Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T56308 Target Info
Target Name Interleukin-11 (IL11)
Synonyms Oprelvekin; IL-11; Adipogenesis inhibitory factor; AGIF
Target Type Clinical trial Target
Gene Name IL11
Biochemical Class Cytokine: interleukin
UniProt ID
P20809
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-204-5p miRNA Info
miRNA Mature AC
MIMAT0000265
Sequence uucccuuugucauccuaugccu
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 ELISA [1]
2 Luciferase Reporter Assay [2]
Representative Target(s) Regulated by This miRNA Alkaline phosphatase tissue-nonspecific (ALPL) Target Info
PPBT_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-211-5p miRNA Info
miRNA Mature AC
MIMAT0000268
Sequence uucccuuugucauccuucgccu
miRNA Species Homo sapiens
Regulation Mechanism miR-211 directly target IL11 by binding to its 3 UTR. [2]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [2]
2 Luciferase Reporter Assay; Microarray; qRT-PCR; Western Blot [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Calcium-activated potassium channel KCa1.1 (KCNMA1) Target Info
KCMA1_HUMAN
miRNA Mature ID hsa-miR-379-5p miRNA Info
miRNA Mature AC
MIMAT0000733
Sequence ugguagacuauggaacguagg
miRNA Species Homo sapiens
Regulation Mechanism miR-379 directly target IL11 by binding to its 3 UTR. [2]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [2]
Representative Target(s) Regulated by This miRNA Focal adhesion kinase 1 (FAK) Target Info
FAK1_HUMAN
Interleukin-11 (IL11) Target Info
IL11_HUMAN
References  Top
REF 1 Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 May 6;52(6):2999-3007.
REF 2 Identification of microRNAs inhibiting TGF--induced IL-11 production in bone metastatic breast cancer cells. PLoS One. 2012;7(5):e37361.
REF 3 New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion. PLoS One. 2013 Sep 5;8(9):e73473.

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