Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05WQR
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| Former ID |
DNC003577
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| Drug Name |
3-(2-Amino-ethyl)-2-methyl-1H-indol-5-ol
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| Synonyms |
HTR5A3-(2-Amino-ethyl)-2-methyl-1H-indol-5-ol
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Canonical SMILES |
CC1=C(C2=C(N1)C=CC(=C2)O)CCN
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| InChI |
1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3
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| InChIKey |
WYWNEDARFVJQSG-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 6 receptor | Target Info | Inhibitor | [2] | |
| 5-hydroxytryptamine receptor 3A | Target Info | Inhibitor | [1] | ||
| 5-hydroxy-tryptamine 3B receptor | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapsehsa04726:Serotonergic synapsehsa04726:Serotonergic synapse | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04375:5HT3 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathway | ||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling eventsR-HSA-975298:Ligand-gated ion channel transportR-HSA-975298:Ligand-gated ion channel transport | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP706:SIDS Susceptibility Pathways | |||||
| Iron uptake and transportWP2670:Iron uptake and transport | |||||
| References | |||||
| REF 1 | J Med Chem. 1990 Jan;33(1):13-6.Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists. | ||||
| REF 2 | J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). | ||||
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