Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T94048 Target Info
Target Name Yes-associated protein 1 (YAP1)
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Target Type Literature-reported Target
Gene Name YAP1
UniProt ID
YAP1_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Fluorescence Resonance Energy Transfer [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase pez (PTPN14) Literature-reported Target Interacting Protein Info
UniProt ID
PTN14_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 14; PTPD2; PEZ
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [5]
5 Affinity Capture-Western [6]
6 Reconstituted Complex [6]
7 Reconstituted Complex [7]
8 Reconstituted Complex [8]
Kinases [+] 4 Kinases +
Interacting Protein Name Serine/threonine-protein kinase LATS1 (LATS1) Interacting Protein Interacting Protein Info
UniProt ID
LATS1_HUMAN 
Synonyms WARTS; wts
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [5]
5 Affinity Capture-Western [9]
6 Affinity Capture-Western [10]
7 Affinity Capture-Western [11]
8 Affinity Capture-Western [12]
9 Affinity Capture-Western [13]
10 Affinity Capture-Western [14]
11 Reconstituted Complex [12]
12 Reconstituted Complex [8]
Interacting Target Name Large tumor suppressor homolog 2 (LATS2) Literature-reported Target Interacting Protein Info
UniProt ID
LATS2_HUMAN 
Synonyms Warts-like kinase; Serine/threonine-protein kinase LATS2; Serine/threonine-protein kinase kpm; KPM; Kinase phosphorylated during mitosis protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [10]
4 Affinity Capture-Western [15]
5 Biochemical Activity [16]
6 Fluorescence Resonance Energy Transfer [3]
Interacting Target Name Erbb4 tyrosine kinase receptor (Erbb-4) Successful Target Interacting Protein Info
UniProt ID
ERBB4_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; P180erbB4; HER4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Co-localization [18]
3 Reconstituted Complex [8]
4 Yeast two hybrid [19]
Interacting Target Name ERK activator kinase 1 (MEK1) Clinical trial Target Interacting Protein Info
UniProt ID
MP2K1_HUMAN 
Synonyms PRKMK1; MKK1; Mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERKkinase 1; MAPK/ERK kinase 1; MAP kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [20]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Protein Name MAGUK p55 subfamily member 5 (MPP5) Interacting Protein Interacting Protein Info
UniProt ID
MPP5_HUMAN 
Synonyms PALS1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [5]
5 Proximity Label-MS [1]
Proteins 14-3-3 [+] 3 Proteins 14-3-3 +
Interacting Target Name AS1 14-3-3 protein eta (YWHAH) Literature-reported Target Interacting Protein Info
UniProt ID
1433F_HUMAN 
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [5]
5 Proximity Label-MS [1]
Interacting Protein Name 14-3-3 protein gamma (YWHAG) Interacting Protein Interacting Protein Info
UniProt ID
1433G_HUMAN 
Synonyms 14.3.3GAMMA; PPP1R170
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [5]
4 Fluorescence Resonance Energy Transfer [3]
5 Proximity Label-MS [1]
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [5]
5 Affinity Capture-Western [21]
Transcription regulators [+] 8 Transcription regulators +
Interacting Protein Name Tumor protein p73 (TP73) Interacting Protein Interacting Protein Info
UniProt ID
P73_HUMAN 
Synonyms P73
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [23]
4 Affinity Capture-Western [24]
5 Affinity Capture-Western [25]
6 Affinity Capture-Western [26]
7 Reconstituted Complex [8]
Interacting Protein Name Transcriptional enhancer factor TEF-1 (TEAD1) Interacting Protein Interacting Protein Info
UniProt ID
TEAD1_HUMAN 
Synonyms AA; NTEF.1; REF1; TCF.13; TCF13; TEAD.1; TEF.1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [21]
3 Affinity Capture-Western [5]
4 Co-localization [5]
5 Proximity Label-MS [1]
Interacting Target Name Mothers against decapentaplegic homolog 7 (SMAD7) Clinical trial Target Interacting Protein Info
UniProt ID
SMAD7_HUMAN 
Synonyms Smad7; SMAD family member 7; SMAD 7; Mothers against DPP homolog 8; Mothers against decapentaplegic homolog 8; MAD homolog 8; hSMAD7
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Co-crystal Structure [28]
3 Reconstituted Complex [8]
4 Yeast two hybrid [27]
Interacting Protein Name Transcriptional enhancer factor TEF-5 (TEAD3) Interacting Protein Interacting Protein Info
UniProt ID
TEAD3_HUMAN 
Synonyms DTEF.1; ETFR.1; TEAD.3; TEAD5; TEF.5; TEF5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [5]
4 Proximity Label-MS [1]
Interacting Protein Name Mad-related protein 1 (SMAD1) Interacting Protein Interacting Protein Info
UniProt ID
SMAD1_HUMAN 
Synonyms Transforming growth factor-beta-signaling protein 1; Smad1; SMAD family member 1; SMAD 1; Mothers against DPP homolog 1; Mothers against decapentaplegic homolog 1; Mad-related protein 1; MADR1; MADH1; MAD homolog 1; JV4-1; BSP-1; BSP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Co-crystal Structure [30]
3 Reconstituted Complex [30]
Interacting Protein Name Runt-related transcription factor 1 (RUNX1) Interacting Protein Interacting Protein Info
UniProt ID
RUNX1_HUMAN 
Synonyms AML1; AML1.EVI.1; AMLCR1; CBFA2; EVI.1; PEBP2aB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [31]
2 Reconstituted Complex [8]
3 Yeast two hybrid [32]
Interacting Target Name Signal transducer and activator of transcription 1 (STAT1) Patented-recorded Target Interacting Protein Info
UniProt ID
STAT1_HUMAN 
Synonyms Transcription factor ISGF-3 components p91/p84; STAT-1; Signal transducers and activators of transcription factor; Signal transducer and activator of transcription 1-alpha/beta; P91
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Co-fractionation [33]
Interacting Target Name Runt-related transcription factor 2 (RUNX2) Literature-reported Target Interacting Protein Info
UniProt ID
RUNX2_HUMAN 
Synonyms SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha Asubunit; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2-alpha A; PEBP2A; PEA2-alpha A; Osteoblast-specific transcription factor 2; OSF-2; OSF2; Oncogene AML-3; Core-binding factor subunit alpha-1; CBF-alpha-1; CBFA1; AML3; Acute myeloid leukemia 3 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [32]
Other proteins [+] 11 Other proteins +
Interacting Protein Name Apoptosis-stimulating of p53 protein 2 (TP53BP2) Interacting Protein Interacting Protein Info
UniProt ID
ASPP2_HUMAN 
Synonyms 53BP2; ASPP2; BBP; P53BP2; PPP1R13A
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [5]
5 Far Western [34]
6 Protein-peptide [34]
7 Proximity Label-MS [1]
8 Reconstituted Complex [35]
9 Yeast two hybrid [35]
Interacting Target Name Angiomotin (AMOT) Literature-reported Target Interacting Protein Info
UniProt ID
AMOT_HUMAN 
Synonyms KIAA1071
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [36]
4 Affinity Capture-Western [37]
5 Reconstituted Complex [38]
Interacting Protein Name Angiomotin-like protein 2 (AMOTL2) Interacting Protein Interacting Protein Info
UniProt ID
AMOL2_HUMAN 
Synonyms LCCP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [5]
5 Proximity Label-MS [1]
Interacting Protein Name InaD-like protein (PATJ) Interacting Protein Interacting Protein Info
UniProt ID
INADL_HUMAN 
Synonyms Cipp; InaD.like; PATJ; hINADL
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [5]
5 Proximity Label-MS [1]
Interacting Protein Name Angiomotin-like protein 1 (AMOTL1) Interacting Protein Interacting Protein Info
UniProt ID
AMOL1_HUMAN 
Synonyms JEAP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Proximity Label-MS [1]
Interacting Protein Name Multiple PDZ domain protein (MPDZ) Interacting Protein Interacting Protein Info
UniProt ID
MPDZ_HUMAN 
Synonyms HYC2; MUPP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Proximity Label-MS [1]
Interacting Protein Name WW domain-binding protein 2 (WBP2) Interacting Protein Interacting Protein Info
UniProt ID
WBP2_HUMAN 
Synonyms WBP.2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [2]
4 Reconstituted Complex [8]
Interacting Protein Name AT-rich interactive domain-containing protein 1A (ARID1A) Interacting Protein Interacting Protein Info
UniProt ID
ARI1A_HUMAN 
Synonyms B120; BAF250; BAF250a; BM029; C1orf4; ELD; MRD14; OSA1; P270; SMARCF1; hELD; hOSA1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [2]
3 Proximity Label-MS [1]
Interacting Protein Name Ras association domain-containing protein 8 (RASSF8) Interacting Protein Interacting Protein Info
UniProt ID
RASF8_HUMAN 
Synonyms C12orf2; HOJ1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Proximity Label-MS [1]
Interacting Protein Name Zinc finger protein ubi-d4 (DPF2) Interacting Protein Interacting Protein Info
UniProt ID
REQU_HUMAN 
Synonyms REQ; UBID4; ubi.d4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Proximity Label-MS [1]
Interacting Protein Name WW domain-binding protein 1 (WBP1) Interacting Protein Interacting Protein Info
UniProt ID
WBP1_HUMAN 
Synonyms WBP.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [39]
2 Reconstituted Complex [8]
References  Top
REF 1 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal. 2013 Nov 19;6(302):rs15.
REF 2 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 3 OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc. Oncogene. 2017 Oct 19;36(42):5852-5860.
REF 4 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Mol Syst Biol. 2013 Dec 22;9:713.
REF 5 Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 2015 May 12;34(10):1349-70.
REF 6 PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71.
REF 7 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 8 Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity. FEBS J. 2014 Dec;281(24):5532-51.
REF 9 Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res. 2008 Apr 15;68(8):2789-94.
REF 10 Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP. Genes Dev. 2010 Nov 1;24(21):2430-9.
REF 11 Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem. 2008 Oct 10;283(41):27534-46.
REF 12 Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem. 2008 Feb 29;283(9):5496-509.
REF 13 RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell. 2007 Sep 21;27(6):962-75.
REF 14 RAR Downregulation Contributes to Colorectal Tumorigenesis and Metastasis by Derepressing the Hippo-Yap Pathway. Cancer Res. 2016 Jul 1;76(13):3813-25.
REF 15 Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73. Blood. 2008 Nov 1;112(9):3856-66.
REF 16 Hippo pathway-dependent and -independent roles of RASSF6. Sci Signal. 2009 Sep 29;2(90):ra59.
REF 17 The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. Mol Cell Biol. 2009 Feb;29(3):892-906.
REF 18 WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem. 2003 Aug 29;278(35):33334-41.
REF 19 Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level. Exp Cell Res. 2004 Apr 1;294(2):469-79.
REF 20 MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. FEBS Lett. 2013 Dec 11;587(24):3921-7.
REF 21 Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17;150(4):780-91.
REF 22 The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. Cell Death Differ. 2007 Apr;14(4):743-51.
REF 23 The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage. Mol Cell. 2005 May 13;18(4):447-59.
REF 24 PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop. Mol Cell. 2008 Dec 26;32(6):803-14.
REF 25 Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell. 2008 Feb 15;29(3):350-61.
REF 26 TGF- Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation. Mol Cell. 2016 Jul 7;63(1):156-66.
REF 27 Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene. 2002 Jul 25;21(32):4879-84.
REF 28 Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF- Pathways. Structure. 2012 Oct 10;20(10):1726-36.
REF 29 Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell. 2009 Nov 13;139(4):757-69.
REF 30 A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 2011 Jun 15;25(12):1275-88.
REF 31 A regulatory circuit controlling Itch-mediated p73 degradation by Runx. J Biol Chem. 2008 Oct 10;283(41):27462-8.
REF 32 A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 1999 May 4;18(9):2551-62.
REF 33 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 34 A single point mutation in a group I WW domain shifts its specificity to that of group II WW domains. J Biol Chem. 1999 Jun 11;274(24):17284-9.
REF 35 Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. J Biol Chem. 2001 Apr 27;276(17):14514-23.
REF 36 Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth. J Biol Chem. 2013 May 24;288(21):15181-93.
REF 37 Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17368-73.
REF 38 The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. Biochem J. 2012 Jun 1;444(2):279-89.
REF 39 The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol. 2001 Nov;21(22):7617-28.

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