Target Information

Target General Infomation
Target ID
T92308
Former ID
TTDS00312
Target Name
DNA (cytosine-5)-methyltransferase
Synonyms
DNA MTase; DNA methyltransferase; M.EcoDcm
Target Type
Successful
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Myelodysplastic syndrome [ICD9: 238.7; ICD10: D46]
Function
This methylase recognizes the double-stranded sequence ccwgg, causes specific methylation on c-2 on both strands.
BioChemical Class
Methyltransferase superfamily
Target Validation
T92308
EC Number
EC 2.1.1.73
Drugs and Mode of Action
Drug(s) Azacitidine Drug Info Approved Myelodysplastic syndrome [537058], [541877]
Curcumin Drug Info Phase 3 Cancer [532348], [542031]
Inhibitor (L-)-S-adenosyl-L-homocysteine Drug Info [530076]
Azacitidine Drug Info [537058]
Curcumin Drug Info [530577]
NSC-106084 Drug Info [530577]
NSC-137546 Drug Info [530577]
NSC-138419 Drug Info [530577]
NSC-154957 Drug Info [530577]
NSC-158324 Drug Info [530577]
NSC-319745 Drug Info [530577]
NSC-345763 Drug Info [530577]
NSC-348926 Drug Info [530577]
NSC-401077 Drug Info [530577]
NSC-54162 Drug Info [530577]
NSC-56071 Drug Info [530577]
NSC-57893 Drug Info [530577]
NSC-622444 Drug Info [530577]
NSC-622445 Drug Info [530577]
NSC-623548 Drug Info [530577]
S-Adenosylhomocysteine Drug Info [530577]
S-tubercidinylhomocysteine Drug Info [530075]
References
Ref 532348Nanocurcumin: a promising therapeutic advancement over native curcumin. Crit Rev Ther Drug Carrier Syst. 2013;30(4):331-68.
Ref 537058The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28. Epub 2009 Feb 5.
Ref 541877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6796).
Ref 542031(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7000).
Ref 530075Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. Epub 2009 Mar 28.SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes.
Ref 530076Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. Epub 2009 Mar 28.Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors.
Ref 530577Bioorg Med Chem. 2010 Jan 15;18(2):822-9. Epub 2009 Nov 27.Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.
Ref 537058The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28. Epub 2009 Feb 5.

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