Target Information

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Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
Drug Property Profile of Target
Target Poor or Non Binders
Target Regulators
Target Profiles in Patients
Target Affiliated Biological Pathways
Target-Related Models and Studies
References
Drug Binding Sites of Target  Top
Ligand Name: MK-591 Ligand Info
Structure Description Crystal structure of human FLAP with MK-591 PDB:2Q7M
Method X-ray diffraction Resolution 4.25 Å Mutation Yes [13]
PDB Sequence
MDQETVGNVV
10
LLAIVTLISV
20
VQNGFFAHKV
30
EHESRTQNGR
40
SFQRTGTLAF
50

ERVYTANQNC
60
VDAYPTFLAV
70
LWSAGLLCSQ
80
VPAAFAGLMY
90
LFVRQKYFVG
100

YLGERTQSTP
110
GYIFGKRIIL
120
FLFLMSVAGI
130
FNYYLIFFF
Residue
Distance (Å)
VAL20
4.503
VAL21
3.472
ASN23
3.310
GLY24
2.976
PHE25
2.881
ALA27
3.241
HIS28
3.652
ASN57
4.538
ASN59
4.362
VAL61
4.522
ASP62
3.235
Residue
Distance (Å)
ALA63
3.393
THR66
4.155
TYR90
4.428
TYR112
3.305
ILE113
3.355
PHE114
3.703
LYS116
2.747
ILE119
2.763
LEU120
3.338
PHE123
3.498
Ligand Name: DG031 Ligand Info
Structure Description Crystal Structures of FLAP bound to DG-031 PDB:6VGC
Method X-ray diffraction Resolution 2.37 Å Mutation No [14]
PDB Sequence
SLDQETVGNV
9
VLLAIVTLIS
19
VVQNGFFAHK
29
VEHESRTTGT
47
LAFERVYTAN
57

QNCVDAYPTF
67
LAVLWSAGLL
77
CSQVPAAFAG
87
LMYLFVRQKY
97
FVGYLPGYIF
114

GKRIILFLFL
124
MSVAGIFNYY
134
LIFFFGSDFE
144
NYIATISTTI
154
SPLL
Residue
Distance (Å)
ASN59
4.936
ASP62
3.498
ALA63
3.650
THR66
3.642
TYR112
3.407
Residue
Distance (Å)
ILE113
3.747
PHE114
4.133
LYS116
2.242
ILE119
3.544
LEU120
4.898
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Fc epsilon RI signaling pathway hsa04664 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
Degree 1 Degree centrality 1.07E-04 Betweenness centrality 0.00E+00
Closeness centrality 1.60E-01 Radiality 1.24E+01 Clustering coefficient 0.00E+00
Neighborhood connectivity 7.00E+00 Topological coefficient 1.00E+00 Eccentricity 14
Download Click to Download the Full PPI Network of This Target

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