Drug Information

Drug General Information
Drug ID
D04JNZ
Former ID
DNC004146
Drug Name
PROSTRATIN
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Investigative [527606]
Structure
Download
2D MOL

3D MOL
Formula
C22H30O6
Canonical SMILES
CC1CC2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)OC(=<br />O)C
InChI
1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17?,20-,21?,22-/m1/s1
InChIKey
BOJKFRKNLSCGHY-KKFGZBDXSA-N
PubChem Compound ID
44302701
Target and Pathway
Target(s) mRNA of PKC-epsilon Target Info Inhibitor [527606]
mRNA of PKC-delta Target Info Inhibitor [527606]
Protein kinase C, delta type Target Info Inhibitor [527606]
mRNA of human PKC-eta Target Info Inhibitor [527606]
Protein kinase C gamma type Target Info Inhibitor [527606]
mRNA of Protein kinase C-theta Target Info Inhibitor [527606]
Protein kinase C, beta type Target Info Inhibitor [527606]
Protein kinase C, alpha type Target Info Inhibitor [527606]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Vascular smooth muscle contraction
Tight junction
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Inflammatory mediator regulation of TRP channels
Type II diabetes mellitus
MicroRNAs in cancerhsa04062:Chemokine signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Type II diabetes mellitushsa04062:Chemokine signaling pathway
Type II diabetes mellitushsa04270:Vascular smooth muscle contraction
Inflammatory mediator regulation of TRP channelshsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
Wnt signaling pathway
VEGF signaling pathway
Focal adhesion
Gap junction
Natural killer cell mediated cytotoxicity
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Insulin secretion
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04064:NF-kappa B signaling pathway
T cell receptor signaling pathway
Adipocytokine signaling pathway
Measleshsa04010:MAPK signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
B cell receptor signaling pathway
Carbohydrate digestion and absorption
Leishmaniasis
Influenza A
Choline metabolism in cancerhsa04010:MAPK signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Pathogenic Escherichia coli infection
Choline metabolism in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
B cell activation
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
T cell activation
Metabotropic glutamate receptor group I pathway
PDGF signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map ST
Pathway Interaction Database Endothelins
LPA receptor mediated events
TCR signaling in na&#xef
LPA4-mediated signaling events
CDC42 signaling events
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2-mediated signaling events
PDGFR-beta signaling pathway
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Downstream signaling in na&#xef
Endothelins
IGF1 pathway
Ceramide signaling pathway
IFN-gamma pathway
ErbB1 downstream signaling
Syndecan-4-mediated signaling events
IL6-mediated signaling events
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
Syndecan-2-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Alpha-synuclein signalingendothelinpathway:Endothelins
Role of Calcineurin-dependent NFAT signaling in lymphocytesendothelinpathway:Endothelins
Retinoic acid receptors-mediated signaling
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling eventsendothelinpathway:Endothelins
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Fc-epsilon receptor I signaling in mast cells
Ras signaling in the CD4+ TCR pathway
JNK signaling in the CD4+ TCR pathway
Canonical NF-kappaB pathway
Signaling events regulated by Ret tyrosine kinase
mTOR signaling pathway
ATF-2 transcription factor network
VEGFR1 specific signals
a6b1 and a6b4 Integrin signaling
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptor
Reactome Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
Calmodulin induced events
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Interferon gamma signalingR-HSA-111465:Apoptotic cleavage of cellular proteins
Interferon gamma signalingR-HSA-114508:Effects of PIP2 hydrolysis
G alpha (z) signalling eventsR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+R-HSA-111465:Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
G alpha (z) signalling eventsR-HSA-114516:Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Depolymerisation of the Nuclear Lamina
Response to elevated platelet cytosolic Ca2+R-HSA-111933:Calmodulin induced events
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Response to elevated platelet cytosolic Ca2+
WikiPathways Hypothetical Network for Drug Addiction
Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Oncostatin M Signaling Pathway
miRs in Muscle Cell Differentiation
GPCR downstream signaling
Effects of PIP2 hydrolysis
Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
Type II interferon signaling (IFNG)
Insulin Signaling
EGF/EGFR Signaling Pathway
MAPK Signaling Pathway
IL-6 signaling pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
DAG and IP3 signaling
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
B Cell Receptor Signaling Pathway
Signaling Pathways in Glioblastoma
Opioid Signalling
Apoptotic execution phase
Type II diabetes mellitusWP69:TCR Signaling Pathway
Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
Effects of PIP2 hydrolysisWP536:Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway Netpath
Response to elevated platelet cytosolic Ca2+WP69:TCR Signaling Pathway
Fc epsilon receptor (FCERI) signaling
TCR signaling
Netrin-1 signaling
Apoptotic execution phaseWP536:Calcium Regulation in the Cardiac Cell
Kit receptor signaling pathway
Signaling by the B Cell Receptor (BCR)
Response to elevated platelet cytosolic Ca2+
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the HeartWP673:ErbB Signaling Pathway
Transcriptional activation by NRF2
Human Complement System
Cardiac Hypertrophic Response
Syndecan interactions
Signaling by SCF-KIT
Gastrin-CREB signalling pathway via PKC and MAPK
T-Cell Receptor and Co-stimulatory Signaling
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Endothelin Pathways
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
Integration of energy metabolism
TOR Signaling
References
Ref 527606J Med Chem. 1992 May 29;35(11):1978-86.A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.
Ref 527606J Med Chem. 1992 May 29;35(11):1978-86.A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.

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