Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06UYI
|
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| Former ID |
DCL000037
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| Drug Name |
AM103
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| Drug Type |
Small molecular drug
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| Indication | Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99] | Discontinued in Phase 2 | [1] | |
| Company |
Amira Pharma.
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C22H20N4O3
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| Canonical SMILES |
CC(=O)CC1=CC2=CC(=CN=C2N1CC(=O)N)OCC3=NC4=CC=CC=C4C=C3
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| InChI |
1S/C22H20N4O3/c1-14(27)8-18-9-16-10-19(11-24-22(16)26(18)12-21(23)28)29-13-17-7-6-15-4-2-3-5-20(15)25-17/h2-7,9-11H,8,12-13H2,1H3,(H2,23,28)
|
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| InChIKey |
NNJQMAFPENKSQD-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 5-lipoxygenase activating protein (FLAP) | Target Info | Inhibitor | [2] |
| NetPath Pathway | IL4 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| WikiPathways | Nuclear Receptors Meta-Pathway | |||
| Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026047) | |||
| REF 2 | AM103 Experimental Treatment for Respiratory Diseases. Amira Pharmaceuticals/GSK. 2009. | |||
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