Target Validation Information
TTD ID	T88285
Target Name	Lactoylglutathione lyase (GLO1)
Type of Target	Clinical trial
Drug Potency against Target	BAICALEIN	Drug Info	IC50 = 11000 nM	[1]
	CYANIDIN	Drug Info	IC50 = 11700 nM	[3]
	PELARGONIDIN CHLORIDE	Drug Info	IC50 = 16400 nM	[3]
	S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 14 nM	[4]
	S-(N-4chlorophenyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 46 nM	[4]
	S-(N-butyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 180 nM	[4]
	S-(N-ethyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 1180 nM	[4]
	S-(N-heptyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 18 nM	[4]
	S-(N-hexyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 16 nM	[4]
	S-(N-methyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 1700 nM	[4]
	S-(N-pentyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 170 nM	[4]
	S-(N-phenyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 160 nM	[4]
	S-(N-propyl-N-hydroxycarbamoyl)glutathione	Drug Info	Ki = 800 nM	[4]
	S-p-bromobenzyl glutatione	Drug Info	Ki = 6280 nM	[2]
References
REF 1	Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Bioorg Med Chem. 2008 Apr 1;16(7):3969-75.
REF 2	Inhibition of glyoxalase I: the first low-nanomolar tight-binding inhibitors. J Med Chem. 2009 Aug 13;52(15):4650-6.
REF 3	Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I. Bioorg Med Chem. 2010 Oct 1;18(19):7029-33.
REF 4	Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.