Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0FX3J
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| Former ID |
DNC004388
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| Drug Name |
S-(N-methyl-N-hydroxycarbamoyl)glutathione
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| Synonyms |
S-Hmcg; S-(N-Hydroxy-N-methylcarbamoyl)glutathione; CHEMBL129435; 144810-23-1; AC1L2R0C; S-(N-methyl-N-hydroxycarbamoyl)glutathione; SCHEMBL3009083; DTXSID00162814; CHEBI:313255; BDBM50092823; S-(Methylhydroxycarbamoyl)glutathione; s-(n-hydroxy-n-methylcarbamoyl) glutathione; C04572; Glycine, N-(N-L-gamma-glutamyl-S-((hydroxymethylamino)carbonyl)-L-cysteinyl)-; (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-[hydroxy(methyl)carbamoyl]sulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H20N4O8S
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| Canonical SMILES |
CN(C(=O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N)O
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| InChI |
1S/C12H20N4O8S/c1-16(24)12(23)25-5-7(10(20)14-4-9(18)19)15-8(17)3-2-6(13)11(21)22/h6-7,24H,2-5,13H2,1H3,(H,14,20)(H,15,17)(H,18,19)(H,21,22)/t6-,7-/m0/s1
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| InChIKey |
RITFSVQFPRZDHQ-BQBZGAKWSA-N
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| CAS Number |
CAS 144810-23-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:313255
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Lactoylglutathione lyase (GLO1) | Target Info | Inhibitor | [1] |
| BioCyc | Methylglyoxal degradation I | |||
| KEGG Pathway | Pyruvate metabolism | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Pathwhiz Pathway | Pyruvaldehyde Degradation | |||
| Pyruvate Metabolism | ||||
| Reactome | Pyruvate metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. | |||
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