Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T77139 Target Info
Target Name MAPK/ERK kinase kinase 3 (MAP3K3)
Synonyms Mitogen-activated protein kinase kinase kinase 3; MEKK3; MEKK 3; MEK kinase 3; MAPKKK3
Target Type Literature-reported Target
Gene Name MAP3K3
Biochemical Class Kinase
UniProt ID
M3K3_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [2]
3 Reconstituted Complex [1]
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
Kinases [+] 4 Kinases +
Interacting Target Name ERK activator kinase 5 (MAP2K5) Literature-reported Target Interacting Protein Info
UniProt ID
MP2K5_HUMAN 
Synonyms PRKMK5; MKK5; Mitogen-activatedprotein kinase kinase 5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase5; MAP kinase kinase 5; Dual specificity mitogen-activated protein kinase kinase 5
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [1]
3 Biochemical Activity [4]
4 Co-localization [2]
5 Reconstituted Complex [4]
6 Yeast two hybrid [5]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [6]
2 Yeast two hybrid [7]
Interacting Target Name MAPK/ERK kinase kinase 2 (MAP3K2) Clinical trial Target Interacting Protein Info
UniProt ID
M3K2_HUMAN 
Synonyms Mitogen-activated protein kinase kinase kinase 2; MEKK2; MEKK 2; MEK kinase 2; MAPKKK2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Reconstituted Complex [4]
Interacting Target Name TGF-beta-activated kinase 1 (MAP3K7) Literature-reported Target Interacting Protein Info
UniProt ID
M3K7_HUMAN 
Synonyms Transforming growth factor-beta-activated kinase 1; TAK1; Mitogen-activated protein kinase kinase kinase 7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Yeast two hybrid [10]
References  Top
REF 1 PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem. 2010 Jan 15;285(3):2077-89.
REF 2 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 3 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004 Feb;6(2):97-105.
REF 4 Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014 Aug 18;33(16):1784-801.
REF 5 MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. J Biol Chem. 2001 Feb 16;276(7):5093-100.
REF 6 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 7 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 8 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 9 Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. Sci Signal. 2009 Oct 20;2(93):ra66.
REF 10 TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem. 2005 Dec 30;280(52):43056-63.

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