Drug General Information
Drug ID
D08TGQ
Former ID
DNC009796
Drug Name
S-tubercidinylhomocysteine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530075]
Structure
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2D MOL

3D MOL

Formula
C15H21N5O5S
Canonical SMILES
C1=CN(C2=C1C(=NC=N2)N)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O
InChI
1S/C15H21N5O5S/c16-8(15(23)24)2-4-26-5-9-10(21)11(22)14(25-9)20-3-1-7-12(17)18-6-19-13(7)20/h1,3,6,8-11,14,21-22H,2,4-5,16H2,(H,23,24)(H2,17,18,19)/t8-,9+,10+,11+,14+/m0/s1
InChIKey
VIRPSVXGKGPXDV-NDXSAKOMSA-N
PubChem Compound ID
Target and Pathway
Target(s) DNA (cytosine-5)-methyltransferase 3B Target Info Inhibitor [530075]
DNA (cytosine-5)-methyltransferase Target Info Inhibitor [530075]
KEGG Pathway Cysteine and methionine metabolism
Metabolic pathways
MicroRNAs in cancer
Reactome PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
DNA methylation
WikiPathways Mesodermal Commitment Pathway
Endoderm Differentiation
Trans-sulfuration and one carbon metabolism
One Carbon Metabolism
miR-targeted genes in lymphocytes - TarBase
References
Ref 530075Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. Epub 2009 Mar 28.SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes.
Ref 530075Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. Epub 2009 Mar 28.SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes.

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