Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0P8JA
|
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| Former ID |
DNC003597
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| Drug Name |
Ro-04-6790
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C12H16N6O2S
|
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| InChI |
InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18)
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| InChIKey |
JELFWSXQTXRMAJ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7980531, 11056903, 11111728, 12015219, 14752063, 26755720, 39341763, 47721695, 47870812, 48095630, 48244483, 48244484, 50111226, 53092140, 57359528, 85209259, 85787460, 90340990, 99381440, 103230014, 103989000, 114157993, 124750194, 124881320, 124881321, 128263141, 134340802, 135650909, 135698492, 140775890, 141679203, 163123420, 179235839, 204360712, 225053443, 226973665, 241376163, 242242309, 249617709, 251963225, 252156869
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 6 receptor | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 274). | ||||
| REF 2 | J Med Chem. 2009 Feb 12;52(3):675-87.Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. | ||||
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