Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T82848 Target Info
Target Name Protein-tyrosine phosphatase pez (PTPN14)
Synonyms Tyrosine-protein phosphatase non-receptor type 14; PTPD2; PEZ
Target Type Literature-reported Target
Gene Name PTPN14
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PTN14_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name WW domain-containing protein 1 (WWP1) Interacting Protein Interacting Protein Info
UniProt ID
WWP1_HUMAN 
Synonyms WW domain-containing protein 1; Tiul1; TGIF-interacting ubiquitin ligase 1; NEDD4-like E3 ubiquitin-protein ligase WWP1; HECT-type E3 ubiquitin transferase WWP1; Atrophin-1-interacting protein 5; AIP5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
COP9 signalosomes [+] 1 COP9 signalosomes +
Interacting Protein Name COP9 signalosome complex subunit 4 (COPS4) Interacting Protein Interacting Protein Info
UniProt ID
CSN4_HUMAN 
Synonyms CSN4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-2 (CUL2) Interacting Protein Interacting Protein Info
UniProt ID
CUL2_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Kinases [+] 2 Kinases +
Interacting Target Name Polo-like kinase 1 (PLK1) Clinical trial Target Interacting Protein Info
UniProt ID
PLK1_HUMAN 
Synonyms STPK13; Serine-threonine protein kinase 13; Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; PLK-1; Plk1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Serine/threonine-protein kinase 3 (STK3) Interacting Protein Interacting Protein Info
UniProt ID
STK3_HUMAN 
Synonyms KRS1; MST2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Proteins 14-3-3 [+] 1 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Yes-associated protein 1 (YAP1) Literature-reported Target Interacting Protein Info
UniProt ID
YAP1_HUMAN 
Synonyms Yorkie homolog; Yes-associated protein YAP65 homolog; YAP65; Transcriptional coactivator YAP1; Protein yorkie homolog; 65 kDa Yes-associated protein
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [1]
5 Reconstituted Complex [1]
Interacting Target Name Proto-oncogene c-Myc (MYC) Literature-reported Target Interacting Protein Info
UniProt ID
MYC_HUMAN 
Synonyms Transcription factor p64; Proto-oncogene c-Myc; Myc proto-oncogene protein; C-myc oncogene; C-myc; Class E basic helix-loop-helix protein 39; bHLHe39
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [4]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Protein KIBRA (WWC1) Interacting Protein Interacting Protein Info
UniProt ID
KIBRA_HUMAN 
Synonyms HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [5]
Interacting Protein Name Leucine-rich repeat protein 1 (LRR1) Interacting Protein Interacting Protein Info
UniProt ID
LLR1_HUMAN 
Synonyms 4.1BBLRR; LRR.1; PPIL5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [1]
Interacting Target Name Angiomotin (AMOT) Literature-reported Target Interacting Protein Info
UniProt ID
AMOT_HUMAN 
Synonyms KIAA1071
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
Interacting Protein Name Protein WWC2 (WWC2) Interacting Protein Interacting Protein Info
UniProt ID
WWC2_HUMAN 
Synonyms BOMB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
References  Top
REF 1 PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1;26(17):1959-71.
REF 2 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle. 2007 Jan 15;6(2):205-17.
REF 5 PTPN14 forms a complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic function. J Biol Chem. 2014 Aug 22;289(34):23693-700.

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