TTD | Drug: D09CLP

Drug General Information
Drug ID	D09CLP
Former ID	DNC009797
Drug Name	(L-)-S-adenosyl-L-homocysteine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530076]
Structure		Download 2D MOL 3D MOL
Formula	C14H20N6O5S
Canonical SMILES	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CSCCC(C(=O)O)N)O)O
InChI	1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKey	ZJUKTBDSGOFHSH-WFMPWKQPSA-N
PubChem Compound ID	439155
Target and Pathway
Target(s)	DNA (cytosine-5)-methyltransferase	Target Info	Inhibitor	[530076]
Target(s)	DNA (cytosine-5)-methyltransferase 3B	Target Info	Inhibitor	[530076]
KEGG Pathway	Cysteine and methionine metabolism
	Metabolic pathways
	MicroRNAs in cancer
Reactome	PRC2 methylates histones and DNA
	NoRC negatively regulates rRNA expression
	DNA methylation
WikiPathways	Mesodermal Commitment Pathway
	Endoderm Differentiation
	Trans-sulfuration and one carbon metabolism
	One Carbon Metabolism
	miR-targeted genes in lymphocytes - TarBase
References
Ref 530076	Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. Epub 2009 Mar 28.Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors.
Ref 530076	Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. Epub 2009 Mar 28.Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors.

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Drug Information