Drug Information

Drug General Information
Drug ID
D0G2OJ
Former ID
DNC007176
Drug Name
Ginkgolide C
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539173]
Structure
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2D MOL

3D MOL
Formula
C20H24O11
InChI
InChI=1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6-,7+,8?,9?,10-,11+,15+,17?,18?,19-,20-/m1/s1
InChIKey
AMOGMTLMADGEOQ-WXQWCWKOSA-N
CAS Number
CAS 15291-76-6
PubChem Compound ID
441295
PubChem Substance ID
9805, 74382529, 135652687, 137038584, 164814218, 179316258, 223439820, 226814869
Target and Pathway
Target(s) Glycine receptor Target Info Inhibitor [528727]
Glycine receptor alpha-1 chain Target Info Inhibitor [528727]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Ligand-gated ion channel transportR-HSA-975298:Ligand-gated ion channel transport
WikiPathways Iron uptake and transport
References
Ref 539173(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1863).
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.

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