TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T33754	Phosphodiesterase 3	D0Z7ZM	Rhucin	Approved	135398744	C22H30N6O4S	474.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C	IC50 = 65000 nM	Poor binder
T33754	Phosphodiesterase 3	D0T5PO	ROLIPRAM	Phase 2	5092	C16H21NO3	275.34	COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D08FOX	Piroximone	Discontinued in Phase 3	55263	C11H11N3O2	217.22	CCC1=C(NC(=O)N1)C(=O)C2=CC=NC=C2	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D00DBE	CI-1018	Discontinued in Phase 2	9865514	C24H20N4O2	396.4	CC1=CC2=C3C(=C1)C(=N[C@H](C(=O)N3CC2)NC(=O)C4=CC=NC=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D00SPK	E-4021	Discontinued in Phase 2	23665864	C22H20ClN4NaO4	462.9	C1CN(CCC1C(=O)[O-])C2=NC3=C(C=C(C=C3)Cl)C(=N2)NCC4=CC5=C(C=C4)OCO5.[Na+]	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D00YPW	ZAPRINAST	Terminated	135399235	C13H13N5O2	271.27	.	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D09SFV	LY294002	Terminated	3973	C19H17NO3	307.3	C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B0P4FZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7,8-trimethoxy-2-naphthoic acid methyl ester	Investigative	10651803	C30H35BrN2O9	647.5	COC1=CC2=CC(=C(C(=C2C(=C1OC)OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B14TIW	3,4-Dipropyl-8,9-dihydro-7H-pyrimido[2,1-f]purin-5-one	Investigative	10492654	C14H21N5O	275.35	CCCN1C=NC2=C1N(C(=O)N3C2=NCCC3)CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B1ANS6	Sulmazole	Investigative	5353	C14H13N3O2S	287.34	COC1=C(C=CC(=C1)S(=O)C)C2=NC3=C(N2)C=CC=N3	IC50 = 50118.72 nM	Poor binder
T33754	Phosphodiesterase 3	B1HS9A	2-[4-[2,3-Bis(hydroxymethyl)-7-methoxy-6-phenylmethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;dihydrochloride	Investigative	45259284	C38H32Cl2N4O5	695.6	COC1=CC2=C(C(=C(C=C2C=C1OCC3=CC=CC=C3)CO)CO)C4=CC(=NC=C4)N5C(=O)C6=CC=CC=C6C(=N5)C7=CN=CC=C7.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B1PXN4	Tert-butyl N-[4-[[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]carbamoyl]pyridin-3-yl]carbamate	Investigative	10696630	C28H27N5O4	497.5	CC(C)(C)OC(=O)NC1=C(C=CN=C1)C(=O)N[C@H]2C(=O)N3CCC4=C3C(=CC=C4)C(=N2)C5=CC=CC=C5	IC50 = 54700 nM	Poor binder
T33754	Phosphodiesterase 3	B1X4DU	2-Methyl-5-benzyl-6-oxo-1,6-dihydropyridine-3-carbonitrile	Investigative	70686743	C14H12N2O	224.26	CC1=C(C=C(C(=O)N1)CC2=CC=CC=C2)C#N	IC50 = 128300 nM	Poor binder
T33754	Phosphodiesterase 3	B2ADU7	2-(Cyclohexylmethyl)-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	12016995	C24H25N3O	371.5	C1CCC(CC1)CN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=C5	IC50 = 102000 nM	Poor binder
T33754	Phosphodiesterase 3	B2L6WO	6,9-Dipropyltetrazolo[5,1-f]purin-5-one	Investigative	10491646	C11H15N7O	261.279	CCCN1C=NC2=C1C3=NN=NN3C(=O)N2CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B2RH0L	1-(3-Chloro-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10650764	C29H33ClN2O8	573	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Cl)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B2S3MG	6-Methoxy-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-12-one	Investigative	15606258	C17H15N3O2	293.32	COC1=NC2=C3C(=C1)CCN3C(=O)CN=C2C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B34ESA	3-(4-Imidazol-1-ylphenyl)-4-methyl-1,4-dihydropyrazol-5-one	Investigative	13946679	C13H12N4O	240.26	CC1C(=NNC1=O)C2=CC=C(C=C2)N3C=CN=C3	IC50 = 140000 nM	Poor binder
T33754	Phosphodiesterase 3	B38KPN	N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	Investigative	10833764	C23H18N4O2	382.4	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B3EAM6	T 0156 Hydrochloride	Investigative	9852041	C31H30ClN5O7	620	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B3GOP9	N-Benzyl-2-butylthieno[3,2-d]pyrimidine-4-amine	Investigative	10590134	C17H19N3S	297.4	CCCCC1=NC2=C(C(=N1)NCC3=CC=CC=C3)SC=C2	IC50 = 97000 nM	Poor binder
T33754	Phosphodiesterase 3	B3M4FN	4-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-3,5-dichlorobenzamide	Investigative	9826435	C24H19Cl2N5O2	480.3	C1CN2C(=O)[C@@H](N=C(C3=CC(=CC1=C32)N)C4=CC=CC=C4)NC(=O)C5=CC(=C(C(=C5)Cl)N)Cl	IC50 = 51600 nM	Poor binder
T33754	Phosphodiesterase 3	B3RH6C	4-Propyl-1,4-dihydro-5H-imidazo[2,1-i]purin-5-one	Investigative	10536740	C10H11N5O	217.23	CCCN1C2=C(C3=NC=CN3C1=O)NC=N2	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B3W0GN	4-Ethyl-2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-4-methyl-3H-pyrazol-3-one	Investigative	13518856	C15H16N4O	268.31	CCC1(C(=NNC1=O)C2=CC=C(C=C2)N3C=CN=C3)C	IC50 = 52000 nM	Poor binder
T33754	Phosphodiesterase 3	B42HIX	1-(2-Thienyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10791038	C25H28N2O6S	484.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC=CS3)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B43EAS	CCK antagonist synthetic 14	Investigative	14208192	C24H18N4O2	394.4	C1=CC=C(C=C1)C2=NC(C(=O)NC3=CC=CC=C32)NC(=O)C4=CC5=CC=CC=C5N4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B43GWY	2-Isopropyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	12016987	C20H19N3O	317.4	CC(C)N1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CC4=CC=CC=C4	IC50 = 86000 nM	Poor binder
T33754	Phosphodiesterase 3	B49ESZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10508072	C29H33BrN2O8	617.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B4F5DN	N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	Investigative	10812634	C27H20N4O2	432.5	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=CC6=CC=CC=C6C=N5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B4GNR0	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-3,5-dichloropyridine-4-carboxamide	Investigative	10504383	C23H17Cl2N5O2	466.3	C1CN2C(=O)[C@@H](N=C(C3=CC(=CC1=C32)N)C4=CC=CC=C4)NC(=O)C5=C(C=NC=C5Cl)Cl	IC50 = 80000 nM	Poor binder
T33754	Phosphodiesterase 3	B4LU9Y	5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one	Investigative	135401477	C17H20N4O2	312.37	CCCC1=NN(C2=C1N=C(NC2=O)C3=CC=CC=C3OCC)C	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B4N0VJ	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	Investigative	10668502	C23H19N5O2	397.4	C1CN2C(=O)[C@@H](N=C(C3=CC(=CC1=C32)N)C4=CC=CC=C4)NC(=O)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B50OKA	2-Butyl-4-(benzyloxy)thieno[3,2-d]pyrimidine	Investigative	10661817	C17H18N2OS	298.4	CCCCC1=NC2=C(C(=N1)OCC3=CC=CC=C3)SC=C2	IC50 = 58000 nM	Poor binder
T33754	Phosphodiesterase 3	B5E8JU	1-(3-Amino-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10840471	C29H35N3O8	553.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)N)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B5M1KV	Hydroxyhomosildenafil	Investigative	135452901	C23H32N6O5S	504.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CCO)OCC)C	IC50 = 62000 nM	Poor binder
T33754	Phosphodiesterase 3	B5YPU0	N-Ethyl-N-[[4-[2-(tetrazol-2-yl)phenyl]phenyl]methyl]-[1,2,4]thiadiazolo[2,3-a]benzimidazol-2-amine	Investigative	44365068	C24H20N8S	452.5	CCN(CC1=CC=C(C=C1)C2=CC=CC=C2N3N=CN=N3)C4=NC5=NC6=CC=CC=C6N5S4	IC50 = 125000 nM	Poor binder
T33754	Phosphodiesterase 3	B60FHJ	5-(2-Ethoxyphenyl)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one	Investigative	135433645	C15H16N4O2	284.31	CCOC1=CC=CC=C1C2=NC3=C(C(=O)N2)N(N=C3C)C	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B63PGL	2-Methoxy-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	Investigative	10764856	C26H23N3O3	425.5	CC1=CC2=C3C(=C1)C(=N[C@H](C(=O)N3CC2)NC(=O)C4=CC=CC=C4OC)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B6CO7V	1-(3,4,5-Trimethoxyphenyl)-3-[[4-(ethoxycarbonyl)piperidino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10817302	C32H37NO10	595.6	CCOC(=O)C1CCN(CC1)C(=O)C2=C(C(=C3C=C(C(=CC3=C2)OC)OC)C4=CC(=C(C(=C4)OC)OC)OC)C(=O)OC	IC50 = 60000 nM	Poor binder
T33754	Phosphodiesterase 3	B6FLE7	N-[6-Chloro-9-(2-fluorophenyl)-12-oxo-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	Investigative	44209387	C26H18ClFN4O2	472.9	C1CN2C(=O)C(N=C(C3=CC(=CC1=C32)Cl)C4=CC=CC=C4F)NC(=O)C5=CC6=CC=CC=C6N5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B6JYK0	[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-[3-hydroxymethyl-6,7-dimethoxy-4-(3,4,5-trimethoxy-phenyl)-naphthalen-2-yl]-methanone	Investigative	10602534	C29H36N2O8	540.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)CO)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B75RUK	4-Amino-3,5-dichloro-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	Investigative	44348994	C24H18Cl2N4O2	465.3	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=CC(=C(C(=C5)Cl)N)Cl	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B7AG1X	1-(1,3-Benzodioxole-5-yl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10792119	C28H30N2O8	522.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC4=C(C=C3)OCO4)C(=O)OC)C(=O)N5CCN(CC5)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B7E5PT	6-Methoxy-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-12-one	Investigative	10541661	C18H16N2O2	292.3	COC1=CC2=C3C(=C1)C(=NCC(=O)N3CC2)C4=CC=CC=C4	IC50 = 77000 nM	Poor binder
T33754	Phosphodiesterase 3	B7EMW3	2-Butyl-5-phenyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	44323257	C20H19N3O	317.4	CCCCN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)C4=CC=CC=C4	IC50 = 68000 nM	Poor binder
T33754	Phosphodiesterase 3	B7MC1N	6,8-Dimethoxy-4-methyl-3H-quinazolin-2-one	Investigative	13813707	C11H12N2O3	220.22	CC1=C2C=C(C=C(C2=NC(=O)N1)OC)OC	IC50 = 190000 nM	Poor binder
T33754	Phosphodiesterase 3	B7VD1F	2-Butyl-4-pyrrolizinothieno[3,2-d]pyrimidine	Investigative	44279648	C14H19N3S	261.39	CCCCC1=NC2=C(C(=N1)N3CCCC3)SC=C2	IC50 = 68000 nM	Poor binder
T33754	Phosphodiesterase 3	B80KSO	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]quinoline-3-carboxamide	Investigative	10789583	C27H21N5O2	447.5	C1CN2C(=O)[C@@H](N=C(C3=CC(=CC1=C32)N)C4=CC=CC=C4)NC(=O)C5=CC6=CC=CC=C6N=C5	IC50 = 53900 nM	Poor binder
T33754	Phosphodiesterase 3	B81LFY	N-[(11R)-6-Amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-2-methoxybenzamide	Investigative	10526455	C25H22N4O3	426.5	COC1=CC=CC=C1C(=O)N[C@H]2C(=O)N3CCC4=C3C(=CC(=C4)N)C(=N2)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B8C0OE	(4-Methyl-piperazin-1-yl)-[8-(3-nitro-phenyl)-[1,7]naphthyridin-6-yl]-methanone	Investigative	10547592	C20H19N5O3	377.4	CN1CCN(CC1)C(=O)C2=NC(=C3C(=C2)C=CC=N3)C4=CC(=CC=C4)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B8E7NX	2-Butyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	44323510	C14H15N3O	241.29	CCCCN1C(=O)C2=C(N1)C3=CC=CC=C3N=C2	IC50 = 136000 nM	Poor binder
T33754	Phosphodiesterase 3	B8EP9B	1-Methyl-5-(2-nitrophenyl)-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one	Investigative	135832642	C15H15N5O3	313.31	CCCC1=NN(C2=C1N=C(NC2=O)C3=CC=CC=C3[N+](=O)[O-])C	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B8F5IL	1-(3,4,5-Trimethoxyphenyl)-3-[(4-oxopiperidino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10650055	C29H31NO9	537.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCC(=O)CC4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B8GC4L	N-(2,6-Difluorobenzyl)-2-butylthieno[3,2-d]pyrimidine-4-amine	Investigative	10830480	C17H17F2N3S	333.4	CCCCC1=NC2=C(C(=N1)NCC3=C(C=CC=C3F)F)SC=C2	IC50 = 64000 nM	Poor binder
T33754	Phosphodiesterase 3	B8O5DE	2-Methyl-5-(4-methylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester	Investigative	70690900	C17H19NO3	285.34	CCOC(=O)C1=C(NC(=O)C(=C1)CC2=CC=C(C=C2)C)C	IC50 = 172500 nM	Poor binder
T33754	Phosphodiesterase 3	B8TZX2	1-(4-Imidazol-1-ylphenyl)-2,3-diazaspiro[4.4]non-1-en-4-one	Investigative	13946685	C16H16N4O	280.32	C1CCC2(C1)C(=NNC2=O)C3=CC=C(C=C3)N4C=CN=C4	IC50 = 54000 nM	Poor binder
T33754	Phosphodiesterase 3	B8UQC3	3(2H)-Isoquinolinone, 4-chloro-6,7-dimethoxy-1-methyl-	Investigative	14067774	C12H12ClNO3	253.68	CC1=C2C=C(C(=CC2=C(C(=O)N1)Cl)OC)OC	IC50 = 62000 nM	Poor binder
T33754	Phosphodiesterase 3	B8Y4LK	3(2H)-Pyridazinone, 5-ethyl-4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-	Investigative	13233885	C15H16N4O	268.31	CCC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 = 74000 nM	Poor binder
T33754	Phosphodiesterase 3	B9BK4M	3-(3-Methyl-2-phenylimidazol-4-yl)-1H-pyridazin-6-one	Investigative	13475882	C14H12N4O	252.27	CN1C(=CN=C1C2=CC=CC=C2)C3=NNC(=O)C=C3	IC50 = 160000 nM	Poor binder
T33754	Phosphodiesterase 3	B9D3TS	2-Methyl-5-benzyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester	Investigative	70690901	C15H15NO3	257.279	CC1=C(C=C(C(=O)N1)CC2=CC=CC=C2)C(=O)OC	IC50 = 163500 nM	Poor binder
T33754	Phosphodiesterase 3	B9EM1H	1-(3,4,5-Trimethoxyphenyl)-3-(piperidinocarbonyl)-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10792156	C29H33NO8	523.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCCCC4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B9F7DC	1-(3,4-Dichlorophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10626417	C27H28Cl2N2O6	547.4	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C=C3)Cl)Cl)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B9H1FP	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-7-chloro-2-naphthoic acid methyl ester	Investigative	10603533	C27H28BrClN2O6	591.9	COC1=C(C(=CC(=C1)C2=C3C=C(C=CC3=CC(=C2C(=O)OC)C(=O)N4CCN(CC4)CCO)Cl)Br)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B9HZ8S	5,8-Dimethoxy-4-methyl-3H-quinazolin-2-one	Investigative	13813706	C11H12N2O3	220.22	CC1=C2C(=CC=C(C2=NC(=O)N1)OC)OC	IC50 = 129000 nM	Poor binder
T33754	Phosphodiesterase 3	B9K6NZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-5-chloro-2-naphthoic acid methyl ester	Investigative	10232923	C27H28BrClN2O6	591.9	COC1=C(C(=CC(=C1)C2=C3C=CC=C(C3=CC(=C2C(=O)OC)C(=O)N4CCN(CC4)CCO)Cl)Br)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B9MY0H	1-(3,4,5-Trimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10626842	C30H36N2O9	568.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	B9R8VI	N-Benzyl-2-(2-methylpropyl)thieno[3,2-d]pyrimidin-4-amine	Investigative	10827879	C17H19N3S	297.4	CC(C)CC1=NC2=C(C(=N1)NCC3=CC=CC=C3)SC=C2	IC50 = 58000 nM	Poor binder
T33754	Phosphodiesterase 3	B9XEJ4	6-(4-(1H-Imidazol-1-yl)phenyl)-5-methylpyridazin-3(2H)-one	Investigative	14099446	C14H12N4O	252.27	CC1=CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	IC50 = 50000 nM	Poor binder
T33754	Phosphodiesterase 3	BA2DJ6	3-[2-(3,4-Dimethoxyphenyl)-1-methylimidazol-4-yl]-4,5-dihydro-1H-pyridazin-6-one	Investigative	13553473	C16H18N4O3	314.34	CN1C=C(N=C1C2=CC(=C(C=C2)OC)OC)C3=NNC(=O)CC3	IC50 = 128000 nM	Poor binder
T33754	Phosphodiesterase 3	BA7SB9	N-[(11R)-6-Methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	Investigative	10718244	C28H22N4O2	446.5	CC1=CC2=C3C(=C1)C(=N[C@H](C(=O)N3CC2)NC(=O)C4=CC5=CC=CC=C5C=N4)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BA7SN4	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-7-methyl-2-naphthoic acid methyl ester	Investigative	10840815	C28H31BrN2O6	571.5	CC1=CC2=C(C(=C(C=C2C=C1)C(=O)N3CCN(CC3)CCO)C(=O)OC)C4=CC(=C(C(=C4)Br)OC)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BA8B1U	9-Benzyl-N,N-dimethyl-2-(trifluoromethyl)purin-6-amine	Investigative	5271722	C15H14F3N5	321.3	CN(C)C1=NC(=NC2=C1N=CN2CC3=CC=CC=C3)C(F)(F)F	IC50 = 61000 nM	Poor binder
T33754	Phosphodiesterase 3	BA92UI	3(2H)-Isoquinolinone, 6,8-dimethoxy-1-methyl-	Investigative	14067800	C12H13NO3	219.24	CC1=C2C(=CC(=O)N1)C=C(C=C2OC)OC	IC50 = 80000 nM	Poor binder
T33754	Phosphodiesterase 3	BABS09	4-[8-(3-Chlorophenyl)-1,7-naphthyridin-6-yl]benzoic Acid	Investigative	10451184	C21H13ClN2O2	360.8	C1=CC(=CC(=C1)Cl)C2=C3C(=CC(=N2)C4=CC=C(C=C4)C(=O)O)C=CC=N3	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BAKE71	5-(2-Hydroxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-D]pyrimidin-7-one	Investigative	136056125	C14H14N4O2	270.29	CCCC1=C2C(=NN1)C(=O)NC(=N2)C3=CC=CC=C3O	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BAX9W7	N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-3-carboxamide	Investigative	10571952	C23H18N4O2	382.4	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=CN=CC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BB0N4P	2-[5-[2,3-Bis(hydroxymethyl)-6,7-dimethoxynaphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochloride	Investigative	45263841	C32H27ClN4O5	583	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CN=C(C=C3)N4C(=O)C5=CC=CC=C5C(=N4)C6=CN=CC=C6)CO)CO.Cl	IC50 = 80000 nM	Poor binder
T33754	Phosphodiesterase 3	BB1XP3	6,7-Dimethoxy-4-(trifluoromethyl)-3H-quinazolin-2-one	Investigative	13365079	C11H9F3N2O3	274.2	COC1=CC2=C(NC(=O)N=C2C=C1OC)C(F)(F)F	IC50 = 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BB74MR	1,4-Dipropyl-1,4-dihydro-5H-imidazo[2,1-i]purin-5-one	Investigative	10706416	C13H17N5O	259.31	CCCN1C=NC2=C1C3=NC=CN3C(=O)N2CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BB92VR	1,4-Dipropyl-7,8-dihydroimidazo[2,1-f]purin-5-one	Investigative	10515565	C13H19N5O	261.32	CCCN1C=NC2=C1C3=NCCN3C(=O)N2CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BBEU89	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-2-naphthoic acid methyl ester	Investigative	10816641	C27H29BrN2O6	557.4	COC1=C(C(=CC(=C1)C2=C(C(=CC3=CC=CC=C32)C(=O)N4CCN(CC4)CCO)C(=O)OC)Br)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BBG85C	6,7-Dipropyltetrazolo[5,1-f]purin-5-one	Investigative	10563356	C11H15N7O	261.279	CCCN1C=NC2=C1N(C(=O)N3C2=NN=N3)CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BBIO52	3,4-Dipropyl-7,8,9,10-tetrahydro-[1,3]diazepino[2,1-f]purin-5-one	Investigative	10613420	C15H23N5O	289.38	CCCN1C=NC2=C1N(C(=O)N3C2=NCCCC3)CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BBN43O	1-(3,4,5-Trimethoxyphenyl)-3-[[4-(hydroxymethyl)piperidino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10792829	C30H35NO9	553.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCC(CC4)CO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BBQ31S	(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-2-yl)-methanol	Investigative	10729204	C14H16O4	248.27	COC1=CC2=CC(=C(C=C2C=C1OC)CO)CO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BC0AT9	1-(3,4,5-Trimethoxyphenyl)-3-[(4-methylpiperazino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10673963	C29H34N2O8	538.6	CN1CCN(CC1)C(=O)C2=C(C(=C3C=C(C(=CC3=C2)OC)OC)C4=CC(=C(C(=C4)OC)OC)OC)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BC3KY5	1-(3,4,5-Trimethoxyphenyl)-6,7-dimethoxy-2,3-naphthalenedicarboxylic acid dimethyl ester	Investigative	44274868	C25H26O9	470.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BC40DN	6-Propyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one	Investigative	135531470	C8H9N7O	219.2	CCCN1C2=C(C3=NN=NN3C1=O)NC=N2	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BC80NT	1-(2-Bromo-4-pyridyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	44274658	C26H28BrN3O6	558.4	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=NC=C3)Br)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BCO5G0	4,7-Dimethyl-N-[(11R)-6-methyl-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyrazolo[5,1-c][1,2,4]triazine-3-carboxamide	Investigative	9825739	C26H23N7O2	465.5	CC1=CC2=C3C(=C1)C(=N[C@H](C(=O)N3CC2)NC(=O)C4=C(N5C(=CC(=N5)C)N=N4)C)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BCQ9N3	5-Phenyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one	Investigative	136056127	C14H14N4O	254.29	CCCC1=C2C(=NN1)C(=O)NC(=N2)C3=CC=CC=C3	IC50 = 63000 nM	Poor binder
T33754	Phosphodiesterase 3	BD3L8G	N-Cyclohexyl-N-methyl-4-[(2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-9-yl)oxy]butanamide	Investigative	135626519	C21H28N4O3	384.5	CN(C1CCCCC1)C(=O)CCCOC2=CC=CC3=C2N=C4NC(=O)CN4C3	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BD3T2P	1,4-Dipropyl-8,9-dihydro-7H-pyrimido[2,1-f]purin-5-one	Investigative	10492653	C14H21N5O	275.35	CCCN1C=NC2=C1C3=NCCCN3C(=O)N2CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BD76NM	N-(6-Methoxy-12-oxo-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-11-yl)pyridine-3-carboxamide	Investigative	11373312	C23H19N5O3	413.4	COC1=NC2=C3C(=C1)CCN3C(=O)C(N=C2C4=CC=CC=C4)NC(=O)C5=CN=CC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BDR9M8	4,4-Diethyl-3-(4-imidazol-1-ylphenyl)-1H-pyrazol-5-one	Investigative	13946684	C16H18N4O	282.34	CCC1(C(=NNC1=O)C2=CC=C(C=C2)N3C=CN=C3)CC	IC50 = 120000 nM	Poor binder
T33754	Phosphodiesterase 3	BE7JQ5	N-(13-Oxo-10-phenyl-1,11-diazatricyclo[7.4.1.05,14]tetradeca-5(14),6,8,10-tetraen-12-yl)-1H-indole-2-carboxamide	Investigative	44209388	C27H22N4O2	434.5	C1CC2=C3C(=CC=C2)C(=NC(C(=O)N3C1)NC(=O)C4=CC5=CC=CC=C5N4)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BEB5V4	3-(4-Acetyl-2,3-dihydro-1,4-benzoxazin-6-yl)-4,5-dihydro-1H-pyridazin-6-one	Investigative	15599408	C14H15N3O3	273.29	CC(=O)N1CCOC2=C1C=C(C=C2)C3=NNC(=O)CC3	IC50 = 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BEC1S6	N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	Investigative	10552011	C28H22N4O3	462.5	COC1=CC2=C3C(=C1)C(=N[C@H](C(=O)N3CC2)NC(=O)C4=CC5=CC=CC=C5C=N4)C6=CC=CC=C6	IC50 = 82000 nM	Poor binder
T33754	Phosphodiesterase 3	BED62N	4-Cyclopentyl-6,7-dimethoxy-1-methyl-2H-isoquinolin-3-one	Investigative	14067812	C17H21NO3	287.35	CC1=C2C=C(C(=CC2=C(C(=O)N1)C3CCCC3)OC)OC	IC50 = 128000 nM	Poor binder
T33754	Phosphodiesterase 3	BEHX76	6-Trifluoromethylsulfonyloxy-8-(3-nitrophenyl)-1,7-naphthyridine	Investigative	10810934	C15H8F3N3O5S	399.3	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C3C(=CC(=N2)OS(=O)(=O)C(F)(F)F)C=CC=N3	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BEM24L	6-(4-Methylsulfonyl-2,3-dihydro-1,4-benzoxazin-6-yl)-2-phenyl-4,5-dihydropyridazin-3-one	Investigative	44350226	C19H19N3O4S	385.4	CS(=O)(=O)N1CCOC2=C1C=C(C=C2)C3=NN(C(=O)CC3)C4=CC=CC=C4	IC50 = 200000 nM	Poor binder
T33754	Phosphodiesterase 3	BEN3V1	[7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-naphtho[2,3-d][1,3]dioxol-6-yl]-methanol	Investigative	10692240	C22H22O7	398.4	COC1=CC(=CC(=C1OC)OC)C2=C3C=C4C(=CC3=CC(=C2CO)CO)OCO4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BEPU95	N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	Investigative	44349295	C27H22N4O3	450.5	COC1=CC2=C3C(=C1)C(=N[C@H](C(=O)N3CC2)NC(=O)C4=CC5=CC=CC=C5N4)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BF60BE	4-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	Investigative	10525677	C24H21N5O2	411.5	C1CN2C(=O)[C@@H](N=C(C3=CC(=CC1=C32)N)C4=CC=CC=C4)NC(=O)C5=CC=C(C=C5)N	IC50 = 86800 nM	Poor binder
T33754	Phosphodiesterase 3	BF9W4G	Methyl 7-[(2-methylpyridin-4-yl)methyl]-8-oxo-2-(pyridin-2-ylmethoxy)-5-(3,4,5-trimethoxyphenyl)-1,7-naphthyridine-6-carboxylate;hydrochloride	Investigative	45264572	C32H31ClN4O7	619.1	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)N=C(C=C3)OCC4=CC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BFAK10	6-(4-Imidazol-1-yl-phenyl)-2-methyl-4,5-dihydro-2H-pyridazin-3-one	Investigative	13233881	C14H14N4O	254.29	CN1C(=O)CCC(=N1)C2=CC=C(C=C2)N3C=CN=C3	IC50 = 110000 nM	Poor binder
T33754	Phosphodiesterase 3	BFD7K3	N-Benzylthieno[3,2-d]pyrimidin-4-amine	Investigative	10610142	C13H11N3S	241.31	C1=CC=C(C=C1)CNC2=NC=NC3=C2SC=C3	IC50 = 68000 nM	Poor binder
T33754	Phosphodiesterase 3	BG0F1E	2-Butyl-N-[(4-phenylphenyl)methyl]thieno[3,2-d]pyrimidin-4-amine	Investigative	10690761	C23H23N3S	373.5	CCCCC1=NC2=C(C(=N1)NCC3=CC=C(C=C3)C4=CC=CC=C4)SC=C2	IC50 = 200000 nM	Poor binder
T33754	Phosphodiesterase 3	BG1T9L	1-Butyl-4-(7-ethoxy-2,3-bis-hydroxymethyl-5-methoxy-naphthalen-1-yl)-3,6-dihydro-1H-pyridin-2-one	Investigative	44324391	C24H31NO5	413.5	CCCCN1CC=C(CC1=O)C2=C(C(=CC3=C2C=C(C=C3OC)OCC)CO)CO	IC50 = 50000 nM	Poor binder
T33754	Phosphodiesterase 3	BG2OL9	3-[(E)-2-[4-(4,5-Dimethylimidazol-1-yl)phenyl]ethenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one	Investigative	44344410	C18H20N4O	308.4	CC1CC(=O)NN=C1/C=C/C2=CC=C(C=C2)N3C=NC(=C3C)C	IC50 = 87000 nM	Poor binder
T33754	Phosphodiesterase 3	BG5AB4	3,4-Dipropyl-3,4-dihydro-5H-imidazo[2,1-i]purin-5-one	Investigative	9859958	C13H17N5O	259.31	CCCN1C=NC2=C1N(C(=O)N3C2=NC=C3)CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BG5X3F	2-[4-[2,3-Bis(hydroxymethyl)naphthalen-1-yl]pyridin-2-yl]-4-pyridin-3-ylphthalazin-1-one;hydrochloride	Investigative	45259281	C30H23ClN4O3	523	C1=CC=C2C(=C1)C=C(C(=C2C3=CC(=NC=C3)N4C(=O)C5=CC=CC=C5C(=N4)C6=CN=CC=C6)CO)CO.Cl	IC50 = 50000 nM	Poor binder
T33754	Phosphodiesterase 3	BHE2C0	1-(3,4,5-Trimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]methyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10792853	C30H38N2O8	554.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)CN4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BI85PY	6,7-Dimethoxy-2-methyl-4-(3,4,5-trimethoxy-phenyl)-benzo[f]isoindole-1,3-dione	Investigative	10550927	C24H23NO7	437.4	CN1C(=O)C2=C(C1=O)C(=C3C=C(C(=CC3=C2)OC)OC)C4=CC(=C(C(=C4)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BIDO97	3-Isoquinolinecarboxylic acid, 2-(4-aminophenyl)-1,2-dihydro-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester, sulfate (1:1)	Investigative	9874535	C32H31N3O11S	665.7	COC1=CC(=CC(=C1OC)OC)C2=C(N(C(=O)C3=C2C=CC(=C3)OCC4=CC=CC=N4)C5=CC=C(C=C5)N)C(=O)OC.OS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BIHJ91	2-Methyl-5-propyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester	Investigative	44178556	C12H17NO3	223.27	CCCC1=CC(=C(NC1=O)C)C(=O)OCC	IC50 = 125100 nM	Poor binder
T33754	Phosphodiesterase 3	BILA49	2-Phenethyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	12016992	C25H21N3O	379.5	C1=CC=C(C=C1)CCN2C(=O)C3=CN(C4=CC=CC=C4C3=N2)CC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BIT6E2	4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-1-(2-methoxy-ethyl)-3,6-dihydro-1H-pyridin-2-one	Investigative	44324507	C24H31NO6	429.5	CCOC1=CC2=CC(=C(C(=C2C=C1OCC)C3=CCN(C(=O)C3)CCOC)CO)CO	IC50 = 57000 nM	Poor binder
T33754	Phosphodiesterase 3	BJ01WX	1-Butyl-4-(6,7-diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-3,6-dihydro-1H-pyridin-2-one	Investigative	44324390	C25H33NO5	427.5	CCCCN1CC=C(CC1=O)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OCC)OCC	IC50 = 50000 nM	Poor binder
T33754	Phosphodiesterase 3	BJ8ZK6	4-(3-Chloro-4-methoxy-benzylamino)-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester	Investigative	44286951	C21H18ClF3N2O3	438.8	CCOC(=O)C1=CN=C2C=C(C=CC2=C1NCC3=CC(=C(C=C3)OC)Cl)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T33754	Phosphodiesterase 3	BJO4C3	2-Butyl-5-(cyclohexylmethyl)-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	44323256	C21H27N3O	337.5	CCCCN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CC4CCCCC4	IC50 = 111000 nM	Poor binder
T33754	Phosphodiesterase 3	BKP81M	PDE4 inhibitor intermediate 1	Investigative	9842576	C21H29NO5	375.5	CC(=O)[C@@]1(CN(C[C@H]1C2=CC(=C(C=C2)OC)OC3CCCC3)C(=O)OC)C	Ki ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BKVA57	Methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(2-pyridin-2-ylethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate;hydrochloride	Investigative	45264635	C33H33ClN4O7	633.1	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCCC4=CC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BL13VU	(3Z)-3-[[3-(2-Bicyclo[2.2.1]heptanyloxy)-4-methoxyphenyl]methylidene]-1H-indol-2-one	Investigative	11726102	C23H23NO3	361.4	COC1=C(C=C(C=C1)/C=C\\2/C3=CC=CC=C3NC2=O)OC4CC5CCC4C5	IC50 = 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BL51JC	(11R,15S)-8-Methyl-4-propyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one	Investigative	10754735	C14H19N5O	273.33	CCCC1=NC2=C(N1)C(=O)N(C3=N[C@@H]4CCC[C@@H]4N23)C	IC50 = 80000 nM	Poor binder
T33754	Phosphodiesterase 3	BL6IY3	4-Propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one	Investigative	135442775	C10H13N5O	219.24	CCCN1C2=NC=NC2=C3NCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BMH5Z1	4-Chloro-N-[(11R)-6-methoxy-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]benzamide	Investigative	44348937	C25H20ClN3O3	445.9	COC1=CC2=C3C(=C1)C(=N[C@H](C(=O)N3CC2)NC(=O)C4=CC=C(C=C4)Cl)C5=CC=CC=C5	IC50 = 62000 nM	Poor binder
T33754	Phosphodiesterase 3	BMIV96	4-Propyl-7,8,9,10-tetrahydropyrimido[2,1-f]purin-5-one	Investigative	135528334	C11H15N5O	233.27	CCCN1C2=NC=NC2=C3NCCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BN1XZ6	3,5-Dichloro-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	Investigative	10694878	C23H16Cl2N4O2	451.3	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=C(C=NC=C5Cl)Cl	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BN9AQ1	6-(4-Carboxyphenyl)-8-(3-cyanophenyl)-1,7-naphthyridine	Investigative	9928390	C22H13N3O2	351.4	C1=CC(=CC(=C1)C2=C3C(=CC(=N2)C4=CC=C(C=C4)C(=O)O)C=CC=N3)C#N	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BNO4D2	1-[(1-Butyl-2-oxo-1,2-dihydropyridin)-4-yl]-6,7-dimethoxynaphthalene-2,3-dimethanol	Investigative	10763354	C23H27NO5	397.5	CCCCN1C=CC(=CC1=O)C2=C3C=C(C(=CC3=CC(=C2CO)CO)OC)OC	IC50 = 80000 nM	Poor binder
T33754	Phosphodiesterase 3	BNQE49	3-Amino-N-[(11R)-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	Investigative	10644497	C23H19N5O2	397.4	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=C(C=NC=C5)N	IC50 = 90000 nM	Poor binder
T33754	Phosphodiesterase 3	BO3FU5	6-(4-Methylsulfonyl-2,3-dihydro-1,4-benzoxazin-6-yl)-2-pentyl-4,5-dihydropyridazin-3-one	Investigative	15599405	C18H25N3O4S	379.5	CCCCCN1C(=O)CCC(=N1)C2=CC3=C(C=C2)OCCN3S(=O)(=O)C	IC50 = 50000 nM	Poor binder
T33754	Phosphodiesterase 3	BO4HU9	N-[(3R)-1-(2-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indol-3-yl]-1H-indole-2-carboxamide	Investigative	10455790	C26H19FN4O2	438.5	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4F)NC(=O)C5=CC6=CC=CC=C6N5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BOGA69	6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one	Investigative	15599407	C12H13N3O2	231.25	C1CC(=O)NN=C1C2=CC3=C(C=C2)OCCN3	IC50 = 50000 nM	Poor binder
T33754	Phosphodiesterase 3	BOM6H7	1,3,7,8-Tetramethylimidazo[4,5-b]quinolin-2-one	Investigative	15065166	C14H15N3O	241.29	CC1=C(C2=CC3=C(N=C2C=C1)N(C(=O)N3C)C)C	IC50 = 70000 nM	Poor binder
T33754	Phosphodiesterase 3	BOM9S0	2-Methyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	12016985	C18H15N3O	289.3	CN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CC4=CC=CC=C4	IC50 = 67000 nM	Poor binder
T33754	Phosphodiesterase 3	BOR72W	1-(2-Methyl-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	44274717	C30H36N2O8	552.6	CC1=CC(=C(C=C1C2=C3C=C(C(=CC3=CC(=C2C(=O)OC)C(=O)N4CCN(CC4)CCO)OC)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BP1Q9U	1-(3,4,5-Trimethoxyphenyl)-3-[(4-hydroxypiperidino)carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	11800567	C29H33NO9	539.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCC(CC4)O	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BP23YG	6-Methoxy-1-methylisoquinolin-3-ol	Investigative	6624932	C11H11NO2	189.21	CC1=C2C=CC(=CC2=CC(=O)N1)OC	IC50 = 160000 nM	Poor binder
T33754	Phosphodiesterase 3	BP5R8O	N-[(11R)-6-Acetamido-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	Investigative	10646721	C25H21N5O3	439.5	CC(=O)NC1=CC2=C3C(=C1)C(=N[C@H](C(=O)N3CC2)NC(=O)C4=CC=NC=C4)C5=CC=CC=C5	IC50 = 70000 nM	Poor binder
T33754	Phosphodiesterase 3	BPC5O6	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-ethoxy-7-methoxy-2-naphthoic acid methyl ester	Investigative	10579873	C30H35BrN2O8	631.5	CCOC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BQ5H8D	Desmethylsildenafil	Investigative	135455980	C21H28N6O4S	460.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCNCC4)OCC)C	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BQAX74	6-Methoxy-1,2,3,4-tetrahydroquinoline-2,4-dione	Investigative	44333357	C10H9NO3	191.18	COC1=CC2=C(C=C1)NC(=O)CC2=O	IC50 = 53000 nM	Poor binder
T33754	Phosphodiesterase 3	BQP1D7	(R)-7-Isopropyl-5-methyl-2-(4-methyl-pentyl)-7,8-dihydro-3H,5H-imidazo[2,1-b]purin-4-one	Investigative	44272155	C17H27N5O	317.4	CC(C)CCCC1=NC2=C(N1)C(=O)N(C3=N[C@@H](CN23)C(C)C)C	IC50 = 65000 nM	Poor binder
T33754	Phosphodiesterase 3	BQTG90	2-Pentyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	12016990	C22H23N3O	345.4	CCCCCN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CC4=CC=CC=C4	IC50 = 120000 nM	Poor binder
T33754	Phosphodiesterase 3	BR5UT2	Ethyl 5-[(2,4-dichlorophenyl)methyl]-2-methyl-6-oxo-1H-pyridine-3-carboxylate	Investigative	70697129	C16H15Cl2NO3	340.2	CCOC(=O)C1=C(NC(=O)C(=C1)CC2=C(C=C(C=C2)Cl)Cl)C	IC50 = 172130 nM	Poor binder
T33754	Phosphodiesterase 3	BR7F3W	(11R,15S)-4-Heptan-4-yl-8-methyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one	Investigative	44272162	C18H27N5O	329.4	CCCC(CCC)C1=NC2=C(N1)C(=O)N(C3=N[C@@H]4CCC[C@@H]4N23)C	IC50 = 80000 nM	Poor binder
T33754	Phosphodiesterase 3	BRIX85	2-Methyl-6-(4-methylsulfonyl-2,3-dihydro-1,4-benzoxazin-6-yl)-4,5-dihydropyridazin-3-one	Investigative	14230056	C14H17N3O4S	323.37	CN1C(=O)CCC(=N1)C2=CC3=C(C=C2)OCCN3S(=O)(=O)C	IC50 = 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BRY3A9	CID 13756813	Investigative	13756813	C22H30N4O3	398.5	CN1C(=O)CN2C1=NC3=C(C2)C=C(C=C3)OCCCC(=O)N(C)C4CCCCC4	IC50 = 76000 nM	Poor binder
T33754	Phosphodiesterase 3	BRZ3S0	1-[(E)-3,4,5-Trimethoxystyryl]-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10651107	C32H38N2O9	594.7	COC1=CC(=CC(=C1OC)OC)/C=C/C2=C3C=C(C(=CC3=CC(=C2C(=O)OC)C(=O)N4CCN(CC4)CCO)OC)OC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BS15CW	4-[8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl]benzoic Acid	Investigative	9999276	C21H13N3O4	371.3	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C3C(=CC(=N2)C4=CC=C(C=C4)C(=O)O)C=CC=N3	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BS4MT6	4-Propyl-8,9,10,11-tetrahydro-7H-[1,3]diazepino[2,1-f]purin-5-one	Investigative	135456675	C12H17N5O	247.3	CCCN1C2=NC=NC2=C3NCCCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BSDH79	3-[2-(3,4-Dimethoxyphenyl)-1-methylimidazol-4-yl]-1H-pyridazin-6-one	Investigative	13553476	C16H16N4O3	312.32	CN1C=C(N=C1C2=CC(=C(C=C2)OC)OC)C3=NNC(=O)C=C3	IC50 = 75000 nM	Poor binder
T33754	Phosphodiesterase 3	BSV3U2	6,7-Dimethoxy-3-(pyrrolidine-1-carbonyl)-1-(3,4,5-trimethoxy-phenyl)-naphthalene-2-carboxylic acid methyl ester	Investigative	10625498	C28H31NO8	509.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCCC4	IC50 = 77000 nM	Poor binder
T33754	Phosphodiesterase 3	BT04OB	6-Methoxy-1,3-benzoxazin-2-one	Investigative	44333376	C9H7NO3	177.16	COC1=CC2=C(C=C1)OC(=O)N=C2	IC50 = 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BT4O1Z	N-Benzyl-6-chloro-2-pyridin-3-ylquinazolin-4-amine;dihydrochloride	Investigative	45261662	C20H17Cl3N4	419.7	C1=CC=C(C=C1)CNC2=NC(=NC3=C2C=C(C=C3)Cl)C4=CN=CC=C4.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T33754	Phosphodiesterase 3	BT5Y3C	3,4-Dipropyl-7,8-dihydroimidazo[2,1-f]purin-5-one	Investigative	9881656	C13H19N5O	261.32	CCCN1C=NC2=C1N(C(=O)N3C2=NCC3)CCC	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BTK12W	Tert-butyl N-[4-[[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]carbamoyl]pyridin-3-yl]carbamate	Investigative	10649414	C28H28N6O4	512.6	CC(C)(C)OC(=O)NC1=C(C=CN=C1)C(=O)N[C@H]2C(=O)N3CCC4=C3C(=CC(=C4)N)C(=N2)C5=CC=CC=C5	IC50 = 58200 nM	Poor binder
T33754	Phosphodiesterase 3	BU1AK8	1-(3,5-Dichlorophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10840332	C27H28Cl2N2O6	547.4	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=CC(=C3)Cl)Cl)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BU7AX8	1-(3-Nitrophenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10506218	C27H29N3O8	523.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BU9QS8	3-Amino-N-[(11R)-6-amino-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]pyridine-4-carboxamide	Investigative	10787820	C23H20N6O2	412.4	C1CN2C(=O)[C@@H](N=C(C3=CC(=CC1=C32)N)C4=CC=CC=C4)NC(=O)C5=C(C=NC=C5)N	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BV4CK7	4-Methylquinazolin-2(1H)-one	Investigative	3015712	C9H8N2O	160.17	CC1=C2C=CC=CC2=NC(=O)N1	IC50 = 138000 nM	Poor binder
T33754	Phosphodiesterase 3	BV8A6B	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-methoxy-2-naphthoic acid methyl ester	Investigative	10674875	C28H31BrN2O7	587.5	COC1=CC2=CC(=C(C(=C2C=C1)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BVO4J9	(11R,15S)-4-Ethyl-8-methyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one	Investigative	44272313	C13H17N5O	259.31	CCC1=NC2=C(N1)C(=O)N(C3=N[C@@H]4CCC[C@@H]4N23)C	IC50 = 150000 nM	Poor binder
T33754	Phosphodiesterase 3	BVW6Z9	2(1H)-Quinazolinone, 6,7-dimethoxy-4-methyl-	Investigative	12726304	C11H12N2O3	220.22	CC1=C2C=C(C(=CC2=NC(=O)N1)OC)OC	IC50 = 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BVX07Q	(11R,15S)-8-Methyl-4-pentan-3-yl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one	Investigative	44272341	C16H23N5O	301.39	CCC(CC)C1=NC2=C(N1)C(=O)N(C3=N[C@@H]4CCC[C@@H]4N23)C	IC50 = 150000 nM	Poor binder
T33754	Phosphodiesterase 3	BW1M0I	1-(3,4,5-Trimethoxyphenyl)-3-(morpholinocarbonyl)-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10625920	C28H31NO9	525.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCOCC4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BX8D0H	9-[(2-Fluorophenyl)methyl]-N-methylpurin-6-amine;methanesulfonic acid	Investigative	44295018	C14H16FN5O3S	353.37	CNC1=C2C(=NC=N1)N(C=N2)CC3=CC=CC=C3F.CS(=O)(=O)O	IC50 = 121000 nM	Poor binder
T33754	Phosphodiesterase 3	BXL2C9	N-[(11S)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	Investigative	11742876	C26H20N4O2	420.5	C1CN2C(=O)[C@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=CC6=CC=CC=C6N5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BY9I3L	N-[2-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-phenyl]-methanesulfonamide	Investigative	136056129	C16H19N5O3S	361.4	CCCC1=NN(C2=C1N=C(NC2=O)C3=CC=CC=C3NS(=O)(=O)C)C	IC50 = 83000 nM	Poor binder
T33754	Phosphodiesterase 3	BYO60E	N-[(11R)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	Investigative	10342086	C26H20N4O2	420.5	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=CC6=CC=CC=C6N5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	BZ35BY	9-Benzyl-2-(trifluoromethyl)purin-6-amine	Investigative	349956	C13H10F3N5	293.25	C1=CC=C(C=C1)CN2C=NC3=C(N=C(N=C32)C(F)(F)F)N	IC50 = 101000 nM	Poor binder
T33754	Phosphodiesterase 3	BZO90F	2-Tert-Butyl-5-benzyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	12016989	C21H21N3O	331.4	CC(C)(C)N1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D01TOR	Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine	Investigative	667555	C20H16N4	312.4	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CN=CC=C4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D02NWF	Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine	Investigative	2573787	C19H15N3S	317.4	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CC=CS4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D09AUL	Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine	Investigative	10266864	C18H15N5	301.3	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)N4C=CN=C4	IC50 = 50000 nM	Poor binder
T33754	Phosphodiesterase 3	D0DL6J	CI-1044	Investigative	9843744	C23H19N5O2	397.4	C1CN2C(=O)[C@@H](N=C(C3=CC(=CC1=C32)N)C4=CC=CC=C4)NC(=O)C5=CN=CC=C5	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D0J7GF	Benzyl-(2-phenyl-quinazolin-4-yl)-amine	Investigative	780643	C21H17N3	311.4	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T33754	Phosphodiesterase 3	D0U8YQ	Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine	Investigative	921562	C20H16N4	312.4	C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder