Protein-Protein Interaction Details
| Protein General Information | Top | ||||
|---|---|---|---|---|---|
| Full Name | Cullin-2 (CUL2) | ||||
| UniProt ID | CUL2_HUMAN | ||||
| Gene Name | CUL2 | ||||
| Gene ID | 8453 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Hypoxia-inducible factor 1 alpha (HIF-1A) | Target Info | PPI Info | [1] | |
| Tumor expressed melanoma antigen (PRAME) | Target Info | PPI Info | [6] | ||
| Interacting Patented-recorded Target(s) | von Hippel-Lindau disease tumor suppressor (VHL) | Target Info | PPI Info | [2] | |
| Interacting Literature-reported Target(s) | JUN activation domain binding protein (COPS5) | Target Info | PPI Info | [3] | |
| Protein-tyrosine phosphatase pez (PTPN14) | Target Info | PPI Info | [4] | ||
| RING-box protein 2 (RNF7) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL. EMBO Rep. 2008 May;9(5):486-91. | ||||
| REF 2 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 3 | Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403. | ||||
| REF 4 | PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71. | ||||
| REF 5 | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell. 2009 Feb 27;33(4):483-95. | ||||
| REF 6 | The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters. EMBO J. 2011 Aug 5;30(18):3786-98. | ||||
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