Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T97035 Target Info
Target Name Tyrosinase (TYR)
Synonyms Tumor rejection antigen AB; SK29-AB; Monophenol monooxygenase; LB24-AB
Target Type Successful Target
Gene Name TYR
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
TYRO_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2012013418
Title Skin Care Compositions Comprising Substituted Monoamines.
Abstract Skin care compositions comprising certain substituted phenethylamines, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin. The compositions comprise 0.001% to 20% of a subtituted monoamine of structure (I) wherein R, is cyclohexyl, pheryl or mono - or di-substituted phenyl substituted by C1-C5 alkyl, C1-C5 alkoxy or phenoxy and R2 is hydrogen or methyl.
Applicant(s) Hindustan Unilever Limited
Representative Drug(s) D00EGV Drug Info N.A. Click to Show More [1]
2 D02TIY Drug Info N.A. [1]
3 D03KNZ Drug Info N.A. [1]
4 D0SD9L Drug Info N.A. [1]
5 D0X5VH Drug Info N.A. [1]
Patent ID WO2014004177
Title Topical Application of 1-Hydroxyl 3,5-Bis(4'Hydroxyl Styryl)Benzene.
Abstract The present invention relates to compositions 1-hydroxyl 3,5-bis(4'hydroxyl styryl)benzene or a cosmetically acceptable salt thereof, and methods of treating human skin using said compositions.
Applicant(s) Johnson & Johnson Consumer Companies, Inc
Representative Drug(s) D0I3KT Drug Info N.A. [1]
Patent ID WO2012154959
Title Peptide Tyrosinase Inhibitors and Uses Thereof.
Abstract Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory pep tides in a topical formulation. Prefened octapeptide sequences are internally rich in tryptophan and/or tyrosine or arginine. The present invention is further directed to kits and compositions containing the present peptides, and methods of treatment of conditions involving expression of tyrosinase, in which the present peptides are administered topically for the treatment of conditions involving melanocyte activity in the skin.
Applicant(s) Elixir Institute of Regenerative Medicine
Patent ID WO2009003034
Title Oligopeptide Tyrosinase Inhibitors and Uses Thereof.
Abstract Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Peptide sequences disclosed include KFEKKFEK and YRSRKYSSWY.
Applicant(s) The Board of Trustes of the Leland Stanford Junior University
Patent ID WO2013073763
Title Heterocyclic Resorcinol Derivatives, Preparation of Same and Cosmetic Uses Thereof.
United States Patent and Trademark Office (USPTO)
Patent ID US8119674
Title 4-Phenylimidazole-2-Thione Tyrosinase Inhibitors and Pharmaceutical/Cosmetic Applications Thereof.
Applicant(s) Galderma Research & Development
Representative Drug(s) D06KKO Drug Info IC50 = 300 nM Click to Show More [1]
2 D0A0RM Drug Info IC50 = 400 nM [1]
3 D0PN6U Drug Info IC50 = 1400 nM [1]
Patent ID US7989483
Title 4-Heteroarylimidazole-2-Thione Tyrosinase Inhibitors and Pharmaceutical/Cosmetic Applications Thereof.
Applicant(s) Galderma Research & Development
Representative Drug(s) D0X0RV Drug Info IC50 = 100 nM Click to Show More [1]
2 D02SGL Drug Info IC50 = 200 nM [1]
3 D0M4EQ Drug Info IC50 = 300 nM [1]
Patent ID US20140234241
Title Novel Benzoic Acid Amide Compound.
Representative Drug(s) D0MM1Y Drug Info IC50 = 800 nM Click to Show More [1]
2 D01RTO Drug Info IC50 = 900 nM [1]
3 D0D2JW Drug Info IC50 = 900 nM [1]
4 D09YKI Drug Info IC50 = 1100 nM [1]
5 D0GW5H Drug Info IC50 = 1400 nM [1]
Patent ID US20130129646
Title Cyclohexyl Carbamate Compounds As Skin and/or Hair Lightening Actives.
Representative Drug(s) D0F3HA Drug Info IC50 = 4700 nM Click to Show More [1]
2 D0J2HH Drug Info IC50 = 4700 nM [1]
3 D03PYA Drug Info IC50 = 5500 nM [1]
4 D0L1SV Drug Info IC50 = 5600 nM [1]
5 D0UT9H Drug Info IC50 = 9500 nM [1]
6 D09VRO Drug Info IC50 = 10000 nM [1]
7 D0LC2G Drug Info IC50 = 94100 nM [1]
8 D06LIQ Drug Info IC50 = 219400 nM [1]
Patent ID US8362305
Title Series of Skin Whitening (Lightening) Compounds.
Representative Drug(s) D0TL2C Drug Info IC50 = 165 nM Click to Show More [1]
2 D0JC3U Drug Info IC50 = 200 nM [1]
3 D0PI1Z Drug Info IC50 = 250 nM [1]
4 D0P6ZB Drug Info IC50 = 350 nM [1]
5 D0X7EQ Drug Info IC50 = 500 nM [1]
6 D0ZJ4M Drug Info IC50 = 500 nM [1]
7 D03MKE Drug Info IC50 = 800 nM [1]
8 D0NR2A Drug Info IC50 = 850 nM [1]
9 D0CH3F Drug Info IC50 = 860 nM [1]
10 D05NHA Drug Info IC50 = 1000 nM [1]
11 D04ZZM Drug Info IC50 = 1020 nM [1]
12 D02JVX Drug Info IC50 = 1800 nM [1]
13 D06WGO Drug Info IC50 = 2000 nM [1]
14 D0RC7R Drug Info IC50 = 3000 nM [1]
15 D06YKN Drug Info IC50 = 5150 nM [1]
16 D01EVP Drug Info IC50 = 8400 nM [1]
17 D0EQ3V Drug Info IC50 = 12800 nM [1]
18 D0E6LU Drug Info IC50 = 50000 nM [1]
19 D0KU5J Drug Info IC50 = 60000 nM [1]
20 D09QZB Drug Info N.A. [1]
21 D0FL1E Drug Info N.A. [1]
22 D0K7LI Drug Info N.A. [1]
23 D0T7BH Drug Info N.A. [1]
Patent ID US20140363388
Title Series of Skin Whitening (Lightening) Compounds.
Representative Drug(s) D0TL2C Drug Info IC50 = 165 nM Click to Show More [1]
2 D0JC3U Drug Info IC50 = 200 nM [1]
3 D0PI1Z Drug Info IC50 = 250 nM [1]
4 D0P6ZB Drug Info IC50 = 350 nM [1]
5 D0X7EQ Drug Info IC50 = 500 nM [1]
6 D0ZJ4M Drug Info IC50 = 500 nM [1]
7 D03MKE Drug Info IC50 = 800 nM [1]
8 D0NR2A Drug Info IC50 = 850 nM [1]
9 D0CH3F Drug Info IC50 = 860 nM [1]
10 D05NHA Drug Info IC50 = 1000 nM [1]
11 D04ZZM Drug Info IC50 = 1020 nM [1]
12 D02JVX Drug Info IC50 = 1800 nM [1]
13 D06WGO Drug Info IC50 = 2000 nM [1]
14 D0RC7R Drug Info IC50 = 3000 nM [1]
15 D06YKN Drug Info IC50 = 5150 nM [1]
16 D01EVP Drug Info IC50 = 8400 nM [1]
17 D0EQ3V Drug Info IC50 = 12800 nM [1]
18 D0E6LU Drug Info IC50 = 50000 nM [1]
19 D0KU5J Drug Info IC50 = 60000 nM [1]
20 D09QZB Drug Info N.A. [1]
21 D0FL1E Drug Info N.A. [1]
22 D0K7LI Drug Info N.A. [1]
23 D0T7BH Drug Info N.A. [1]
Patent ID US8889881
Title Novel Compound Having Skin-Whitening, Anti-Oxidizing and Ppar Activities and Medical Use Therefor.
Representative Drug(s) D00DYI Drug Info N.A. Click to Show More [1]
2 D00JQA Drug Info N.A. [1]
3 D01CFL Drug Info N.A. [1]
4 D03PLQ Drug Info N.A. [1]
5 D0AE8D Drug Info N.A. [1]
6 D0HH4L Drug Info N.A. [1]
7 D0IB3Z Drug Info N.A. [1]
8 D0J6DS Drug Info N.A. [1]
9 D0MT3J Drug Info N.A. [1]
10 D0WT1C Drug Info N.A. [1]
11 D0YX1C Drug Info N.A. [1]
12 D0Z0DX Drug Info N.A. [1]
Patent ID US8846012
Title Melanin Production Inhibitor.
Representative Drug(s) D00LSQ Drug Info N.A. Click to Show More [1]
2 D02CXZ Drug Info N.A. [1]
3 D02WJB Drug Info N.A. [1]
4 D0A2RI Drug Info N.A. [1]
5 D0K2XK Drug Info N.A. [1]
6 D0KR9E Drug Info N.A. [1]
7 D0U5GU Drug Info N.A. [1]
Patent ID US8476251
Title Skin Care Compositions Comprising Substituted Diamines.
Representative Drug(s) D01QYA Drug Info N.A. Click to Show More [1]
2 D0L0CV Drug Info N.A. [1]
3 D0QU3G Drug Info N.A. [1]
Patent ID US8435548
Title Peptide Derivatives and Cosmetic Composition Comprising The Same.
Representative Drug(s) D08OJB Drug Info N.A. Click to Show More [1]
2 D0AG7M Drug Info N.A. [1]
3 D0CI2U Drug Info N.A. [1]
4 D0F0VF Drug Info N.A. [1]
5 D0QC9I Drug Info N.A. [1]
6 D0X4EC Drug Info N.A. [1]
Patent ID US8425885
Title Substituted 3-(Phenoxymethyl) Benzyl Amines and Personal Care Compositions.
Representative Drug(s) D0CP6B Drug Info N.A. Click to Show More [1]
2 D0MA7A Drug Info N.A. [1]
3 D0Q1NF Drug Info N.A. [1]
4 D0VY9O Drug Info N.A. [1]
5 D0XO4I Drug Info N.A. [1]
6 D0Z1LJ Drug Info N.A. [1]
Patent ID US20150164758
Title Tyrosinase Inhibitors.
Representative Drug(s) D07UBZ Drug Info N.A. Click to Show More [1]
2 D0H4LK Drug Info N.A. [1]
Patent ID US20150017111
Title Compound Having Skin-Whitening, Anti-Oxidizing and Ppar Activities and Medical Use Therefor.
Representative Drug(s) D00DYI Drug Info N.A. Click to Show More [1]
2 D00JQA Drug Info N.A. [1]
3 D01CFL Drug Info N.A. [1]
4 D03PLQ Drug Info N.A. [1]
5 D0AE8D Drug Info N.A. [1]
6 D0HH4L Drug Info N.A. [1]
7 D0IB3Z Drug Info N.A. [1]
8 D0J6DS Drug Info N.A. [1]
9 D0MT3J Drug Info N.A. [1]
10 D0WT1C Drug Info N.A. [1]
11 D0YX1C Drug Info N.A. [1]
12 D0Z0DX Drug Info N.A. [1]
Patent ID US20150010484
Title Method for Anti-Skin Aging Using Caffeamide Derivative.
Representative Drug(s) D07RUH Drug Info N.A. Click to Show More [1]
2 D09EFW Drug Info N.A. [1]
Patent ID US20140256830
Title Resorcinol Compounds for Dermatological Use.
Representative Drug(s) D00QVY Drug Info N.A. Click to Show More [1]
2 D07PSJ Drug Info N.A. [1]
3 D07RJD Drug Info N.A. [1]
4 D0G5CV Drug Info N.A. [1]
5 D0H0UC Drug Info N.A. [1]
6 D0IH6G Drug Info N.A. [1]
7 D0K1UO Drug Info N.A. [1]
8 D0K6TN Drug Info N.A. [1]
9 D0Q1HU Drug Info N.A. [1]
10 D0QR0E Drug Info N.A. [1]
11 D0ZT3U Drug Info N.A. [1]
Patent ID US20140023603
Title Novel Compound Having Skin-Whitening, Anti-Oxidizing and Ppar Activities and Medical Use Therefor.
Representative Drug(s) D03NCL Drug Info N.A. Click to Show More [1]
2 D03PZZ Drug Info N.A. [1]
3 D09JLP Drug Info N.A. [1]
4 D09MHU Drug Info N.A. [1]
5 D0A8UJ Drug Info N.A. [1]
6 D0G7XW Drug Info N.A. [1]
7 D0HO0I Drug Info N.A. [1]
8 D0J0BB Drug Info N.A. [1]
9 D0JR0P Drug Info N.A. [1]
10 D0K5JG Drug Info N.A. [1]
11 D0N7BW Drug Info N.A. [1]
12 D0SJ1U Drug Info N.A. [1]
Patent ID US20130272983
Title Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and Their Use In Cosmetic or Dermatological Compositions.
Representative Drug(s) D01VTT Drug Info N.A. Click to Show More [1]
2 D06LMS Drug Info N.A. [1]
3 D0J4YH Drug Info N.A. [1]
4 D0O3JR Drug Info N.A. [1]
5 D0SF6C Drug Info N.A. [1]
6 D0SJ4S Drug Info N.A. [1]
Patent ID US20110039898
Title Method for Scavenging Free Radicals and Inhibiting Tyrosinase and Melanin.
Representative Drug(s) D03FQY Drug Info N.A. Click to Show More [1]
2 D0FQ3D Drug Info N.A. [1]
Patent ID US20120323012
Title 4-(Azacycloalkyl)-Benzene-1, 3-Diol Derivatives As Tyrosinase Inhibitors and Their Synthesis and Use Thereof.
Representative Drug(s) D04HEW Drug Info IC50 = 200 nM [1]
Patent ID US20130266526
Title Dihydroxyfumaric Acid Derivatives and The Use Thereof for Skin Lightening.
Representative Drug(s) D0LA2R Drug Info N.A. [1]
Patent ID US8822428
Title Double-Stranded Rna Oligonucleotides Which Inhibit Tyrosinase Expression.
Patent ID US8193154
Title Oligopeptide Tyrosinase Inhibitors and Uses Thereof.
Patent ID US8026208
Title Peptide Tyrosinase Inhibitors and Uses Thereof.
Patent ID US6132740
Title Resorcinol Derivatives.
Patent ID US5399785
Title Tyrosinase Activity Inhibitor.
Patent ID US5026686
Title Antiviral Peptides.
Patent ID US4959393
Title Skin Depigmental Agent.
Patent ID US20140112878
Title ATyrosinase Inhibitor.
Patent ID US20130164233
Title Skin-Whitening Essence Composition Containing Tyrosinase Inhibitor.
Patent ID US20120321577
Title Skin-Whitening Composition Containing Tyrosinase Inhibitor.
Patent ID US20080131382
Title Skin Lightening Agents, Compositions and Methods.
European Patent Office (EPO)
Patent ID EP2529735
Title 4-(Heterocycloalkyl) Benzene-1, 3-Diol Compounds As Tyrosinase Inhibitors, Process for The Preparation Thereof and Use Thereof In Human Medicine and Also In Cosmetics.
Representative Drug(s) D0W6ZO Drug Info IC50 = 100 nM Click to Show More [1]
2 D01NJW Drug Info IC50 = 400 nM [1]
Patent ID EP2746253
Title Novel Compounds with Skin Lightening Properties.
Representative Drug(s) D02EGY Drug Info N.A. Click to Show More [1]
2 D03BRP Drug Info N.A. [1]
3 D05XAH Drug Info N.A. [1]
4 D07DFC Drug Info N.A. [1]
5 D0P0PT Drug Info N.A. [1]
6 D0UT0X Drug Info N.A. [1]
Patent ID EP2295403
Title Compound with Carboxyl Acid Group and Amide Group and Application Thereof.
Representative Drug(s) D00YRS Drug Info N.A. Click to Show More [1]
2 D01ZCC Drug Info N.A. [1]
3 D06FUM Drug Info N.A. [1]
4 D07PNX Drug Info N.A. [1]
5 D0EH4P Drug Info N.A. [1]
6 D0W8RV Drug Info N.A. [1]
Patent ID EP0341664
Title Skin Depigmental Agent.
China National Intellectual Property Administration (CNIPA)
Patent ID CN103371924
Title ATyrosinase Retardant.
Canadian Intellectual Property Office (CIPO)
Patent ID CA2835755
Title Family of Aryl, Heteroaryl, O-Aryl and O-Heteroaryl Carbasugars.
Representative Drug(s) D0DW3Z Drug Info IC50 = 328 nM [1]
References  Top
REF 1 Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62.

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