Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | PAK-1 protein kinase (PAK1) | Literature-reported | Target Info | ||
UniProt ID | PAK1_HUMAN | ||||
Gene Name | PAK1 | ||||
Gene ID | 5058 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Estrogen receptor (ESR) | Target Info | PPI Info | [2] | ||
Interacting Clinical trial Target(s) | NCK adaptor protein 1 (NCK1) | Target Info | PPI Info | [3] | |
Interacting Literature-reported Target(s) | Ras-related C3 botulinum toxin substrate 1 (RAC1) | Target Info | PPI Info | [4] | |
PAK-1 protein kinase (PAK1) | Target Info | PPI Info | [5] |
References | Top | ||||
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REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 2 | P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res. 2006 Feb 1;66(3):1694-701. | ||||
REF 3 | A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J. 2001 Feb 1;20(3):457-65. | ||||
REF 4 | Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J Biol Chem. 1998 Apr 10;273(15):8776-82. | ||||
REF 5 | Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell. 2002 Jan;9(1):73-83. |
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