Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15745 | Target Info | |||
| Target Name | Bromodomain adjacent to zinc finger 2B (BAZ2B) | ||||
| Synonyms | hWALp4; KIAA1476; Bromodomain adjacent to zinc finger domain protein 2B | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | BAZ2B | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Acetaminophen | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B in complex with fragment-5 N09428 | PDB:4CUT | ||||
| Method | X-ray diffraction | Resolution | 1.83 Å | Mutation | No | [1] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Adenine | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with fragment F59 | PDB:5DYX | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [2] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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| Ligand Name: PMID25719566C1 | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with E11919 BAZ2-ICR analogue | PDB:4XUA | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [3] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .43C or .43C2 or .43C3 or :343C;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1890 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1897 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: GSK2801 | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex WITH GSK2801 | PDB:4RVR | ||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [4] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKVS
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3WQ or .3WQ2 or .3WQ3 or :33WQ;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1897 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: PMID25719566C7 | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with BAZ2-ICR chemical probe | PDB:4XUB | ||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [3] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .43D or .43D2 or .43D3 or :343D;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1890 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1897 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 5-Aminoindazole | Ligand Info | |||||
| Structure Description | PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09440a | PDB:5PB7 | ||||
| Method | X-ray diffraction | Resolution | 1.66 Å | Mutation | No | [5] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8H4 or .8H42 or .8H43 or :38H4;style chemicals stick;color identity;select .A:1893 or .A:1898 or .A:1901 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-Bromo-1H-imidazole | Ligand Info | |||||
| Structure Description | PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09724a | PDB:5PBC | ||||
| Method | X-ray diffraction | Resolution | 1.77 Å | Mutation | No | [5] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ES3 or .ES32 or .ES33 or :3ES3;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone | Ligand Info | |||||
| Structure Description | PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09645a | PDB:5PBF | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [5] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8HJ or .8HJ2 or .8HJ3 or :38HJ;style chemicals stick;color identity;select .A:1888 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4'-Hydroxyacetophenone | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 4'-Hydroxyacetophenone (SGC - Diamond I04-1 fragment screening) | PDB:5CQ8 | ||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | No | [6] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AC6 or .AC62 or .AC63 or :3AC6;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 6-Chloropurine | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 6-CHLOROPURINE (SGC - Diamond I04-1 fragment screening) | PDB:5CUD | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [7] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ES4 or .ES42 or .ES43 or :3ES4;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3'-Hydroxyacetophenone | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 3'-Hydroxyacetophenone (SGC - Diamond I04-1 fragment screening) | PDB:5CQ4 | ||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [8] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .53C or .53C2 or .53C3 or :353C;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 4-Acetamidobenzoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 4-Acetamidobenzoic acid (SGC - Diamond I04-1 fragment screening) | PDB:5CUG | ||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [9] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TYZ or .TYZ2 or .TYZ3 or :3TYZ;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 1-Acetyl-4-(4-hydroxyphenyl)piperazine | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 1-Acetyl-4-(4-hydroxyphenyl)piperazine (SGC - Diamond I04-1 fragment screening) | PDB:5CUA | ||||
| Method | X-ray diffraction | Resolution | 1.89 Å | Mutation | No | [10] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .54U or .54U2 or .54U3 or :354U;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 6-Hydroxypicolinic acid | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 6-Hydroxypicolinic acid (SGC - Diamond I04-1 fragment screening) | PDB:5CQ3 | ||||
| Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | No | [11] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .53B or .53B2 or .53B3 or :353B;style chemicals stick;color identity;select .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 2,3-Ethylenedioxybenzoic Acid (SGC - Diamond I04-1 fragment screening) | PDB:5CQ5 | ||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [12] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .53E or .53E2 or .53E3 or :353E;style chemicals stick;color identity;select .A:1926 or .A:1927 or .A:1930 or .A:1934 or .A:1944 or .A:1945 or .A:1946 or .A:1965 or .A:1966 or .A:1969; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,6-Pyridinedicarboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 2,6-Pyridinedicarboxylic acid (SGC - Diamond I04-1 fragment screening) | PDB:5CQ6 | ||||
| Method | X-ray diffraction | Resolution | 1.97 Å | Mutation | No | [13] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PDC or .PDC2 or .PDC3 or :3PDC;style chemicals stick;color identity;select .A:1895 or .A:1896 or .A:1902 or .A:1903; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-{1-[2-(Hydroxymethyl)phenyl]-7-Phenoxyindolizin-3-Yl}ethanone | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone (GSK2847449A) | PDB:4IR5 | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [4] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IR5 or .IR52 or .IR53 or :3IR5;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1892 or .A:1893 or .A:1894 or .A:1897 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-Hydroxyquinoline | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B in complex with fragment-4 N09496 | PDB:4CUS | ||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [14] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ES1 or .ES12 or .ES13 or :3ES1;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (2R)-1,2,3,4-tetrahydroquinoline-2,7-diol | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B in complex with fragment-6 N09645 | PDB:4CUU | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [15] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y6M or .Y6M2 or .Y6M3 or :3Y6M;style chemicals stick;color identity;select .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-{1-[2-(Methylsulfonyl)phenyl]-7-Phenoxyindolizin-3-Yl}ethanone | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with 1-{1-[2-(METHYLSULFONYL)PHENYL]-7-PHENOXYINDOLIZIN-3-YL}ETHANONE (GSK2838097A) | PDB:4IR6 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [4] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IR6 or .IR62 or .IR63 or :3IR6;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1897 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-(Hydroxymethyl)-6-methylpyridin-3-ol | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B in complex with fragment-3 N09555 | PDB:4CUR | ||||
| Method | X-ray diffraction | Resolution | 1.84 Å | Mutation | No | [16] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LA7 or .LA72 or .LA73 or :3LA7;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1939 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-(8-chloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)ethanone | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with compound-6 E11322 | PDB:4NRA | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [17] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .2LW or .2LW2 or .2LW3 or :32LW;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-methyl-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with compound-3 N01186 | PDB:4NRC | ||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | No | [17] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .2LY or .2LY2 or .2LY3 or :32LY;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 4-Fluorobenzamidoxime | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B in complex with fragment-1 N09421 | PDB:4CUP | ||||
| Method | X-ray diffraction | Resolution | 1.88 Å | Mutation | No | [18] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ZYB or .ZYB2 or .ZYB3 or :3ZYB;style chemicals stick;color identity;select .A:1893 or .A:1898 or .A:1901 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Methanol | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B in complex with fragment-1 N09421 | PDB:4CUP | ||||
| Method | X-ray diffraction | Resolution | 1.88 Å | Mutation | No | [18] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MOH or .MOH2 or .MOH3 or :3MOH;style chemicals stick;color identity;select .A:1870 or .A:1871 or .A:1874 or .A:1888 or .A:1893 or .A:1901 or .A:1918 or .A:1919 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N6-Acetyl-L-lysine | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with acetylated lysine | PDB:4NR9 | ||||
| Method | X-ray diffraction | Resolution | 1.98 Å | Mutation | No | [17] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ALY or .ALY2 or .ALY3 or :3ALY;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2~{s})-1-(4-Fluorophenyl)sulfonyl-~{n}-(2-Methyl-5,6-Dihydro-4~{h}-Cyclopenta[c]pyrazol-3-Yl)pyrrolidine-2-Carboxamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 1-methyl-cyclopentapyrazole compound 13 | PDB:5OR9 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [19] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JR5 or .JR52 or .JR53 or :3JR5;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-[7-Amino-1-(Pyrimidin-2-Yl)indolizin-3-Yl]ethanone | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with 1-[7-amino-1-(pyrimidin-2-yl)indolizin-3-yl]ethanone (GSK2833282A) | PDB:4IR3 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [4] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1FK or .1FK2 or .1FK3 or :31FK;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[(1-aminocyclohexyl)methyl]-1-methyl-6-oxopyridine-3-carboxamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 1-methylpyridinone compound 3 | PDB:6FGT | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [20] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .D9T or .D9T2 or .D9T3 or :3D9T;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1939 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-methyl-6-oxidanylidene-~{N}-(2-pyrrolidin-1-ylethyl)pyridine-3-carboxamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 1-methylpyridinone compound 4 | PDB:6FGU | ||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [20] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .D9Q or .D9Q2 or .D9Q3 or :3D9Q;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1-[7-(Morpholin-4-Yl)-1-(Pyridin-2-Yl)indolizin-3-Yl]ethanone | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with 1-[7-(morpholin-4-yl)-1-(pyridin-2-yl)indolizin-3-yl]ethanone (GSK2834113A) | PDB:4IR4 | ||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [4] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IR4 or .IR42 or .IR43 or :3IR4;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1897 or .A:1898 or .A:1901 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-{4-[3-(1h-Imidazol-1-Yl)propyl]-5-Methyl-4h-1,2,4-Triazol-3-Yl}-1-Methyl-1h-Pyrazol-5-Amine | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with a triazolo ligand | PDB:3Q2F | ||||
| Method | X-ray diffraction | Resolution | 2.06 Å | Mutation | No | [21] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OAM or .OAM2 or .OAM3 or :3OAM;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-(2-aminoethyl)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 1-methylpyridinone compound 1 | PDB:6FH6 | ||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [20] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .D8Q or .D8Q2 or .D8Q3 or :3D8Q;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1939 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-Methyl-2-(Tetrahydro-2h-Pyran-4-Yloxy)benzamide | Ligand Info | |||||
| Structure Description | Crystal Structure of the bromodomain of human BAZ2B in complex with compound-1 N01197 | PDB:4NRB | ||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [17] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .2LX or .2LX2 or .2LX3 or :32LX;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-(4-Methoxyphenyl)sulfanyl-~{n}-(2-Methyl-5,6-Dihydro-4~{h}-Cyclopenta[c]pyrazol-3-Yl)ethanamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 1-methyl-cyclopentapyrazole compound 30 | PDB:5ORB | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [19] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JR6 or .JR62 or .JR63 or :3JR6;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-fluoro-N-{3-[(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)formamido]propyl}benzamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 1-methylpyridinone compound 2 | PDB:6FH7 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [20] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .EN2 or .EN22 or .EN23 or :3EN2;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1890 or .A:1891 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[(3s)-3-Hydroxy-3-Methoxypropyl]phenol | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B in complex with fragment-2 N09594 | PDB:4CUQ | ||||
| Method | X-ray diffraction | Resolution | 2.11 Å | Mutation | No | [22] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5K3 or .5K32 or .5K33 or :35K3;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Imidazole-4-methanol | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with fragment F39 | PDB:5DYU | ||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | No | [2] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MZ0 or .MZ02 or .MZ03 or :3MZ0;style chemicals stick;color identity;select .A:1882 or .A:1883 or .A:1884 or .A:1885 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950 or .A:1960; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-(1-Acetyl-1h-Indol-3-Yl)-N-(5-Hydroxy-2-Methylphenyl)acetamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH47 | PDB:5E73 | ||||
| Method | X-ray diffraction | Resolution | 1.71 Å | Mutation | No | [23] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .UO1 or .UO12 or .UO13 or :3UO1;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-(1-Acetyl-1h-Indol-3-Yl)-N-(5-Hydroxy-2-Methylphenyl)-3-(Trifluoromethyl)benzamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH50 | PDB:5E74 | ||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [23] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5KH or .5KH2 or .5KH3 or :35KH;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-Methyltrimethylacetamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with N-methyltrimethylacetamide | PDB:5E9M | ||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [2] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BAE or .BAE2 or .BAE3 or :3BAE;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[(1S)-1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)ethyl]-2-methylpyridin-3-amine | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 5 | PDB:5L8U | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [24] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6RS or .6RS2 or .6RS3 or :36RS;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[(3R)-1,1-dioxothian-3-yl]-2-methylpyridin-3-amine | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 2 | PDB:5L8T | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [24] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6RR or .6RR2 or .6RR3 or :36RR;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1892 or .A:1893 or .A:1894 or .A:1897 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 1H-Indazol-6-amine | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with fragment F103 | PDB:5E9L | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6AI or .6AI2 or .6AI3 or :36AI;style chemicals stick;color identity;select .A:1893 or .A:1898 or .A:1901 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: methyl 4-propionyl-1H-pyrrole-2-carboxylate | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 4-propionyl-pyrrole derivative 2 | PDB:5MGF | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [25] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7MW or .7MW2 or .7MW3 or :37MW;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Ethyl 4-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate | Ligand Info | |||||
| Structure Description | Crystal structure of BAZ2B bromodomain in complex with 1-methylpyridine derivative 1 | PDB:5MGE | ||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [25] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7MX or .7MX2 or .7MX3 or :37MX;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 6-Hydroxyindole | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with fragment F60 | PDB:5E9I | ||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [2] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .F60 or .F602 or .F603 or :3F60;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1905 or .A:1936 or .A:1939 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-Methyl-~{n}-[(1~{s})-1-Thieno[3,2-B]pyridin-6-Ylethyl]pyridin-3-Amine | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 6 | PDB:5L99 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [24] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6S0 or .6S02 or .6S03 or :36S0;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-Methyl-~{n}-[(2~{s})-2-Methylsulfonylcyclopentyl]pyridin-3-Amine | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 3 | PDB:5L97 | ||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [24] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6RW or .6RW2 or .6RW3 or :36RW;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1898 or .A:1901 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-Chloro-1H-imidazole | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with fragment F275 | PDB:5E9K | ||||
| Method | X-ray diffraction | Resolution | 2.07 Å | Mutation | No | [2] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5KX or .5KX2 or .5KX3 or :35KX;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-Chloro-N-methylpicolinamide | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 4-chloropyridine derivative 3 | PDB:5MGG | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [25] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7MU or .7MU2 or .7MU3 or :37MU;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-Methyl-~{n}-[(2~{r})-1-Methylsulfonylpropan-2-Yl]pyridin-3-Amine | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 1 | PDB:5L96 | ||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | No | [24] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6RZ or .6RZ2 or .6RZ3 or :36RZ;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1892 or .A:1893 or .A:1894 or .A:1897 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[(1S)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]-2-methylpyridin-3-amine | Ligand Info | |||||
| Structure Description | Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 4 | PDB:5L98 | ||||
| Method | X-ray diffraction | Resolution | 2.26 Å | Mutation | No | [24] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFKV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6RY or .6RY2 or .6RY3 or :36RY;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-(2-Phenylethyl)acetamide | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with N-Acetyl-2-phenylethylamine (SGC - Diamond I04-1 fragment screening) | PDB:5CUC | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [26] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .54W or .54W2 or .54W3 or :354W;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N,N-dimethylquinoxaline-6-carboxamide | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with N,N-dimethylquinoxaline-6-carboxamide (SGC - Diamond I04-1 fragment screening) | PDB:5CQ7 | ||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | No | [27] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .53G or .53G2 or .53G3 or :353G;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-Amino-6-chlorobenzothiazole | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 2-Amino-6-chlorobenzothiazole (SGC - Diamond I04-1 fragment screening) | PDB:5CU8 | ||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [28] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .54T or .54T2 or .54T3 or :354T;style chemicals stick;color identity;select .A:1887 or .A:1888 or .A:1889 or .A:1891 or .A:1892 or .A:1893 or .A:1894 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 5-chloro-N,1-dimethyl-1H-pyrazole-4-carboxamide | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with AGN-PC-04G0SS (SGC - Diamond I04-1 fragment screening) | PDB:5CUE | ||||
| Method | X-ray diffraction | Resolution | 2.08 Å | Mutation | No | [29] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .54Y or .54Y2 or .54Y3 or :354Y;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate | Ligand Info | |||||
| Structure Description | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 314268-40-1 (SGC - Diamond I04-1 fragment screening) | PDB:5CUB | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [30] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .54V or .54V2 or .54V3 or :354V;style chemicals stick;color identity;select .A:1888 or .A:1889 or .A:1893 or .A:1898 or .A:1901 or .A:1940 or .A:1943 or .A:1944 or .A:1950; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-amino-N-(1,3-thiazol-2-yl)acetamide | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B PHD zinc finger in complex with Fr 21 | PDB:6FHQ | ||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [31] |
| PDB Sequence |
HMSIMKVYCQ
1935 ICRKGDNEEL1945 LLLCDGCDKG1955 CHTYCHRPKI1965 TTIPDGDWFC1975 PACIAKAS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DE5 or .DE52 or .DE53 or :3DE5;style chemicals stick;color identity;select .A:1943 or .A:1944 or .A:1945 or .A:1946 or .A:1947 or .A:1948 or .A:1949 or .A:1950 or .A:1968 or .A:1969 or .A:1971 or .A:1972 or .A:1973; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-amino-N-(4-aminophenyl)acetamide | Ligand Info | |||||
| Structure Description | Crystal structure of human BAZ2B PHD zinc finger in complex with Fr23 | PDB:6FI1 | ||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [31] |
| PDB Sequence |
MSIMKVYCQI
1936 CRKGDNEELL1946 LLCDGCDKGC1956 HTYCHRPKIT1966 TIPDGDWFCP1976 ACIAKAS |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .D3H or .D3H2 or .D3H3 or :3D3H;style chemicals stick;color identity;select .A:1943 or .A:1944 or .A:1945 or .A:1946 or .A:1947 or .A:1948 or .A:1949 or .A:1950 or .A:1968 or .A:1969 or .A:1971 or .A:1972 or .A:1973; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal Structure of Human Baz2B in Complex with Fragment-5 N09428 | ||||
| REF 2 | High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography. ACS Chem Biol. 2016 Mar 18;11(3):800-7. | ||||
| REF 3 | Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. | ||||
| REF 4 | Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2016 Feb 25;59(4):1410-24. | ||||
| REF 5 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun. 2017 Apr 24;8:15123. | ||||
| REF 6 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 4'-Hydroxyacetophenone (SGC - Diamond I04-1 fragment screening) | ||||
| REF 7 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 6-CHLOROPURINE (SGC - Diamond I04-1 fragment screening) | ||||
| REF 8 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 3'-Hydroxyacetophenone (SGC - Diamond I04-1 fragment screening) | ||||
| REF 9 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 4-Acetamidobenzoic acid (SGC - Diamond I04-1 fragment screening) | ||||
| REF 10 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 1-Acetyl-4-(4-hydroxyphenyl)piperazine (SGC - Diamond I04-1 fragment screening) | ||||
| REF 11 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 6-Hydroxypicolinic acid (SGC - Diamond I04-1 fragment screening) | ||||
| REF 12 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 2,3-Ethylenedioxybenzoic Acid (SGC - Diamond I04-1 fragment screening) | ||||
| REF 13 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 2,6-Pyridinedicarboxylic acid (SGC - Diamond I04-1 fragment screening) | ||||
| REF 14 | Crystal Structure of Human Baz2B in Complex with Fragment-4 N09496 | ||||
| REF 15 | Crystal Structure of Human Baz2B in Complex with Fragment-6 N09645 | ||||
| REF 16 | Crystal Structure of Human Baz2B in Complex with Fragment-3 N09553 | ||||
| REF 17 | Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J Med Chem. 2013 Dec 27;56(24):10183-7. | ||||
| REF 18 | Crystal Structure of Human Baz2B in Complex with Fragment-1 N09421 | ||||
| REF 19 | Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking. J Chem Inf Model. 2017 Oct 23;57(10):2584-2597. | ||||
| REF 20 | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains. ChemMedChem. 2018 Jul 18;13(14):1479-1487. | ||||
| REF 21 | Crystal Structure of the bromodomain of human BAZ2B in complex with a triazolo ligand | ||||
| REF 22 | Crystal Structure of Human Baz2B in Complex with Fragment-2 N09594 | ||||
| REF 23 | The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains. J Med Chem. 2016 Apr 14;59(7):3087-97. | ||||
| REF 24 | Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation. J Med Chem. 2016 Nov 10;59(21):9919-9927. | ||||
| REF 25 | Discovery of BAZ2A bromodomain ligands. Eur J Med Chem. 2017 Oct 20;139:564-572. | ||||
| REF 26 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with N-Acetyl-2-phenylethylamine (SGC - Diamond I04-1 fragment screening) | ||||
| REF 27 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with N,N-dimethylquinoxaline-6-carboxamide (SGC - Diamond I04-1 fragment screening) | ||||
| REF 28 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 2-Amino-6-chlorobenzothiazole (SGC - Diamond I04-1 fragment screening) | ||||
| REF 29 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with AGN-PC-04G0SS (SGC - Diamond I04-1 fragment screening) | ||||
| REF 30 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 314268-40-1 (SGC - Diamond I04-1 fragment screening) | ||||
| REF 31 | Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach. ACS Chem Biol. 2018 Apr 20;13(4):915-921. | ||||
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