Target Information

Target General Information

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Target ID

T08735 (Former ID: TTDS00505)

Target Name

Aspergillus Mannitol 2-dehydrogenase (Asperg M2DH)

Synonyms

MDH; M2DH

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Gene Name

Asperg M2DH

Target Type

Successful target

[1]

Disease

[+] 2 Target-related Diseases

Bronchiectasis [ICD-11: CA24]

Kidney failure [ICD-11: GB60-GB6Z]

Function

Catalyzes the NAD(H)-dependent interconversion of D- fructose and D-mannitol in the mannitol metabolic pathway. Has a preference for NADH over NADPH.

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BioChemical Class

Short-chain dehydrogenases reductase

UniProt ID

M2DH_ASPFU

Sequence

MAPLKLNSRNLSQIAAAGGALVKIPTYQRGRAVKEGIVHIGVGGFHRAHLAVYIDQLMQK
HGVNDYAICGVGLQPFDSAMRDALASQDHLYTLIERSAKGSFAHVIGSINSYLFAPDNRE
AVIAKMAHPDTKIVSLTITESGYYYNENTHELQSEHPDIQFDLDPANEKAPRTTFGFLYA
GLTRRYQQGLKPFTVMSCDNMQKNGSITRHMLESFARLRNPEVAEWIAEEGAFPNAMVDR
ITPQTSETDKTALAEKFGIVDSWPVVTEPFTQWVIEDQFSDGRPPFEKVGVQVVKDVHAV
EQFEKHKLRLLNGSHSALGYPGQLAGFQYVHEVMANPLFRKFVWQMMQEEVKPLLPEIPG
VDIDEYCNTLIERFTNPTIMDQLPRICLNASGKIPQFIMPSIAEAIWETGPFRRLCFVAA
AWFHYIKGVDDRGKPFEVVDPMREELQAKARAGGNDPSELLSIKSLFGDDLRNDERFLRE
ITTAMNDIARDGIMKTLPKYIN

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Drugs and Modes of Action

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Approved Drug(s)

[+] 1 Approved Drugs

Mannitol

Drug Info

Approved

Bronchiectasis

[2], [3]

Mode of Action

[+] 1 Modes of Action

Activator

[+] 1 Activator drugs

Mannitol

Drug Info

[1]

Drug Binding Sites of Target

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Ligand Name: NADH

Ligand Info

Structure Description

Mannitol-2-dehydrogenase bound to NADH from Aspergillus fumigatus

PDB:7RK5

Method

X-ray diffraction

Resolution

2.10 Å

Mutation

[4]

PDB Sequence

APLKLNSRNL

¹¹

SQIAAAGGAL

²¹

VKIPTYQRGR

³¹

AVKEGIVHIG

⁴¹

VGGFHRAHLA

⁵¹

VYIDQLMQKH

⁶¹

GVNDYAICGV

⁷¹

GLQPFDSAMR

⁸¹

DALASQDHLY

⁹¹

TLIERSAKGS

¹⁰¹

FAHVIGSINS

¹¹¹

YLFAPDNREA

¹²¹

VIAKMAHPDT

¹³¹

KIVSLTITES

¹⁴¹

GYYYNENTHE

¹⁵¹

LQSEHPDIQF

¹⁶¹

DLDPANEKAP

¹⁷¹

RTTFGFLYAG

¹⁸¹

LTRRYQQGLK

¹⁹¹

PFTVMSCDNM

²⁰¹

QKNGSITRHM

²¹¹

LESFARLRNP

²²¹

EVAEWIAEEG

²³¹

AFPNAMVDRI

²⁴¹

TPQTSETDKT

²⁵¹

ALAEKFGIVD

²⁶¹

SWPVVTEPFT

²⁷¹

QWVIEDQFSD

²⁸¹

GRPPFEKVGV

²⁹¹

QVVKHAVEQF

³⁰³

EKHKLRLLNG

³¹³

SHSALGYPGQ

³²³

LAGFQYVHEV

³³³

MANPLFRKFV

³⁴³

WQMMQEEVKP

³⁵³

LLPEIPGVDI

³⁶³

DEYCNTLIER

³⁷³

FTNPTIMDQL

³⁸³

PRICLNASGK

³⁹³

IPQFIMPSIA

⁴⁰³

EAIWETGPFR

⁴¹³

RLCFVAAAWF

⁴²³

HYIKGVDDRG

⁴³³

KPFEVVDPMR

⁴⁴³

EELQAKARAG

⁴⁵³

GNDPSELLSI

⁴⁶³

KSLFGDDLRN

⁴⁷³

DERFLREITT

⁴⁸³

AMNDIARDGI

⁴⁹³

MKTLPKYING

⁵⁰³

Residue

Distance (Å)

ILE40

4.793

GLY41

3.341

VAL42

3.500

GLY43

3.416

GLY44

2.968

PHE45

2.843

HIS46

4.381

LEU73

4.151

GLN74

3.272

ASP77

2.499

THR137

3.230

ILE138

3.398

THR139

3.601

SER141

4.334

GLY142

3.353

Residue

Distance (Å)

TYR144

4.657

THR174

4.045

CYS198

4.132

ASP199

3.181

ASN200

2.913

VAL238

4.076

ASP239

4.874

ARG240

3.451

ILE241

3.555

THR242

2.807

PRO243

4.855

GLN244

4.231

LYS307

3.676

ARG385

4.063

Click to View More Binding Site Information of This Target with Different Ligands

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

There is no similarity protein (E value < 0.005) for this target

References

Top

REF 1

Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies o... Chem Biol Interact. 2009 Mar 16;178(1-3):274-82.

REF 2

FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016080.

REF 3

Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

REF 4

Mannitol-2-dehydrogenase bound to NADH from Aspergillus fumigatus

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