Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T89534 Target Info
Target Name Estrogen receptor (ESR)
Synonyms Nuclear receptor subfamily 3 group A member 1; NR3A1; Estradiol receptor; ESR; ER-alpha; ER
Target Type Successful Target
Gene Name ESR1
Biochemical Class Nuclear hormone receptor
UniProt ID
ESR1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 6 Acid anhydride hydrolases +
Interacting Target Name ATP-dependent RNA helicase DDX5 (DDX5) Clinical trial Target Interacting Protein Info
UniProt ID
DDX5_HUMAN 
Synonyms RNA helicase p68; Probable ATP-dependent RNA helicase DDX5; HLR1; HELR; G17P1; DEAD box protein 5
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Yeast two hybrid [3]
Interacting Protein Name ATP-dependent RNA helicase DDX3X (DDX3X) Interacting Protein Interacting Protein Info
UniProt ID
DDX3X_HUMAN 
Synonyms CAP.Rf; DBX; DDX14; DDX3; HLP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Reconstituted Complex [4]
Interacting Protein Name Unconventional myosin-Ic (MYO1C) Interacting Protein Interacting Protein Info
UniProt ID
MYO1C_HUMAN 
Synonyms MMI.beta; MMIb; NMI; myr2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Protein Name Probable ATP-dependent RNA helicase DDX17 (DDX17) Interacting Protein Interacting Protein Info
UniProt ID
DDX17_HUMAN 
Synonyms P72; RH70
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
3 Yeast two hybrid [3]
Interacting Protein Name ATP-dependent RNA helicase A (DHX9) Interacting Protein Interacting Protein Info
UniProt ID
DHX9_HUMAN 
Synonyms DDX9; LKP; NDH2; NDHII; RHA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Eukaryotic initiation factor 4A-I (EIF4A1) Interacting Protein Interacting Protein Info
UniProt ID
IF4A1_HUMAN 
Synonyms DDX2A; EIF.4A; EIF4A; eIF.4A.I; eIF4A.I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Actins [+] 4 Actins +
Interacting Protein Name Beta-actin (ACTB) Interacting Protein Interacting Protein Info
UniProt ID
ACTB_HUMAN 
Synonyms BRWS1; PS1TP5BP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Reconstituted Complex [4]
Interacting Protein Name Actin-related protein 2 (ACTR2) Interacting Protein Interacting Protein Info
UniProt ID
ARP2_HUMAN 
Synonyms ARP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Protein Name Actin-related protein 3 (ACTR3) Interacting Protein Interacting Protein Info
UniProt ID
ARP3_HUMAN 
Synonyms ARP3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Protein Name Alpha-cardiac actin (ACTC1) Interacting Protein Interacting Protein Info
UniProt ID
ACTC_HUMAN 
Synonyms ACTC; ASD5; CMD1R; CMH11; LVNC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Acyltransferases [+] 8 Acyltransferases +
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [5]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [8]
6 Fluorescence Resonance Energy Transfer [9]
7 Fluorescence Resonance Energy Transfer [10]
8 Protein-peptide [11]
9 Reconstituted Complex [12]
10 Reconstituted Complex [13]
11 Reconstituted Complex [14]
12 Reconstituted Complex [6]
13 Reconstituted Complex [15]
14 Reconstituted Complex [16]
15 Reconstituted Complex [3]
16 Reconstituted Complex [17]
17 Reconstituted Complex [18]
18 Reconstituted Complex [19]
19 Reconstituted Complex [20]
20 Reconstituted Complex [21]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [22]
4 Affinity Capture-Western [5]
5 Affinity Capture-Western [23]
6 Affinity Capture-Western [24]
7 Affinity Capture-Western [25]
8 Affinity Capture-Western [26]
9 Affinity Capture-Western [27]
10 Affinity Capture-Western [28]
11 Affinity Capture-Western [29]
12 Co-fractionation [30]
13 Fluorescence Resonance Energy Transfer [27]
14 Fluorescence Resonance Energy Transfer [10]
15 Fluorescence Resonance Energy Transfer [31]
16 Protein-peptide [11]
17 Reconstituted Complex [6]
18 Reconstituted Complex [32]
19 Reconstituted Complex [33]
20 Reconstituted Complex [24]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [35]
4 Affinity Capture-Western [36]
5 Biochemical Activity [37]
6 Reconstituted Complex [34]
7 Reconstituted Complex [14]
8 Reconstituted Complex [32]
9 Reconstituted Complex [4]
10 Reconstituted Complex [17]
11 Yeast two hybrid [3]
12 Yeast two hybrid [17]
Interacting Protein Name Breast cancer type 1 susceptibility protein (BRCA1) Interacting Protein Interacting Protein Info
UniProt ID
BRCA1_HUMAN 
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [38]
3 Affinity Capture-Western [35]
4 Affinity Capture-Western [39]
5 Affinity Capture-Western [40]
6 Affinity Capture-Western [41]
7 Affinity Capture-Western [42]
8 Affinity Capture-Western [43]
9 Affinity Capture-Western [44]
10 Reconstituted Complex [45]
11 Reconstituted Complex [41]
12 Reconstituted Complex [43]
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Affinity Capture-Western [47]
3 Affinity Capture-Western [48]
4 Affinity Capture-Western [49]
5 Reconstituted Complex [48]
Interacting Target Name Linear ubiquitin chain assembly complex (RBCK1) Literature-reported Target Interacting Protein Info
UniProt ID
HOIL1_HUMAN 
Synonyms XAP4; XAP3; Ubiquitin-conjugating enzyme 7-interacting protein 3; UBCE7IP3; RNF54; RING-type E3 ubiquitin transferase HOIL-1; RING finger protein 54; RanBP-type and C3HC4-type zinc finger-containing protein 1; HOIL-1; Hepatitis B virus X-associated protein 4; Heme-oxidized IRP2 ubiquitin ligase 1; HBV-associated factor 4; C20orf18
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Affinity Capture-Western [51]
3 Reconstituted Complex [50]
Interacting Target Name Tripartite motif-containing 24 (TRIM24) Literature-reported Target Interacting Protein Info
UniProt ID
TIF1A_HUMAN 
Synonyms Tripartite motif-containing protein 24; Transcription intermediary factor 1-alpha; TIF1-alpha; TIF1A; TIF1; RNF82; RING-type E3 ubiquitin transferase TIF1-alpha; RING finger protein 82; E3 ubiquitin-protein ligase TRIM24
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [52]
3 Reconstituted Complex [21]
Interacting Protein Name E3 ubiquitin-protein ligase HECTD1 (HECTD1) Interacting Protein Interacting Protein Info
UniProt ID
HECD1_HUMAN 
Synonyms EULIR
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [53]
2 Affinity Capture-Western [23]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) Interacting Protein Interacting Protein Info
UniProt ID
TAB2_HUMAN 
Synonyms CHTD2; MAP3K7IP2; TAB.2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [54]
2 Affinity Capture-Western [55]
3 Affinity Capture-Western [56]
4 Reconstituted Complex [55]
5 Reconstituted Complex [56]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Caveolin 1 (CAV1) Literature-reported Target Interacting Protein Info
UniProt ID
CAV1_HUMAN 
Synonyms Caveolin-1; Caveolin1; Cav-1; CAV
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [57]
2 Co-localization [58]
3 Reconstituted Complex [57]
Beta-transducin repeats [+] 3 Beta-transducin repeats +
Interacting Target Name WD repeat-containing protein 5 (WDR5) Literature-reported Target Interacting Protein Info
UniProt ID
WDR5_HUMAN 
Synonyms BMP2-induced 3-kb gene protein; BIG3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [59]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
Interacting Protein Name Histone-binding protein RBBP4 (RBBP4) Interacting Protein Interacting Protein Info
UniProt ID
RBBP4_HUMAN 
Synonyms NURF55; RBAP48; lin.53
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [61]
Interacting Protein Name Histone-binding protein RBBP7 (RBBP7) Interacting Protein Interacting Protein Info
UniProt ID
RBBP7_HUMAN 
Synonyms RbAp46
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [61]
Carbon-nitrogen hydrolases [+] 3 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [62]
3 Affinity Capture-Western [63]
4 Co-localization [64]
5 Reconstituted Complex [65]
Interacting Target Name Histone deacetylase 4 (HDAC4) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC4_HUMAN 
Synonyms KIAA0288; HD4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [66]
2 Reconstituted Complex [67]
3 Reconstituted Complex [66]
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [55]
3 Reconstituted Complex [4]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Interacting Protein Info
UniProt ID
CCND1_HUMAN 
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL-1 oncogene; BCL-1; BCL1; B-cell lymphoma 1 protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [68]
2 Reconstituted Complex [45]
3 Yeast two hybrid [68]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Target Name Serine/threonine PP1-alpha (PPP1CA) Successful Target Interacting Protein Info
UniProt ID
PP1A_HUMAN 
Synonyms Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase 1alpha; PPP1A; PP-1A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name PP2A subunit A isoform PR65-alpha (PPP2R1A) Interacting Protein Interacting Protein Info
UniProt ID
2AAA_HUMAN 
Synonyms PP2A.Aalpha; PP2AAALPHA; PR65A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [53]
2 Reconstituted Complex [4]
Heat shock proteins [+] 4 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Luminescence [69]
2 Affinity Capture-MS [46]
3 Affinity Capture-Western [70]
4 Affinity Capture-Western [48]
5 Affinity Capture-Western [49]
6 Affinity Capture-Western [71]
7 Affinity Capture-Western [47]
8 Affinity Capture-Western [72]
9 Affinity Capture-Western [51]
10 Reconstituted Complex [73]
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [74]
2 Affinity Capture-MS [46]
3 Affinity Capture-Western [48]
4 Affinity Capture-Western [72]
5 Affinity Capture-Western [74]
6 Reconstituted Complex [73]
7 Reconstituted Complex [4]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [46]
4 Affinity Capture-Western [47]
5 Affinity Capture-Western [48]
6 Affinity Capture-Western [46]
Interacting Protein Name Heat shock protein beta-1 (HSPB1) Interacting Protein Interacting Protein Info
UniProt ID
HSPB1_HUMAN 
Synonyms Stress-responsive protein 27; SRP27; HspB1; HSP28; HSP 27; Heat shock protein beta-1; Heat shock 27 kDa protein; Estrogen-regulated 24 kDa protein; 28 kDa heat shock protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [75]
2 Reconstituted Complex [4]
Isomerases [+] 3 Isomerases +
Interacting Protein Name Prostaglandin E synthase 3 (PTGES3) Interacting Protein Interacting Protein Info
UniProt ID
TEBP_HUMAN 
Synonyms P23; TEBP; cPGES
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Affinity Capture-Western [49]
3 Reconstituted Complex [73]
Interacting Target Name DNA topoisomerase II beta (TOP2B) Successful Target Interacting Protein Info
UniProt ID
TOP2B_HUMAN 
Synonyms Topo IIbeta; TOP2beta; TOP2B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [76]
Interacting Target Name FK506-binding protein 5 (FKBP5) Literature-reported Target Interacting Protein Info
UniProt ID
FKBP5_HUMAN 
Synonyms PPIase FKBP5; Peptidyl-prolyl cis-trans isomerase FKBP5; HSP90-binding immunophilin; FKBP54; FKBP-51; FKBP51; FKBP-5; FF1 antigen; Androgen-regulated protein 6; AIG6; 54 kDa progesterone receptor-associated immunophilin; 51 kDa FKBP; 51 kDa FK506-binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [46]
2 Reconstituted Complex [73]
Kinases [+] 5 Kinases +
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-Western [77]
2 Affinity Capture-Western [78]
3 Co-localization [79]
4 Co-localization [64]
5 Co-localization [80]
6 Fluorescence Resonance Energy Transfer [79]
7 Reconstituted Complex [80]
8 Yeast two hybrid [81]
9 Yeast two hybrid [82]
10 Yeast two hybrid [79]
11 Yeast two hybrid [83]
Interacting Target Name PAK-1 protein kinase (PAK1) Literature-reported Target Interacting Protein Info
UniProt ID
PAK1_HUMAN 
Synonyms Serine/threonine-protein kinase PAK 1; PAK-1; p65-PAK; p21-activated kinase 1; Alpha-PAK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [84]
2 Biochemical Activity [85]
3 Reconstituted Complex [85]
Interacting Protein Name DNA-directed RNA polymerase II subunit RPB1 (POLR2A) Interacting Protein Interacting Protein Info
UniProt ID
RPB1_HUMAN 
Synonyms POLR2; POLRA; RPB1; RPBh1; RPO2; RPOL2; RpIILS; hRPB220; hsRPB1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [80]
3 Reconstituted Complex [4]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [86]
2 Affinity Capture-Western [87]
Interacting Target Name DNA-dependent protein kinase catalytic (PRKDC) Clinical trial Target Interacting Protein Info
UniProt ID
PRKDC_HUMAN 
Synonyms P460; HYRC1; HYRC; DNPK1; DNA-PKcs; DNA-PK catalytic subunit; DNA-PK; DNA-dependent protein kinase catalytic subunit; DNA-dependent protein kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [76]
Mediator complexes [+] 3 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [88]
2 Affinity Capture-Western [14]
3 Fluorescence Resonance Energy Transfer [9]
4 Reconstituted Complex [89]
5 Reconstituted Complex [14]
6 Reconstituted Complex [3]
7 Reconstituted Complex [88]
8 Reconstituted Complex [9]
9 Yeast two hybrid [3]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 12 (MED12) Interacting Protein Interacting Protein Info
UniProt ID
MED12_HUMAN 
Synonyms ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [14]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 14 (MED14) Interacting Protein Interacting Protein Info
UniProt ID
MED14_HUMAN 
Synonyms CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [88]
3 Reconstituted Complex [14]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor beta (ESR2) Successful Target Interacting Protein Info
UniProt ID
ESR2_HUMAN 
Synonyms Oestrogen receptor beta; Nuclear receptor subfamily 3 group A member 2; NR3A2; ESTRB; ER-beta; Erbeta; Beta-1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Luminescence [90]
2 Affinity Capture-MS [91]
3 Affinity Capture-Western [92]
4 Affinity Capture-Western [93]
5 Co-purification [94]
6 Reconstituted Complex [95]
7 Yeast two hybrid [82]
One-carbon transferases [+] 2 One-carbon transferases +
Interacting Protein Name Histone-lysine N-methyltransferase 2D (KMT2D) Interacting Protein Interacting Protein Info
UniProt ID
KMT2D_HUMAN 
Synonyms AAD10; ALR; CAGL114; KABUK1; KMS; MLL2; MLL4; TNRC21
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [59]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
4 Co-localization [96]
Interacting Target Name Histone-lysine N-methyltransferase SETD7 (SETD7) Literature-reported Target Interacting Protein Info
UniProt ID
SETD7_HUMAN 
Synonyms SET9; SET7/9; SET7; SET domain-containing protein 7; Lysine N-methyltransferase 7; KMT7; KIAA1717; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [97]
2 Protein-peptide [97]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name S-nitrosoglutathione reductase (CBR1) Clinical trial Target Interacting Protein Info
UniProt ID
CBR1_HUMAN 
Synonyms ProstaglandinE(2) 9reductase; Prostaglandin 9ketoreductase; NADPHdependent carbonyl reductase 1; CBR1; Carbonyl reductase [NADPH] 1; 15hydroxyprostaglandin dehydrogenase [NADP(+)]
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [75]
2 Affinity Capture-MS [5]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [98]
2 Reconstituted Complex [99]
Ribosomal proteins [+] 8 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein eL18 (RPL18) Interacting Protein Interacting Protein Info
UniProt ID
RL18_HUMAN 
Synonyms L18
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Large ribosomal subunit protein uL30 (RPL7) Interacting Protein Interacting Protein Info
UniProt ID
RL7_HUMAN 
Synonyms L7; humL7.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Large ribosomal subunit protein eL8 (RPL7A) Interacting Protein Interacting Protein Info
UniProt ID
RL7A_HUMAN 
Synonyms L7A; SURF3; TRUP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Large ribosomal subunit protein uL6 (RPL9) Interacting Protein Interacting Protein Info
UniProt ID
RL9_HUMAN 
Synonyms L9; NPC.A.16
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Large ribosomal subunit protein uL10 (RPLP0) Interacting Protein Interacting Protein Info
UniProt ID
RLA0_HUMAN 
Synonyms L10E; LP0; P0; PRLP0; RPP0
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Single copy abundant protein (RPS4X) Interacting Protein Interacting Protein Info
UniProt ID
RS4X_HUMAN 
Synonyms CCG2; DXS306; RPS4; S4; SCAR; SCR10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Small ribosomal subunit protein eS8 (RPS8) Interacting Protein Interacting Protein Info
UniProt ID
RS8_HUMAN 
Synonyms S8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Small ribosomal subunit protein uS4 (RPS9) Interacting Protein Interacting Protein Info
UniProt ID
RS9_HUMAN 
Synonyms S9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Transcription regulators [+] 13 Transcription regulators +
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [100]
3 Affinity Capture-Western [37]
4 Affinity Capture-Western [5]
5 Affinity Capture-Western [8]
6 Co-crystal Structure [101]
7 Fluorescence Resonance Energy Transfer [10]
8 Protein-peptide [11]
9 Reconstituted Complex [102]
10 Reconstituted Complex [13]
11 Reconstituted Complex [6]
12 Reconstituted Complex [103]
13 Reconstituted Complex [4]
14 Reconstituted Complex [104]
15 Yeast two hybrid [105]
16 Yeast two hybrid [13]
17 Yeast two hybrid [17]
18 Yeast two hybrid [82]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Affinity Capture-Western [36]
3 Affinity Capture-Western [77]
4 Reconstituted Complex [34]
5 Reconstituted Complex [15]
6 Yeast two hybrid [106]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [36]
2 Affinity Capture-Western [63]
3 Affinity Capture-Western [107]
4 Affinity Capture-Western [108]
5 Co-localization [109]
6 Reconstituted Complex [110]
Interacting Target Name Aryl hydrocarbon receptor (AHR) Successful Target Interacting Protein Info
UniProt ID
AHR_HUMAN 
Synonyms Class E basic helix-loop-helix protein 76; Class E basic helixloophelix protein 76; bHLHe76; AhR; Ah receptor
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [111]
2 Biochemical Activity [111]
3 Co-purification [111]
4 Reconstituted Complex [104]
5 Reconstituted Complex [110]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [77]
2 Affinity Capture-Western [55]
3 Co-localization [64]
4 Reconstituted Complex [3]
5 Yeast two hybrid [3]
Interacting Target Name Forkhead box protein O1A (FOXO1) Literature-reported Target Interacting Protein Info
UniProt ID
FOXO1_HUMAN 
Synonyms FOXO1A; Forkhead in rhabdomyosarcoma; Forkhead box protein O1A; Forkhead box protein O1; FKHR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [112]
2 Reconstituted Complex [113]
3 Reconstituted Complex [33]
4 Yeast two hybrid [113]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [114]
2 Affinity Capture-Western [29]
3 Affinity Capture-Western [115]
4 Reconstituted Complex [115]
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Reconstituted Complex [116]
3 Reconstituted Complex [3]
4 Yeast two hybrid [3]
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [117]
3 Affinity Capture-Western [118]
Interacting Target Name CCAAT/enhancer binding protein beta (CEBPB) Literature-reported Target Interacting Protein Info
UniProt ID
CEBPB_HUMAN 
Synonyms Transcription factor CCAAT/enhancer-binding protein beta; Transcription factor 5; TCF-5; TCF5; PP9092; Nuclear factor NF-IL6; Liver-enriched inhibitory protein; Liver activator protein; LIP; LAP; CCAAT/enhancer-binding protein beta; C/EBP beta
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [107]
2 Co-localization [109]
3 Reconstituted Complex [119]
Interacting Target Name Transcription factor AP-1 (JUN) Discontinued Target Interacting Protein Info
UniProt ID
JUN_HUMAN 
Synonyms V-jun avian sarcoma virus 17 oncogene homolog; Transcription factor AP-1; Proto-oncogene c-jun; P39; C-jun proto-oncogene; AP-1 transcription factor; AP1; Activator protein-1; Activator protein 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [120]
2 Reconstituted Complex [121]
Interacting Target Name Metastasis associated gene-1 (MTA1) Literature-reported Target Interacting Protein Info
UniProt ID
MTA1_HUMAN 
Synonyms Metastasis-associated protein MTA1; Metastasisassociated protein MTA1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [122]
2 Reconstituted Complex [122]
Interacting Protein Name Myb-binding protein 1A (MYBBP1A) Interacting Protein Interacting Protein Info
UniProt ID
MBB1A_HUMAN 
Synonyms P160; PAP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [123]
2 Affinity Capture-Western [124]
3 Reconstituted Complex [123]
4 Reconstituted Complex [99]
5 Reconstituted Complex [125]
6 Yeast two hybrid [125]
Other proteins [+] 21 Other proteins +
Interacting Target Name Nucleophosmin (NPM1) Clinical trial Target Interacting Protein Info
UniProt ID
NPM_HUMAN 
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
4 Reconstituted Complex [4]
Interacting Protein Name Nuclear receptor-interacting protein 1 (NRIP1) Interacting Protein Interacting Protein Info
UniProt ID
NRIP1_HUMAN 
Synonyms RIP140
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Reconstituted Complex [126]
3 Reconstituted Complex [127]
4 Reconstituted Complex [128]
Interacting Protein Name Prohibitin-2 (PHB2) Interacting Protein Interacting Protein Info
UniProt ID
PHB2_HUMAN 
Synonyms BAP; BCAP37; Bap37; PNAS.141; REA; p22
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [62]
2 Affinity Capture-Western [129]
3 Co-localization [64]
4 Yeast two hybrid [130]
Interacting Target Name Gelsolin (GSN) Literature-reported Target Interacting Protein Info
UniProt ID
GELS_HUMAN 
Synonyms GSN; Brevin; AGEL; Actindepolymerizing factor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [124]
2 Reconstituted Complex [131]
3 Reconstituted Complex [132]
Interacting Protein Name Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) Interacting Protein Interacting Protein Info
UniProt ID
ASH2L_HUMAN 
Synonyms ASH2; ASH2L1; ASH2L2; Bre2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [59]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
Interacting Protein Name BAG family molecular chaperone regulator 1 (BAG1) Interacting Protein Interacting Protein Info
UniProt ID
BAG1_HUMAN 
Synonyms BAG.1; HAP; RAP46
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Affinity Capture-Western [49]
3 Reconstituted Complex [133]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) Interacting Protein Interacting Protein Info
UniProt ID
HNRPQ_HUMAN 
Synonyms GRY.RBP; GRYRBP; HNRNPQ; HNRPQ1; NSAP1; PP68; hnRNP.Q
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [5]
3 Reconstituted Complex [4]
Interacting Protein Name Nuclear receptor coactivator 6 (NCOA6) Interacting Protein Interacting Protein Info
UniProt ID
NCOA6_HUMAN 
Synonyms AIB3; ASC2; NRC; PRIP; RAP250; TRBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [76]
3 Reconstituted Complex [134]
Interacting Protein Name Transcription factor HMX3 (PELP1) Interacting Protein Interacting Protein Info
UniProt ID
PELP1_HUMAN 
Synonyms MNAR; P160
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [135]
3 Protein-peptide [136]
Interacting Protein Name Retinoblastoma-binding protein 5 (RBBP5) Interacting Protein Interacting Protein Info
UniProt ID
RBBP5_HUMAN 
Synonyms RBQ3; SWD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [59]
2 Affinity Capture-Western [59]
3 Affinity Capture-Western [60]
Interacting Protein Name Translocating chain-associated membrane protein 1 (TRAM1) Interacting Protein Interacting Protein Info
UniProt ID
TRAM1_HUMAN 
Synonyms PNAS8; TRAM; TRAMP
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [13]
2 Yeast two hybrid [105]
3 Yeast two hybrid [13]
Interacting Protein Name Tuberin (TSC2) Interacting Protein Interacting Protein Info
UniProt ID
TSC2_HUMAN 
Synonyms LAM; PPP1R160; TSC4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [137]
2 Reconstituted Complex [137]
3 Reconstituted Complex [138]
Interacting Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target Interacting Protein Info
UniProt ID
PARP1_HUMAN 
Synonyms Protein poly-ADP-ribosyltransferase PARP1; PPOL; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-Western [76]
Interacting Target Name Nucleolin (NCL) Clinical trial Target Interacting Protein Info
UniProt ID
NUCL_HUMAN 
Synonyms Protein C23; Nucleolin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Drebrin (DBN1) Interacting Protein Interacting Protein Info
UniProt ID
DREB_HUMAN 
Synonyms D0S117E
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Myosin light polypeptide 6 (MYL6) Interacting Protein Interacting Protein Info
UniProt ID
MYL6_HUMAN 
Synonyms ESMLC; LC17; LC17.GI; LC17.NM; LC17A; LC17B; MLC.3; MLC1SM; MLC3NM; MLC3SM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) Interacting Protein Interacting Protein Info
UniProt ID
ROA1_HUMAN 
Synonyms Single-strand RNA-binding protein; HNRPA1; hnRNP core protein A1; hnRNP A1; Heterogeneous nuclear ribonucleoprotein A1; Helix-destabilizing protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) Interacting Protein Interacting Protein Info
UniProt ID
ROA2_HUMAN 
Synonyms HNRPA2B1; hnRNP A2/B1; Heterogeneous nuclear ribonucleoproteins A2/B1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Reconstituted Complex [4]
Interacting Protein Name T-complex protein 1 subunit beta (CCT2) Interacting Protein Interacting Protein Info
UniProt ID
TCPB_HUMAN 
Synonyms 99D8.1; CCT.beta; CCTB; HEL.S.100n; PRO1633; TCP.1.beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Reconstituted Complex [4]
Interacting Protein Name THO complex subunit 4 (ALYREF) Interacting Protein Interacting Protein Info
UniProt ID
THOC4_HUMAN 
Synonyms ALY; ALY/REF; BEF; REF; THOC4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Reconstituted Complex [4]
References  Top
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