Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T88752 Target Info
Target Name Ras-related C3 botulinum toxin substrate 1 (RAC1)
Synonyms Cell migration-inducing gene5 protein
Target Type Literature-reported Target
Gene Name RAC1
Biochemical Class Small GTPase
UniProt ID
RAC1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 4 Acyltransferases +
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [2]
4 Reconstituted Complex [3]
Interacting Protein Name E3 ubiquitin-protein ligase HACE1 (HACE1) Interacting Protein Interacting Protein Info
UniProt ID
HACE1_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [5]
3 Affinity Capture-Western [6]
4 Co-purification [5]
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-Western [2]
Interacting Protein Name E3 ubiquitin-protein ligase SH3RF1 (SH3RF1) Interacting Protein Interacting Protein Info
UniProt ID
SH3R1_HUMAN 
Synonyms POSH; RNF142; SH3MD2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Yeast two hybrid [8]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Synaptojanin-2 (SYNJ2) Interacting Protein Interacting Protein Info
UniProt ID
SYNJ2_HUMAN 
Synonyms INPP5H
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Yeast two hybrid [9]
3 Yeast two hybrid [8]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Melatonin receptor type 1A (MTNR1A) Successful Target Interacting Protein Info
UniProt ID
MTR1A_HUMAN 
Synonyms Mel-1A-R; Mel1AR; Mel1a receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Reconstituted Complex [11]
Kinases [+] 2 Kinases +
Interacting Target Name PAK-1 protein kinase (PAK1) Literature-reported Target Interacting Protein Info
UniProt ID
PAK1_HUMAN 
Synonyms Serine/threonine-protein kinase PAK 1; PAK-1; p65-PAK; p21-activated kinase 1; Alpha-PAK
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [13]
3 Yeast two hybrid [8]
Interacting Target Name PAK-2 protein kinase (PAK2) Literature-reported Target Interacting Protein Info
UniProt ID
PAK2_HUMAN 
Synonyms Serine/threonine-protein kinase PAK 2; S6/H4 kinase; PAK65; PAK-2; p21-activated kinase 2; Gamma-PAK
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [13]
2 Yeast two hybrid [8]
Other proteins [+] 10 Other proteins +
Interacting Protein Name Rho GDP-dissociation inhibitor 1 (ARHGDIA) Interacting Protein Interacting Protein Info
UniProt ID
GDIR1_HUMAN 
Synonyms GDIA1; HEL.S.47e; NPHS8; RHOGDI; RHOGDI.1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-MS [15]
3 Affinity Capture-Western [16]
4 Co-crystal Structure [17]
5 Co-purification [18]
6 Reconstituted Complex [17]
7 Yeast two hybrid [18]
8 Yeast two hybrid [19]
Interacting Protein Name Ras GTPase-activating-like protein IQGAP1 (IQGAP1) Interacting Protein Interacting Protein Info
UniProt ID
IQGA1_HUMAN 
Synonyms HUMORFA01; SAR1; p195
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-MS [15]
3 Affinity Capture-Western [20]
4 Reconstituted Complex [21]
5 Reconstituted Complex [13]
Interacting Target Name Beta-chimaerin (CHN2) Literature-reported Target Interacting Protein Info
UniProt ID
CHIO_HUMAN 
Synonyms Rho-GTPase-activating protein 3; CHN2; Beta-chimerin; Beta2-chimaerin
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Fluorescence Resonance Energy Transfer [22]
3 Reconstituted Complex [22]
4 Reconstituted Complex [23]
Interacting Protein Name Arfaptin-2 (ARFIP2) Interacting Protein Interacting Protein Info
UniProt ID
ARFP2_HUMAN 
Synonyms POR1
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [24]
2 Yeast two hybrid [25]
3 Yeast two hybrid [24]
Interacting Protein Name Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1) Interacting Protein Interacting Protein Info
UniProt ID
GDS1_HUMAN 
Synonyms GDS1; SmgGDS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Yeast two hybrid [27]
3 Yeast two hybrid [8]
Interacting Protein Name Ras GTPase-activating-like protein IQGAP2 (IQGAP2) Interacting Protein Interacting Protein Info
UniProt ID
IQGA2_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-MS [15]
3 Reconstituted Complex [28]
Interacting Target Name T-lymphoma invasion and metastasis 1 (TIAM1) Literature-reported Target Interacting Protein Info
UniProt ID
TIAM1_HUMAN 
Synonyms T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-crystal Structure [29]
2 Reconstituted Complex [30]
Interacting Protein Name Rho guanine nucleotide exchange factor 6 (ARHGEF6) Interacting Protein Interacting Protein Info
UniProt ID
ARHG6_HUMAN 
Synonyms COOL2; Cool.2; MRX46; PIXA; alpha.PIX; alphaPIX
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [31]
Interacting Protein Name Rho guanine nucleotide exchange factor 7 (ARHGEF7) Interacting Protein Interacting Protein Info
UniProt ID
ARHG7_HUMAN 
Synonyms BETA.PIX; COOL.1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [31]
Interacting Protein Name Ras GTPase-activating-like protein IQGAP3 (IQGAP3) Interacting Protein Interacting Protein Info
UniProt ID
IQGA3_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-MS [15]
References  Top
REF 1 AMPylation of Rho GTPases subverts multiple host signaling processes. J Biol Chem. 2014 Nov 21;289(47):32977-88.
REF 2 IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012 Jan 4;31(1):14-28.
REF 3 cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation. Oncogene. 2014 Nov 27;33(48):5534-45.
REF 4 The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1. Dev Cell. 2011 Nov 15;21(5):959-65.
REF 5 The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation. Oncogene. 2013 Mar 28;32(13):1735-42.
REF 6 Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation. Sci Rep. 2017 Mar 20;7:44779.
REF 7 Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. J Biol Chem. 2012 Jan 13;287(3):2247-56.
REF 8 A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
REF 9 Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis. Curr Biol. 2000 Nov 2;10(21):1383-6.
REF 10 Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol Cell Proteomics. 2007 May;6(5):835-44.
REF 11 Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. J Pineal Res. 2016 Jan;60(1):95-108.
REF 12 Integrin 7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion. Blood. 2011 Jun 9;117(23):6202-13.
REF 13 Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J Biol Chem. 1998 Apr 10;273(15):8776-82.
REF 14 The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2. Traffic. 2010 Feb;11(2):198-209.
REF 15 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.
REF 16 RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility. J Biol Chem. 2012 Apr 20;287(17):13752-60.
REF 17 Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation. Biochemistry. 2001 Aug 28;40(34):10007-13.
REF 18 Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex. Biochemistry. 2001 Aug 28;40(34):10014-22.
REF 19 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 20 IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 1996 Jun 17;15(12):2997-3005.
REF 21 Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem. 1996 Sep 20;271(38):23363-7.
REF 22 Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J. 2006 May 17;25(10):2062-74.
REF 23 Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor. J Biol Chem. 2001 May 25;276(21):18303-12.
REF 24 Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J. 1996 Aug 1;15(15):3778-86.
REF 25 Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1. Biochem Biophys Res Commun. 2001 Aug 3;285(5):1267-73.
REF 26 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 27 SmgGDS displays differential binding and exchange activity towards different Ras isoforms. Oncogene. 2002 Apr 4;21(15):2425-32.
REF 28 The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho famil... Mol Cell Biol. 1996 Sep;16(9):4869-78.
REF 29 Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature. 2000 Dec 7;408(6813):682-8.
REF 30 Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J Biol Chem. 2001 Dec 14;276(50):47530-41.
REF 31 Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. EMBO J. 2004 Sep 1;23(17):3492-504.

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