Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57307 | Target Info | |||
| Target Name | STE20-related serine/threonine-protein kinase (SLK) | ||||
| Synonyms | hSLK; STE20-related kinase; STE20-like kinase | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLK | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Phosphonothreonine | Ligand Info | |||
| Canonical SMILES | CC(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C4H10NO6P/c1-2(3(5)4(6)7)11-12(8,9)10/h2-3H,5H2,1H3,(H,6,7)(H2,8,9,10)/t2-,3+/m1/s1 | ||||
| InChIKey | USRGIUJOYOXOQJ-GBXIJSLDSA-N | ||||
| PubChem Compound ID | 3246323 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 2JFL CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
YEHVTRDLNP
30 EDFWEIIGEL40 GDGAFGKVYK50 AQNKETSVLA60 AAKVIDTKSE70 EELEDYMVEI 80 DILASCDHPN90 IVKLLDAFYY100 ENNLWILIEF110 CAGGAVDAVM120 LELERPLTES 130 QIQVVCKQTL140 DALNYLHDNK150 IIHRDLKAGN160 ILFTLDGDIK170 LADFGVSAKN 180 TRIQRRDFIG192 TPYWMAPEVV202 MCETSKDRPY212 DYKADVWSLG222 ITLIEMAEIE 232 PPHHELNPMR242 VLLKIAKSEP252 PTLAQPSRWS262 SNFKDFLKKC272 LEKNVDARWT 282 TSQLLQHPFV292 TVDSNKPIRE302 LIAEAK
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| PDB ID: 2UV2 Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5- Cyclopropyl-1H-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
YEHVTRDLNP
30 EDFWEIIGEL40 GDFGKVYKAQ52 NKETSVLAAA62 KVIDTKSEEE72 LEDYMVEIDI 82 LASCDHPNIV92 KLLDAFYYEN102 NLWILIEFCA112 GGAVDAVMLE122 LERPLTESQI 132 QVVCKQTLDA142 LNYLHDNKII152 HRDLKAGNIL162 FTLDGDIKLA172 DFGVSAKNTR 182 TIQRRDSFIG192 TPYWMAPEVV202 MCETSKDRPY212 DYKADVWSLG222 ITLIEMAEIE 232 PPHHELNPMR242 VLLKIAKSEP252 PTLAQPSRWS262 SNFKDFLKKC272 LEKNVDARWT 282 TSQLLQHPFV292 TVDSNKPIRE302 LIAEAK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 2008 Feb 20;27(4):704-14. | ||||
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