Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57307 | Target Info | |||
| Target Name | STE20-related serine/threonine-protein kinase (SLK) | ||||
| Synonyms | hSLK; STE20-related kinase; STE20-like kinase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLK | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Tivozanib | Ligand Info | |||||
| Structure Description | STE20-like serine/threonine-protein kinase (SLK) in complex with Tivozanib | PDB:8BEM | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
SMKQYEHVKR
26 DLNPEDFWEI36 IGELGDGGKV48 YKAQNKETSV58 LAAAKVIDTK68 SEEELEDYMV 78 EIDILASCDH88 PNIVKLLDAF98 YYENNLWILI108 EFCAGGAVDA118 VMLELERPLT 128 ESQIQVVCKQ138 TLDALNYLHD148 NKIIHRDLKA158 GNILFTLDGD168 IKLADFGSFI 191 GTPYWMAPEV201 VMCETPYDYK215 ADVWSLGITL225 IEMAEIEPPH235 HELNPMRVLL 245 KIAKSEPPTL255 AQPSRWSSNF265 KDFLKKCLEK275 NVDARWTTSQ285 LLQHPFVTVD 295 SNKPIRELIA305 EAKA
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LEU40
3.725
GLY41
4.305
VAL48
3.639
ALA61
3.113
ALA62
4.700
LYS63
3.734
TYR76
3.900
GLU79
3.361
ILE80
3.347
LEU83
4.108
VAL92
3.995
ILE106
3.983
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| Ligand Name: Cdk1/2 inhibitor III | Ligand Info | |||||
| Structure Description | Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide | PDB:2J51 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [2] |
| PDB Sequence |
YEHVTRDLNP
30 EDFWEIIGEL40 GDGAFGKVYK50 AQNKETSVLA60 AAKVIDTKSE70 EELEDYMVEI 80 DILASCDHPN90 IVKLLDAFYY100 ENNLWILIEF110 CAGGAVDAVM120 LELERPLTES 130 QIQVVCKQTL140 DALNYLHDNK150 IIHRDLKAGN160 ILFTLDGDIK170 LADFGVSAKN 180 TRTIQRRDSF190 IGTPYWMAPE200 VVMCETSKDR210 PYDYKADVWS220 LGITLIEMAE 230 IEPPHHELNP240 MRVLLKIAKS250 EPPTLAQPSR260 WSSNFKDFLK270 KCLEKNVDAR 280 WTTSQLLQHP290 FVTVDSNKPI300 RELIAEAK
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: L-serine-O-phosphate | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | PDB:2JFL | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [2] |
| PDB Sequence |
YEHVTRDLNP
30 EDFWEIIGEL40 GDGAFGKVYK50 AQNKETSVLA60 AAKVIDTKSE70 EELEDYMVEI 80 DILASCDHPN90 IVKLLDAFYY100 ENNLWILIEF110 CAGGAVDAVM120 LELERPLTES 130 QIQVVCKQTL140 DALNYLHDNK150 IIHRDLKAGN160 ILFTLDGDIK170 LADFGVSAKN 180 TRIQRRDFIG192 TPYWMAPEVV202 MCETSKDRPY212 DYKADVWSLG222 ITLIEMAEIE 232 PPHHELNPMR242 VLLKIAKSEP252 PTLAQPSRWS262 SNFKDFLKKC272 LEKNVDARWT 282 TSQLLQHPFV292 TVDSNKPIRE302 LIAEAK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SEP or .SEP2 or .SEP3 or :3SEP;style chemicals stick;color identity;select .A:185 or .A:186 or .A:187 or .A:188 or .A:190 or .A:191; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Phosphonothreonine | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | PDB:2JFL | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [2] |
| PDB Sequence |
YEHVTRDLNP
30 EDFWEIIGEL40 GDGAFGKVYK50 AQNKETSVLA60 AAKVIDTKSE70 EELEDYMVEI 80 DILASCDHPN90 IVKLLDAFYY100 ENNLWILIEF110 CAGGAVDAVM120 LELERPLTES 130 QIQVVCKQTL140 DALNYLHDNK150 IIHRDLKAGN160 ILFTLDGDIK170 LADFGVSAKN 180 TRIQRRDFIG192 TPYWMAPEVV202 MCETSKDRPY212 DYKADVWSLG222 ITLIEMAEIE 232 PPHHELNPMR242 VLLKIAKSEP252 PTLAQPSRWS262 SNFKDFLKKC272 LEKNVDARWT 282 TSQLLQHPFV292 TVDSNKPIRE302 LIAEAK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TPO or .TPO2 or .TPO3 or :3TPO;style chemicals stick;color identity;select .A:179 or .A:180 or .A:181 or .A:182 or .A:184 or .A:185 or .A:186 or .A:187 or .A:188 or .A:208; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [4-({4-[(5-Cyclopropyl-1h-Pyrazol-3-Yl)amino]quinazolin-2-Yl}imino)cyclohexa-2,5-Dien-1-Yl]acetonitrile | Ligand Info | |||||
| Structure Description | Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5- Cyclopropyl-1H-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile | PDB:2UV2 | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [2] |
| PDB Sequence |
YEHVTRDLNP
30 EDFWEIIGEL40 GDFGKVYKAQ52 NKETSVLAAA62 KVIDTKSEEE72 LEDYMVEIDI 82 LASCDHPNIV92 KLLDAFYYEN102 NLWILIEFCA112 GGAVDAVMLE122 LERPLTESQI 132 QVVCKQTLDA142 LNYLHDNKII152 HRDLKAGNIL162 FTLDGDIKLA172 DFGVSAKNTR 182 TIQRRDSFIG192 TPYWMAPEVV202 MCETSKDRPY212 DYKADVWSLG222 ITLIEMAEIE 232 PPHHELNPMR242 VLLKIAKSEP252 PTLAQPSRWS262 SNFKDFLKKC272 LEKNVDARWT 282 TSQLLQHPFV292 TVDSNKPIRE302 LIAEAK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GVD or .GVD2 or .GVD3 or :3GVD;style chemicals stick;color identity;select .A:40 or .A:41 or .A:48 or .A:61 or .A:63 or .A:108 or .A:109 or .A:110 or .A:111 or .A:112 or .A:113 or .A:114 or .A:115 or .A:159 or .A:160 or .A:162 or .A:172 or .A:173; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-(1,3-Benzothiazol-2-ylamino)-4-(2-methoxyphenyl)pyrrole-2,5-dione | Ligand Info | |||||
| Structure Description | Human SLK bound to a maleimide inhibitor | PDB:6HVD | ||||
| Method | X-ray diffraction | Resolution | 1.63 Å | Mutation | No | [3] |
| PDB Sequence |
MKQYEHVTRD
27 LNPEDFWEII37 GELGDGAFGK47 VYKAQNKETS57 VLAAAKVIDT67 KSEEELEDYM 77 VEIDILASCD87 HPNIVKLLDA97 FYYENNLWIL107 IEFCAGGAVD117 AVMLELERPL 127 TESQIQVVCK137 QTLDALNYLH147 DNKIIHRDLK157 AGNILFTLDG167 DIKLADFGVS 177 AKNTRSFIGT193 PYWMAPEVVM203 CETSKDRPYD213 YKADVWSLGI223 TLIEMAEIEP 233 PHHELNPMRV243 LLKIAKSEPP253 TLAQPSRWSS263 NFKDFLKKCL273 EKNVDARWTT 283 SQLLQHPFVT293 VDSNKPIREL303 IAEAKA
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GUQ or .GUQ2 or .GUQ3 or :3GUQ;style chemicals stick;color identity;select .A:40 or .A:41 or .A:42 or .A:43 or .A:48 or .A:61 or .A:63 or .A:92 or .A:108 or .A:109 or .A:110 or .A:111 or .A:114 or .A:115 or .A:159 or .A:160 or .A:161 or .A:162 or .A:172 or .A:173; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine | Ligand Info | |||||
| Structure Description | Human SLK with SB-440719 | PDB:4USF | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [4] |
| PDB Sequence |
SMKQYEHVTR
26 DLNPEDFWEI36 IGELGDGAFG46 KVYKAQNKET56 SVLAAAKVID66 TKSEEELEDY 76 MVEIDILASC86 DHPNIVKLLD96 AFYYENNLWI106 LIEFCAGGAV116 DAVMLELERP 126 LTESQIQVVC136 KQTLDALNYL146 HDNKIIHRDL156 KAGNILFTLD166 GDIKLADFGV 176 SAKTPYWMAP199 EVVMCERPYD213 YKADVWSLGI223 TLIEMAEIEP233 PHHELNPMRV 243 LLKIAKSEPP253 TLAQPSRWSS263 NFKDFLKKCL273 EKNVDARWTT283 SQLLQHPFVT 293 VDSNKPIREL303 IAEAKAE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6UI or .6UI2 or .6UI3 or :36UI;style chemicals stick;color identity;select .A:40 or .A:45 or .A:48 or .A:61 or .A:62 or .A:63 or .A:83 or .A:106 or .A:107 or .A:108 or .A:109 or .A:110 or .A:111 or .A:112 or .A:114 or .A:115 or .A:159 or .A:160 or .A:162 or .A:172 or .A:173 or .A:174 or .A:175; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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LEU40
3.899
PHE45
3.195
VAL48
3.924
ALA61
3.334
ALA62
4.345
LYS63
3.502
LEU83
3.881
ILE106
3.409
LEU107
4.979
ILE108
3.582
GLU109
3.842
PHE110
3.682
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | STE20-like serine/threonine-protein kinase (SLK) in complex with Tivozanib | ||||
| REF 2 | Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 2008 Feb 20;27(4):704-14. | ||||
| REF 3 | Human SLK bound to a maleimide inhibitor | ||||
| REF 4 | Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103. | ||||
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