Drug Information

Drug General Information
Drug ID
D09FAZ
Former ID
DAP000640
Drug Name
Azacitidine
Synonyms
Azacitidina; Azacitidinum; Azacytidine; Ladakamycin; Mylosar; Vidaza; Mylo sar; Pharmion Brand of Azacitidine;A 2385; Antibiotic U 18496; U 18496; Wr 183027; Azacitidina [INN-Spanish]; Azacitidine [USAN:INN]; Azacitidinum [INN-Latin]; NS-17; Pyrimidine antimetabolite: inhibits nucleic acid replication; U-18496; Vidaz (TN); Vidaza (TN); WR-183027; Azacitidine (JAN/USAN/INN); S-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-(8CI); 2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one; 4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one; 4-Amino-1-beta-d-ribofuranosyl-1,3,5-triazin-2(1H)-one; 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triaz; 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one; 4-amino-1-beta-L-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5 AZC; 5 Azacytidine; 5-AC; 5-AZAC; 5-AZCR; 5-aza-CR; 5-azacitidine; 5-azacytidine; 5-azacytidine, Mylosar, Ladakamycin, Vidaza, Azacitidine; 5AzaC
Drug Type
Small molecular drug
Indication Myelodysplastic syndrome [ICD9: 238.7; ICD10:D46] Approved [537058], [541877]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C8H12N4O5
InChI
InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
InChIKey
NMUSYJAQQFHJEW-KVTDHHQDSA-N
CAS Number
CAS 320-67-2
PubChem Compound ID
9444
PubChem Substance ID
13439, 596456, 3139592, 8140000, 8148227, 8149830, 8156757, 11335300, 11360539, 11364156, 11364964, 11366718, 11367526, 11369280, 11370088, 11372756, 11373127, 11374582, 11375688, 11377442, 11378259, 11461511, 11484628, 11488602, 11491324, 11492737, 11495076, 12013374, 14749656, 15019893, 17390033, 17397176, 17404599, 24278211, 24890525, 26612306, 26679741, 26752817, 29228037, 46509032, 47216641, 47662119, 47810606, 47885263, 48034961, 48259073, 48334340, 48413245, 48415593, 48422584
ChEBI ID
ChEBI:2038
SuperDrug ATC ID
L01BC07
Target and Pathway
Target(s) DNA (cytosine-5)-methyltransferase Target Info Inhibitor [537058]
References
Ref 537058The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28. Epub 2009 Feb 5.
Ref 541877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6796).
Ref 537058The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28. Epub 2009 Feb 5.

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