Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T47236 Target Info
Target Name Sterol regulatory element binding protein-1 (SREBF1)
Synonyms bHLHd1; Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding protein 1; SREBP1; SREBP-1; SREBP 1; Class D basic helix-loop-helix protein 1
Target Type Literature-reported Target
Gene Name SREBF1
UniProt ID
P36956
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-185-5p miRNA Info
miRNA Mature AC
MIMAT0000455
Sequence uggagagaaaggcaguuccuga
miRNA Species Homo sapiens
Regulation Mechanism SREBP-1 mRNAs is a direct target of miR-185. [1]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [1]
Representative Target(s) Regulated by This miRNA Androgen receptor (AR) Target Info
ANDR_HUMAN
Arachidonate 12-lipoxygenase (12-LOX) Target Info
LOX12_HUMAN
miRNA Mature ID hsa-miR-33a-5p miRNA Info
miRNA Mature AC
MIMAT0000091
Sequence gugcauuguaguugcauugca
miRNA Species Homo sapiens
Regulation Mechanism SREBF1 is a miR-33 target gene. [2]
Evidence Score (E-score) 1 +
1 qRT-PCR; Western Blot [2]
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter A1 (ABCA1) Target Info
ABCA1_HUMAN
ATP-binding cassette transporter B11 (ABCB11) Target Info
ABCBB_HUMAN
miRNA Mature ID hsa-miR-342-3p miRNA Info
miRNA Mature AC
MIMAT0000753
Sequence ucucacacagaaaucgcacccgu
miRNA Species Homo sapiens
Regulation Mechanism Luciferase activities of SREBP-1 was significantly decreased in miR-342 transfected prostate cancer cells which confirms that SREBP-1 mRNAs is the direct target of miR-342. [1]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [1]
Representative Target(s) Regulated by This miRNA DNA [cytosine-5]-methyltransferase 1 (DNMT1) Target Info
DNMT1_HUMAN
E2F transcription factor 1 (E2F1) Target Info
E2F1_HUMAN
References  Top
REF 1 MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. PLoS One. 2013 Aug 9;8(8):e70987.
REF 2 MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. Nat Commun. 2013;4:2883.

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