miRNA General Information
miRNA Mature ID hsa-miR-141-3p
miRNA Stemloop AC MI0000457
miRNA Stemloop ID hsa-mir-141
Sequence uaacacugucugguaaagaugg
TTD Target(s) Regulated by This miRNA Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
Peroxisome proliferator-activated receptor alpha (PPARA) Successful Target Target Info [2]
Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target Target Info [3]
Transforming growth factor beta 2 (TGFB2) Clinical trial Target Target Info [4]
Bromodomain-containing protein 3 (BRD3) Clinical trial Target Target Info [5]
Stress-activated protein kinase JNK2 (JNK2) Preclinical Target Target Info [5]
M-phase inducer phosphatase 1 (MPIP1) Literature-reported Target Target Info [6]
M-phase inducer phosphatase 3 (MPIP3) Literature-reported Target Target Info [7]
Activin receptor type IIB (ACVR2B) Literature-reported Target Target Info [8]
MEK kinase kinase 4 (MAP4K4) Patented-recorded Target Target Info [9]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [5]
Homeodomain interacting protein kinase 2 (HIPK2) Literature-reported Target Target Info [10]
Orphan nuclear receptor SHP (NR0B2) Literature-reported Target Target Info [11]
S100 calcium-binding protein A6 (S100A6) Literature-reported Target Target Info [12]
Eukaryotic initiation factor 4E (EIF4E) Literature-reported Target Target Info [13]
Hepatoma-derived growth factor (HDGF) Literature-reported Target Target Info [14]
T-lymphoma invasion and metastasis 1 (TIAM1) Literature-reported Target Target Info [15]
Yes-associated protein 1 (YAP1) Literature-reported Target Target Info [16]
Zinc finger E-box-binding homeobox 2 (ZEB2) Literature-reported Target Target Info [17]
Protein(s) Regulated by This miRNA 14-3-3 protein gamma Regulated Protein [18]
C-terminal-binding protein 2 Regulated Protein [19]
CAAX prenyl protease 1 homolog Regulated Protein [20]
Chromodomain Y-like protein Regulated Protein [19]
Circadian locomoter output cycles protein kaput Regulated Protein [21]
Circadian locomoter output cycles protein kaput Regulated Protein [22]
ELAV-like protein 4 Regulated Protein [23]
Engulfment and cell motility protein 2 Regulated Protein [24]
Erbin Regulated Protein [24]
Heterogeneous nuclear ribonucleoprotein D0 Regulated Protein [25]
Homeobox protein DLX-5 Regulated Protein [26]
Homeobox protein Hox-B5 Regulated Protein [24]
Kelch-like protein 20 Regulated Protein [24]
Krueppel-like factor 11 Regulated Protein [24]
Krueppel-like factor 12 Regulated Protein [27]
Krueppel-like factor 5 Regulated Protein [21]
Methylcytosine dioxygenase TET1 Regulated Protein [28]
Methylcytosine dioxygenase TET3 Regulated Protein [28]
Pappalysin-1 Regulated Protein [29]
PH domain leucine-rich repeat-containing protein phosphatase 1 Regulated Protein [30]
PH domain leucine-rich repeat-containing protein phosphatase 2 Regulated Protein [30]
Protein VAC14 homolog Regulated Protein [24]
Ras and Rab interactor 2 Regulated Protein [24]
Ras association domain-containing protein 2 Regulated Protein [24]
Receptor-type tyrosine-protein phosphatase delta Regulated Protein [24]
Retinoblastoma-associated protein Regulated Protein [12]
Septin-7 Regulated Protein [24]
Serine/threonine-protein kinase 3 Regulated Protein [21]
SHC-transforming protein 1 Regulated Protein [24]
Signal transducer and activator of transcription 4 Regulated Protein [32]
Splicing factor, proline- and glutamine-rich Regulated Protein [33]
Tafazzin Regulated Protein [34]
Trafficking protein particle complex subunit 2B Regulated Protein [35]
Transcription factor 7-like 1 Regulated Protein [24]
Transcription factor Dp-2 Regulated Protein [5]
Transmembrane 4 L6 family member 1 Regulated Protein [37]
Ubiquitin carboxyl-terminal hydrolase BAP1 Regulated Protein [24]
Ubiquitin-associated protein 1 Regulated Protein [5]
WD repeat-containing protein 37 Regulated Protein [24]
Zinc finger E-box-binding homeobox 1 Regulated Protein [17]
Zinc finger protein ZFPM2 Regulated Protein [24]
References
REF 1 Anti-proliferative role and prognostic implication of miR-141 in gastric cancer. Am J Transl Res. 2016 Aug 15;8(8):3549-57.
REF 2 MicroRNA-141 represses HBV replication by targeting PPARA. PLoS One. 2012;7(3):e34165.
REF 3 miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med. 2011 Nov 20;17(12):1627-35.
REF 4 A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008 Jun;9(6):582-9.
REF 5 microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis. 2010 Apr;31(4):559-66.
REF 6 miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation. Biochim Biophys Acta. 2014 Sep;1843(9):2114-21.
REF 7 MicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25B. Onco Targets Ther. 2013 Apr 10;6:349-54.
REF 8 miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms. Carcinogenesis. 2012 May;33(5):1014-21.
REF 9 miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4. Mol Cancer Ther. 2013 Nov;12(11):2569-80.
REF 10 miR-141 regulates TGF-1-induced epithelial-mesenchymal transition through repression of HIPK2 expression in renal tubular epithelial cells. Int J Mol Med. 2015 Feb;35(2):311-8.
REF 11 miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein. Prostate. 2012 Oct 1;72(14):1514-22.
REF 12 Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a. Oncogene. 2015 Jul;34(28):3676-87.
REF 13 Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E. Cell Host Microbe. 2011 Jan 20;9(1):58-69.
REF 14 miR-141 suppresses proliferation and motility of gastric cancer cells by targeting HDGF. Mol Cell Biochem. 2014 Mar;388(1-2):211-8.
REF 15 MiR-141 suppresses the migration and invasion of HCC cells by targeting Tiam1. PLoS One. 2014 Feb 13;9(2):e88393.
REF 16 Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. Nucleic Acids Res. 2016 Sep 6;44(15):7120-31.
REF 17 The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008 May 30;283(22):14910-4.
REF 18 miRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesity.J Proteome Res. 2012 Jun 1;11(6):3358-69.
REF 19 MicroRNAs coordinately regulate protein complexes.BMC Syst Biol. 2011 Aug 25;5:136.
REF 20 MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24.J Cell Sci. 2013 Dec 1;126(Pt 23):5422-31.
REF 21 A combined computational-experimental approach predicts human microRNA targets. Genes Dev. 2004 May 15;18(10):1165-78.
REF 22 Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology. 2006 Jun;130(7):2113-29.
REF 23 miR-375 inhibits differentiation of neurites by lowering HuD levels.Mol Cell Biol. 2010 Sep;30(17):4197-210.
REF 24 Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.Cell. 2009 Dec 11;139(6):1096-108.
REF 25 MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor ZEB1 and the protein kinase AKT.J Biol Chem. 2014 Nov 7;289(45):31433-47.
REF 26 MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5.J Biol Chem. 2009 Jul 17;284(29):19272-9.
REF 27 MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis.Mol Cancer. 2017 Jan 17;16(1):11.
REF 28 Regulation of miR-200c and miR-141 by Methylation in Prostate Cancer. Prostate. 2016 Sep;76(13):1146-59.
REF 29 MicroRNA-141 inhibits vascular smooth muscle cell proliferation through targeting PAPP-A. Int J Clin Exp Pathol. 2015 Nov 1;8(11):14401-8.
REF 30 MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2.FEBS Lett. 2014 Aug 25;588(17):3055-61.
REF 31 Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a. Oncogene. 2015 Jul;34(28):3676-87.
REF 32 Down-regulation of miR-141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4.Cell Physiol Biochem. 2014;33(4):1003-12.
REF 33 Identification of human microRNA targets from isolated argonaute protein complexes.RNA Biol. 2007 Jun;4(2):76-84.
REF 34 MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZ.Cell Death Dis. 2015 Jan 29;6:e1623.
REF 35 MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha.Gastroenterology. 2008 Nov;135(5):1624-1635.e24.
REF 36 microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis. 2010 Apr;31(4):559-66.
REF 37 hsa-miR-141 downregulates TM4SF1 to inhibit pancreatic cancer cell invasion and migration.Int J Oncol. 2014 Feb;44(2):459-66.
REF 38 The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008 May 30;283(22):14910-4.

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