Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T53159 Target Info
Target Name ERK activator kinase 7 (MAP2K7)
Synonyms Stress-activated protein kinase kinase 4; SKK4; SAPKK4; SAPKK-4; SAPK kinase 4; PRKMK7; Mitogen-activated protein kinase kinase 7; MKK7; MEK7; MEK 7; MAPKK 7; MAPK/ERK kinase7; MAPK/ERK kinase 7; MAP kinase kinase 7; JNKK2; JNKK 2; JNK-activating kinase 2; JNK kinase 2; JNK activating kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; C-Jun N-terminal kinase kinase 2
Target Type Literature-reported Target
Gene Name MAP2K7
Biochemical Class Kinase
UniProt ID
MP2K7_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 3 Kinases +
Interacting Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target Interacting Protein Info
UniProt ID
MK08_HUMAN 
Synonyms Stress-activated protein kinase 1c; SAPK1c; SAPK1; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Biochemical Activity [5]
6 Biochemical Activity [6]
7 Biochemical Activity [2]
8 Biochemical Activity [4]
9 Biochemical Activity [7]
10 Reconstituted Complex [2]
Interacting Target Name MAPK/ERK kinase kinase 2 (MAP3K2) Clinical trial Target Interacting Protein Info
UniProt ID
M3K2_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK 2; MEK kinase 2; MAPKKK2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [6]
3 Co-fractionation [1]
Interacting Target Name Leucine-rich repeat kinase 2 (LRRK2) Clinical trial Target Interacting Protein Info
UniProt ID
LRRK2_HUMAN 
Synonyms PARK8; LRRK2 S935 phosphorylation; LRRK2 G2019S mutation; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [9]
Other proteins [+] 1 Other proteins +
Interacting Target Name JNK-interacting protein 1 peptide (pepJIP1) Patented-recorded Target Interacting Protein Info
UniProt ID
JIP1_HUMAN 
Synonyms PRKM8IP; Mitogen-activated protein kinase 8-interacting protein 1; JNK-interacting protein 1; JNK MAP kinase scaffold protein 1; JIP-1; JIP1; Islet-brain 1; IB-1; IB1; C-Jun-amino-terminal kinase-interacting protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-fractionation [11]
References  Top
REF 1 Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr;20(7):2334-42.
REF 2 Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases. J Biol Chem. 2006 May 12;281(19):13169-79.
REF 3 Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK. Arthritis Rheum. 2003 Sep;48(9):2450-60.
REF 4 Neddylation controls basal MKK7 kinase activity in breast cancer cells. Oncogene. 2016 May 19;35(20):2624-33.
REF 5 Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42.
REF 6 Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801.
REF 7 Caspase-mediated cleavage of JNK during stress-induced apoptosis. Biochem Biophys Res Commun. 2003 Jul 11;306(4):837-42.
REF 8 MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem. 2010 Mar;112(6):1593-604.
REF 9 The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. J Neurochem. 2009 May;109(4):959-68.
REF 10 Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. J Virol. 2006 Aug;80(15):7667-75.
REF 11 Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. PLoS One. 2008 Feb 20;3(2):e1660.

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