Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T44861 Target Info
Target Name Protein kinase C delta (PRKCD)
Synonyms nPKC-delta; Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; PKC-delta
Target Type Clinical trial Target
Gene Name PRKCD
Biochemical Class Kinase
UniProt ID
Q05655
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-181c-5p miRNA Info
miRNA Mature AC
MIMAT0000258
Sequence aacauucaaccugucggugagu
miRNA Species Homo sapiens
Regulation Mechanism miR-181c regulated the expression of PRKCD by combining with its 3' UTR. [2]
Evidence Score (E-score) 2 +
1 Dual Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay [2]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Bone morphogenetic protein receptor (BMPR2) Target Info
BMPR2_HUMAN
miRNA Mature ID hsa-miR-26a-1-3p miRNA Info
miRNA Mature AC
MIMAT0004499
Sequence ccuauucuugguuacuugcacg
miRNA Species Homo sapiens
Regulation Mechanism miR-26a directly targets PRKCD crucial for insulin signaling and metabolism of lipid and glucose. [3]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Caspase-3 (CASP3) Target Info
CASP3_HUMAN
References  Top
REF 1 MiR-181 family: regulators of myeloid differentiation and acute myeloid leukemia as well as potential therapeutic targets.Oncogene. 2015 Jun;34(25):3226-39.
REF 2 MiR181c inhibits ovarian cancer metastasis and progression by targeting PRKCD expression. Int J Clin Exp Med. 2015 Sep 15;8(9):15198-205.
REF 3 MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. J Clin Invest. 2015 Jun;125(6):2497-509.

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