Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T08735 Target Info
Target Name Aspergillus Mannitol 2-dehydrogenase (Asperg M2DH)
Synonyms MDH; M2DH
Target Type Successful Target
Gene Name Asperg M2DH
Biochemical Class Short-chain dehydrogenases reductase
UniProt ID
M2DH_ASPFU
Drug Binding Sites of Target  Top
Ligand Name: NADH Ligand Info
Structure Description Mannitol-2-dehydrogenase bound to NADH from Aspergillus fumigatus PDB:7RK5
Method X-ray diffraction Resolution 2.10 Å Mutation No [1]
PDB Sequence
APLKLNSRNL
11
SQIAAAGGAL
21
VKIPTYQRGR
31
AVKEGIVHIG
41
VGGFHRAHLA
51

VYIDQLMQKH
61
GVNDYAICGV
71
GLQPFDSAMR
81
DALASQDHLY
91
TLIERSAKGS
101

FAHVIGSINS
111
YLFAPDNREA
121
VIAKMAHPDT
131
KIVSLTITES
141
GYYYNENTHE
151

LQSEHPDIQF
161
DLDPANEKAP
171
RTTFGFLYAG
181
LTRRYQQGLK
191
PFTVMSCDNM
201

QKNGSITRHM
211
LESFARLRNP
221
EVAEWIAEEG
231
AFPNAMVDRI
241
TPQTSETDKT
251

ALAEKFGIVD
261
SWPVVTEPFT
271
QWVIEDQFSD
281
GRPPFEKVGV
291
QVVKHAVEQF
303

EKHKLRLLNG
313
SHSALGYPGQ
323
LAGFQYVHEV
333
MANPLFRKFV
343
WQMMQEEVKP
353

LLPEIPGVDI
363
DEYCNTLIER
373
FTNPTIMDQL
383
PRICLNASGK
393
IPQFIMPSIA
403

EAIWETGPFR
413
RLCFVAAAWF
423
HYIKGVDDRG
433
KPFEVVDPMR
443
EELQAKARAG
453

GNDPSELLSI
463
KSLFGDDLRN
473
DERFLREITT
483
AMNDIARDGI
493
MKTLPKYING
503

S
Residue
Distance (Å)
ILE40
4.793
GLY41
3.341
VAL42
3.500
GLY43
3.416
GLY44
2.968
PHE45
2.843
HIS46
4.381
LEU73
4.151
GLN74
3.272
ASP77
2.499
THR137
3.230
ILE138
3.398
THR139
3.601
SER141
4.334
GLY142
3.353
Residue
Distance (Å)
TYR144
4.657
THR174
4.045
CYS198
4.132
ASP199
3.181
ASN200
2.913
VAL238
4.076
ASP239
4.874
ARG240
3.451
ILE241
3.555
THR242
2.807
PRO243
4.855
GLN244
4.231
LYS307
3.676
ARG385
4.063
References  Top
REF 1 Mannitol-2-dehydrogenase bound to NADH from Aspergillus fumigatus

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