Protein-Protein Interaction Details
Protein General Information | Top | ||||
---|---|---|---|---|---|
Full Name | Mad-related protein 1 (SMAD1) | ||||
UniProt ID | SMAD1_HUMAN | ||||
Gene Name | SMAD1 | ||||
Gene ID | 4086 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Literature-reported Target(s) | E3 ubiquitin-protein ligase NEDD4 (NEDD4) | Target Info | PPI Info | [1] | |
Enhancer of filamentation 1 (NEDD9) | Target Info | PPI Info | [2] | ||
Yes-associated protein 1 (YAP1) | Target Info | PPI Info | [3] | ||
Runt-related transcription factor 2 (RUNX2) | Target Info | PPI Info | [4] | ||
Interacting Preclinical Target(s) | Mothers against decapentaplegic homolog 3 (SMAD3) | Target Info | PPI Info | [5] |
References | Top | ||||
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REF 1 | Phospho-Smad1 modulation by nedd4 E3 ligase in BMP/TGF- signaling. J Bone Miner Res. 2011 Jul;26(7):1411-24. | ||||
REF 2 | A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1. EMBO J. 2000 Dec 15;19(24):6759-69. | ||||
REF 3 | Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell. 2009 Nov 13;139(4):757-69. | ||||
REF 4 | A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10549-54. | ||||
REF 5 | Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol. 1997 May;17(5):2521-8. |
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