Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57307 | Target Info | |||
| Target Name | STE20-related serine/threonine-protein kinase (SLK) | ||||
| Synonyms | hSLK; STE20-related kinase; STE20-like kinase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLK | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cdk1/2 inhibitor III | Ligand Info | |||
| Canonical SMILES | C1=CC(=C(C(=C1)F)NC(=S)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F | ||||
| InChI | 1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23) | ||||
| InChIKey | ARIOBGGRZJITQX-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 5330812 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2J51 Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
YEHVTRDLNP
30 EDFWEIIGEL40 GDGAFGKVYK50 AQNKETSVLA60 AAKVIDTKSE70 EELEDYMVEI 80 DILASCDHPN90 IVKLLDAFYY100 ENNLWILIEF110 CAGGAVDAVM120 LELERPLTES 130 QIQVVCKQTL140 DALNYLHDNK150 IIHRDLKAGN160 ILFTLDGDIK170 LADFGVSAKN 180 TRTIQRRDSF190 IGTPYWMAPE200 VVMCETSKDR210 PYDYKADVWS220 LGITLIEMAE 230 IEPPHHELNP240 MRVLLKIAKS250 EPPTLAQPSR260 WSSNFKDFLK270 KCLEKNVDAR 280 WTTSQLLQHP290 FVTVDSNKPI300 RELIAEAK
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| PDB ID: 2JFL CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
YEHVTRDLNP
30 EDFWEIIGEL40 GDGAFGKVYK50 AQNKETSVLA60 AAKVIDTKSE70 EELEDYMVEI 80 DILASCDHPN90 IVKLLDAFYY100 ENNLWILIEF110 CAGGAVDAVM120 LELERPLTES 130 QIQVVCKQTL140 DALNYLHDNK150 IIHRDLKAGN160 ILFTLDGDIK170 LADFGVSAKN 180 TRIQRRDFIG192 TPYWMAPEVV202 MCETSKDRPY212 DYKADVWSLG222 ITLIEMAEIE 232 PPHHELNPMR242 VLLKIAKSEP252 PTLAQPSRWS262 SNFKDFLKKC272 LEKNVDARWT 282 TSQLLQHPFV292 TVDSNKPIRE302 LIAEAK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 2008 Feb 20;27(4):704-14. | ||||
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