Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | MAPK/ERK kinase kinase 2 (MAP3K2) | Clinical trial | Target Info | ||
UniProt ID | M3K2_HUMAN | ||||
Gene Name | MAP3K2 | ||||
Gene ID | 10746 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Clinical trial Target(s) | MAPK/ERK kinase kinase 2 (MAP3K2) | Target Info | PPI Info | [1] | |
X-linked inhibitor of apoptosis protein (XIAP) | Target Info | PPI Info | [2] | ||
Interacting Literature-reported Target(s) | ERK activator kinase 5 (MAP2K5) | Target Info | PPI Info | [3] | |
MAPK/ERK kinase kinase 3 (MAP3K3) | Target Info | PPI Info | [4] | ||
ERK activator kinase 7 (MAP2K7) | Target Info | PPI Info | [5] |
References | Top | ||||
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REF 1 | Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). Oncogene. 2008 Mar 20;27(13):1930-8. | ||||
REF 2 | XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. Cell Signal. 2008 Nov;20(11):2107-12. | ||||
REF 3 | MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. J Biol Chem. 2001 Feb 16;276(7):5093-100. | ||||
REF 4 | Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801. | ||||
REF 5 | Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr;20(7):2334-42. |
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