-Dimethyl-7alpha,8alpha-propano-4,5,7,8-tetrahydro-3H-imidazo[2,1-b]purine-4-one; (6aR,9aS)-5,6a,7,8,9,9a-Hexahydro-2,5-dimethyl-cyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one

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Activity

IC50 > 300000 nM

[19]

Compound Name

1-Butyl-3-propyl-5,7-dihydro-4H-purine-2,6-dione

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Investigative

Compound Info

Synonyms

CHEMBL110304; XT-44; BDBM50471412

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Activity

IC50 > 300000 nM

[27]

Compound Name

4-Methyl-6-(4-methylpiperazin-1-yl)-3H-quinazolin-2-one

Click to Show/Hide

Investigative

Compound Info

Synonyms

CHEMBL435758; SCHEMBL10744666; BDBM50226902

Click to Show/Hide

Activity

IC50 = 300000 nM

[30]

Compound Name

Ethyl 5-[(3-chlorophenyl)methyl]-6-oxo-2-phenyl-1H-pyridine-3-carboxylate

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Investigative

Compound Info

Synonyms

CHEMBL2069981; BDBM50485537

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Activity

IC50 = 312400 nM

[34]

Compound Name

2,4,7,13-Tetrazatricyclo[7.4.0.03,7]trideca-1(9),2,10,12-tetraen-5-one

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Investigative

Compound Info

Synonyms

CHEMBL307996; BDBM50227198; DB-102976

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Activity

IC50 = 330000 nM

[4]

Compound Name

N,9-Dimethyl-2-(trifluoromethyl)purin-6-amine

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Investigative

Compound Info

Synonyms

CHEMBL301502

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Activity

IC50 = 331000 nM

[17]

Compound Name

9-Benzyl-N-methylpurin-6-amine;methanesulfonic acid

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Investigative

Compound Info

Synonyms

CHEMBL50040

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Activity

IC50 = 339000 nM

[17]

Compound Name

9-(2-Fluorobenzyl)-N-methyl-2-(trifluoromethyl)-9H-purin-6-amine

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Investigative

Compound Info

Synonyms

CHEMBL299650; SCHEMBL185397; 9-[(2-fluorophenyl)methyl]-N-methyl-2-(trifluoromethyl)purin-6-amine; BDBM50058212; [9-(2-Fluoro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-methyl-amine

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Activity

IC50 = 380000 nM

[17]

Compound Name

6-Oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile

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Investigative

Compound Info

Synonyms

UNII-9V1XHG6QRM; 9V1XHG6QRM; 2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile; CHEMBL58782; 1,2-dihydro-2-oxo-5-(4-pyridinyl)-nicotinonitrile; 6-Odbcn; Inamrinone nitrile [USP]; SCHEMBL7281879; DTXSID70159918; (N-(1,6-Dihydro-6-oxo-(3,4'-bipyridine)-5-carbonitrile); ZINC155538; BDBM50024966; Inamrinone related compound C [USP]; AKOS022645570; MCULE-1980235207; 5-cyano[3,4'-bipyridin]-6(1H)-one; Inamrinone related compound C [USP-RS]; 5-cyano-[3,4'-bipyridin]-6(1H)-one; ST50999862; 2-oxo-5-(4-pyridyl)hydropyridine-3-carbonitrile; 1,6-Dihydro-6-oxo-3,4'-bipyridine-5-carbonitrile; 6-Oxo-1,6-dihydro-(3,4'-bipyridine)-5-carbonitrile; 6-Oxo-1,6-dihydro-[3,4'']bipyridinyl-5-carbonitrile; [3,4'-Bipyridine]-5-carbonitrile,1,6-dihydro-6-oxo-, hydrobromide (1:1)

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Activity

IC50 = 380000 nM

[36]

Compound Name

1H-Imidazo(4,5-b)pyridine, 2-(2,4-dimethoxyphenyl)-

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Investigative

Compound Info

Synonyms

CHEMBL43406; 2-(2,4-Dimethoxyphenyl)-1H-imidazo(4,5-b)pyridine; 2-(2,4-dimethoxyphenyl)-1H-imidazo[4,5-b]pyridine; 2-(2,4-Dimethoxy-phenyl)-3H-imidazo[4,5-b]pyridine; AR-L 57BS; 2-(2,4-dimethoxyphenyl)-3H-imidazo[4,5-b]pyridine; SCHEMBL6040494; SCHEMBL11770981; AR-L-57; DTXSID50228055; ZINC5115747; BDBM50020868; AKOS011056149; MCULE-1037524258; AM20061499; 2-(2,4-Dimethoxy-phenyl)-1H-imidazo[4,5-b]pyridine; 2-(2,4-dimethoxy-phenyl)-3H-imidazo[5,4-b]pyridine

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Activity

IC50 = 390000 nM

[35]

Compound Name

5-[(2-Chlorophenyl)methyl]-2-methyl-6-oxo-1H-pyridine-3-carbonitrile

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Investigative

Compound Info

Synonyms

CHEMBL2069986; BDBM50485543

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Activity

IC50 = 423200 nM

[34]

Compound Name

Ethyl 14-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18),16-pentaene-17-carboxylate

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Investigative

Compound Info

Synonyms

CHEMBL151056; BDBM50225507

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Activity

IC50 > 500000 nM

[35]

Compound Name

2,4-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-one

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Investigative

Compound Info

Synonyms

CHEMBL49812; BDBM50225751

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Activity

IC50 = 590000 nM

[14]

Compound Name

6-(1,4,5,6-Tetrahydro-6-oxopyridazin-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one

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Investigative

Compound Info

Synonyms

CHEMBL341348; SCHEMBL7342072; BDBM50228461; MFCD08446715; ZINC19892366; 6-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-4H-1,4-benzoxazin-3-one; 6-(3,4-dihydro-3-oxo-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one; 6-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one; 6-[(1,4,5,6-Tetrahydro-6-oxopyridazin)-3-yl]-4H-1,4-benzoxazin-3(2H)-one

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Activity

IC50 = 630000 nM

[12]

Compound Name

Proxyphylline

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Investigative

Compound Info

Synonyms

Proxiphylline; Purophyllin; Monophylline; Spasmolysin; Brontyl; Sanwaphyllin; Sigophyl; Theoden; Thean; Theon; Oxypropyltheophylline; 7-(2-Hydroxypropyl)theophylline; Proxy-Retardoral; Hydroxypropyltheophylline; 7-(beta-Hydroxypropyl)theophylline; 2-Hydroxypropyl-7-theophylline; Theophylline, 7-(2-hydroxypropyl)-; Proxylphylline; 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine; NSC 163343; CHEMBL37390; MLS000069521; .beta.-Hydroxypropyltheophylline; 7-(.beta.-Hydroxypropyl)theophylline; Proxiphyllinum; SMR000058629; DSSTox_CID_3536; 7-(.beta.-Hydroxypropyl)-1,3-dimethylxanthine; DSSTox_RID_77068; DSSTox_GSID_23536; Proxifilina; Proxyphyllinum; beta-Oxypropyltheophyllin; UNII-13G1DMN4P0; Proxifilina [INN-Spanish]; Proxyphyllinum [INN-Latin]; Proxyphylline [INN:BAN:JAN]; EINECS 210-028-7; Proxyfylline; Proxyphyllin; Spantin; 7-(-Hydroxypropyl)theophylline; 7-(beta-Hydroxypropyl)-1,3-dimethylxanthine; 13G1DMN4P0; Monophyllin (TN); NCGC00016521-01; Opera_ID_1170; Prestwick0_000890; Prestwick1_000890; Prestwick2_000890; Prestwick3_000890; Proxyphylline (JAN/INN); SCHEMBL35569; BSPBio_000680; 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione; SPBio_002899; BPBio1_000748; 7-(b-Hydroxypropyl)theophylline; DTXSID5023536; HMS1570B22; HMS2097B22; HMS2233E08; HMS3371A07; HMS3886C07; Pharmakon1600-01505915; HY-B1742; KS-000017UY; Tox21_110471; BDBM50028190; KM0393; MFCD00022833; NSC163343; NSC759279; PDSP1_001132; PDSP2_001116; s4932; SBB058155; 3,3-dimethyl-1H-purine-2,6-dione; AKOS015967318; Tox21_110471_1; CCG-213993; CS-7727; DB13449; MCULE-2304226036; NSC-163343; NSC-759279; Proxyphylline; Monophylline, Spasmolysin; NCGC00018121-02; NCGC00018121-03; NCGC00018121-07; NCGC00179479-01; AS-11774; 7-(2-hydroxypropyl)-1,3-dimethylxanthine; SBI-0207057.P001; DB-053586; AB00513948; FT-0603485; ST50409303; D01771; AB00384297_13; SR-01000003009; Q7252904; SR-01000003009-2; W-105265; BRD-A28887267-001-03-7; 1,3-DIMETHYL-7-(2-HYDROXYPROPYL)-2,6-DIOXOPURINE

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Activity

Ki = 1000000 nM

[37]

Compound Name

1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (R)-

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Investigative

Compound Info

Synonyms

UNII-S0ELR18QO5; S0ELR18QO5; CHEMBL37019; Proxyphylline, (R)-; (R)-PROXYPHYLLINE; 7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; ZINC57348; DTXSID60235654; BDBM50028191; (R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

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Activity

Ki = 1100000 nM

[37]

Compound Name

1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (S)-

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Investigative

Compound Info

Synonyms

UNII-YV88341QW3; CHEMBL290644; YV88341QW3; NCGC00016521-01; Proxyphylline, (S)-; (S)-PROXYPHYLLINE; SCHEMBL35570; 7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; ZINC57347; DTXSID00235653; BDBM50028192; NCGC00018121-01; NCGC00018121-04; A16821; UNII-13G1DMN4P0 component KYHQZNGJUGFTGR-LURJTMIESA-N; UNII-13G1DMN4P0 component KYHQZNGJUGFTGR-ZCFIWIBFSA-N; (S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

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Activity

Ki = 1200000 nM

[37]

Compound Name

2,2-Difluoro-6-methyl-7-pyridin-4-yl-4H-pyrido[3,2-b][1,4]thiazin-3-one

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Investigative

Compound Info

Synonyms

CHEMBL315286; BDBM50469987; 7-(4-Pyridinyl)-2,2-difluoro-6-methyl-2H-pyrido[3,2-b]-1,4-thiazin-3(4H)-one

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Activity

IC50 > 3000000 nM

[38]

Click to Show/Hide the Information of All Non Binders

References

Top

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Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans. J Med Chem. 1996 Jul 5;39(14):2696-704.

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Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors. J Med Chem. 1998 Oct 8;41(21):4021-35.

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9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. J Med Chem. 1997 Jun 6;40(12):1768-70.

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Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity. J Med Chem. 1987 Nov;30(11):1955-62.

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New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3303-6.

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