miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-342-3p | ||||
miRNA Stemloop AC | MI0000805 | ||||
miRNA Stemloop ID | hsa-mir-342 | ||||
Sequence | ucucacacagaaaucgcacccgu | ||||
TTD Target(s) Regulated by This miRNA | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | Target Info | [1] | |
E2F transcription factor 1 (E2F1) | Clinical trial Target | Target Info | [2] | ||
Metastasis adhesion protein (MTDH) | Literature-reported Target | Target Info | [3] | ||
Sterol regulatory element binding protein-1 (SREBF1) | Literature-reported Target | Target Info | [4] | ||
T-lymphoma invasion and metastasis 1 (TIAM1) | Literature-reported Target | Target Info | [5] | ||
Protein(s) Regulated by This miRNA | Ankyrin repeat domain-containing protein 49 | Regulated Protein | [6] | ||
Baculoviral IAP repeat-containing protein 6 | Regulated Protein | [7] | |||
Bone morphogenetic protein 7 | Regulated Protein | [8] | |||
C-terminal-binding protein 2 | Regulated Protein | [9] | |||
Calcium/calmodulin-dependent protein kinase II inhibitor 1 | Regulated Protein | [5] | |||
Cytoplasmic polyadenylation element-binding protein 4 | Regulated Protein | [5] | |||
DNA-binding protein inhibitor ID-4 | Regulated Protein | [11] | |||
E3 ubiquitin-protein transferase RMND5A | Regulated Protein | [5] | |||
Gem-associated protein 4 | Regulated Protein | [8] | |||
Glucose-induced degradation protein 8 homolog | Regulated Protein | [5] | |||
NF-kappa-B essential modulator | Regulated Protein | [12] | |||
Sterol regulatory element-binding protein 2 | Regulated Protein | [4] | |||
Synaptopodin 2-like protein | Regulated Protein | [5] | |||
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | Regulated Protein | [12] | |||
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | Regulated Protein | [12] | |||
References | |||||
REF 1 | MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. Carcinogenesis. 2011 Jul;32(7):1033-42. | ||||
REF 2 | miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer. Carcinogenesis. 2015 Dec;36(12):1464-73. | ||||
REF 3 | Long noncoding RNA FTX is upregulated in gliomas and promotes proliferation and invasion of glioma cells by negatively regulating miR-342-3p. Lab Invest. 2017 Apr;97(4):447-457. | ||||
REF 4 | MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. PLoS One. 2013 Aug 9;8(8):e70987. | ||||
REF 5 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 6 | MicroRNA profiling in chemoresistant and chemosensitive acute myeloid leukemia.Cytogenet Genome Res. 2013;141(4):272-6. | ||||
REF 7 | miR-342 overexpression results in a synthetic lethal phenotype in BRCA1-mutant HCC1937 breast cancer cells.Oncotarget. 2016 Apr 5;7(14):18594-604. | ||||
REF 8 | Downregulation of miR-342 is associated with tamoxifen resistant breast tumors.Mol Cancer. 2010 Dec 20;9:317. | ||||
REF 9 | Obesity-Associated MiR-342-3p Promotes Adipogenesis of Mesenchymal Stem Cells by Suppressing CtBP2 and Releasing C/EBP from CtBP2 Binding.Cell Physiol Biochem. 2015;35(6):2285-98. | ||||
REF 10 | MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676. | ||||
REF 11 | miR-342 regulates BRCA1 expression through modulation of ID4 in breast cancer.PLoS One. 2014 Jan 27;9(1):e87039. | ||||
REF 12 | miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-B pathway.Biochem Biophys Res Commun. 2015 Feb 13;457(3):370-7. | ||||
REF 13 | MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. PLoS One. 2013 Aug 9;8(8):e70987. |
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