miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-141-3p | ||||
miRNA Stemloop AC | MI0000457 | ||||
miRNA Stemloop ID | hsa-mir-141 | ||||
Sequence | uaacacugucugguaaagaugg | ||||
TTD Target(s) Regulated by This miRNA | Insulin-like growth factor I receptor (IGF1R) | Successful Target | Target Info | [1] | |
Peroxisome proliferator-activated receptor alpha (PPARA) | Successful Target | Target Info | [2] | ||
Stress-activated protein kinase 2a (p38 alpha) | Clinical trial Target | Target Info | [3] | ||
Transforming growth factor beta 2 (TGFB2) | Clinical trial Target | Target Info | [4] | ||
Bromodomain-containing protein 3 (BRD3) | Clinical trial Target | Target Info | [5] | ||
Stress-activated protein kinase JNK2 (JNK2) | Preclinical Target | Target Info | [5] | ||
M-phase inducer phosphatase 1 (MPIP1) | Literature-reported Target | Target Info | [6] | ||
M-phase inducer phosphatase 3 (MPIP3) | Literature-reported Target | Target Info | [7] | ||
Activin receptor type IIB (ACVR2B) | Literature-reported Target | Target Info | [8] | ||
MEK kinase kinase 4 (MAP4K4) | Patented-recorded Target | Target Info | [9] | ||
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [5] | ||
Homeodomain interacting protein kinase 2 (HIPK2) | Literature-reported Target | Target Info | [10] | ||
Orphan nuclear receptor SHP (NR0B2) | Literature-reported Target | Target Info | [11] | ||
S100 calcium-binding protein A6 (S100A6) | Literature-reported Target | Target Info | [12] | ||
Eukaryotic initiation factor 4E (EIF4E) | Literature-reported Target | Target Info | [13] | ||
Hepatoma-derived growth factor (HDGF) | Literature-reported Target | Target Info | [14] | ||
T-lymphoma invasion and metastasis 1 (TIAM1) | Literature-reported Target | Target Info | [15] | ||
Yes-associated protein 1 (YAP1) | Literature-reported Target | Target Info | [16] | ||
Zinc finger E-box-binding homeobox 2 (ZEB2) | Literature-reported Target | Target Info | [17] | ||
Protein(s) Regulated by This miRNA | 14-3-3 protein gamma | Regulated Protein | [18] | ||
C-terminal-binding protein 2 | Regulated Protein | [19] | |||
CAAX prenyl protease 1 homolog | Regulated Protein | [20] | |||
Chromodomain Y-like protein | Regulated Protein | [19] | |||
Circadian locomoter output cycles protein kaput | Regulated Protein | [21] | |||
Circadian locomoter output cycles protein kaput | Regulated Protein | [22] | |||
ELAV-like protein 4 | Regulated Protein | [23] | |||
Engulfment and cell motility protein 2 | Regulated Protein | [24] | |||
Erbin | Regulated Protein | [24] | |||
Heterogeneous nuclear ribonucleoprotein D0 | Regulated Protein | [25] | |||
Homeobox protein DLX-5 | Regulated Protein | [26] | |||
Homeobox protein Hox-B5 | Regulated Protein | [24] | |||
Kelch-like protein 20 | Regulated Protein | [24] | |||
Krueppel-like factor 11 | Regulated Protein | [24] | |||
Krueppel-like factor 12 | Regulated Protein | [27] | |||
Krueppel-like factor 5 | Regulated Protein | [21] | |||
Methylcytosine dioxygenase TET1 | Regulated Protein | [28] | |||
Methylcytosine dioxygenase TET3 | Regulated Protein | [28] | |||
Pappalysin-1 | Regulated Protein | [29] | |||
PH domain leucine-rich repeat-containing protein phosphatase 1 | Regulated Protein | [30] | |||
PH domain leucine-rich repeat-containing protein phosphatase 2 | Regulated Protein | [30] | |||
Protein VAC14 homolog | Regulated Protein | [24] | |||
Ras and Rab interactor 2 | Regulated Protein | [24] | |||
Ras association domain-containing protein 2 | Regulated Protein | [24] | |||
Receptor-type tyrosine-protein phosphatase delta | Regulated Protein | [24] | |||
Retinoblastoma-associated protein | Regulated Protein | [12] | |||
Septin-7 | Regulated Protein | [24] | |||
Serine/threonine-protein kinase 3 | Regulated Protein | [21] | |||
SHC-transforming protein 1 | Regulated Protein | [24] | |||
Signal transducer and activator of transcription 4 | Regulated Protein | [32] | |||
Splicing factor, proline- and glutamine-rich | Regulated Protein | [33] | |||
Tafazzin | Regulated Protein | [34] | |||
Trafficking protein particle complex subunit 2B | Regulated Protein | [35] | |||
Transcription factor 7-like 1 | Regulated Protein | [24] | |||
Transcription factor Dp-2 | Regulated Protein | [5] | |||
Transmembrane 4 L6 family member 1 | Regulated Protein | [37] | |||
Ubiquitin carboxyl-terminal hydrolase BAP1 | Regulated Protein | [24] | |||
Ubiquitin-associated protein 1 | Regulated Protein | [5] | |||
WD repeat-containing protein 37 | Regulated Protein | [24] | |||
Zinc finger E-box-binding homeobox 1 | Regulated Protein | [17] | |||
Zinc finger protein ZFPM2 | Regulated Protein | [24] | |||
References | |||||
REF 1 | Anti-proliferative role and prognostic implication of miR-141 in gastric cancer. Am J Transl Res. 2016 Aug 15;8(8):3549-57. | ||||
REF 2 | MicroRNA-141 represses HBV replication by targeting PPARA. PLoS One. 2012;7(3):e34165. | ||||
REF 3 | miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med. 2011 Nov 20;17(12):1627-35. | ||||
REF 4 | A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008 Jun;9(6):582-9. | ||||
REF 5 | microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis. 2010 Apr;31(4):559-66. | ||||
REF 6 | miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation. Biochim Biophys Acta. 2014 Sep;1843(9):2114-21. | ||||
REF 7 | MicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25B. Onco Targets Ther. 2013 Apr 10;6:349-54. | ||||
REF 8 | miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms. Carcinogenesis. 2012 May;33(5):1014-21. | ||||
REF 9 | miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4. Mol Cancer Ther. 2013 Nov;12(11):2569-80. | ||||
REF 10 | miR-141 regulates TGF-1-induced epithelial-mesenchymal transition through repression of HIPK2 expression in renal tubular epithelial cells. Int J Mol Med. 2015 Feb;35(2):311-8. | ||||
REF 11 | miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein. Prostate. 2012 Oct 1;72(14):1514-22. | ||||
REF 12 | Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a. Oncogene. 2015 Jul;34(28):3676-87. | ||||
REF 13 | Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E. Cell Host Microbe. 2011 Jan 20;9(1):58-69. | ||||
REF 14 | miR-141 suppresses proliferation and motility of gastric cancer cells by targeting HDGF. Mol Cell Biochem. 2014 Mar;388(1-2):211-8. | ||||
REF 15 | MiR-141 suppresses the migration and invasion of HCC cells by targeting Tiam1. PLoS One. 2014 Feb 13;9(2):e88393. | ||||
REF 16 | Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. Nucleic Acids Res. 2016 Sep 6;44(15):7120-31. | ||||
REF 17 | The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008 May 30;283(22):14910-4. | ||||
REF 18 | miRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesity.J Proteome Res. 2012 Jun 1;11(6):3358-69. | ||||
REF 19 | MicroRNAs coordinately regulate protein complexes.BMC Syst Biol. 2011 Aug 25;5:136. | ||||
REF 20 | MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24.J Cell Sci. 2013 Dec 1;126(Pt 23):5422-31. | ||||
REF 21 | A combined computational-experimental approach predicts human microRNA targets. Genes Dev. 2004 May 15;18(10):1165-78. | ||||
REF 22 | Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology. 2006 Jun;130(7):2113-29. | ||||
REF 23 | miR-375 inhibits differentiation of neurites by lowering HuD levels.Mol Cell Biol. 2010 Sep;30(17):4197-210. | ||||
REF 24 | Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.Cell. 2009 Dec 11;139(6):1096-108. | ||||
REF 25 | MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor ZEB1 and the protein kinase AKT.J Biol Chem. 2014 Nov 7;289(45):31433-47. | ||||
REF 26 | MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5.J Biol Chem. 2009 Jul 17;284(29):19272-9. | ||||
REF 27 | MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis.Mol Cancer. 2017 Jan 17;16(1):11. | ||||
REF 28 | Regulation of miR-200c and miR-141 by Methylation in Prostate Cancer. Prostate. 2016 Sep;76(13):1146-59. | ||||
REF 29 | MicroRNA-141 inhibits vascular smooth muscle cell proliferation through targeting PAPP-A. Int J Clin Exp Pathol. 2015 Nov 1;8(11):14401-8. | ||||
REF 30 | MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2.FEBS Lett. 2014 Aug 25;588(17):3055-61. | ||||
REF 31 | Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a. Oncogene. 2015 Jul;34(28):3676-87. | ||||
REF 32 | Down-regulation of miR-141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4.Cell Physiol Biochem. 2014;33(4):1003-12. | ||||
REF 33 | Identification of human microRNA targets from isolated argonaute protein complexes.RNA Biol. 2007 Jun;4(2):76-84. | ||||
REF 34 | MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZ.Cell Death Dis. 2015 Jan 29;6:e1623. | ||||
REF 35 | MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha.Gastroenterology. 2008 Nov;135(5):1624-1635.e24. | ||||
REF 36 | microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis. 2010 Apr;31(4):559-66. | ||||
REF 37 | hsa-miR-141 downregulates TM4SF1 to inhibit pancreatic cancer cell invasion and migration.Int J Oncol. 2014 Feb;44(2):459-66. | ||||
REF 38 | The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008 May 30;283(22):14910-4. |
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