Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T03189 Target Info
Target Name Tumor expressed melanoma antigen (PRAME)
Synonyms Preferentially expressed antigen of melanoma; Opa-interacting protein 4; OIP-4; Melanoma antigen preferentially expressed in tumors; MAPE
Target Type Clinical trial Target
Gene Name PRAME
UniProt ID
PRAME_HUMAN 
Target Interacting Proteins  Top
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-2 (CUL2) Interacting Protein Interacting Protein Info
UniProt ID
CUL2_HUMAN 
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-Western [1]
6 Affinity Capture-Western [4]
7 Affinity Capture-Western [5]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Elongin-B (ELOB) Interacting Protein Interacting Protein Info
UniProt ID
ELOB_HUMAN 
Synonyms ELOB; SIII
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [1]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [5]
Interacting Protein Name Elongin-C (ELOC) Interacting Protein Interacting Protein Info
UniProt ID
ELOC_HUMAN 
Synonyms SIII; eloC
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [1]
5 Affinity Capture-Western [4]
6 Affinity Capture-Western [5]
References  Top
REF 1 The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters. EMBO J. 2011 Aug 5;30(18):3786-98.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 4 The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. PLoS One. 2012;7(8):e42822.
REF 5 PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs. PLoS One. 2013;8(2):e58052.

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