TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T33754	Phosphodiesterase 3	D0DF2M	PMID28870136-Compound-48	Patented	2153	C7H8N4O2	180.16	CN1C2=C(C(=O)N(C1=O)C)NC=N2	IC50 = 240000 nM	Non binder
T33754	Phosphodiesterase 3	D07FHZ	Ro 20-1724	Terminated	5087	C15H22N2O3	278.35	CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC	IC50 > 300000 nM	Non binder
T33754	Phosphodiesterase 3	B10IBT	1-Benzyl-3-propylquinoxaline-2(1H)-one	Investigative	10826458	C18H18N2O	278.3	CCCC1=NC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	B1I4TE	5,6a(R),7,8,9,9a(S)-Hexahydro-2,5-dimethylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one	Investigative	10776762	C12H15N5O	245.28	CC1=NC2=C(N1)C(=O)N(C3=N[C@@H]4CCC[C@@H]4N23)C	IC50 > 300000 nM	Non binder
T33754	Phosphodiesterase 3	B2KSL9	2,4,7,13-Tetrazatricyclo[7.4.0.03,7]trideca-1(9),2,10,12-tetraen-5-one	Investigative	136058107	C9H8N4O	188.19	C1C2=C(N=CC=C2)N=C3N1CC(=O)N3	IC50 = 330000 nM	Non binder
T33754	Phosphodiesterase 3	B2UT0F	4-Benzylsulfanyl-2-butylthieno[3,2-d]pyrimidine	Investigative	10543311	C17H18N2S2	314.5	CCCCC1=NC2=C(C(=N1)SCC3=CC=CC=C3)SC=C2	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	B30HUV	6-[4-(2-Ethoxy-2-phenylethyl)piperazin-1-yl]sulfonyl-N-methyl-N-phenylquinazolin-4-amine	Investigative	13066339	C29H33N5O3S	531.7	CCOC(CN1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)N=CN=C3N(C)C4=CC=CC=C4)C5=CC=CC=C5	Ki = 270000 nM	Non binder
T33754	Phosphodiesterase 3	B32JOL	2,4-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-one	Investigative	13946690	C12H10N4O	226.23	C1C(=NNC1=O)C2=CC=C(C=C2)N3C=CN=C3	IC50 = 590000 nM	Non binder
T33754	Phosphodiesterase 3	B42HJK	N-Benzyl-2-(4-butylphenoxy)thieno[3,2-d]pyrimidin-4-amine	Investigative	44352576	C23H23N3OS	389.5	CCCCC1=CC=C(C=C1)OC2=NC3=C(C(=N2)NCC4=CC=CC=C4)SC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	B43PFU	N-Benzyl-2-(cyclohexylmethyl)thieno[3,2-d]pyrimidine-4-amine	Investigative	10688351	C20H23N3S	337.5	C1CCC(CC1)CC2=NC3=C(C(=N2)NCC4=CC=CC=C4)SC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	B4JW6C	9-(2-Fluorobenzyl)-N-methyl-2-(trifluoromethyl)-9H-purin-6-amine	Investigative	9818702	C14H11F4N5	325.26	CNC1=C2C(=NC(=N1)C(F)(F)F)N(C=N2)CC3=CC=CC=C3F	IC50 = 380000 nM	Non binder
T33754	Phosphodiesterase 3	B4W9HS	N,9-Dimethyl-2-(trifluoromethyl)purin-6-amine	Investigative	10704663	C8H8F3N5	231.18	CNC1=C2C(=NC(=N1)C(F)(F)F)N(C=N2)C	IC50 = 331000 nM	Non binder
T33754	Phosphodiesterase 3	B57WNT	6-Oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile	Investigative	131989	C11H7N3O	197.19	C1=CN=CC=C1C2=CNC(=O)C(=C2)C#N	IC50 = 380000 nM	Non binder
T33754	Phosphodiesterase 3	B5BC1H	Proxyphylline	Investigative	4977	C10H14N4O3	238.24	CC(CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 1000000 nM	Non binder
T33754	Phosphodiesterase 3	B5G2JW	5-[(2-Chlorophenyl)methyl]-2-methyl-6-oxo-1H-pyridine-3-carbonitrile	Investigative	70695095	C14H11ClN2O	258.7	CC1=C(C=C(C(=O)N1)CC2=CC=CC=C2Cl)C#N	IC50 = 423200 nM	Non binder
T33754	Phosphodiesterase 3	B5PMJ6	4,4-Dimethyl-3-(4-pyridin-4-ylphenyl)-1H-pyrazol-5-one	Investigative	13946687	C16H15N3O	265.31	CC1(C(=NNC1=O)C2=CC=C(C=C2)C3=CC=NC=C3)C	IC50 = 220000 nM	Non binder
T33754	Phosphodiesterase 3	B5RIF6	Ethyl 5-[(3-chlorophenyl)methyl]-6-oxo-2-phenyl-1H-pyridine-3-carboxylate	Investigative	70686742	C21H18ClNO3	367.8	CCOC(=O)C1=C(NC(=O)C(=C1)CC2=CC(=CC=C2)Cl)C3=CC=CC=C3	IC50 = 312400 nM	Non binder
T33754	Phosphodiesterase 3	B5SMX6	2-(4-Imidazol-1-ylanilino)-1,4-dihydroimidazol-5-one	Investigative	14177142	C12H11N5O	241.25	C1C(=O)NC(=N1)NC2=CC=C(C=C2)N3C=CN=C3	IC50 = 250000 nM	Non binder
T33754	Phosphodiesterase 3	B65JKE	Ethyl 14-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18),16-pentaene-17-carboxylate	Investigative	44367306	C22H26N2O2	350.5	CCC1CCN2CCC3=C4C2C1C=C(N4C5=CC=CC=C35)C(=O)OCC	IC50 > 500000 nM	Non binder
T33754	Phosphodiesterase 3	B6OV3Y	2-Propyl-4-benzylpyrido[2,3-b]pyrazine-3(4H)-one	Investigative	10564633	C17H17N3O	279.34	CCCC1=NC2=C(N=CC=C2)N(C1=O)CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	B6S9FJ	N-Benzyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-amine	Investigative	10734331	C18H14N4S	318.4	C1=CC=C(C=C1)CNC2=NC(=NC3=C2SC=C3)C4=CC=NC=C4	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	B78HIA	2,2-Difluoro-6-methyl-7-pyridin-4-yl-4H-pyrido[3,2-b][1,4]thiazin-3-one	Investigative	10469627	C13H9F2N3OS	293.29	CC1=NC2=C(C=C1C3=CC=NC=C3)SC(C(=O)N2)(F)F	IC50 > 3000000 nM	Non binder
T33754	Phosphodiesterase 3	B8CJE0	6-(1,4,5,6-Tetrahydro-6-oxopyridazin-3-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one	Investigative	15599415	C12H11N3O3	245.23	C1CC(=O)NN=C1C2=CC3=C(C=C2)OCC(=O)N3	IC50 = 630000 nM	Non binder
T33754	Phosphodiesterase 3	B94GUT	2-Butyl-5-(3-aminobenzyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	44323427	C21H22N4O	346.4	CCCCN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CC4=CC(=CC=C4)N	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	B9FK7T	9-[(2-Fluorophenyl)methyl]-6-piperidin-1-ylpurine;hydrochloride	Investigative	45260180	C17H19ClFN5	347.8	C1CCN(CC1)C2=NC=NC3=C2N=CN3CC4=CC=CC=C4F.Cl	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	B9P6UN	9-Benzyl-N-methylpurin-6-amine;methanesulfonic acid	Investigative	44295200	C14H17N5O3S	335.38	CNC1=C2C(=NC=N1)N(C=N2)CC3=CC=CC=C3.CS(=O)(=O)O	IC50 = 339000 nM	Non binder
T33754	Phosphodiesterase 3	BA5Y6C	N-Benzyl-2-phenethylthieno[3,2-d]pyrimidine-4-amine	Investigative	10593644	C21H19N3S	345.5	C1=CC=C(C=C1)CCC2=NC3=C(C(=N2)NCC4=CC=CC=C4)SC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BB30HZ	N,N-Dibenzyl-2-butylthieno[3,2-d]pyrimidine-4-amine	Investigative	10786459	C24H25N3S	387.5	CCCCC1=NC2=C(C(=N1)N(CC3=CC=CC=C3)CC4=CC=CC=C4)SC=C2	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BBDS62	2-Butyl-5-phenethyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	44323270	C22H23N3O	345.4	CCCCN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CCC4=CC=CC=C4	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BCO56F	N-(6-Methyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)acetamide	Investigative	205981	C11H15N5O	233.27	CCCC1=NC(=CN2C1=NN=C2NC(=O)C)C	Ki = 217000 nM	Non binder
T33754	Phosphodiesterase 3	BEB59N	N-Benzyl-N-methyl-2-butylthieno[3,2-d]pyrimidine-4-amine	Investigative	10852535	C18H21N3S	311.4	CCCCC1=NC2=C(C(=N1)N(C)CC3=CC=CC=C3)SC=C2	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BEG1A9	1-Butyl-3-propyl-5,7-dihydro-4H-purine-2,6-dione	Investigative	44339609	C12H20N4O2	252.31	CCCCN1C(=O)C2C(N=CN2)N(C1=O)CCC	IC50 > 300000 nM	Non binder
T33754	Phosphodiesterase 3	BF3C5W	2-Butyl-3-benzylquinazoline-4(3H)-one	Investigative	10779997	C19H20N2O	292.4	CCCCC1=NC2=CC=CC=C2C(=O)N1CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BFB82G	N-(Cyclohexylmethyl)-2-butylthieno[3,2-d]pyrimidine-4-amine	Investigative	10494678	C17H25N3S	303.5	CCCCC1=NC2=C(C(=N1)NCC3CCCCC3)SC=C2	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BFY6T9	N-Methyl-9-(2-phenylethyl)-2-(trifluoromethyl)purin-6-amine	Investigative	10567758	C15H14F3N5	321.3	CNC1=C2C(=NC(=N1)C(F)(F)F)N(C=N2)CCC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BG8XV2	N,2-Dibenzyl-7H-purin-6-amine	Investigative	10663161	C19H17N5	315.4	C1=CC=C(C=C1)CC2=NC3=C(C(=N2)NCC4=CC=CC=C4)NC=N3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BH84YM	N-Butyl-9-[(2-fluorophenyl)methyl]purin-6-amine;hydrochloride	Investigative	45260248	C16H19ClFN5	335.81	CCCCNC1=C2C(=NC=N1)N(C=N2)CC3=CC=CC=C3F.Cl	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BI13HZ	N-Benzyl-2-phenylthieno[3,2-d]pyrimidine-4-amine	Investigative	10805458	C19H15N3S	317.4	C1=CC=C(C=C1)CNC2=NC(=NC3=C2SC=C3)C4=CC=CC=C4	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BJCH18	3-Benzyl-2-butylpyrido[2,3-d]pyrimidin-4-one	Investigative	44352733	C18H19N3O	293.4	CCCCC1=NC2=C(C=CC=N2)C(=O)N1CC3=CC=CC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BK96LG	9-[(2-Fluorophenyl)methyl]-N,8-dimethylpurin-6-amine;methanesulfonic acid	Investigative	44294818	C15H18FN5O3S	367.4	CC1=NC2=C(N=CN=C2N1CC3=CC=CC=C3F)NC.CS(=O)(=O)O	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BL4DP8	N-Benzyl-2-piperidin-1-ylthieno[3,2-d]pyrimidin-4-amine	Investigative	44352624	C18H20N4S	324.4	C1CCN(CC1)C2=NC3=C(C(=N2)NCC4=CC=CC=C4)SC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BM1QS8	N-(2-Butylthieno[3,2-d]pyrimidin-4-yl)benzamide	Investigative	10567025	C17H17N3OS	311.4	CCCCC1=NC2=C(C(=N1)NC(=O)C3=CC=CC=C3)SC=C2	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BN25GR	5-[(2,4-Dichlorophenyl)methyl]-2-methyl-6-oxo-1H-pyridine-3-carbonitrile	Investigative	70695096	C14H10Cl2N2O	293.1	CC1=C(C=C(C(=O)N1)CC2=C(C=C(C=C2)Cl)Cl)C#N	IC50 = 280700 nM	Non binder
T33754	Phosphodiesterase 3	BN6X9U	4-Ethyl-3-(4-imidazol-1-ylphenyl)-1,4-dihydropyrazol-5-one	Investigative	13946680	C14H14N4O	254.29	CCC1C(=NNC1=O)C2=CC=C(C=C2)N3C=CN=C3	IC50 = 270000 nM	Non binder
T33754	Phosphodiesterase 3	BQ4CU7	(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol	Investigative	149784	C14H23N5O	277.37	CCCCCC[C@@H]([C@@H](C)O)N1C=NC2=C(N=CN=C21)N	Ki > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BR5D0B	1H-Imidazo(4,5-b)pyridine, 2-(2,4-dimethoxyphenyl)-	Investigative	156890	C14H13N3O2	255.27	COC1=CC(=C(C=C1)C2=NC3=C(N2)C=CC=N3)OC	IC50 = 390000 nM	Non binder
T33754	Phosphodiesterase 3	BSD2W8	4-(4-Imidazol-1-yl-phenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one	Investigative	44279839	C17H18N4O	294.35	C1CCC2C(C1)C(=NNC2=O)C3=CC=C(C=C3)N4C=CN=C4	IC50 = 220000 nM	Non binder
T33754	Phosphodiesterase 3	BT2AE9	2-Butyl-N-cyclohexylthieno[3,2-d]pyrimidine-4-amine	Investigative	10266192	C16H23N3S	289.4	CCCCC1=NC2=C(C(=N1)NC3CCCCC3)SC=C2	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BT6QC5	4-Methyl-6-(4-methylpiperazin-1-yl)-3H-quinazolin-2-one	Investigative	13563538	C14H18N4O	258.32	CC1=C2C=C(C=CC2=NC(=O)N1)N3CCN(CC3)C	IC50 = 300000 nM	Non binder
T33754	Phosphodiesterase 3	BV5IT4	N-Benzyl-2-(cyclopentylmethyl)thieno[3,2-d]pyrimidine-4-amine	Investigative	10758281	C19H21N3S	323.5	C1CCC(C1)CC2=NC3=C(C(=N2)NCC4=CC=CC=C4)SC=C3	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BW9EM5	1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (R)-	Investigative	158962	C10H14N4O3	238.24	C[C@H](CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 1100000 nM	Non binder
T33754	Phosphodiesterase 3	BXD8Z7	1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (S)-	Investigative	158961	C10H14N4O3	238.24	C[C@@H](CN1C=NC2=C1C(=O)N(C(=O)N2C)C)O	Ki = 1200000 nM	Non binder
T33754	Phosphodiesterase 3	BXD92B	N-Benzyl-N-propyl-2-butylthieno[3,2-d]pyrimidine-4-amine	Investigative	10783300	C20H25N3S	339.5	CCCCC1=NC2=C(C(=N1)N(CCC)CC3=CC=CC=C3)SC=C2	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BXVP10	9-[(2-Fluorophenyl)methyl]-N-methyl-2-phenylpurin-6-amine;methanesulfonic acid	Investigative	44295026	C20H20FN5O3S	429.5	CNC1=C2C(=NC(=N1)C3=CC=CC=C3)N(C=N2)CC4=CC=CC=C4F.CS(=O)(=O)O	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	BZ46HO	9-[(2-Fluorophenyl)methyl]-N,2-dimethylpurin-6-amine;methanesulfonic acid	Investigative	44295178	C15H18FN5O3S	367.4	CC1=NC(=C2C(=N1)N(C=N2)CC3=CC=CC=C3F)NC.CS(=O)(=O)O	IC50 = 250000 nM	Non binder
T33754	Phosphodiesterase 3	BZ86OK	2-(Cyclobutylmethyl)-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	12016994	C22H21N3O	343.4	C1CC(C1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=C5	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	D0S4JI	9-BENZYL-9H-ADENINE	Investigative	20262	C12H11N5	225.25	C1=CC=C(C=C1)CN2C=NC3=C(N=CN=C32)N	IC50 > 200000 nM	Non binder
T33754	Phosphodiesterase 3	D0V5BX	NITRAQUAZONE	Investigative	68765	C16H13N3O4	311.29	CCN1C(=O)C2=CC=CC=C2N(C1=O)C3=CC(=CC=C3)[N+](=O)[O-]	IC50 > 200000 nM	Non binder