Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46642 | Target Info | |||
| Target Name | Arachidonate 5-lipoxygenase activating protein (FLAP) | ||||
| Synonyms |
MK-886-binding protein; FLAP; ALOX5AP
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| Target Type | Discontinued Target | ||||
| Gene Name | ALOX5AP | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CID 56837589
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417529; SCHEMBL10161983; BDBM50078144
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). J Med Chem. 2015 Feb 26;58(4):1669-90. | ||||
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