Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T16691 | ||||
Target Name | 5-hydroxytryptamine 6 receptor | ||||
Target Type | Clinical Trial |
||||
Drug Potency against Target | N,N-diethyl-2-(1H-indol-3-yl)ethanamine | Drug Info | Ki = 575 nM | [528416] | |
2-Benzyl-4-piperazin-1-yl-1H-benzimidazole | Drug Info | Ki = 31 nM | [530637] | ||
5-MEO-DMT | Drug Info | Ki = 13 nM | [528416] | ||
1-phenylthio-N,N-dimethyltryptamine | Drug Info | Ki = 90 nM | [529258] | ||
6-(piperazin-1-yl)-3-tosyl-1H-indazole | Drug Info | Ki = 27 nM | [531198] | ||
1-Benzenesulfonyl-3-piperidin-3-yl-1H-indole | Drug Info | Ki = 1 nM | [527703] | ||
5-(4-Methylpiperazin-1-yl)-3-tosyl-1H-indazole | Drug Info | IC50 = 112 nM | [531198] | ||
E-6837 | Drug Info | Ki = 0.7 nM | [529929] | ||
6-tosyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole | Drug Info | Ki = 29 nM | [529564] | ||
4-(piperazin-1-yl)-1H-indole | Drug Info | Ki = 2700 nM | [527760] | ||
4-(1H-indol-1-ylsulfonyl)benzenamine | Drug Info | Ki = 10 nM | [527760] | ||
1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-indole | Drug Info | Ki = 1 nM | [527760] | ||
4-(1H-Indol-3-ylmethyl)-phenylamine | Drug Info | Ki = 2530 nM | [527501] | ||
N-(4-(2-aminoethyl)phenyl)benzenesulfonamide | Drug Info | Ki = 38 nM | [528373] | ||
OCTOCLOTHEPIN | Drug Info | Ki < 50 nM | [527474] | ||
4-(4-methoxy-1H-indol-1-ylsulfonyl)benzenamine | Drug Info | Ki = 3.3 nM | [528206] | ||
4-(6-methoxy-1H-indol-1-ylsulfonyl)benzenamine | Drug Info | Ki = 1.8 nM | [528206] | ||
[2-(3-Benzyl-3H-indol-1-yl)-ethyl]-dimethyl-amine | Drug Info | Ki = 6 nM | [527212] | ||
2-Ethyl-5-methoxy-3-piperidin-4-yl-1H-indole | Drug Info | IC50 = 300 nM | [527665] | ||
WAY-181187 | Drug Info | Ki = 2 nM | [530366] | ||
3-(phenylsulfonyl)-1-(piperidin-4-yl)-1H-indole | Drug Info | Ki = 91 nM | [530698] | ||
SPIPERONE | Drug Info | Ki = 1595 nM | [526655] | ||
2-(1-tosyl-1H-indol-3-yl)ethanamine | Drug Info | Ki = 8 nM | [529112] | ||
(+/-)-nantenine | Drug Info | Ki = 257 nM | [530558] | ||
4-(piperazin-1-yl)-3-tosyl-1H-indazole | Drug Info | Ki = 134 nM | [531198] | ||
Ro-04-6790 | Drug Info | Ki = 47 nM | [529929] | ||
3-(2-Amino-ethyl)-2-methyl-1H-indol-5-ol | Drug Info | Ki = 400 nM | [526655] | ||
Ro-63-0563 | Drug Info | Ki = 512 nM | [529191] | ||
2-(1-benzyl-1H-inden-3-yl)-N,N-dimethylethanamine | Drug Info | Ki = 3 nM | [529929] | ||
QUIPAZINE | Drug Info | Ki = 3600 nM | [526655] | ||
[2-(3-Benzyl-3H-inden-1-yl)-ethyl]-methyl-amine | Drug Info | Ki = 3 nM | [527501] | ||
4-(3H-Inden-1-ylmethyl)-phenylamine | Drug Info | Ki = 11800 nM | [527501] | ||
2-(4-(benzenesulfonyl)phenyl)-1-aminoethane | Drug Info | Ki = 37 nM | [528373] | ||
[2-(3-Benzyl-indol-1-yl)-ethyl]-dimethyl-amine | Drug Info | Ki = 32 nM | [527501] | ||
4-(Indan-1-ylsulfanyl)-phenylamine | Drug Info | Ki = 4200 nM | [527501] | ||
N-(3-(2-aminoethyl)phenyl)benzenesulfonamide | Drug Info | Ki = 21 nM | [528373] | ||
4-(3-benzenesulfonamidophenyl)piperazine | Drug Info | Ki = 62 nM | [528373] | ||
1-(2-Methoxy-phenyl)-piperazine | Drug Info | Ki = 1.2 nM | [527463] | ||
N-(3-(3-aminopropyl)phenyl)benzenesulfonamide | Drug Info | Ki = 230 nM | [528373] | ||
4-(4-benzenesulfonamidophenyl)piperazine | Drug Info | Ki = 85 nM | [528373] | ||
N-(3-(aminomethyl)phenyl)benzenesulfonamide | Drug Info | Ki = 290 nM | [528373] | ||
4-(3-benzenesulfonylphenyl)piperazine | Drug Info | Ki = 1.2 nM | [528373] | ||
2-(3-phenylthio)phenyl)-1-aminoethane | Drug Info | Ki = 115 nM | [528373] | ||
N-(3-aminophenyl)benzenesulfonamide | Drug Info | Ki = 2840 nM | [528373] | ||
4-(4-benzenesulfonylphenyl)piperazine | Drug Info | Ki = 6.9 nM | [528373] | ||
4-(2-benzenesulfonylphenyl)piperazine | Drug Info | Ki = 4000 nM | [528373] | ||
4-Indan-1-ylmethyl-phenylamine | Drug Info | Ki = 6100 nM | [527501] | ||
4-(4,6-dinitro-1H-indol-1-ylsulfonyl)benzenamine | Drug Info | Ki = 980 nM | [527760] | ||
4-Inden-(1E)-ylidenemethyl-phenylamine | Drug Info | Ki = 640 nM | [527501] | ||
EDMT | Drug Info | Ki = 16 nM | [529929] | ||
4-((1H-indol-1-yl)methyl)benzenamine | Drug Info | Ki = 8200 nM | [528630] | ||
N,N-dimethyl-2-(1-tosyl-1H-indol-3-yl)ethanamine | Drug Info | Ki = 2.5 nM | [528630] | ||
DIMEBOLIN | Drug Info | Ki = 26 nM | [530540] | ||
N-phenyl-3-(2-aminoethyl)benzenesulfonamide | Drug Info | Ki = 70 nM | [528373] | ||
2-(3-benzenesulfonyl)phenyl-1-aminoethane | Drug Info | Ki = 50 nM | [528373] | ||
5-METHOXYTRYPTAMINE | Drug Info | Ki < 50 nM | [527474] | ||
SEROTONIN | Drug Info | IC50 = 27.5 nM | [530739] | ||
METHIOTHEPIN | Drug Info | IC50 = 2.4 nM | [530739] | ||
3-(phenylsulfonyl)-1-(pyrrolidin-3-yl)-1H-indole | Drug Info | Ki = 5 nM | [530698] | ||
3-(phenylsulfonyl)-1-(piperidin-3-yl)-1H-indole | Drug Info | Ki = 13 nM | [530698] | ||
SB-742457 | Drug Info | Ki = 0.25 nM | [552840] | ||
5,6-dichloro-3,4-dihydroquinazolin-2-amine | Drug Info | Ki = 1157 nM | [529148] | ||
SB-271046 | Drug Info | Ki = 0.66 nM | [530058] | ||
1-(3-(benzyloxy)-2-methylphenyl)piperazine | Drug Info | Ki = 1.3 nM | [530058] | ||
SB-357134 | Drug Info | Ki = 3 nM | [529191] | ||
4-(Naphthalene-1-sulfonyl)-phenylamine | Drug Info | Ki = 34 nM | [527463] | ||
4-(3-Methyl-indole-1-sulfonyl)-phenylamine | Drug Info | Ki = 12 nM | [527463] | ||
WAY-466 | Drug Info | Ki = 1 nM | [527381] | ||
1-Naphthalen-1-yl-piperazine | Drug Info | Ki = 100 nM | [527463] | ||
4-(1H-Inden-1-ylmethyl)-phenylamine | Drug Info | Ki = 4470 nM | [527501] | ||
4-(Indane-1-sulfonyl)-phenylamine | Drug Info | Ki = 740 nM | [527501] | ||
2-(3-(phenylsulfonyl)-1H-indol-1-yl)ethanamine | Drug Info | Ki = 25 nM | [530209] | ||
2-(1-benzyl-1H-indol-3-yl)-N,N-dimethylethanamine | Drug Info | Ki = 6 nM | [529929] | ||
1-Benzenesulfonyl-3-piperidin-4-yl-1H-indole | Drug Info | IC50 = 19.5 nM | [527339] | ||
WAY-208466 | Drug Info | Ki = 4.8 nM | [530209] | ||
CHLOROPHENYLPIPERAZINE | Drug Info | Ki = 2300 nM | [526655] | ||
2-(1-(phenylsulfonyl)-1H-indol-3-yl)ethanamine | Drug Info | Ki = 10 nM | [529112] | ||
[2-(3H-Indol-1-yl)-ethyl]-dimethyl-amine | Drug Info | Ki = 1900 nM | [527212] | ||
Action against Disease Model | SB-742457 | The effect of a selective 5-HT(6) receptor antagonist SB-742457 to reverse sub-chronic phencyclidine (PCP)-induced cognitive deficits in female rats was examined. The PCP-induced selective reversal learning deficit was significantly improved by SB-742457. | [552992] | Drug Info | |
The Effect of Target Knockout, Knockdown or Genetic Variations | 5-HT6 receptors are the latest serotonin receptors to be identified by molecular cloning. Their high affinity for a wide range of drugs used in psychiatry, coupled with their intriguing distribution in the brain, has stimulated significant interest. Antisense oligonucleotides, antipeptide antibodies, selective radioligands, knockout mice, and selective antagonists of the 5-ht6 receptor have recently become available. Surprisingly, 5-ht6 receptors appear to regulate cholinergic neurotransmission in the brain, rather than the expected interaction as modulators of dopaminergic transmission. This interaction predicts a possible role for 5-ht6 receptor antagonists in the treatment of learning and memory disorders. Furthermore, polymorphisms in the sequence of the 5-ht6 receptor gene may provide a genetic tool to further our understanding of the differential responses of patients to antipsychotic medications | [528416] | |||
References | |||||
Ref 528416 | Bioorg Med Chem Lett. 2006 Nov 15;16(22):5832-5. Epub 2006 Aug 30.Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. | ||||
Ref 530637 | J Med Chem. 2010 Feb 11;53(3):1357-69.Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation. | ||||
Ref 528416 | Bioorg Med Chem Lett. 2006 Nov 15;16(22):5832-5. Epub 2006 Aug 30.Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. | ||||
Ref 529258 | J Med Chem. 2008 Feb 14;51(3):603-11. Epub 2008 Jan 18.Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. | ||||
Ref 531198 | J Med Chem. 2010 Nov 11;53(21):7639-46.5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists. | ||||
Ref 527703 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4780-5.Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists. | ||||
Ref 531198 | J Med Chem. 2010 Nov 11;53(21):7639-46.5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists. | ||||
Ref 529929 | J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. | ||||
Ref 529564 | Bioorg Med Chem Lett. 2008 Jul 15;18(14):3929-31. Epub 2008 Jun 13.A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands. | ||||
Ref 527760 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. | ||||
Ref 527760 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. | ||||
Ref 527760 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 527474 | J Med Chem. 2005 Mar 24;48(6):1781-95.Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands. | ||||
Ref 528206 | Bioorg Med Chem Lett. 2006 Jul 15;16(14):3793-6. Epub 2006 May 18.Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. | ||||
Ref 528206 | Bioorg Med Chem Lett. 2006 Jul 15;16(14):3793-6. Epub 2006 May 18.Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. | ||||
Ref 527212 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4569-73.Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors. | ||||
Ref 527665 | Bioorg Med Chem Lett. 2005 Oct 1;15(19):4230-4.2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. | ||||
Ref 530366 | J Med Chem. 2009 Oct 8;52(19):6153-7.Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists. | ||||
Ref 530698 | Bioorg Med Chem Lett. 2010 Mar 1;20(5):1657-60. Epub 2010 Jan 21.3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. | ||||
Ref 526655 | J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). | ||||
Ref 529112 | J Med Chem. 2007 Nov 15;50(23):5535-8. Epub 2007 Oct 19.Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. | ||||
Ref 530558 | Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. Epub 2009 Nov 20.Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. | ||||
Ref 531198 | J Med Chem. 2010 Nov 11;53(21):7639-46.5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists. | ||||
Ref 529929 | J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. | ||||
Ref 552992 | Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms. Psychopharmacology (Berl). 2010 Jan;208(1):23-36. doi: 10.1007/s00213-009-1702-5. Epub 2009 Oct 23. | ||||
Ref 526655 | J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). | ||||
Ref 529191 | Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. Epub 2007 Nov 17.Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. | ||||
Ref 529929 | J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. | ||||
Ref 526655 | J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 527463 | Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11.1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 527760 | Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. Epub 2005 Sep 23.Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 529929 | J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. | ||||
Ref 528630 | Bioorg Med Chem Lett. 2007 Mar 15;17(6):1691-4. Epub 2007 Jan 4.Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors. | ||||
Ref 528630 | Bioorg Med Chem Lett. 2007 Mar 15;17(6):1691-4. Epub 2007 Jan 4.Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors. | ||||
Ref 530540 | Eur J Med Chem. 2010 Feb;45(2):782-9. Epub 2009 Oct 31.8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 528373 | J Med Chem. 2006 Aug 24;49(17):5217-25.Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | ||||
Ref 527474 | J Med Chem. 2005 Mar 24;48(6):1781-95.Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands. | ||||
Ref 530739 | J Med Chem. 2010 Mar 25;53(6):2521-7.5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists. | ||||
Ref 530739 | J Med Chem. 2010 Mar 25;53(6):2521-7.5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists. | ||||
Ref 530698 | Bioorg Med Chem Lett. 2010 Mar 1;20(5):1657-60. Epub 2010 Jan 21.3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. | ||||
Ref 530698 | Bioorg Med Chem Lett. 2010 Mar 1;20(5):1657-60. Epub 2010 Jan 21.3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. | ||||
Ref 552840 | 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics. 2008 Jul;5(3):458-69. doi: 10.1016/j.nurt.2008.05.008. | ||||
Ref 529148 | Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. | ||||
Ref 530058 | Bioorg Med Chem Lett. 2009 May 1;19(9):2409-12. Epub 2009 Mar 25.Synthesis and SAR of tolylamine 5-HT6 antagonists. | ||||
Ref 530058 | Bioorg Med Chem Lett. 2009 May 1;19(9):2409-12. Epub 2009 Mar 25.Synthesis and SAR of tolylamine 5-HT6 antagonists. | ||||
Ref 529191 | Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. Epub 2007 Nov 17.Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. | ||||
Ref 527463 | Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11.1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. | ||||
Ref 527463 | Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11.1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. | ||||
Ref 527381 | J Med Chem. 2005 Jan 27;48(2):353-6.Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. | ||||
Ref 527463 | Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11.1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 527501 | Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91.Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. | ||||
Ref 530209 | Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. Epub 2009 May 29.Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. | ||||
Ref 529929 | J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. | ||||
Ref 527339 | Bioorg Med Chem Lett. 2005 Jan 17;15(2):379-83.N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists. | ||||
Ref 530209 | Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. Epub 2009 May 29.Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. | ||||
Ref 526655 | J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). | ||||
Ref 529112 | J Med Chem. 2007 Nov 15;50(23):5535-8. Epub 2007 Oct 19.Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. | ||||
Ref 527212 | Bioorg Med Chem Lett. 2004 Sep 6;14(17):4569-73.Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.