Target Information
Target General Infomation | |||||
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Target ID |
T50269
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Former ID |
TTDR00771
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Target Name |
Glycine receptor alpha-1 chain
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Gene Name |
GLRA1
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Synonyms |
Glycine receptor 48 kDa subunit; Strychnine binding subunit; Strychnine-insensitive glycine receptor; GLRA1
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Target Type |
Successful
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Disease | Muscle spasm [ICD10: M62.838] | ||||
Function |
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
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BioChemical Class |
Neurotransmitter receptor
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Target Validation |
T50269
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UniProt ID | |||||
Sequence |
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ |
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Drugs and Mode of Action | |||||
Inhibitor | 10-methoxy-ginkgolide C | Drug Info | [528727] | ||
3,14-DIDEHYDROGINKGOLIDE A | Drug Info | [528727] | |||
3-demethoxy-3-D-lyxopyranosylaminothiocolchicine | Drug Info | [528408] | |||
3-demethoxy-3-D-mannopyranosylaminothiocolchicine | Drug Info | [528408] | |||
3-demethoxy-3-D-xylopyranosylaminothiocolchicine | Drug Info | [528408] | |||
3-demethoxy-3-L-fucopyranosylaminothiocolchicine | Drug Info | [528408] | |||
3-demethoxy-3D-glucopyranosylaminothiocolchicine | Drug Info | [528408] | |||
D-Serine | Drug Info | [551378] | |||
GINKGOLIDE A | Drug Info | [528727] | |||
Ginkgolide C | Drug Info | [528727] | |||
Ginkgolide J | Drug Info | [528727] | |||
Ginkgolide M | Drug Info | [528727] | |||
GINKOLIDE B | Drug Info | [528727] | |||
STRYCHNINE | Drug Info | [528408] | |||
THIOCOLCHICOSIDE | Drug Info | [528408] | |||
Pathways | |||||
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Reactome | Ligand-gated ion channel transport | ||||
References | |||||
Ref 467510 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4171). |
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